Intraperitoneal immunotherapy to prevent peritoneal carcinomatosis in patients with advanced gastrointestinal malignancies.

Abstract:

:Prognosis of peritoneal carcinomatosis (PC) from GI tract cancers remains poor. As 30% of patients develop PC after curative surgery, prevention of PC during cancer resection would be desirable. Regarding physiopathology of PC and intraperitoneal immunology, intraoperative application of trifunctional antibodies offers advanced opportunities for destruction of intraperitoneal tumor cells and prevention of PC. First results indicated, the intraoperative treatment with trifunctional antibodies was safe and clinically feasible. Long-term results will be available in 2010.

journal_name

J Surg Oncol

authors

Ströhlein MA,Heiss MM

doi

10.1002/jso.21338

subject

Has Abstract

pub_date

2009-09-15 00:00:00

pages

329-30

issue

4

eissn

0022-4790

issn

1096-9098

journal_volume

100

pub_type

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