Abstract:
:Locally recurrent cancer of the rectum has been under-recognized as a complication, although it affects up to 40% of patients treated with surgery alone. Even in the best centers, rates average 25%. While radiotherapy may reduce recurrence, it is now apparent that total mesorectal excision is the most effective modality, with rates as low as 5%. The dramatic decrease in local recurrence can also be linked to increased survival in prospective studies, an effect more significant than any adjuvant therapy. The options, however, for patients with locally recurrent cancer are limited. Fifteen percent of patients with this complication die without systemic spread. Salvage by surgery offers potential cure. Other than anastomotic recurrences that can be locally resected, the best approach for long-term survival is an extensive surgical procedure requiring en bloc removal of adjacent organs and pelvic structures-so-called composite resection. With careful selection, 30% 5-year survival can be achieved and palliation is considerable, with 50% long-term local control. Intraoperative radiotherapy and brachytherapy, and/or preoperative chemoradiation may provide better results in future. Newer techniques of coloanal anastomosis, improved urinary diversion, and myocutaneous flaps for perineal reconstruction radically reduce the morbidity of these procedures. The approach to recurrent rectal cancer requires a sophisticated multidisciplinary team to obtain optimum results.
journal_name
J Surg Oncoljournal_title
Journal of surgical oncologyauthors
Temple WJ,Saettler EBdoi
10.1002/(sici)1096-9098(200001)73:1<47::aid-jso12>subject
Has Abstractpub_date
2000-01-01 00:00:00pages
47-58issue
1eissn
0022-4790issn
1096-9098pii
10.1002/(SICI)1096-9098(200001)73:1<47::AID-JSO12>journal_volume
73pub_type
杂志文章,评审abstract::The effectiveness of MFC (mitomycin C, 5-fluorouracil and cytosine arabinoside) therapy for nonresectable cancers and cancers recurring after surgery was investigated in 60 patients with solid cancers aged 26 to 69 years. Treatment was effective in 28 patients (47%) including seven (12%) who showed a very good respons...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930100507
更新日期:1978-01-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Malignant mesothelioma is a lethal disease. Aggressive multimodality treatment protocols are reportedly associated with improved survival, but the apparent survival benefits may simply reflect patient selection and the variable natural history of this malignancy. Before embarking on our own pr...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.1143
更新日期:2001-11-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Desmoplastic melanoma (DM) is a rare variant of cutaneous melanoma. Our goal was to study the surgical management of DM, identify prognostic factors, and impact of treatment options. METHODS:Patients with DM (n = 1,735) were identified from the Surveillance, Epidemiology, and End Results data...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.21778
更新日期:2011-02-01 00:00:00
abstract::Cecal carcinoma has been associated with a poorer prognosis than other colon carcinomas because of the presumed longstanding obscure symptoms. In a combined study of three Dutch hospitals, a total of 166 patients with cecal carcinoma were evaluated after right hemicolectomy. Special emphasis was placed on clinical sym...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930440309
更新日期:1990-07-01 00:00:00
abstract::Several months (an average of 12.86 months) after perineal needling of the cancerous prostate for the purpose of obtaining tissue for biopsy, a tumor nodule becomes clinically evident in the subcutaneous tissue of the perineum, at the site of the needling in 0.34% of the cases. This nodule presents the same histologic...
journal_title:Journal of surgical oncology
pub_type: 杂志文章,评审
doi:10.1002/jso.2930350309
更新日期:1987-07-01 00:00:00
abstract::Intraoperative radiation therapy (IORT) was delivered to remnant rat liver after partial hepatectomy to determine the chronic effects of treatment on survival, blood chemistry, liver weight, and histology. Survival at one year was 100%. Remnant liver weight was markedly increased in all animals. Liver function appeare...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930500205
更新日期:1992-06-01 00:00:00
abstract::"Taking less treating better" has been one of the major improvements of breast cancer surgery in the last four decades. The application of this principle translates into equivalent survival of breast cancer conserving treatment (BCT) when compared to mastectomy, with a better cosmetic outcome. While it is relatively e...
