Comparative analysis of immunohistochemical markers with invasiveness and histologic differentiation in squamous cell carcinoma and basal cell carcinoma of the skin.

Abstract:

BACKGROUND:This study evaluates several tumor-related markers to examine the expression pattern of markers according to the invasiveness and histopathologic differentiation of squamous cell carcinoma and basal cell carcinoma. METHODS:Ninety-four cases of squamous cell carcinoma and 108 cases of basal cell carcinoma using tissue array in order to determine correlations between the expression of Ki-67, p53, EGFR, CD44v6, MMP-1 and MMP-3, invasiveness and histologic differentiation. In order to determine invasiveness, we measured the depth of invasion in resected tissues. RESULTS:The depth of invasion showed a correlation with CD44v6 expression of tumor cell in both squamous cell carcinoma and basal cell carcinoma (P = 0.009, P = 0.036, respectively) and with the MMP-1 expression of stromal cell in squamous cell carcinoma (P = 0.010). The differentiation of squamous cell carcinoma was correlated with Ki-67 index. The loss of palisading arrangement in basal cell carcinoma was correlated with the MMP-1 expression of stromal cells (P = 0.045). CONCLUSIONS:CD44v6 and MMP-1, expressed in tumor cells and stromal cells respectively, are significant markers associated with the invasiveness of tumors in squamous cell carcinoma and basal cell carcinoma of the skin and that it will be helpful to evaluate the invasiveness by measuring the expression of these markers.

journal_name

J Surg Oncol

authors

Son KD,Kim TJ,Lee YS,Park GS,Han KT,Lim JS,Kang CS

doi

10.1002/jso.21006

subject

Has Abstract

pub_date

2008-06-01 00:00:00

pages

615-20

issue

7

eissn

0022-4790

issn

1096-9098

journal_volume

97

pub_type

杂志文章
  • Lymph node assessment in cervical cancer: prognostic and therapeutic implications.

    abstract::Lymph node status is not part of the staging system for cervical cancer, but provides important information for prognosis and treatment. This article reviews the incidence and patterns of lymph node metastasis, and the issues surrounding surgical assessment of lymph nodes. The preoperative assessment of lymph nodes by...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章,评审

    doi:10.1002/jso.21199

    authors: Gien LT,Covens A

    更新日期:2009-03-15 00:00:00

  • Src activity is increased in gastrointestinal stromal tumors--analysis of associations with clinical and other molecular tumor characteristics.

    abstract:BACKGROUND:Increased activity of Src has been found in several human cancers, and often is associated with poor clinical outcome. The present study aimed to determine whether Src activity is increased in gastrointestinal stromal tumors (GIST), and whether it correlates with established tumor or patient characteristics ...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.23544

    authors: Rotert JV,Leupold J,Hohenberger P,Nowak K,Allgayer H

    更新日期:2014-05-01 00:00:00

  • Long-term morbidity of patients with early breast cancer after sentinel lymph node biopsy compared to axillary lymph node dissection.

    abstract:BACKGROUND AND OBJECTIVES:Sentinel lymph node biopsy (SLNB) is widely accepted as an excellent method in the management of early breast cancer in patients with clinically negative axillary lymph nodes. Since SLNB requires less traumatic surgery to the axilla than axillary lymph node dissection (ALND), it was assumed to...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.20406

    authors: Schulze T,Mucke J,Markwardt J,Schlag PM,Bembenek A

    更新日期:2006-02-01 00:00:00

  • Fibrosarcoma of nose and paranasal sinuses.

    abstract::Involvement of nose and maxilla by fibrosarcoma is extremely rare. Only a few cases of fibrosarcoma arising in this region are reported in the world literature. Two cases of fibrosarcoma are described, and the literature relating to this disease entity is briefly reviewed. Salient features helping in the diagnosis and...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.2930150109

    authors: Agarwal MK,Gupta S,Gupta OP,Samant HC

    更新日期:1980-01-01 00:00:00

  • Considerations appropriate to a clinical trial of definitive radiation therapy in adenocarcinoma of the pancreas.

    abstract::The Author describes criteria for selection of patients who might be eligible for entry into a clinical trial of definitive Radiation Therapy for adenocarcinoma of the pancreas. Most emphasis is placed on careful surgical staging, target volume and location, and the use of bypass procedures when appropriate. ...

    journal_title:Journal of surgical oncology

    pub_type: 临床试验,杂志文章

    doi:10.1002/jso.2930070208

    authors: Cavanaugh PJ

    更新日期:1975-01-01 00:00:00

  • Brachytherapy in lung cancer.

