Application of 99mTc labeled chimeric Fab fragments of monoclonal antibody A7 for immunoscintigraphy of pancreatic carcinoma.

Abstract:

BACKGROUND:One of the reasons for the poor prognosis of pancreatic carcinoma is the difficulty of obtaining an early diagnosis of pancreatic carcinoma. One possibility is the application of radioimmunoscintigraphy using radiolabeled monoclonal antibodies (Mabs). METHODS:We labeled chimeric (human/mouse) Fab fragments of Mab A7 (chA7Fab) with (99m)Tc and examined the distribution of (99m)Tc-labeled chA7Fab in nude mice bearing human pancreatic carcinoma. RESULTS:The tumor accumulation of (99m)Tc-labeled chA7Fab was larger than that of (99m)Tc-labeled A7 from 2 to 6 hr after injection. (99m)Tc-labeled chA7Fab disappeared from blood more rapidly than (99m)Tc-labeled A7. For all resected normal tissues except kidney, the accumulation of (99m)Tc-labeled chA7Fab was low and similar to that of (99m)Tc-labeled A7. CONCLUSIONS:Because the half-life of (99m)Tc is short (6 hr), chA7Fab, which accumulates rapidly in tumors, may be a better carrier of (99m)Tc than intact Mab A7.

journal_name

J Surg Oncol

authors

Otsuji E,Matsumura H,Okamoto K,Toma A,Kuriu Y,Ichikawa D,Hagiwara A,Yamagishi H

doi

10.1002/jso.10311

subject

Has Abstract

pub_date

2003-11-01 00:00:00

pages

160-5

issue

3

eissn

0022-4790

issn

1096-9098

journal_volume

84

pub_type

杂志文章
  • Intraperitoneal cisplatin with sodium thiosulfate protection in rats with intestinal anastomoses.

    abstract::Intraperitoneal (IP) cisplatin administered at the time of intraabdominal malignancies such as gastric cancer may prevent or delay intraabdominal recurrence. Perioperative IP cisplatin raises concerns regarding systemic toxicity and retardation of wound healing. Systemic cisplatin toxicity may be reduced by administer...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.2930520415

    authors: Wile AG,Dileo SK,Gossett DA,Lao XY

    更新日期:1993-04-01 00:00:00

  • Combination therapy with mitomycin C, 5-fluorouracil, and cytosine arabinoside for nonresectable malignant tumor in man.

    abstract::The effectiveness of MFC (mitomycin C, 5-fluorouracil and cytosine arabinoside) therapy for nonresectable cancers and cancers recurring after surgery was investigated in 60 patients with solid cancers aged 26 to 69 years. Treatment was effective in 28 patients (47%) including seven (12%) who showed a very good respons...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.2930100507

    authors: Yamaguchi T,Nakamura M

    更新日期:1978-01-01 00:00:00

  • The epidermal growth factor receptor gene sequence is highly conserved in primary gastric cancers.

    abstract:BACKGROUND AND OBJECTIVES:Recent studies have disclosed the presence of somatic mutations in the epidermal growth factor receptor (EGFR) gene in non-small cell lung cancers (NSCLC), and susceptibility to the EGFR tyrosine kinase inhibitor (gefitinib) was determined by the presence of mutations in the kinase domain of t...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.20426

    authors: Mimori K,Nagahara H,Sudo T,Ishii H,Yamashita K,Barnard GF,Mori M

    更新日期:2006-01-01 00:00:00

  • Long noncoding RNA LINC01133 inhibits oral squamous cell carcinoma metastasis through a feedback regulation loop with GDF15.

    abstract:BACKGROUND AND OBJECTIVES:Long noncoding RNAs (lncRNAs) play key roles in carcinoma metastasis. We aimed to investigate lncRNA LINC01133 in oral squamous cell carcinoma (OSCC) metastasis. METHODS:The RNA levels of LINC01133 and growth and differentiation factor 15 (GDF15) in tissue samples from OSCC patients, and OSCC...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.25278

    authors: Kong J,Sun W,Zhu W,Liu C,Zhang H,Wang H

    更新日期:2018-12-01 00:00:00

  • Multimodality treatment of intrahepatic cholangiocarcinoma: A review.

    abstract::Intrahepatic cholangiocarcinoma (iCCA) is the second most common primary hepatic cancer in the United States. Currently, curative treatment involves aggressive surgery. Chemotherapy and radiation treatments have been used for unresectable tumors with some success. Optimizing the use of current and developing novel mul...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章,评审

    doi:10.1002/jso.24093

    authors: Simo KA,Halpin LE,McBrier NM,Hessey JA,Baker E,Ross S,Swan RZ,Iannitti DA,Martinie JB

    更新日期:2016-01-01 00:00:00

  • Minimally invasive gastrectomy for gastric adenocarcinoma in the United States: Utilization and short-term oncologic outcomes.

