Abstract:
BACKGROUND:The aim of this study was to develop a prediction model for the presence and location of lymph node metastasis (LNM) in early gastric cancer. METHOD:We reviewed medical records of 4 929 patients who underwent radical gastrectomy for early gastric cancer. Variables of age, sex, lymphatic invasion, depth of invasion, location, gross type, differentiation, and tumor size were analyzed. Logistic regression analysis was used to determine independent predictors of LNM at each LN station. RESULT:Overall incidence of LNM was 9.1% (448/4 929 patients). For the presence of LNM, risk factors of age, sex, lymphatic invasion, depth of invasion, anatomical part, gross ulceration, size, and tumor differentiation were significantly associated with LNM. The area under the curve (AUC) for predicting LNM after validation was 0.834 for the test set. For the location of LNM, age, sex, lymphatic invasion, depth of invasion, anatomical part, circumferential portion, gross type, differentiation, and tumor size were significantly associated with LNM. The AUC of each LN station was favorable with the test set. CONCLUSION:Predicting the location of metastatic LNs appeared to be possible in patients with early gastric cancer.
journal_name
J Surg Oncoljournal_title
Journal of surgical oncologyauthors
Kim SM,Lee H,Min BH,Kim JJ,An JY,Choi MG,Bae JM,Kim S,Sohn TS,Lee JHdoi
10.1002/jso.25628subject
Has Abstractpub_date
2019-09-01 00:00:00pages
670-675issue
4eissn
0022-4790issn
1096-9098journal_volume
120pub_type
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