Abstract:
BACKGROUND AND OBJECTIVES:The most common cause of failure in large segment bone allografts used for oncologic reconstruction is allograft fracture. Reinforcement with pressurized intramedullary cement may improve the mechanical properties of allografts. METHODS:We reviewed the prospectively collected records of 45 patients who underwent en bloc resection of an extremity bone tumor and reconstruction using an allograft with intramedullary cement. RESULTS:Seven allografts were used for arthrodesis, 20 were intercalary, and 18 were osteochondral. Twenty eight of 45 patients were alive at a mean 5.8 years (SD 1.9; range 3-11.2) with 24 allografts in situ. In these 45 patients, there were four allograft fractures and four infections. Six of these complications resulted in allograft removal. The estimated 5-year allograft survival rate was 86% (95% confidence interval 74-98%). Seven patients required secondary autogenous bone grafting for non-unions. Function measured by the Toronto Extremity Salvage Score and the 1987 and 1993 Musculoskeletal Tumor Society Rating Scales demonstrated a consistent pattern with worse function in patients with osteochondral allografts and best function with intercalary allografts. CONCLUSIONS:These results suggest the addition of intramedullary cement to large segment bone allografts improves their survival by decreasing the fracture risk, particularly for allografts used for arthrodesis and intercalary reconstructions.
journal_name
J Surg Oncoljournal_title
Journal of surgical oncologyauthors
Gerrand CH,Griffin AM,Davis AM,Gross AE,Bell RS,Wunder JSdoi
10.1002/jso.10316subject
Has Abstractpub_date
2003-12-01 00:00:00pages
198-208issue
4eissn
0022-4790issn
1096-9098journal_volume
84pub_type
杂志文章abstract:BACKGROUND AND OBJECTIVES:Malignant cartilage tumors demonstrate chemotherapeutic resistance through undetermined mechanisms. P-glycoprotein is the protein product of the multiple drug resistance gene 1 (MDR-1) and confers multidrug chemotherapeutic resistance in a variety of malignancies. METHODS:MDR-1 expression was...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/(sici)1096-9098(199706)65:2<95::aid-jso5>3
更新日期:1997-06-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Development of second primary carcinomas after thoracic esophagectomy has become of much concern, because recently the prognosis of thoracic esophageal carcinoma after esophagectomy with extended lymph node dissection has been improving. We report our experience of diagnosing and treatment sec...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/(sici)1096-9098(199710)66:2<130::aid-jso11
更新日期:1997-10-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:The aggressiveness and greater malignant potential of cancers are characterized by several biological phenomena such as accelerated growth invasiveness, and the ability to form distant metastasis. Thus, knowledge of such biological difference may be a more accurate prognosticator for cancer pa...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.20309
更新日期:2005-12-15 00:00:00
abstract::We investigated the incidence of thyroid nodules in female uremic patients on maintenance hemodialysis using a high-frequency sonographic scanner. In 47 (21.0%) of the 224 female normal controls and 33 (55.0%) of the 60 female patients, thyroid nodules were detected. The difference in these incidences between controls...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930540405
更新日期:1993-12-01 00:00:00
abstract::A study was carried out to determine the interrelationship between the inhalation of nitrogen dioxide (0.4 +/- 0.50 ppm), lung metastases development from circulating cancer cells, and death rate from such metastases. C57 BL/6J mice were used in these experiments. Animals were divided into control and NO2-exposed grou...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930280115
更新日期:1985-01-01 00:00:00
abstract::While hepatic resection of metastatic colorectal carcinoma is accepted as effective in selected patients, resection of metastases to other solid organs has not gained wide acceptance. We retrospectively reviewed the records of 49 patients who had resection of isolated pulmonary (18 patients) and hepatic (31 patients) ...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930430303
更新日期:1990-03-01 00:00:00
abstract:PURPOSE:Little is known about long-term radiographic findings after treatment with accelerated partial breast irradiation (APBI). METHODS:Univariate and multivariate analysis of factors leading to formation and resolution of seroma were performed in patients treated with lumpectomy and APBI. RESULTS:Post-treatment im...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.24646
更新日期:2017-08-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Curative hepatic resection (CHR) was a modality that provides possibility of long-term survival for hepatocellular carcinoma (HCC). So far, prognostic factors of male patients with HCC after CHR remain unclear. Purposes of the present study were to identify these factors and to compare them wi...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.20678
更新日期:2007-03-15 00:00:00