journal_title:Journal of surgical oncology
pub_type: 杂志文章,评审
doi:10.1002/jso.23596
更新日期:2014-07-01 00:00:00
abstract::A new combined cancer chemotherapy regimen of mitomycin C (MMC) and cisplatin (DDP) showed synergistic antitumor activity against human gastric cancer xenografts St-40 and SC-1-NU in BALB/c nu/nu mice. The drugs were administered intraperitoneally at doses of 2 or 4 mg/kg for MMC and 3 or 6 mg/kg for DDP, respectively...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930560408
更新日期:1994-08-01 00:00:00
abstract:BACKGROUND:Receptor-binding cancer antigen expressed on SiSO cells (RCAS1) has been reported to act as a ligand for a receptor present on normal peripheral lymphocytes and to induce apoptotic cell death. We aimed to elucidate the significance of RCAS1 expression in human esophageal squamous cell carcinomas (ESCC). MET...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.20249
更新日期:2005-05-01 00:00:00
abstract::Desmoglein I (DGI) is major component of the desmosomal membrane core that plays an important role in epithelial cell adhesion. The aim of this study was to explore the correlation between the expression of DGI and the clinicopathological findings of esophageal cancer. DGI expression was immunohistochemically examined...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930570207
更新日期:1994-10-01 00:00:00
abstract:INTRODUCTION:The Siewert classification has been used to plan treatment for tumours of the gastro-oesophageal junction since its proposal in the 1980s. The purpose of this study was to assess its continued relevance by evaluating whether there were differences in the biology and clinical characteristics of adenocarcino...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.23484
更新日期:2014-03-01 00:00:00
abstract:BACKGROUND/AIMS:We compared overall survival (OS) of patients with a solitary large (>5 cm) hepatocellular carcinoma (HCC) treated surgically or by transarterial chemoembolization (TACE). METHODS:The archived records of HCC patients registered at the Korean Central Cancer Registry from 2003 through 2005 (registry A, n...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.24519
更新日期:2017-03-01 00:00:00
abstract:INTRODUCTION:Two to three percent of the patients with extremity melanoma develop in-transit metastases in the course of their disease. When local treatments fail, isolated limb perfusion (ILP) is a reasonable option, but is generally only applied to patients without evidence of distant metastases. We assessed the valu...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.20297
更新日期:2005-08-01 00:00:00
abstract::The human tumor stem cell assay (HTSCA) was applied to 103 primary and metastatic colorectal carcinomas. Thirty-four carcinomas could not be evaluated for colony formation (clonogenicity) because of microbial contamination. Of the remaining 69 carcinomas, 18 (26%) demonstrated clonal growth in vitro. Colony formation ...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930200311
更新日期:1982-07-01 00:00:00
abstract::Over the last decade, the use of neoadjuvant chemo-radiation has been an integral part of the care of patients with locally advanced rectal cancer. However, emerging data are beginning to challenge the current treatment paradigm of neoadjuvant chemo-radiation followed by radical resection and subsequent adjuvant chemo...
