当前位置： SCI文献检索 > JOURNAL OF SURGICAL ONCOLOGY期刊下所有文献 > The relevance of the Siewert classification in the era of multimodal therapy for adenocarcinoma of the gastro-oesophageal junction.

The relevance of the Siewert classification in the era of multimodal therapy for adenocarcinoma of the gastro-oesophageal junction.

Abstract：

INTRODUCTION:The Siewert classification has been used to plan treatment for tumours of the gastro-oesophageal junction since its proposal in the 1980s. The purpose of this study was to assess its continued relevance by evaluating whether there were differences in the biology and clinical characteristics of adenocarcinomas by Siewert type, in a contemporary cohort of patients, in whom the majority had received neoadjuvant chemotherapy. METHODS:A prospective database was reviewed for all patients who underwent resection from 2005 to 2011 and analysed with regard to Siewert classification determined from the pathological specimen, treatment and clinicopathological outcomes. RESULTS:Two hundred and sixteen patients underwent oesophagogastric resection: 133 for type I, 51 for type II and 33 for type III tumours. 135 Patients (62.5%) received neoadjuvant chemotherapy with no difference between groups. There were no significant differences in age, sex, pT stage, pN stage, pM stage, ASA, or inpatient complications between patients with adenocarcinoma based on their Siewert classification. There was a significant increase in maximum tumour diameter (P = 0.023), perineural invasion (P = 0.021) and vascular invasion (P = 0.020), associated with more distal tumours (Type III > Type II > Type I). Median overall survival was significantly shorter for more distal tumours (Type I: 4.96 years vs. Type II: 3.3 years vs. Type III: 2.64 years; P = 0.04). The surgical approach did not influence survival. CONCLUSION:In the era of multi-modal treatment pathological Siewert tumour type is of prognostic value, as patients with Type III disease are likely to have larger and more aggressive tumours that lead to worse outcomes.

journal_name

J Surg Oncol

journal_title

Journal of surgical oncology

authors

Curtis NJ,Noble F,Bailey IS,Kelly JJ,Byrne JP,Underwood TJ

doi

10.1002/jso.23484

subject

Has Abstract

pub_date

2014-03-01 00:00:00

pages

202-7

issue

3

eissn

0022-4790

issn

1096-9098

journal_volume

109

pub_type

杂志文章

相关文献

JOURNAL OF SURGICAL ONCOLOGY文献大全
  • Immunotherapy and whole-body hyperthermia as combined modality treatment of a subcutaneous murine sarcoma.

    abstract：:Interleukin-2 and hyperthermia have been used individually to treat a variety of tumors in both experimental and human trials. Combined adoptive immunotherapy and hyperthermia is an exciting new line of investigation. Previous work in our laboratory has shown that combined local hyperthermia and rIL-2 therapy can sign...

    journal_title：Journal of surgical oncology

    pub_type： 杂志文章

    doi：10.1002/jso.2930530310

    authors： Geehan DM,Fabian DF,Lefor AT

    更新日期：1993-07-01 00:00:00

  • Autologous transfusions for cancer patients undergoing elective ablative surgery.

    abstract：:Patients who have cancer are exposed to the adverse consequences of blood transfusions, such as transmissible diseases. This study presents an examination of a program of autologous blood deposit for cancer patients undergoing elective surgical procedures. Over a 3-year period, 235 patients deposited 388 units of auto...

    journal_title：Journal of surgical oncology

    pub_type： 杂志文章

    doi：10.1002/jso.2930430106

    authors： Lichtiger B,Huh YO,Armintor M,Fischer HE

    更新日期：1990-01-01 00:00:00

  • Ex vivo indocyanine green fluorescence imaging for the detection of lymph node involvement in advanced-stage ovarian cancer.

    abstract：BACKGROUND AND OBJECTIVES:The aim of this study was to evaluate the role of indocyanine green (ICG) fluorescence imaging (FI) for the ex vivo detection of metastatic lymph nodes (LNs) in advanced stage ovarian cancer (AOC). METHODS:Paraffin-embedded LNs from patients included in a previous ICG-FI study (Protocol NCT01...

    journal_title：Journal of surgical oncology

    pub_type： 临床试验,杂志文章

    doi：10.1002/jso.25263

    authors： Pop CF,Veys I,Gomez Galdon M,Moreau M,Larsimont D,Donckier V,Bourgeois P,Liberale G

    更新日期：2018-12-01 00:00:00

  • Tumor spectrum of adult intussusception.