abstract:OBJECTIVES:This study investigated late toxicity and infield progression-free survival in patients with locally recurrent rectal cancer (LRRC) who had previously received irradiation to the pelvis. METHODS:Twenty-two patients were treated by reirradiation to the pelvis between January 2000 and August 2007. All patient...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.23023
更新日期:2012-06-01 00:00:00
abstract::The clinical evidence suggests that the steroid hormones may influence the biologic course of tumors of soft tissue. In an attempt to characterize the possible steroid hormone dependency of soft tissue, we studied the incidence and distribution of cytosolic receptors for the steroid hormones in benign and malignant tu...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930280203
更新日期:1985-02-01 00:00:00
abstract:BACKGROUND:The presence of human papillomavirus (HPV)-specific antibodies in patients with head and neck cancer at enrollment has prognostic significance. In cervical carcinoma patients, the decrease of HPV E6/E7-specific antibodies appears to be associated with a better prognosis. METHODS:This prospective study with ...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.25473
更新日期:2019-08-01 00:00:00
abstract:OBJECTIVE:Significant controversy exists concerning the factors affecting survival after secondary cytoreduction (SCR) in recurrent ovarian cancer. This study aims to identify factors independently associated with survival after SCR. METHODS:We retrospectively retrieved 39 patients with recurrent ovarian cancer. All p...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.21686
更新日期:2010-11-01 00:00:00
abstract:BACKGROUND:The optimal treatment strategy for patients with esophageal adenocarcinoma (EAC) remains undetermined. This study compared outcomes in patients undergoing neoadjuvant chemotherapy (nCT) and neoadjuvant chemoradiotherapy (nCRT) for EAC. METHODS:Patients who underwent nCT or nCRT followed by surgery for EAC w...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.25089
更新日期:2018-06-01 00:00:00
abstract::We studied the effect of tumor size on monoclonal antibody (mAb) in a murine hepatic model. Intrasplenic injection of HT-29 LMM metastatic human colon cancer cell line reproducibility results in hepatic metastases formation in congenitally athymic mice. HT-29-15, a murine mAb of the IgG1 class reactive with the HT-29 ...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930490409
更新日期:1992-04-01 00:00:00
abstract:BACKGROUND:Surgical resection provides the only potentially curative treatment of pancreatic cancer. Neoadjuvant chemotherapy and/or radiation (NAT) is used to downstage patients with borderline resectable tumors. The objective of this study was to examine the postoperative morbidity and mortality of NAT after pancreat...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.25183
更新日期:2018-09-01 00:00:00
abstract:BACKGROUND:One of the reasons for the poor prognosis of pancreatic carcinoma is the difficulty of obtaining an early diagnosis of pancreatic carcinoma. One possibility is the application of radioimmunoscintigraphy using radiolabeled monoclonal antibodies (Mabs). METHODS:We labeled chimeric (human/mouse) Fab fragments ...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.10311
更新日期:2003-11-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:It is unclear if a specific strategy for simultaneous treatment of primary thymic neoplasms and pleural metastases confers benefit for Masaoka stage IVA disease. We reviewed our experience with thymic neoplasms with concurrent pleural metastases to identify factors influencing outcomes. METHO...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.25981
更新日期:2020-09-01 00:00:00
abstract::A comparative study of alpha-fetoprotein (AFP) and carcinoembryonic antigen (CEA) in serum was made by radioimmunoassay in 66 patients with pancreatobiliary disease with and without obstructive jaundice. biliary concentrations of these proteins were assayed in 12 patients with benign and 7 patients with malignant dise...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930190411
更新日期:1982-04-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Retinoids are metabolized in human intestinal epithelial cells to all-trans retinoic acid; however, it is unknown whether these cells express retinoid receptors, and whether sensitivity or resistance to the hormone is associated with a particular pattern of expression of retinoid-responsive ge...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/(sici)1096-9098(199711)66:3<156::aid-jso2>
更新日期:1997-11-01 00:00:00
abstract:AIM:To evaluate the efficacy of stereotactic body radiation therapy (SBRT) in small hepatocellular carcinoma (HCC) patients. METHODS:From March 2009 to April 2015, we treated 132 small HCC patients with SBRT. Eligibility criteria included longest tumor diameter ≤5.0 cm; Child-Turcotte-Pugh (CTP) Class A or B; unfeasib...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.24128
更新日期:2016-02-01 00:00:00
abstract::With the rapid uptake of the robotic approach in gynecologic surgery, a thorough understanding of the technology, including its uses and limitations, is critical to maximize patient outcomes and safety. This review discusses the role of training modalities and development of curricula for robotic surgery. Furthermore,...