    abstract::Brachytherapy, the direct application of a radioactive isotope into the tumor bed, delivers a high dose to the tumor as compared to the surrounding normal tissue. Interstitial brachytherapy, the placement of the isotope into a tumor bed where no lumen exists, has been described but is utilized infrequently in clinical...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章,评审

    doi:10.1002/(sici)1096-9098(199801)67:1<60::aid-jso13>

    authors: Gaspar LE

    更新日期:1998-01-01 00:00:00

  • Leiomyosarcoma of Meckel's diverticulum: a case report and review of the literature.

    abstract::A case of leiomyosarcoma of a Meckel's diverticulum, presenting as an acute appendicitis, is reported. The literature is reviewed with particular emphasis on current trends in the diagnosis and management of leiomyosarcomas of the small intestine. ...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.2930320207

    authors: Saadia R,Decker GA

    更新日期:1986-06-01 00:00:00

  • Large bowel lymphoma: an analysis of prognostic factors and therapy in 53 patients.

    abstract:BACKGROUND AND OBJECTIVES:We performed a retrospective analysis to assess the influence of different prognostic factors, including the International Prognostic Index (IPI), that can predict the outcome in patients with primary large bowel lymphoma (Stage IE) treated with combined therapy (surgery followed by chemothera...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.10103

    authors: Avilés A,Neri N,Huerta-Guzmán J

    更新日期:2002-06-01 00:00:00

  • Interleukin-10 and interferon-gamma levels within the peritoneal cavity of patients with gastric cancer.

    abstract:BACKGROUND AND OBJECTIVES:Immune status in the peritoneal cavity of patients with gastric cancer remains largely unknown. To clarify the clinical significance of the host immune response within the peritoneal cavity, we examined the levels of interferon-gamma (IFN-gamma), a type 1 cytokine, and interleukin-10 (IL-10), ...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.1131

    authors: Majima T,Ichikura T,Seki S,Takayama E,Hiraide H,Mochizuki H

    更新日期:2001-10-01 00:00:00

  • Histologic staging in malignant melanoma: cross-sectional area revisited.

    abstract:BACKGROUND AND OBJECTIVES:Tumor thickness is considered the single most important predictor of survival in clinically localized malignant melanoma. A recent study found tumor volume a more sensitive predictor of survival than thickness. Volume measurement, however, is complicated, time consuming, and based on biologica...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/(sici)1096-9098(199810)69:2<83::aid-jso7>3

    authors: Temple CF,Huchcroft SA,Hurlbut DJ,Davidson JS

    更新日期:1998-10-01 00:00:00

  • Epithelial-mesenchymal transition inducer Snail1 and invasive potential of intraductal breast cancer.

    abstract:BACKGROUND AND OBJECTIVES:Transcription factor Snail1 is a key inducer of epithelial-mesenchymal transition (EMT), a biological process implicated in the cancer progression and metastasis. The aim of the study was to investigate Snail1 expression in DCIS found on breast biopsy and assess its predictive value for the fi...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.24708

    authors: Szynglarewicz B,Kasprzak P,Donizy P,Biecek P,Halon A,Matkowski R

    更新日期:2017-11-01 00:00:00

  • Fractal heterogeneity of peripheral blood flow: implications for hematogenous metastases.

    abstract:BACKGROUND AND OBJECTIVES:To determine how inhomogeneities in blood perfusion might affect the number of metastases that develop within an individual with cancer. METHODS:Experiments with lung metastases in mice, involving 320 treatment groups and 3165 mice, were reviewed. Inhomogeneities in the distribution of metast...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/1096-9098(200006)74:2<116::AID-JSO7>3.0.CO

    authors: Kendal WS

    更新日期:2000-06-01 00:00:00

  • Lymph node metastases in splenic flexure colon cancer: Is subtotal colectomy warranted?

    abstract:BACKGROUND AND OBJECTIVES:Tumors of the splenic flexure (TSF) can be associated with metastatic lymph nodes (LN) along the left colic pedicle, but also along the superior mesenteric vessels. We aimed to detail the anatomical distribution of metastatic LNs in patients undergoing elective subtotal colectomy for TSF. MET...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.25169

    authors: Manceau G,Mori A,Bardier A,Augustin J,Breton S,Vaillant JC,Karoui M

    更新日期:2018-11-01 00:00:00

  • Spontaneous regression of breast carcinoma: follow-up report and literature review.

    abstract::A case of spontaneous complete regression of metastatic breast carcinoma (malignant pleural effusion and bone metastases) with previously reported from M. D. Anderson Hospital and Tumor Institute. The patient did not receive any form of hormonal manipulation or systemic chemotherapy. This patient has now relapsed afte...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.2930190107

    authors: Ross MB,Buzdar AU,Hortobagyi GN,Lukeman JM

    更新日期:1982-01-01 00:00:00

  • Nonsteroid antiinflammatory drugs and tamoxifen for desmoid tumors and carcinoma of the stomach.