    abstract：INTRODUCTION:Adult intussusception is rare. Most general and colorectal surgeons are unfamiliar with its etiology and optimal management. PATIENTS AND METHODS:Patients older than 16 years and diagnosed with intestinal intussusception between January 1990 and June 2006 were retrospectively reviewed. Data related to pre...

    journal_title：Journal of surgical oncology

    pub_type： 杂志文章

    doi：10.1002/jso.21117

    authors： Chiang JM,Lin YS

    更新日期：2008-11-01 00:00:00

  • The mortality rate from lung metastases in animals inhaling nitrogen dioxide (NO2).

    abstract：:A study was carried out to determine the interrelationship between the inhalation of nitrogen dioxide (0.4 +/- 0.50 ppm), lung metastases development from circulating cancer cells, and death rate from such metastases. C57 BL/6J mice were used in these experiments. Animals were divided into control and NO2-exposed grou...

    journal_title：Journal of surgical oncology

    pub_type： 杂志文章

    doi：10.1002/jso.2930280115

    authors： Richters A,Richters V,Alley WP

    更新日期：1985-01-01 00:00:00

  • Application of 99mTc labeled chimeric Fab fragments of monoclonal antibody A7 for immunoscintigraphy of pancreatic carcinoma.

    abstract：BACKGROUND:One of the reasons for the poor prognosis of pancreatic carcinoma is the difficulty of obtaining an early diagnosis of pancreatic carcinoma. One possibility is the application of radioimmunoscintigraphy using radiolabeled monoclonal antibodies (Mabs). METHODS:We labeled chimeric (human/mouse) Fab fragments ...

    journal_title：Journal of surgical oncology

    pub_type： 杂志文章

    doi：10.1002/jso.10311

    authors： Otsuji E,Matsumura H,Okamoto K,Toma A,Kuriu Y,Ichikawa D,Hagiwara A,Yamagishi H

    更新日期：2003-11-01 00:00:00

  • Impact of patient age on the outcome of primary breast carcinoma.

    abstract：BACKGROUND AND OBJECTIVES:The poorer outcome amongst younger breast cancer patients continues to be an issue of debate. In order to clarify the prognostic value of patient age, we retrospectively analyzed the data of 1098 breast cancer patients. METHODS:Patients were divided into two groups based on the age 35 (Group ...

    journal_title：Journal of surgical oncology

    pub_type： 杂志文章

    doi：10.1002/jso.10088

    authors： Park BW,Kim SI,Kim EK,Yang WI,Lee KS

    更新日期：2002-05-01 00:00:00

  • Human papillomavirus-related cell cycle markers can predict survival outcomes following a transoral lateral oropharyngectomy for tonsillar squamous cell carcinoma.

    abstract：OBJECTIVES:To identify the prognostic implications of human papillomavirus (HPV)-related cell cycle marker profiles in patients who have received a transoral lateral oropharyngectomy (TLO) as a primary treatment for tonsillar squamous cell carcinoma (TSCC). PATIENTS AND METHODS:Immunohistochemical profiles of HPV-rela...

    journal_title：Journal of surgical oncology

    pub_type： 杂志文章

    doi：10.1002/jso.23672

    authors： Ryu CH,Ryu J,Cho KH,Moon SH,Yun T,Lee SH,Choi MK,Park WS,Jung YS

    更新日期：2014-09-01 00:00:00

  • Screening for lung cancer: the US studies.

    abstract：:Efforts in lung cancer screening with chest X-ray (CXR) and sputum cytology in the 1970s and 1980s were negative. In the ensuing decade, the early lung cancer action project (ELCAP), and the Mayo screening study showed the promise of low-dose CT. These and other studies led to the National lung screening study (NLST),...

    journal_title：Journal of surgical oncology

    pub_type： 杂志文章,评审

    doi：10.1002/jso.23391

    authors： Midthun DE,Jett JR

    更新日期：2013-10-01 00:00:00

  • Effective and efficient lymphaticovenular anastomosis using preoperative ultrasound detection technique of lymphatic vessels in lower extremity lymphedema.

    abstract：BACKGROUND:Identification of functional lymphatic vessels and localization of lymphatic vessels are important for lymphaticovenular anastomosis (LVA). Indocyanine green (ICG) lymphography is useful for localization of superficial lymphatic vessels where dermal backflow is not observed, but not for lymphatic vessels in ...

    journal_title：Journal of surgical oncology

    pub_type： 杂志文章

    doi：10.1002/jso.24812

    authors： Hayashi A,Hayashi N,Yoshimatsu H,Yamamoto T

    更新日期：2018-02-01 00:00:00

  • Immune-competent cells of regional lymph nodes in colorectal cancer patients: II. Immunohistochemical analysis of Leu-7+ cells.

