Side effects of levamisole given to neoplastic patients as adjuvant to surgery: a new case of agranulocytosis.

Abstract:

:Side-effects to levamisole given as adjuvant to surgery in a consecutive series of 203 neoplastic patients are reported: Thirty-four patients (16.7%) suffered gastric adverse reactions; 8 (3.9%) allergic; 6 (2.9%) intestinal; 6 (2.9% neurologic; 4 (1.9%) severe hyperthermia (more than 40.5 degrees C); 3 (1.4%) flu-like illness; 1 (0.4% leucopenia; and 1 (0.4%) agranulocytosis. Withdrawal rate was 5.4% or 11 patients. Side effects appeared sex-related (39.0% in females, 17.7% in males; with seven female dropout out of 11), unrelated to other eventual adjuvant treatments, and reappearing at a new challenge with levamisole. The opportunity of very close control of patients taking levamisole for at least the first months is discussed.

journal_name

J Surg Oncol

authors

Colizza S,Bagolan P,Di Paola M

doi

10.1002/jso.2930160310

subject

Has Abstract

pub_date

1981-01-01 00:00:00

pages

259-64

issue

3

eissn

0022-4790

issn

1096-9098

journal_volume

16

pub_type

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