Abstract:
:Depression is a common emotional disorder associated with increased risk of suicide and rate of disability. In this double-blinded control study, we tested the efficacy of modified electroconvulsive therapy (MECT) in patients with treatment resistant depression (TRD) using the Hamilton Depression Rating Scale for Depression (HAMD). The total scores of HAMD were found to be significantly decreased after the treatment. The genotyping of catechol-O-methyltransferase (COMT) was carried out with polymerase chain reaction-based testing. Our results demonstrated that frequency of mutant COMT alleles in TRD patients was significantly higher than that of the controls indicating a correlation of the enzyme genotype to the occurrence of TRD. Moreover, the patients homozygous for wild-type COMT gene (G/G) were evidenced to be more sensitive to MECT treatment than those with an heterozygous mutant genotype (A/G).
journal_name
Cell Biochem Biophysjournal_title
Cell biochemistry and biophysicsauthors
Lin Z,He H,Zhang C,Wang Z,Jiang M,Li Q,Lan X,Zhang M,Huang Xdoi
10.1007/s12013-014-0361-2subject
Has Abstractpub_date
2015-04-01 00:00:00pages
1387-93issue
3eissn
1085-9195issn
1559-0283pii
10.1007/s12013-014-0361-2journal_volume
71pub_type
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