    abstract:BACKGROUND AND OBJECTIVES:When performed at select centers, minimally invasive gastrectomy (MIG) for gastric adenocarcinoma is associated with reduced perioperative morbidity, and similar oncologic outcomes as compared to open gastrectomy (OG). Utilization of, and outcomes associated with, MIG in the United States have...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.24052

    authors: Ecker BL,Datta J,McMillan MT,Poe SL,Drebin JA,Fraker DL,Dempsey DT,Karakousis GC,Roses RE

    更新日期:2015-11-01 00:00:00

  • An unusual late radiotherapy-related complication requiring surgery in anal canal carcinoma.

    abstract::We herein describe an unusual late radiation-related complication requiring surgery in a 60-year-old male affected by anal epidermoid carcinoma. The patient presented with obstructed defecation and ulcerated perianal lesions. The perianal biopsies were positive for anal squamous carcinoma. Transanal diagnostic investi...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/1096-9098(200006)74:2<167::AID-JSO17>3.0.C

    authors: Cicchini C,Stazi A,Ciardi A,Ghini C,Indinnimeo M

    更新日期:2000-06-01 00:00:00

  • Isolated limb infusion as a model to test new agents to treat metastatic melanoma.

    abstract::The limb model of in-transit disease can expand our understanding of treating melanoma because of the ease of obtaining tissue biopsies for correlative studies and the availability of preclinical animal models that allow validation of novel therapeutic strategies. This review will focus on regional therapy for in-tran...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章,评审

    doi:10.1002/jso.23502

    authors: Lidsky ME,Speicher PJ,Jiang B,Tsutsui M,Tyler DS

    更新日期:2014-03-01 00:00:00

  • Mammary carcinoma--multidisciplinary treatment with bilateral mastectomy and immediate reconstruction.

    abstract::The classical concepts pertaining to the natural history of mammary carcinoma and its treatment must be reviewed if survival rate is to be improved. By the time diagnosis is established, a fair amount of cases of carcinoma of the breast present distant, clinically undetectable micrometastases, which will not be affect...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.2930140211

    authors: Gentil F,Callia W,de Souza e Sá A,Cavalcanti S,Garcia E,Giannotti Filho O,Varella AD

    更新日期:1980-01-01 00:00:00

  • Giant cell tumor of bone: oncologic and functional results.

    abstract::Giant cell tumor of bone is a challenging surgical problem due to its mostly aggressive growth with tendency to recur locally, to develop in rare instances pulmonary metastases without histologic evidence of malignant changes, and due to its potential to dedifferentiate into a frankly malignant tumor in a limited numb...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.2930570408

    authors: Renard AJ,Veth RP,Pruszczynski M,Wobbes T,Lemmens JA,van Horn JR

    更新日期:1994-12-01 00:00:00

  • Leveraging the increased rates of pathologic complete response after neoadjuvant treatment in breast cancer to de-escalate surgical treatments.

    abstract:INTRODUCTION:Breast conservative surgery (BCS) and sentinel lymph node biopsy (SLNB) after neoadjuvant treatment (NAT) is safe and effective for selected patients. This aim of this study is to evaluate the impact of anatomic site of response on outcomes and to assess the real population who may benefit from nonsurgical...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.26236

    authors: Esgueva A,Siso C,Espinosa-Bravo M,Sobrido C,Miranda I,Salazar JP,Rubio IT

    更新日期:2021-01-01 00:00:00

  • Desmoplastic melanoma - the step-child in the melanoma family?

    abstract:BACKGROUND AND OBJECTIVES:Desmoplastic melanoma (DM) is a rare variant of cutaneous melanoma. Our goal was to study the surgical management of DM, identify prognostic factors, and impact of treatment options. METHODS:Patients with DM (n = 1,735) were identified from the Surveillance, Epidemiology, and End Results data...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.21778

    authors: Wasif N,Gray RJ,Pockaj BA

    更新日期:2011-02-01 00:00:00

  • Lymph node assessment in cervical cancer: prognostic and therapeutic implications.

    abstract::Lymph node status is not part of the staging system for cervical cancer, but provides important information for prognosis and treatment. This article reviews the incidence and patterns of lymph node metastasis, and the issues surrounding surgical assessment of lymph nodes. The preoperative assessment of lymph nodes by...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章,评审

    doi:10.1002/jso.21199

    authors: Gien LT,Covens A

    更新日期:2009-03-15 00:00:00

  • Targeting integrins and enhanced permeability and retention (EPR) effect for optical imaging of oral cancer.

    abstract:BACKGROUND AND OBJECTIVES:Near-infrared (NIR) fluorescence optical imaging is a promising technique to assess the tumor margins during cancer surgery. This technique requires targeting by specific fluorescence agents to differentiate tumor from normal surrounding tissue. We assessed the feasibility of cancer detection ...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.22102

    authors: Keereweer S,Mol IM,Kerrebijn JD,Van Driel PB,Xie B,Baatenburg de Jong RJ,Vahrmeijer AL,Löwik CW

