Influence of Val108/158Met COMT Gene Polymorphism on the Efficacy of Modified Electroconvulsive Therapy in Patients with Treatment Resistant Depression.

Abstract:

:Depression is a common emotional disorder associated with increased risk of suicide and rate of disability. In this double-blinded control study, we tested the efficacy of modified electroconvulsive therapy (MECT) in patients with treatment resistant depression (TRD) using the Hamilton Depression Rating Scale for Depression (HAMD). The total scores of HAMD were found to be significantly decreased after the treatment. The genotyping of catechol-O-methyltransferase (COMT) was carried out with polymerase chain reaction-based testing. Our results demonstrated that frequency of mutant COMT alleles in TRD patients was significantly higher than that of the controls indicating a correlation of the enzyme genotype to the occurrence of TRD. Moreover, the patients homozygous for wild-type COMT gene (G/G) were evidenced to be more sensitive to MECT treatment than those with an heterozygous mutant genotype (A/G).

journal_name

Cell Biochem Biophys

authors

Lin Z,He H,Zhang C,Wang Z,Jiang M,Li Q,Lan X,Zhang M,Huang X

doi

10.1007/s12013-014-0361-2

subject

Has Abstract

pub_date

2015-04-01 00:00:00

pages

1387-93

issue

3

eissn

1085-9195

issn

1559-0283

pii

10.1007/s12013-014-0361-2

journal_volume

71

pub_type

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