Arsenic Trioxide and Icariin Show Synergistic Anti-leukemic Activity.

abstract：:Surfactin, purified from Bacillus subtilis natto TK-1, inhibited proliferation of human breast cancer MCF-7 cells in a dose- and time-dependent manner, with IC(50) at 24, 48, and 72 h of 82.6, 27.3, and 14.8 microM, respectively. Surfactin-induced cell death was considered to be apoptotic by observing the typical apop...

journal_title：Cell biochemistry and biophysics

authors： Cao X,Wang AH,Jiao RZ,Wang CL,Mao DZ,Yan L,Zeng B

更新日期：2009-01-01 00:00:00

abstract：:The peritoneal mesothelium acts as a regulator of serosal responses to injury, infection, and neoplastic diseases. After inflammation of the serosal surfaces, proinflammatory cytokines induce an "activated" mesothelial cell phenotype, the mitochondrial aspect of which has not previously been studied. After incubation ...

journal_title：Cell biochemistry and biophysics

authors： Stadlmann S,Renner K,Pollheimer J,Moser PL,Zeimet AG,Offner FA,Gnaiger E

更新日期：2006-01-01 00:00:00

abstract：:The n-alkane-assimilating diploid yeast, Candida tropicalis, possesses two acetoacetyl-CoA thiolase (Thiolase I) isozymes encoded by one allele: peroxisomal and cytosolic Thiolase Is encoded by both CT-T1A and CT-T1B. To clarify the function of peroxisomal and cytosolic Thiolase Is, the site-directed mutation leading ...

journal_title：Cell biochemistry and biophysics

authors： Ueda M,Kanayama N,Tanaka A

更新日期：2000-01-01 00:00:00

abstract：:There are over 10,000 C2H2-type zinc finger (ZF) domains distributed among more than 1,000 ZF proteins in the human genome. These domains are frequently observed to be involved in sequence-specific DNA binding, and uncharacterized domains are typically assumed to facilitate DNA interactions. However, some ZFs also fac...

journal_title：Cell biochemistry and biophysics

authors： Brayer KJ,Kulshreshtha S,Segal DJ

更新日期：2008-01-01 00:00:00

abstract：:Curcumin is a yellow-orange dye widely used as a spice, food coloring and food preservative. It also exhibits a broad range of therapeutic effects against different disorders such as cancer, diabetes, or neurodegenerative diseases. As a compound insoluble in water curcumin accumulates in cell membranes and due to this...

journal_title：Cell biochemistry and biophysics

authors： Duda M,Cygan K,Wisniewska-Becker A

更新日期：2020-06-01 00:00:00

abstract：:Reactive oxygen species (ROS) are involved in a variety of biological phenomena, such as mutation, carcinogenesis, inflammation, aging, development, and signal transduction. Intracellular generation of ROS might lead to the activation of redox signaling or oxidative stress. Nonetheless, it is difficult to estimate whe...

journal_title：Cell biochemistry and biophysics

authors： Martinovich GG,Martinovich IV,Cherenkevich SN,Sauer H

更新日期：2010-11-01 00:00:00

abstract：:The mechanism of induction of cardiomyocyte (CM) dedifferentiation, as seen in chronic hibernating myocardium, is largely unknown. Recently, a cellular model was proposed consisting of long-term cocultures of adult rabbit CMs and cardiac fibroblasts in which typical structural characteristics of hibernation-like dedif...

journal_title：Cell biochemistry and biophysics

authors： Driesen RB,Verheyen FK,Dispersyn GD,Thoné F,Lenders MH,Ramaekers FC,Borgers M

更新日期：2006-01-01 00:00:00

abstract：:To explore therapeutic effects and underlying mechanism of Salubrinal combined with Ulinastatin (UTI) on acute Paraquat (PQ) poisoning. Four hundred rats were randomly allocated into UTI group, SAL group, SAL + UTI and control group according to random number table with 100 rats in each group. Acute PQ poisoning model...

journal_title：Cell biochemistry and biophysics

authors： Guo H,Jiang C,Sun X

更新日期：2014-12-01 00:00:00

abstract：:Non-esterified fatty acids (NEFAs) act as signaling molecules involved in regulating genes expression to modulate lipid metabolism. However, the regulation mechanism of NEFAs on lipid metabolism in dairy cows is unclear. The AMP-activated protein kinase (AMPK) signaling pathway plays a key role in regulating hepatic l...

journal_title：Cell biochemistry and biophysics

authors： Li X,Li X,Chen H,Lei L,Liu J,Guan Y,Liu Z,Zhang L,Yang W,Zhao C,Fu S,Li P,Liu G,Wang Z

更新日期：2013-01-01 00:00:00

abstract：:A new intraoperative cisplatin administration method for patients with locally advanced gastric cancer (AGC) and without peritoneal metastasis, fibrin-sealant-delivered cisplatin chemotherapy, was reported, and its safety, pharmacokinetics, and efficacy were compared with cisplatin hyperthermic intraperitoneal perfusi...