    abstract::The results of treatment of desmoid tumor patients with nonsteroid antiinflammatory drugs alone or in combination with tamoxifen are described. Tumor growth was inhibited in six of seven patients. Nonsteroid antiinflammatory drugs administered along with 5-fluorouracil and cyclophosphamide and other inhibitors of T-su...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.2930220314

    authors: Waddell WR,Gerner RE,Reich MP

    更新日期:1983-03-01 00:00:00

  • Anticancer chemosensitivity profile of freshly separated human pancreatic cancer cells assessed by DNA synthesis inhibition assay.

    abstract::The chemosensitivity of 49 freshly separated human pancreatic cancers to seven kinds of anticancer agents were assessed by a DNA synthesis (3H-thymidine incorporation) inhibition assay. DNA synthesis is higher in involved lymph nodes (n = 7), malignant effusion (n = 15), liver metastasis (n = 7), primary cancer (n = 1...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.2930570206

    authors: Masai Y,Nio Y,Tsubono M,Tseng CC,Kawabata K,Hayashi H,Ishigami S,Imamura M

    更新日期:1994-10-01 00:00:00

  • Local treatment with electrochemotherapy of superficial angiosarcomas: Efficacy and safety results from a multi-institutional retrospective study.

    abstract:BACKGROUND:Angiosarcoma is an aggressive vascular neoplasm with a high propensity for local recurrence. Electrochemotherapy is an emerging skin-directed therapy, exerting prominent cytotoxic activity, and antivascular effects. Its efficacy in angiosarcoma has not been investigated. METHODS:This multicenter retrospecti...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.24287

    authors: Guida M,Campana LG,Curatolo P,Strippoli S,Bonadies A,Grilz G,Cabula C,Rotunno R,Bucher S,Solari N,Santoriello A,Valpione S,Rossi CR

    更新日期:2016-08-01 00:00:00

  • A single blinded randomized controlled trial comparing semi-mechanical with hand-sewn cervical anastomosis after esophagectomy for cancer (SHARE-study).

    abstract:OBJECTIVE:The aim was to compare leak rate between hand-sewn end-to-end anastomosis (ETE) and semi-mechanical anastomosis (SMA) after esophagectomy with gastric tube reconstruction. BACKGROUND DATA:The optimal surgical technique for creation of an anastomosis in the neck after esophagectomy is unclear. METHODS:Patien...

    journal_title:Journal of surgical oncology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1002/jso.26209

    authors: Nederlof N,Tilanus HW,de Vringer T,van Lanschot JJB,Willemsen SP,Hop WCJ,Wijnhoven BPL

    更新日期:2020-12-01 00:00:00

  • Prognostic factors in Hodgkin's disease.

    abstract::The clinical records and treatment results of 163 patients with Hodgkin's disease, who were seen at Ellis Fischel State Cancer Hospital (EFSCH) between 1940 and 1971, were reviewed and analyzed. More than 200 clinical and histological variables were recorded for each case of Hodgkin's disease, including details of rad...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.2930070402

    authors: Say C,Lee YT,Hori J,Spratt JS Jr

    更新日期:1975-01-01 00:00:00

  • Malignant mesenchymoma of median nerve: combined nerve sheath sarcoma and liposarcoma.

    abstract::A malignant mesenchymoma consisting of nerve sheath sarcoma and liposarcoma occurred in the right median nerve of a 29-year-old man who did not have stigmata of von Recklinghausen neurofibromatosis. It produced pain at the affected part, referred pain to the palm, and weakness of muscles supplied by branches of this n...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.2930250214

    authors: Shuangshoti S,Benjavongkulchai S,Chittmittrapap S

    更新日期:1984-02-01 00:00:00

  • The frontal bone skull post for image guided surgery of the nasopharynx.

    abstract:BACKGROUND AND OBJECTIVES:To describe the use of the mastoid skull post of a surgical image guidance system for image guided surgery and intraoperative navigation of the nasopharynx. This adaptation overcomes the limitations of a headset frame or head clamp and can be applied to open and closed surgery of the nasal cav...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.21005

    authors: Vlantis AC,Chan HS,Hung T,Tong MC,Van Hasselt CA

    更新日期:2008-05-01 00:00:00

  • Colony stimulating activity in sera of erythroleukemic mice (RLV-A).

    abstract::RLV-A serum activity was measured by the agar colony assay to determine the effect of this erythroid dyscrasia on the granulopoietic humoral regulator, colony stimulating factor (CSF). In general, the sera of early, midstage and terminal animals not given endotoxin had high cluster forming properties compared to norma...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.2930130312

    authors: Koltun L,Lobue J,Gordon AS,Fredrickson TN

    更新日期:1980-01-01 00:00:00

  • Evaluation of the effects of type II radical hysterectomy in the treatment of 960 patients with stage IB-IIB cervical carcinoma: A retrospective study.

