Hexamethylmelamine and melphalan as salvage therapy in advanced ovarian carcinoma.

Abstract:

:Ten patients with advanced ovarian carcinoma were treated with hexamethylmelamine and melphalan after failing first-line combination chemotherapy. In eight patients residual disease was evident only at second-look laparotomy. Surgical debulking was accomplished in four patients but only two patients had residual disease of less than 2 cm. Two of these four patients are alive without evidence of disease to 20 and 24 months. The remaining patients have expired (median survival 6 months). The combination of hexamethylmelamine and melphalan after surgical debulking at second-look operation may improve the salvage of patients with advanced ovarian carcinoma.

journal_name

J Surg Oncol

authors

Tempero MA,Kessinger A

doi

10.1002/jso.2930210305

subject

Has Abstract

pub_date

1982-11-01 00:00:00

pages

159-61

issue

3

eissn

0022-4790

issn

1096-9098

journal_volume

21

pub_type

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