journal_title:Journal of surgical oncology
pub_type: 杂志文章,评审
doi:10.1002/jso.24006
更新日期:2015-12-01 00:00:00
abstract:BACKGROUND:To evaluate the efficacy and toxicity of pre-operative radiotherapy (RT) combined with oral tegafur-uracil (UFUR) plus leucovorin (LV) in rectal cancer. PATIENTS:Sixty-five patients with rectal adenocarcinoma (clinical staged T2-4N0-2M0) received pelvic RT of 45 Gy in 20 fractions over 28 days. Concurrent c...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.20168
更新日期:2005-03-15 00:00:00
abstract:BACKGROUND:A tracheobronchial injury is an uncommon complication of an esophagectomy. Differences in outcomes may exist for patients with injuries detected intraoperatively and postoperatively. METHODS:A retrospective review was performed for patients who underwent an esophagectomy for cancer at Jackson Memorial Hospi...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.23577
更新日期:2014-06-01 00:00:00
abstract::Twenty-six patients with esophageal carcinoma at stage pT4 underwent esophagectomy with lymph node dissection leaving part of the tumor in adjacent organs. Several plastic catheters were fixed to the tumor bed and led to the outside of the thorax for postoperative brachytherapy. Using these catheters, the patients und...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/(SICI)1096-9098(199607)62:3<214::AID-JSO12
更新日期:1996-07-01 00:00:00
abstract::The history of a patient presenting with metachronous bilateral breast cancer displaying histiocytoid features is reviewed. Although regional metastases were noted, this patient has not demonstrated an aggressive systemic disease pattern. In the past, histiocytoid breast cancer has been classified as either a lipid-ri...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930310410
更新日期:1986-04-01 00:00:00
abstract::Between 1989 and 1991, 150 patients with ovarian cancer were treated with chemotherapy, including cisplatin, in the Tokai Ovarian Tumor Study Group. Of these patients, 25 underwent cytoreductive surgery with lymphadenectomy, including removal of either pelvic or para-aortic lymph nodes, and 36 underwent both lymphaden...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930600403
更新日期:1995-12-01 00:00:00
abstract:BACKGROUND:The aim of this study was to develop a prediction model for the presence and location of lymph node metastasis (LNM) in early gastric cancer. METHOD:We reviewed medical records of 4 929 patients who underwent radical gastrectomy for early gastric cancer. Variables of age, sex, lymphatic invasion, depth of i...
journal_title:Journal of surgical oncology
pub_type: 临床试验,杂志文章
doi:10.1002/jso.25628
更新日期:2019-09-01 00:00:00
abstract:BACKGROUND:Reconstruction after excision of the humeral malignancy is a challenging issue for the reconstructive surgeon. The combined use of a fibular flap and allograft can provide a reliable reconstructive option. This article describes the authors' experience with this technique for the treatment of segmental bone ...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.21922
更新日期:2011-09-01 00:00:00
abstract::High-quality data support multiple clinical benefits of integrating palliative care into routine oncology care. Though these data come largely from the medical oncology literature, data from surgical oncology populations support similar associations between palliative care integration and improved clinical outcomes, a...
journal_title:Journal of surgical oncology
pub_type: 杂志文章,评审
doi:10.1002/jso.25454
更新日期:2019-07-01 00:00:00
abstract:BACKGROUND:Positron emission tomography/computed tomography (PET/CT) scanning is commonly used for the preoperative staging of patients with at least intermediate thickness (>1 mm) melanomas. Its role in staging at initial diagnosis for clinically asymptomatic patients is not yet established. METHODS:We examined recor...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.23549
更新日期:2014-06-01 00:00:00