    abstract：:Distribution of Leu-7+ cells in cancer tissues and regional lymph nodes was immunohistochemically examined to estimate the role of NK cells in colorectal cancer patients. Leu-7+ cells were rarely observed both in the primary and distant metastatic lesions, but the number of these cells was large in the germinal center...

    journal_title：Journal of surgical oncology

    pub_type： 杂志文章

    doi：10.1002/jso.2930450406

    authors： Adachi W,Usuda N,Sugenoya A,Iida F

    更新日期：1990-12-01 00:00:00

  • Breast-specific factors determine cosmetic outcome and patient satisfaction after breast-conserving therapy: Results from the randomized COBALT study.

    abstract：BACKGROUND AND OBJECTIVES:To identify breast-specific factors and the role of tumor, treatment, and patient-related items in influencing patient opinion on cosmesis and satisfaction after breast-conserving therapy (BCT). METHODS:Data from the randomized COBALT study was used. At 3, 12, and 36 months, 128 patients with...

    journal_title：Journal of surgical oncology

    pub_type： 杂志文章,随机对照试验

    doi：10.1002/jso.25012

    authors： Volders JH,Negenborn VL,Haloua MH,Krekel NMA,Jóźwiak K,Meijer S,van den Tol PM

    更新日期：2018-04-01 00:00:00

  • Impact of screening mammography and change in surgeons' attitudes on the pattern of primary care of breast cancer at a community hospital.

    abstract：:To gauge the impact of screening mammography and opinions regarding surgical procedures on the pattern of primary surgical care of breast cancer, tumor registry statistics from 1980-81 were compared to those from 1987 at a large community hospital. Over the course of six years, there was a significant increase in the ...

    journal_title：Journal of surgical oncology

    pub_type： 杂志文章

    doi：10.1002/jso.2930450104

    authors： Goldsweig HG,O'Sullivan M

    更新日期：1990-09-01 00:00:00

  • Calculation of breast volumes from mammogram: Comparison of four separate equations relative to mastectomy specimen volumes.

    abstract：BACKGROUND AND OBJECTIVES:Accurately assessing breast volume (BV) relative to the volume of breast tissue to be removed could help objectively determine the optimal surgical candidates for breast conserving surgery. The objective of this study was to determine the optimal mammography-based method of BV estimation. MET...

    journal_title：Journal of surgical oncology

    pub_type： 杂志文章

    doi：10.1002/jso.25076

    authors： Rostas JW,Bhutiani N,Crigger M,Crawford SMW,Hollenbach RB,Heidrich SR,Martin RCG 2nd,McMasters KM,Ajkay N

    更新日期：2018-06-01 00:00:00

  • Unusual presentation of carcinoma of the vermiform appendix: a report of two cases.

    abstract：:Two unusual presentations of perforated mucoid adenocarcinoma of the appendix are described. One patient presented with a large periappendicular abscess that extended into the gluteal region, the other with a retroperitoneal abscess and abscesses in the right flank and groin. Recognition of the source of the abscess m...

    journal_title：Journal of surgical oncology

    pub_type： 杂志文章

    doi：10.1002/jso.2930250409

    authors： Waizbard E,Michowitz M,Baratz M,Papo J,Stavorovsky M

    更新日期：1984-04-01 00:00:00

  • Ampullary adenocarcinoma: Defining predictors of survival and the impact of adjuvant therapy following surgical resection for stage I disease.

    abstract：BACKGROUND AND OBJECTIVES:Outcomes and recommendations regarding adjuvant therapy (AT) for stage I ampullary adenocarcinoma (AAC) are inadequately described. We sought to determine factors associated with survival and better define the impact of AT. METHODS:The NCDB was queried for stage I AAC patients undergoing rese...

    journal_title：Journal of surgical oncology

    pub_type： 杂志文章

    doi：10.1002/jso.25021

    authors： Stiles ZE,Behrman SW,Deneve JL,Glazer ES,Dong L,Wan JY,Martin MG,Dickson PV

    更新日期：2018-06-01 00:00:00

  • Identification of preoperative factors associated with outcomes following surgical management of intra-abdominal recurrent or metastatic GIST following neoadjuvant tyrosine kinase inhibitor therapy.

    abstract：BACKGROUND:The role of surgical resection in the treatment of patients with metastatic/recurrent gastrointestinal stromal tumors (GIST) is unclear. The aim of this study was to identify preoperative factors associated with oncologic outcomes for recurrent/metastatic GIST after tyrosine kinase inhibitor (TKI) therapy. ...

