The steroid hormone receptors in tumors of adipose tissue.

Abstract:

:The clinical evidence suggests that the steroid hormones may influence the biologic course of tumors of soft tissue. In an attempt to characterize the possible steroid hormone dependency of soft tissue, we studied the incidence and distribution of cytosolic receptors for the steroid hormones in benign and malignant tumors of adipose tissue origin. All specimens were assayed for the steroid hormone receptors by charcoal dextran technique and analyzed by the method of Scatchard. The results show a high incidence of cytosolic estrogen and glucocorticoid receptors in tumors of adipose tissue origin except in lipoma and well differentiated liposarcoma. The binding parameter of these receptors suggests that the receptors may be responsive to physiologic steroid hormonal milieu.

journal_name

J Surg Oncol

authors

Chaudhuri PK,Walker MJ,Beattie CW,Das Gupta TK

doi

10.1002/jso.2930280203

subject

Has Abstract

pub_date

1985-02-01 00:00:00

pages

87-9

issue

2

eissn

0022-4790

issn

1096-9098

journal_volume

28

pub_type

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