Expression of extracellular matrix molecules in brain metastasis.

Abstract:

BACKGROUND AND OBJECTIVES:The objectives of this study were to investigate the role of growth factors and matrix metalloproteinases in the brain metastasis. METHODS:Tumors from 40 patients with brain metastasis (30 lung cancer, 10 breast cancer) were studied to investigate the expression-patterns of EGFR, MT1-MMP, MMP7, and CD44 using the immunostaining and RT -PCR analysis. RESULTS:EGFR immunostaining was detected in 92% (23/25) and 70% (7/10) of brain metastasis from lung adenocarcinoma and breast cancer, respectively. MT1-MMP immunostaining was also detected in 80% (20/25) and 50% (5/10) of brain metastasis from lung adenocarcinoma and breast cancer, respectively. EGFR mRNA was detected in 83.3% (25/30) and 70% (7/10) of brain metastasis from lung cancer and breast cancer, respectively. MT1-MMP mRNA was detected in 73.3% (22/30) specimens of brain metastasis from lung cancer, and only 13.3% (4/30) specimens of these patients expressed MMP7 mRNA. CONCLUSIONS:The high expression of EGFR and MT1-MMP indicates that a extracellular matrix remodeling may be playing an important role in brain metastasis.

journal_name

J Surg Oncol

authors

Yoshida S,Takahashi H

doi

10.1002/jso.21296

subject

Has Abstract

pub_date

2009-07-01 00:00:00

pages

65-8

issue

1

eissn

0022-4790

issn

1096-9098

journal_volume

100

pub_type

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