    journal_title：Journal of surgical oncology

    pub_type： 杂志文章

    doi：10.1002/jso.24988

    authors： Roland CL,Bednarski BK,Watson K,Torres KE,Cormier JN,Wang WL,Lazar AJ,Somaiah N,Hunt KK,Feig BW

    更新日期：2018-04-01 00:00:00

  • The effect of preoperative transarterial chemoembolization of resectable hepatocellular carcinoma on clinical and economic outcomes.

    abstract：BACKGROUND:Hepatocellular carcinoma (HCC) is one of the most malignant cancers in the world. The effect of preoperative transarterial chemoembolization (TACE) for resectable HCC is still controversial and cost-associated treatments are unknown. METHODS:We retrospectively compared clinical outcomes and resource utiliza...

    journal_title：Journal of surgical oncology

    pub_type： 杂志文章

    doi：10.1002/jso.21248

    authors： Lee KT,Lu YW,Wang SN,Chen HY,Chuang SC,Chang WT,Shi HY,Ker CG,Chiu HC

    更新日期：2009-05-01 00:00:00

  • Spinal metastases of basal cell carcinoma.

    abstract：:A case of spine metastasis of basal cell carcinoma and review of the literature are presented. The treatment approach is discussed. ...

    journal_title：Journal of surgical oncology

    pub_type： 杂志文章

    doi：10.1002/jso.2930250109

    authors： Weshler Z,Leviatan A,Peled I,Wexler M

    更新日期：1984-01-01 00:00:00

  • Serological evaluation of human brain tumors using a microradioisotopic staphylococcal protein A assay.

    abstract：:A microradioisotopic staphylococcal protein A assay was applied to the serological evaluation of preoperative sera from brain tumor patients. The assay was performed in Terasaki plates, and a stainless steel punch and multiholed die facilitated sample prearation. Using allogeneic astrocytoma target cells, 15/19 of the...

    journal_title：Journal of surgical oncology

    pub_type： 杂志文章

    doi：10.1002/jso.2930140306

    authors： Cohen AM,Wood WC

    更新日期：1980-01-01 00:00:00

  • Histiocytoid carcinoma: a variant of breast cancer.

    abstract：:The history of a patient presenting with metachronous bilateral breast cancer displaying histiocytoid features is reviewed. Although regional metastases were noted, this patient has not demonstrated an aggressive systemic disease pattern. In the past, histiocytoid breast cancer has been classified as either a lipid-ri...

    journal_title：Journal of surgical oncology

    pub_type： 杂志文章

    doi：10.1002/jso.2930310410

    authors： Eisenberg BL,Bagnall JW,Harding CT 3rd

    更新日期：1986-04-01 00:00:00

  • Performance of prognostic scores and staging systems in predicting long-term survival outcomes after surgery for intrahepatic cholangiocarcinoma.

    abstract：INTRODUCTION:We sought to validate the commonly used prognostic models and staging systems for intrahepatic cholangiocarcinoma (ICC) in a large multi-center patient cohort. METHODS:The overall (OS) and disease free survival (DFS) prognostic discriminatory ability of various commonly used models were assessed in a larg...

    journal_title：Journal of surgical oncology

    pub_type： 杂志文章

    doi：10.1002/jso.24759

    authors： Buettner S,Galjart B,van Vugt JLA,Bagante F,Alexandrescu S,Marques HP,Lamelas J,Aldrighetti L,Gamblin TC,Maithel SK,Pulitano C,Margonis GA,Weiss M,Bauer TW,Shen F,Poultsides GA,Marsh JW,IJzermans JNM,Groot Koerkamp B

    更新日期：2017-12-01 00:00:00

  • Detubularized rectosigmoid neobladder in women after cystectomy for bladder cancer.

    abstract：BACKGROUND AND OBJECTIVES:We present the long-term functional results of a new technique for bladder substitution after cystectomy for bladder cancer in women. METHODS:Between 1991 and 1995, 10 women underwent radical cystectomy for bladder cancer with a new technique. We created a detubularized rectosigmoid neobladde...

    journal_title：Journal of surgical oncology

    pub_type： 杂志文章

    doi：10.1002/1096-9098(200005)74:1<49::aid-jso12>3.0.co

    authors： Mearini E,Mearini L,Zucchi A,Costantini E,Goracci G,Porena M

    更新日期：2000-05-01 00:00:00

  • Expression of RCAS1 in esophageal squamous cell carcinoma is associated with a poor prognosis.

    abstract：BACKGROUND:Receptor-binding cancer antigen expressed on SiSO cells (RCAS1) has been reported to act as a ligand for a receptor present on normal peripheral lymphocytes and to induce apoptotic cell death. We aimed to elucidate the significance of RCAS1 expression in human esophageal squamous cell carcinomas (ESCC). MET...

