Inhibitory properties of a bovine pineal tripeptide, threonylseryllysine, on serum follicle-stimulating hormone.

Abstract:

:Administration of the bovine pineal peptide threonylseryllysine (TSL) to unilaterally ovariectomized (UO) mice as a single intraperitoneal injection on the day of UO reduced the 5-day compensatory ovarian hypertrophy. The same dose of TSL (175 ng/animal) significantly (p less than 0.01) reduced serum follicle stimulating hormone (FSH) in UO mice 24 h after surgery and administration of the peptide. In other experiments, adult male rats were anesthetized with urethane and given an intravenous injection of luteinizing hormone releasing hormone (LRH) followed by TSL in doses ranging from 1.5 to 1,500 ng/animal. TSL significantly delayed (p less than 0.05) the 15- and 30-min surge of serum FSH observed in control animals after 120 or 180 min in 3 of the 4 doses used (1.5, 15 and 1,500 ng/animal). In the animals receiving 150 ng TSL the LRH-induced FSH surge was delayed (p less than 0.05) until 30 min. The results indicate that the pineal tripeptide may inhibit or modify FSH secretion in the mouse and rat.

journal_name

Neuroendocrinology

journal_title

Neuroendocrinology

authors

Orts RJ,Bruot BC,Sartin JL

doi

10.1159/000123056

subject

Has Abstract

pub_date

1980-08-01 00:00:00

pages

92-5

issue

2

eissn

0028-3835

issn

1423-0194

journal_volume

31

pub_type

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