journal_title：Cell biochemistry and biophysics

authors： Huang O,Lu X,Xu X,Shi Y

更新日期：2015-03-01 00:00:00

abstract：:Cellular responses to external signals often reflect alterations in gene expression. The activation of cell surface hormone or growth factor receptors upon the binding of appropriate ligands mobilizes signal transduction cascades that can ultimately impact the activity of defined sets of transcription factors. The int...

journal_title：Cell biochemistry and biophysics

authors： DeFranco DB

更新日期：1999-01-01 00:00:00

abstract：:We investigated theoretically and experimentally the Ca2+-contraction coupling in rat tracheal smooth muscle. [Ca2+]i, isometric contraction and myosin light chain (MLC) phosphorylation were measured in response to 1 mM carbachol. Theoretical modeling consisted in coupling a model of Ca2+-dependent MLC kinase (MLCK) a...

journal_title：Cell biochemistry and biophysics

authors： Mbikou P,Fajmut A,Brumen M,Roux E

更新日期：2006-01-01 00:00:00

abstract：:Many macrophage functions are modulated by fatty acids (FAs), including cytokine release, such as tumor necrosis factor-α (TNF-α). TNF-α is of great interest due to its role in the inflammation process observed in several diseases such as rheumatoid arthritis, atherosclerosis, and obesity. However, the mechanisms by w...

journal_title：Cell biochemistry and biophysics

authors： de Lima-Salgado TM,Alba-Loureiro TC,do Nascimento CS,Nunes MT,Curi R

更新日期：2011-03-01 00:00:00

abstract：:Red blood cell (RBC) adhesion to vessel wall endothelium is a potent catalyst of vascular occlusion and occurs in oxidative stress states such as hemoglobinopathies and cardiovascular conditions. These are often treated with vitamin E (VitE), a "classic" antioxidant. In this study, we examined the effects of VitE on R...

journal_title：Cell biochemistry and biophysics

authors： Koshkaryev A,Barshtein G,Yedgar S

更新日期：2010-04-01 00:00:00

abstract：:We have examined the association of insulin receptors (IR) and downstream signaling molecules with membrane microdomains in rat basophilic leukemia (RBL-2H3) cells following treatment with insulin or tris(2-pyridinecarbxylato)chromium(III) (Cr(pic)(3)). Single-particle tracking demonstrated that individual IR on these...

journal_title：Cell biochemistry and biophysics

authors： Al-Qatati A,Winter PW,Wolf-Ringwall AL,Chatterjee PB,Van Orden AK,Crans DC,Roess DA,Barisas BG

更新日期：2012-04-01 00:00:00

abstract：:The elimination of viral covalently closed circular DNA (cccDNA) from the nucleus of infected hepatocytes is an obstacle to achieving sustained viral clearance during antiviral therapy of chronic hepatitis B virus (HBV) infection. The aim of our study was to determine whether treatment with siRNA is able to suppress v...

journal_title：Cell biochemistry and biophysics

authors： Li G,Jiang G,Lu J,Chen S,Cui L,Jiao J,Wang Y

更新日期：2014-07-01 00:00:00

abstract：:Insulin increases glucose uptake and metabolism in skeletal muscle by signal transduction via protein phosphorylation cascades. Insulin action on signal transduction is impaired in skeletal muscle from Type 2 diabetic subjects, underscoring the contribution of molecular defects to the insulin resistant phenotype. This...

journal_title：Cell biochemistry and biophysics

authors： Karlsson HK,Zierath JR

更新日期：2007-01-01 00:00:00

abstract：:The simultaneous determination of adhesion and deformability parameters of erythrocytes was carried out through a microfluidic device, which uses an inverted optical microscope with new image acquisition and analysis technologies. Also, an update of the models describing erythrocyte adhesion and deformation was propos...

journal_title：Cell biochemistry and biophysics

authors： Londero CM,Riquelme BD

更新日期：2020-11-07 00:00:00

abstract：:Azurin, a small blue copper protein from the bacterial species Pseudomonas aeruginosa, is mostly a beta-sheet protein arranged into a single domain. Previous folding studies have shown that the equilibrium denaturation of the holoprotein follows a two-state process; however, upon removal of the copper, the denaturatio...

journal_title：Cell biochemistry and biophysics

authors： Hansen JE,McBrayer MK,Robbins M,Suh Y

更新日期：2002-01-01 00:00:00

abstract：:Either the role of the adaptive immune system or the interaction between innate and adaptive immune systems in familial Mediterranean fever (FMF) is not clear so far. So, we planned to search for the interaction between the innate and adaptive immune systems in the pathogenesis of FMF by investigating polymorphism for...