    journal_title：Journal of surgical oncology

    pub_type： 杂志文章

    doi：10.1002/jso.20249

    authors： Kato H,Nakajima M,Masuda N,Faried A,Sohda M,Fukai Y,Miyazaki T,Fukuchi M,Tsukada K,Kuwano H

    更新日期：2005-05-01 00:00:00

  • The effect of mixed distributions on the methods of survival analysis.

    abstract：:A study of the effectiveness of preoperative radiation as an adjuvant for surgery for patients with invasive bladder carcinoma revealed a subpopulation of patients having advanced disease who could not benefit from radiation treatment. The effect of such a group of patients on the efficiency of 2 common nonparametric ...

    journal_title：Journal of surgical oncology

    pub_type： 杂志文章

    doi：10.1002/jso.2930100111

    authors： Bross DS

    更新日期：1978-01-01 00:00:00

  • Evaluation of a hydrogel based breast biopsy marker (HydroMARK®) as an alternative to wire and radioactive seed localization for non-palpable breast lesions.

    abstract：BACKGROUND AND OBJECTIVES:HydroMARK® is a newly available biopsy marker for image-guided needle biopsies of non-palpable breast lesions. Objective was to determine if the marker could be utilized independently for lesion localization using intra-operative ultrasound alone. METHODS:A single institution retrospective re...

    journal_title：Journal of surgical oncology

    pub_type： 杂志文章

    doi：10.1002/jso.22146

    authors： Klein RL,Mook JA,Euhus DM,Rao R,Wynn RT,Eastman AB,Leitch AM

    更新日期：2012-05-01 00:00:00

  • A review of thyroid cancer with intermediate differentiation.

    abstract：BACKGROUND AND OBJECTIVES:Tall cell (TCV), columnar cell (CCV), insular (IC), diffuse sclerosing (DSPTC) and solid/trabecular are uncommon subtypes of thyroid cancer, which have generally been described in case reports or small series in the world literature. Due to the rarity of these thyroid cancers, their clinical b...

    journal_title：Journal of surgical oncology

    pub_type： 杂志文章,评审

    doi：10.1002/jso.20044

    authors： Sywak M,Pasieka JL,Ogilvie T

    更新日期：2004-04-01 00:00:00

  • A single blinded randomized controlled trial comparing semi-mechanical with hand-sewn cervical anastomosis after esophagectomy for cancer (SHARE-study).

    abstract：OBJECTIVE:The aim was to compare leak rate between hand-sewn end-to-end anastomosis (ETE) and semi-mechanical anastomosis (SMA) after esophagectomy with gastric tube reconstruction. BACKGROUND DATA:The optimal surgical technique for creation of an anastomosis in the neck after esophagectomy is unclear. METHODS:Patien...

    journal_title：Journal of surgical oncology

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1002/jso.26209

    authors： Nederlof N,Tilanus HW,de Vringer T,van Lanschot JJB,Willemsen SP,Hop WCJ,Wijnhoven BPL

    更新日期：2020-12-01 00:00:00

  • Prognostic utility of albumin-bilirubin grade for short- and long-term outcomes following hepatic resection for intrahepatic cholangiocarcinoma: A multi-institutional analysis of 706 patients.

    abstract：BACKGROUND:The objective of the current study was to define the impact of albumin-bilirubin (ALBI) grade on short- as well as long-term outcomes among patients with intrahepatic cholangiocarcinoma (ICC). METHODS:Patients who underwent hepatectomy for ICC between 1990 and 2016 were identified using an international mul...

    journal_title：Journal of surgical oncology

    pub_type： 杂志文章,多中心研究

    doi：10.1002/jso.25486

    authors： Tsilimigras DI,Hyer JM,Moris D,Sahara K,Bagante F,Guglielmi A,Aldrighetti L,Alexandrescu S,Marques HP,Shen F,Koerkamp BG,Endo I,Pawlik TM,other members of the International Intrahepatic Cholangiocarcinoma Study Group.

    更新日期：2019-08-01 00:00:00

  • Pigmented villonodular synovitis of joints.

    abstract：OBJECTIVES:The objective of this study is to present two series of cases of pigmented villonodular disease of joints (PVNS) treated at different periods. The 215 cases from our hospital are current (1972-2009) and those 62 from the Jaffe collection from 1920 to 1968. METHODS:By use of our computerized tumor data syste...

    journal_title：Journal of surgical oncology

    pub_type： 杂志文章

    doi：10.1002/jso.21835

    authors： Mankin H,Trahan C,Hornicek F

    更新日期：2011-04-01 00:00:00