    abstract:BACKGROUND AND OBJECTIVES:This retrospective study evaluated the feasibility and effectiveness of type II radical hysterectomies alone, or in combination with adjuvant treatment, for the treatment of patients with stage IB-IIB cervical cancer with or without high-risk factors. METHODS:A total of 960 stage IB-IIB patie...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.21800

    authors: Zheng M,Huang L,He L,Ding H,Wang HY,Zheng LM

    更新日期:2011-04-01 00:00:00

  • Overexpression of hERG1 in resected esophageal squamous cell carcinomas: a marker for poor prognosis.

    abstract:BACKGROUND AND OBJECTIVES:The aim of this study was to evaluate the expression and prognostic roles of human ether à go-go related gene (hERG1) potassium channels in resected esophageal squamous cell carcinoma. METHODS:Expression of hERG1 protein and mRNA was detected by immunohistochemistry and reverse transcription ...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.20891

    authors: Ding XW,Luo HS,Luo B,Xu DQ,Gao S

    更新日期:2008-01-01 00:00:00

  • Leveraging the increased rates of pathologic complete response after neoadjuvant treatment in breast cancer to de-escalate surgical treatments.

    abstract:INTRODUCTION:Breast conservative surgery (BCS) and sentinel lymph node biopsy (SLNB) after neoadjuvant treatment (NAT) is safe and effective for selected patients. This aim of this study is to evaluate the impact of anatomic site of response on outcomes and to assess the real population who may benefit from nonsurgical...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.26236

    authors: Esgueva A,Siso C,Espinosa-Bravo M,Sobrido C,Miranda I,Salazar JP,Rubio IT

    更新日期:2021-01-01 00:00:00

  • Screening and surgical prophylaxis for hereditary cancer syndromes with high risk of endometrial and ovarian cancer.

    abstract::In the era of advanced cancer genomics, our recognition of hereditary cancer mutations continues to increase. Two of these conditions, which carry an increased risk of female cancers including endometrial, ovarian, breast, are hereditary breast and ovarian cancer syndrome and Lynch syndrome. Risk-reducing surgery, suc...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章,评审

    doi:10.1002/jso.25645

    authors: Bercow AS,Eisenhauer EL

    更新日期:2019-10-01 00:00:00

  • A cardiogastric fistula after gastric tube interposition. A case report and review of literature.

    abstract::A patient is presented with massive hematemesis caused by a fistula between the left cardiac atrium and a gastric tube interposition, which was constructed after esophagectomy for esophageal cancer 3 years earlier. ...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.20432

    authors: Schouten van der Velden AP,Ruers TJ,Bonenkamp JJ

    更新日期:2007-01-01 00:00:00

  • Addition of adjuvant hepatic artery infusion to systemic chemotherapy following resection of colorectal liver metastases is associated with reduced liver-related mortality.

    abstract:BACKGROUND:After resection of colorectal liver metastases (CRLM), recurrent disease in the liver is a major cause of death but may be reduced with the addition of adjuvant hepatic arterial infusion (HAI) chemotherapy to systemic chemotherapy (SYS). OBJECTIVE:This study investigates organ-specific causes of death in pa...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.25916

    authors: Srouji R,Narayan R,Boerner T,Buisman F,Seier K,Gonen M,Balachandran VP,Drebin J,Jarnagin WR,Kingham TP,Wei A,Kemeny NE,D'Angelica M

    更新日期:2020-06-01 00:00:00

  • Effect of trauma on implantation of metastatic tumor in bone in mice.

    abstract::We studied the influence of surgical trauma to the iliac bone on the implantation of I.V. injected tumor cells, which formed tumor in the surgical wounds of 27/84 mice (32%). None of these mice or nonsurgical mice developed tumor in the opposite or uninjured pelvic bone (P < 0.0001). When different numbers (10(5), 5 x...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.2930560311

    authors: Lee JY,Murphy SM,Scanlon EF

    更新日期:1994-07-01 00:00:00

  • Advancements in imaging technology for microvascular free tissue transfer.

    abstract::The use of preoperative imaging has become routine for many reconstructive microsurgeons to help localize perforators for planning of microvascular free flaps. However, with advancements in imaging technology, perforator mapping represents only one potential benefit as virtual planning and medical modeling, and flap t...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章,评审

    doi:10.1002/jso.25194

    authors: Chang EI,Chu CK,Chang EI

    更新日期:2018-10-01 00:00:00