Abstract:
BACKGROUND AND OBJECTIVE:Tumor-associated macrophages (TAMs) are well known to have distinct roles in tumor progression and metastasis. However, the role of TAMs in chemoresistance has not been fully investigated. The aim of this study is to examine whether TAMs, especially M2 macrophages, are associated with the tumor response to chemotherapy with esophageal cancers. METHODS:Using 210 tissues from patients with esophageal cancer who underwent surgery, we calculated the number of intratumoral CD68(+) macrophages, CD163(+) macrophages, and CD8(+) lymphocytes using immunohistochemistry. CD68 and CD163 were used as markers for whole macrophages and M2 macrophages, respectively. RESULTS:Infiltration of CD68(+) macrophages and CD163(+) macrophages was significantly associated with tumor depth, lymphatic invasion, and venous invasion. High infiltration of CD68(+) macrophages and CD163(+) macrophages was significantly associated with poor prognosis for patients undergoing neoadjuvant chemotherapy. Regarding the response to chemotherapy, high infiltration of CD68(+) and CD163(+) macrophages had a significant association with poor response to chemotherapy, both clinically and pathologically (P < 0.001, P < 0.001). Multivariate analysis showed that infiltration of CD163(+) macrophages was an independent prognostic factor in patients undergoing neoadjuvant chemotherapy. CONCLUSIONS:Infiltration of TAMs, especially M2 macrophages, is associated with a poor response to chemotherapy and poor prognosis of patients with esophageal cancer.
journal_name
J Surg Oncoljournal_title
Journal of surgical oncologyauthors
Sugimura K,Miyata H,Tanaka K,Takahashi T,Kurokawa Y,Yamasaki M,Nakajima K,Takiguchi S,Mori M,Doki Ydoi
10.1002/jso.23881subject
Has Abstractpub_date
2015-05-01 00:00:00pages
752-9issue
6eissn
0022-4790issn
1096-9098journal_volume
111pub_type
杂志文章abstract::Wilms' tumor, renal cell carcinoma, and neuroblastoma in animals were transplanted from donors to recipients with strong histocompatibility differences. No strong evidence of the privileged site theory was found in this study and no obvious evidence of an immunosuppressive effect of testosterone was found. The most im...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930140111
更新日期:1980-01-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:When performed at select centers, minimally invasive gastrectomy (MIG) for gastric adenocarcinoma is associated with reduced perioperative morbidity, and similar oncologic outcomes as compared to open gastrectomy (OG). Utilization of, and outcomes associated with, MIG in the United States have...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.24052
更新日期:2015-11-01 00:00:00
abstract::Tumor-associated antigen(s) from a specimen of human malignant melanoma and from spent culture medium of a melanoma cell line were extracted and purified. The incidence of antibody activity to these antigens, in sera from cancer patients with neoplasms of various histologic types, was higher (65--83%) than normal dono...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930130112
更新日期:1980-01-01 00:00:00
abstract:OBJECTIVES:The objective of this study is to present two series of cases of pigmented villonodular disease of joints (PVNS) treated at different periods. The 215 cases from our hospital are current (1972-2009) and those 62 from the Jaffe collection from 1920 to 1968. METHODS:By use of our computerized tumor data syste...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.21835
更新日期:2011-04-01 00:00:00
abstract:BACKGROUND:Detection of tumor cells in lymph nodes (LNs) removed during the treatment of pulmonary tumor by radical surgery is limited by the possibilities of standard histopathological methods. The goal of this study was to obtain more accurate pTNM status by a more sensitive detection of micrometastases in LNs. METH...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.24826
更新日期:2018-02-01 00:00:00
abstract::Fifteen fetal thymuses and 100 thymomas were examined concerning the degree of differentiation of thymic epithelial cells by light and electron microscopy. The following results were obtained. The embryologic process of the fetal thymus was categorized into four stages (8, 12, 15, and 17 weeks or more of gestation) ba...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930310212
更新日期:1986-02-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:It is not clear whether sentinel lymph node biopsy (SLNB) can be applied to patients with a second breast cancer or recurrence occurring at previously treated breast. The purpose of this study was to assess the feasibility of SLNB procedure in patients with recurrent breast cancer. METHODS:Pa...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.24423
更新日期:2016-12-01 00:00:00
abstract::Intraperitoneal (IP) cisplatin administered at the time of intraabdominal malignancies such as gastric cancer may prevent or delay intraabdominal recurrence. Perioperative IP cisplatin raises concerns regarding systemic toxicity and retardation of wound healing. Systemic cisplatin toxicity may be reduced by administer...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930520415
更新日期:1993-04-01 00:00:00
abstract::This article describes the Danish National Indicator Project that aims to document and improve the quality of care at national level. Specific clinical indicators, standards, and prognostic factors have been developed for eight diseases (e.g. lung cancer). It has been implemented in all clinical departments in Denmark...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.21192
更新日期:2009-06-15 00:00:00
abstract::We reviewed the literature concerning the effect of extended lymph node dissection on survival in patients with gastrointestinal cancer. Most retrospective and/or prospective nonrandomized comparative studies have claimed that extended lymph node dissection significantly improves survival rate in patients with esophag...
