Tumor cell karyotypes in malignant melanoma.

Abstract:

:Fifteen malignant melanomas were subjected to chromosomal analysis, in order to determine whether the number of chromosomes in a tumor cell could be correlated to a clinical prognosis. The protocol involved a direct technique which utilized a Colcemid blockade of spindle formation in mitosis to allow study of metaphase chromosomes. The direct method was chosen to reveal chromosome changes in the tumor cell in situ rather than changes in the cultured cell. Two tumors yielded chromosome spreads which could be counted and correlated with a clinical prognosis. Failure to obtain other adequate chromosome spreads were accounted for by the presence of tissue necrosis and the absence of viable tumor cells.

journal_name

J Surg Oncol

authors

Henry WM,Didolkar MS,Lopez R,Tomei LD

doi

10.1002/jso.2930110107

subject

Has Abstract

pub_date

1979-01-01 00:00:00

pages

31-8

issue

1

eissn

0022-4790

issn

1096-9098

journal_volume

11

pub_type

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