journal_title：Cell biochemistry and biophysics

authors： Gunesacar R,Erken E,Dinkci S

更新日期：2013-03-01 00:00:00

abstract：:In this study, the anti-proliferative effect of physcion, an anthraquinone derivative isolated and characterized from both terrestrial and marine sources, against human gastric cancer SGC-7901 cells was investigated and the underlying mechanisms were explored. Physcion reduced SGC-7901 cell viability in a dose- and ti...

journal_title：Cell biochemistry and biophysics

authors： Xiong Y,Ren L,Wang Z,Hu Z,Zhou Y

更新日期：2015-11-01 00:00:00

abstract：:Skin fibrosis is one of the major features of scleroderma. WNT/β-catenin signaling is associated with the progression of skin fibrosis. In this study, we aimed to determine the effect of icaritin (IT), a natural compound, on scleroderma-related skin fibrosis and its mechanisms. We found that IT could reduce the expres...

journal_title：Cell biochemistry and biophysics

authors： Li M,Liu Q,He S,Kong X,Lin J,Huang Y,Wu W,Wu J

更新日期：2020-10-30 00:00:00

abstract：:Intensive treatment for newborns with trisomy 13 is controversial because of their lethal prognosis. We report the better life prognosis of patients with trisomy 13 who received intensive treatment. At our hospital, we provided an intensive management to such patients including resuscitation and surgical procedures as...

journal_title：Cell biochemistry and biophysics

authors： Tsukada K,Imataka G,Suzumura H,Arisaka O

更新日期：2012-07-01 00:00:00

abstract：:The three-dimensional structure of the saccharopine reductase enzyme from the budding yeast Saccharomyces cerevisiae was determined to 1.7-A resolution in the apo form by using molecular replacement. The enzyme monomer consists of three domains: domain I is a variant of the Rossmann fold, domain II folds into a alpha/...

journal_title：Cell biochemistry and biophysics

authors： Andi B,Cook PF,West AH

更新日期：2006-01-01 00:00:00

abstract：:MicroRNAs (miRs) play important roles in initiation and progression of many pathologic processes. However, the roles of miRs in diabetic nephropathy remain unclear. This study was to determine whether miR-21 was involved in diabetic nephropathy and to explore the relationship between miR-21 and MMP9/TIMP1 expression i...

journal_title：Cell biochemistry and biophysics

authors： Wang J,Gao Y,Ma M,Li M,Zou D,Yang J,Zhu Z,Zhao X

更新日期：2013-11-01 00:00:00

abstract：:Myocardium viability in ischemic heart failure (HF) may affect the effect of cardiac resynchronization therapy (CRT). We hypothesized that longitudinal strain of 2D-STE, which reflects myocardium viability, can predict the response to CRT in patients with ischemic HF. 2D-STE was performed in 42 patients with HF, 1 wee...

journal_title：Cell biochemistry and biophysics

authors： Ma CY,Liu S,Yang J,Tang L,Zhang LM,Li N,Yu B

更新日期：2014-09-01 00:00:00

abstract：:We study the suitable depth for epidural puncture in primiparas so as to decrease epidural complications and provide anesthesiologists with an appropriate insertion guide. A prospective study of 87 primipara patients receiving labor analgesia who had epidural punctures in the course of vaginal delivery were randomly d...

journal_title：Cell biochemistry and biophysics

authors： Luo Y,Zhang D,Zheng J,Yang Q,An X,Chen Y,Yu D,Yang Z

更新日期：2015-03-01 00:00:00

abstract：:Chloride intracellular channel 1 (CLIC1) is a sensor of oxidative stress in endothelial cells (EC). However, the mechanism by which CLIC1 mediate the regulation of endothelial dysfunction has not been established. In this study, overexpressed CLIC1 impaired the ability of the vascular cells to resist oxidative damage ...

journal_title：Cell biochemistry and biophysics

authors： Lu D,Le Y,Ding J,Dou X,Mao W,Zhu J

更新日期：2021-01-11 00:00:00

abstract：:A method is presented to separate rabbit cardiac ventricular myosin isoenzymes (V(1), V(2), V(3)), which are large and important contractile proteins. This polyacrylamide gel electrophoresis--using a slab minigel format--does not involve preparation of an acrylamide gradient or denaturing conditions. The isoenzyme mig...

journal_title：Cell biochemistry and biophysics

authors： Garcia Pomblum SC,Pomblum VJ,Gams E,Reiser PJ,Schipke JD

更新日期：2003-01-01 00:00:00

abstract：:The phosphatidylinositol 3-kinase/AKT (PI3K/AKT) pathway plays a critical role in human cancer. We determined the expression patterns of class I PI3K catalytic subunits and evaluated their importance in the development or progression of colorectal cancer (CRC). For this purpose, expression of class I PI3K isoforms was...

journal_title：Cell biochemistry and biophysics

authors： Cui B,Tao J,Yang Y

更新日期：2012-01-01 00:00:00