journal_title:Journal of surgical oncology
pub_type: 杂志文章,评审
doi:10.1002/(sici)1096-9098(199705)65:1<57::aid-jso12>
更新日期:1997-05-01 00:00:00
abstract::The use of plasma albumin (ALB), transferrin (TFN), prealbumin (TBPA), retinol-binding protein (RBP), triceps skin fold (TSF), and midarm muscle circumference (MAMC) as determinants of response to nutritional therapy (TPN) was investigated in 40 cancer patients during preoperative TPN. Thirty-one patients received 90%...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930290306
更新日期:1985-07-01 00:00:00
abstract::Australia has the world's highest incidence of skin cancer. Despite excellent prevention and early diagnosis education programs and an increasing percentage of the population with darker and more UV tolerant skins, skin cancer remains a major and expensive community medical problem. However, primary and secondary prev...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.20086
更新日期:2004-07-01 00:00:00
abstract::Among women who have undergone surgery for breast cancer, the risk of recurrence, especially distant metastases, peaks 1-2 years postsurgery. Recent clinical trial evidence suggests that initial adjuvant therapy with an aromatase inhibitor (AI) can reduce this early risk of recurrence. According to the recently update...
journal_title:Journal of surgical oncology
pub_type: 杂志文章,评审
doi:10.1002/jso.21801
更新日期:2011-06-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Some schwannomas in the central nervous system may demonstrate relatively aggressive behavior in pathological findings and clinical course. We evaluate the diagnostic values of telomerase activity and telomere length in the clinicopathological behavior of schwannomas. METHODS:Thirty surgical ...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.10139
更新日期:2002-10-01 00:00:00
abstract::In the twentieth century, lymph node dissection based on metastatic distribution has developed as the standard procedure for surgical management of gastrointestinal cancer [1]. The fear that invisible micrometastases might be present has encouraged aggressive resection with lymphadenectomy to control the disease. Howe...
journal_title:Journal of surgical oncology
pub_type: 杂志文章,评审
doi:10.1002/jso.10065
更新日期:2002-03-01 00:00:00
abstract:BACKGROUND:This study evaluates several tumor-related markers to examine the expression pattern of markers according to the invasiveness and histopathologic differentiation of squamous cell carcinoma and basal cell carcinoma. METHODS:Ninety-four cases of squamous cell carcinoma and 108 cases of basal cell carcinoma us...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.21006
更新日期:2008-06-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:The genetic alterations involved in extrahepatic bile duct (EHBD) cancer are poorly understood. Our aim was to identify aberrations of the K-ras, p53, and APC genes in EHBD cancer. METHODS:We investigated aberrations of these genes in 52 EHBD cancers using polymerase chain reaction (PCR) sing...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/(sici)1096-9098(200003)73:3<158::aid-jso9>
更新日期:2000-03-01 00:00:00
abstract::Diffuse malignant peritoneal mesothelioma (DMPM) is an uncommon and locally aggressive tumor with poor prognosis. Currently, no standard therapy is available. The biology of this disease is still poorly understood. We performed a systematic search of relevant studies on clinical management and biological research of D...