journal_title:Journal of surgical oncology
pub_type: 杂志文章,评审
doi:10.1002/jso.24267
更新日期:2016-09-01 00:00:00
abstract::Two synchronous primary lung carcinomas presenting bilaterally are rare. Their presentation, predisposing factors, and treatment are similar to those of single lung carcinomas. The authors present the first reported case known to them of three synchronous primary lung carcinomas involving both lungs. These tumors fulf...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930340408
更新日期:1987-04-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:To assess the surgical and survival outcomes after secondary cytoreductive surgery (SCRS) in patients with platinum-sensitive recurrent epithelial ovarian cancer (EOC) and to identify patients who would most benefit from SCRS. METHODS:Inclusion criteria consisted of (1) recurrent EOC; (2) dis...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.21470
更新日期:2010-04-01 00:00:00
abstract::Fibrosarcoma is a rare primary malignant tumor of the mediastinum. Three cases are presented with different presenting symptoms and clinical manifestations. Thoracotomy with biopsy of the mass is the only method for arriving at a definitive histologic diagnosis. ...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930120103
更新日期:1979-01-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:The purpose of this study was to estimate the risk factors having relationships with pathologic fracture of osteosarcoma of extremities and to evaluate the role of limb salvage surgery in this group of patients. METHODS:We retrospectively analyzed 28 consecutive cases of pathologic fracture o...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.23150
更新日期:2012-12-01 00:00:00
abstract::A case of synovial sarcoma in the abdominal wall of a 50-year-old Iraq female is reported. The ultrastructure of the tumor has been studied. Eight other cases of synovial sarcoma in the abdominal wall which reported in the English literature up to 1978 have been reviewed. Synovial sarcomas in the abdominal wall tend t...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930180403
更新日期:1981-01-01 00:00:00
abstract::This report describes the findings of an extra-adrenal paraganglioma and chondroma of the lung in an elderly man. Tissue analysis of the paraganglioma showed a high level of catecholamines, as well as the presence of somatostatin and small amounts of other peptide hormones. Immunoperoxidase staining demonstrated the d...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930350205
更新日期:1987-06-01 00:00:00
abstract::A massive lymphatic leak developed following radical retroperitoneal lymph node dissection for recurrent extragonadal seminoma. Chylous ascites persisted for over 3 months, with an average daily external drainage of 1.5 liters, and was successfully treated with a peritoneovenous shunt. ...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930360315
更新日期:1987-11-01 00:00:00
abstract:BACKGROUND:Pulmonary metastasectomy (PM) for metastatic sarcoma can result in long-term survival. The purpose of this study was to describe factors associated with survival in a series of patients undergoing PM for metastatic sarcoma. METHODS:We reviewed all patients undergoing PM for metastatic sarcoma over a 12-year...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.23961
更新日期:2015-07-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:This study aimed to evaluate treatment outcomes of acral melanoma (AM) based on the excision margin. METHODS:A retrospective cohort study was conducted for patients with primary AM, analyzing recurrence rates, local and in-transit recurrence-free survival (LITRFS), disease-free survival (DFS)...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.24442
更新日期:2016-12-01 00:00:00
abstract::Cancer of the oral cavity remains a major problem in the United States as well as in many other countries, some of which record as much as 30% of all their cancers to be in the oral region. Despite numerous advances in the fields of epidemiology and etiology, little is known of the molecular basis of oral cancer. Adva...
journal_title:Journal of surgical oncology
pub_type: 杂志文章,评审
doi:10.1002/jso.2930470209
更新日期:1991-06-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Near-infrared (NIR) fluorescence optical imaging is a promising technique to assess the tumor margins during cancer surgery. This technique requires targeting by specific fluorescence agents to differentiate tumor from normal surrounding tissue. We assessed the feasibility of cancer detection ...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.22102
更新日期:2012-06-01 00:00:00
abstract::Neoadjuvant systemic breast cancer therapy is the administration of systemic therapy to eligible breast cancer patients prior to surgery. This treatment modality was developed out of necessity to downstage inoperable tumors, but it has evolved into a tool for breast conservation surgery. The neoadjuvant approach is al...
journal_title:Journal of surgical oncology
pub_type: 杂志文章,评审
doi:10.1002/jso.21696
更新日期:2011-03-15 00:00:00
abstract::We have operated upon six patients with cervical esophageal carcinoma and reconstructed these with free jejunal graft. The pathology of all six patients was squamous cell carcinoma, and no patient had apparent distant metastasis. The procedure was a two team approach. While the surgical oncology team resected the esop...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930420307
更新日期:1989-11-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:There are no reports concerning surgical treatment on pulmonary metastases from gastric cancer. The aims of this study were to characterize patients with pulmonary metastasis from gastric cancer and to determine the efficacy of surgical therapy. METHODS:Between 1977 and 1993, 3,076 patients u...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/(sici)1096-9098(199811)69:3<147::aid-jso5>
更新日期:1998-11-01 00:00:00
abstract:BACKGROUND:Angiosarcoma is an aggressive vascular neoplasm with a high propensity for local recurrence. Electrochemotherapy is an emerging skin-directed therapy, exerting prominent cytotoxic activity, and antivascular effects. Its efficacy in angiosarcoma has not been investigated. METHODS:This multicenter retrospecti...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.24287
更新日期:2016-08-01 00:00:00