Outcomes and clinical predictors of improved survival in a patients undergoing pulmonary metastasectomy for sarcoma.

Abstract:

BACKGROUND:Pulmonary metastasectomy (PM) for metastatic sarcoma can result in long-term survival. The purpose of this study was to describe factors associated with survival in a series of patients undergoing PM for metastatic sarcoma. METHODS:We reviewed all patients undergoing PM for metastatic sarcoma over a 12-year period (2000-2012). Multivariate analyses were used to identify factors associated with outcomes. Survival was calculated with Kaplan-Meier and Cox proportional hazard models. RESULTS:A total of 120 patients underwent PM with a median follow-up was 48 months. Among 81 (85%) patients who presented with local disease, the median disease free interval (DFI) was 13 months and median overall survival (OS) was 48 months. Fourteen patients (15%) had synchronous metastasis with a median OS of 21 months. On multivariate analysis, synchronous metastasis (P = 0.005), older age (P = 0.02), and number of lung lesions (P = 0.003) were associated with poor survival. The median OS of patients with a DFI ≥12 versus <12 months following primary resection was 93 and 43 months (P = 0.004). CONCLUSION:While patients with a DFI >12 months have the best OS following PM, patients with a DFI <12 months also have excellent outcomes as compared to systemic therapy and should be considered for PM.

journal_name

J Surg Oncol

authors

Dossett LA,Toloza EM,Fontaine J,Robinson LA,Reed D,Druta M,Letson DG,Zager JS,Gonzalez RJ

doi

10.1002/jso.23961

subject

Has Abstract

pub_date

2015-07-01 00:00:00

pages

103-6

issue

1

eissn

0022-4790

issn

1096-9098

journal_volume

112

pub_type

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