journal_title:Journal of surgical oncology
pub_type: 杂志文章,评审
doi:10.1002/jso.21787
更新日期:2011-06-01 00:00:00
abstract::There are a number of retroperitoneal pathologies that may be confused with adrenal tumors. It is important to suspect and recognize these conditions as their management and work up might be different than adrenal tumors. This review will go in to the differential diagnosis and unique features of these conditions. A m...
journal_title:Journal of surgical oncology
pub_type: 杂志文章,评审
doi:10.1002/jso.23133
更新日期:2012-10-01 00:00:00
abstract:BACKGROUND:Extrapleural pneumonectomy for malignant pleural mesothelioma is considered an aggressive procedure, but symptomatic and quality of life changes are unknown. METHODS:Between 1997 and 2004, 16 consecutive patients underwent extrapleural pneumonectomy for mesothelioma followed by chemo-radiotherapy. Tumor-rel...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.21261
更新日期:2009-09-01 00:00:00
abstract::Eccrine porocarcinoma, a malignancy of the eccrine sweat glands, is extremely rare. Our report and a review of the literature (70 cases) emphasize the features of this tumor. Age at time of treatment ranged from 19 to 94 years (mean 67 years). Duration of the lesion ranged from two months to 50 years; 31 (44%) had the...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930550413
更新日期:1994-04-01 00:00:00
abstract::The efficacy of killing small cell lung cancer (SCLC) cells at the G1, S, and G2-M phase of the cell-cycle by a new 111In-bleomycin complex (111In-BLMC) was investigated. SCLC cells (N417, H526, H209) were synchronized by double thymidine block and assessed by DNA content with flow cytometry, and the period for the ma...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930400203
更新日期:1989-02-01 00:00:00
abstract::From August 1979 to May 1986, various brachytherapy techniques were applied at Memorial Sloan Kettering Cancer Center (MSKCC) in an adjuvant setting with/without surgery and external radiation therapy in the management of advanced malignant melanoma. Thirty-three patients underwent brachytherapy procedures. The patien...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930430407
更新日期:1990-04-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Tumor angiogenesis is receiving increased attention as a prognostic factor and also as a possible target for new anticancer agents. We investigated whether extent of vascular endothelial growth factor (VEGF) mRNA expression correlated with degree of neovascularization, and whether this express...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/(sici)1096-9098(199712)66:4<257::aid-jso7>
更新日期:1997-12-01 00:00:00
abstract::Tumors attached or adjacent to critical structures can often not be completely resected or resected with adequate surgical margins. Sites involving major blood vessels, the paravertebral spaces, or critical abdominal structures often present technical difficulties for standard brachytherapy procedures using I-125 or I...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930420112
更新日期:1989-09-01 00:00:00
abstract::Intrahepatic cholangiocarcinoma (iCCA) is the second most common primary hepatic cancer in the United States. Currently, curative treatment involves aggressive surgery. Chemotherapy and radiation treatments have been used for unresectable tumors with some success. Optimizing the use of current and developing novel mul...
journal_title:Journal of surgical oncology
pub_type: 杂志文章,评审
doi:10.1002/jso.24093
更新日期:2016-01-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Variants of CD44 have been proposed to be important in promoting tumor progression and metastasis. We attempted to determine the expression of CD44v6 product in advanced gastric cancer and to evaluate its prognostic value. METHODS:The expression of CD44v6 was analyzed immunohistochemically in...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.10082
更新日期:2002-04-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:The most common cause of failure in large segment bone allografts used for oncologic reconstruction is allograft fracture. Reinforcement with pressurized intramedullary cement may improve the mechanical properties of allografts. METHODS:We reviewed the prospectively collected records of 45 pa...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.10316
更新日期:2003-12-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Recent studies have disclosed the presence of somatic mutations in the epidermal growth factor receptor (EGFR) gene in non-small cell lung cancers (NSCLC), and susceptibility to the EGFR tyrosine kinase inhibitor (gefitinib) was determined by the presence of mutations in the kinase domain of t...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.20426
更新日期:2006-01-01 00:00:00
abstract:OBJECTIVE:This study aimed to investigate the association between different metastatic sites and survival in endometrial cancer (EC) patients with International Federation of Gynecology and Obstetrics (FIGO) stage IVB disease. METHODS:FIGO stage IVB patients with EC were selected from the surveillance, epidemiology, a...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.26102
更新日期:2020-10-01 00:00:00