Abstract:
:Discovered roughly 10 yr ago, Jak2 tyrosine kinase has emerged as a critical molecule in mammalian development, physiology, and disease. Here, we review the early history of Jak2 and its role in health and disease. We will also review its critical role in mediating cytokine-dependent signal transduction. Additionally, more recent work demonstrating the importance of Jak2 in G protein-coupled receptor and tyrosine kinase growth factor receptor signal transduction will be discussed. The cellular and biochemical mechanisms by which Jak2 tyrosine kinase is activated and regulated within the cell also will be reviewed. Finally, structure-function and pharmacological-based studies that identified structural motifs and amino acids within Jak2 that are critical for its function will be examined. By reviewing the biology of Jak2 tyrosine kinase at the molecular, cellular, and physiological levels, we hope to advance the understanding of how a single gene can have such a profound impact on development, physiology, and disease.
journal_name
Cell Biochem Biophysjournal_title
Cell biochemistry and biophysicsauthors
Sandberg EM,Wallace TA,Godeny MD,VonDerLinden D,Sayeski PPdoi
10.1385/cbb:41:2:207subject
Has Abstractpub_date
2004-01-01 00:00:00pages
207-32issue
2eissn
1085-9195issn
1559-0283pii
CBB:41:2:207journal_volume
41pub_type
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