    更新日期:2012-06-01 00:00:00

  • Regional chemotherapy is indicated after surgical resection of colorectal metastases to the liver: a debate.

    abstract::Surgical resection for selected patients with hepatic metastases from colorectal cancer can cure approximately one-fourth of these patients. The addition of regional chemotherapy as an attempt to improve this statistic has been extensively investigated in clinical trials. As part of a multidisciplinary educational pro...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章,评审

    doi:10.1002/jso.10171

    authors: Khushalani NI,McKinley BP,Gibbs JF,Leichman CG,Petrelli NJ

    更新日期:2003-01-01 00:00:00

  • Glutathione and phospholipid depletion of liver tumors after arterial ischemia.

    abstract::Breakdown of membrane phospholipids is a causative event leading to irreversible cell injury after ischemia and reperfusion insults, which might be one mechanism leading to liver tumor cell death after repeated arterial ischemia as well. After 2 hr of hepatic dearterialization followed by 30 min of reperfusion tumor p...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/(SICI)1096-9098(199604)61:4<284::AID-JSO11

    authors: Wang LQ,Persson BG,Xu N,Seidegård J,Jeppsson B,Bengmark S

    更新日期:1996-04-01 00:00:00

  • Intravenous electrocardiography helps inexperienced operators to place totally implantable venous access device more accurately.

    abstract:BACKGROUND:Proper tip position is a major determinant of totally implantable venous access device (TIVAD) outcome. The aim of this study is to analyze the potential utilization of intravenous electrocardiography (IV-ECG) to help inexperienced operators for TIVAD placement. PATIENTS AND METHODS:This is a retrospective,...

    journal_title:Journal of surgical oncology

    pub_type: 临床试验,杂志文章

    doi:10.1002/jso.23000

    authors: Wang YC,Huang CH,Lin FS,Lin WY,Fan SZ,Lin CP,Sun WZ

    更新日期:2012-06-15 00:00:00

  • A computerized tumor-registry system for persons who do not love computers.

    abstract::A new simplified system for updating a cancer registry has been developed in the Biostatistics Department of Roswell Park Memorial Institute. It was designed to serve the needs of maintaining a registry for a cooperative cancer research group. The Data-Update Procedure at a Remote Terminal (DUPART) system has general ...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.2930070508

    authors: Johnson IC,Blumenson LE,Bross ID

    更新日期:1975-01-01 00:00:00

  • Histologic trends in thyroid cancer 1969-1993: a clinico-pathologic analysis of the relative proportion of anaplastic carcinoma of the thyroid.

    abstract:BACKGROUND:It was observed that new presentations of anaplastic carcinoma of the thyroid had become infrequent in the last two decades. METHODS:All cases of thyroid cancer seen at our centre between 1969-1993 (n = 2921) were classified as papillary 49%, follicular 34%, medullary 7.5%, anaplastic 4.7%, and other 4.8%. ...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/(SICI)1096-9098(199612)63:4<251::AID-JSO7>

    authors: Agrawal S,Rao RS,Parikh DM,Parikh HK,Borges AM,Sampat MB

    更新日期:1996-12-01 00:00:00

  • Acute appendicitis as a sign of a colorectal carcinoma.

    abstract::The relationship of acute appendicitis occurring previous to cancer in colon and rectum was studied in the consecutive records of 561 patients, of 40 years of age and older, operated upon with an appendectomy because of acute appendicitis. Sixteen (2.9%) of these patients were readmitted within three years because of ...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.2930200105

    authors: Arnbjörnsson E

    更新日期:1982-05-01 00:00:00

  • Molecular markers for breast cancer diagnosis, prognosis and targeted therapy.

    abstract::Precision medicine involves understanding the molecular drivers unique to an individual patient's cancer so that specific factors may be targeted with the goal of improved patient outcomes. The purpose of this article is to review standard of care and research grade (non-standard of care) biomarkers in breast cancer t...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章,评审

    doi:10.1002/jso.23732

    authors: Lang JE,Wecsler JS,Press MF,Tripathy D

    更新日期:2015-01-01 00:00:00

  • Significance of palliative gastrectomy for late-stage gastric cancer patients.

    abstract:PURPOSE:To investigate the significance of palliative gastrectomy for different types of metastatic gastric cancer patients displaying peritoneal dissemination, hepatic metastasis, distant lymph node metastasis occurring locally during late-stage disease, and multi-organ metastases. METHODS:We performed a retrospectiv...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.23158

    authors: Chen S,Li YF,Feng XY,Zhou ZW,Yuan XH,Chen YB

    更新日期:2012-12-01 00:00:00

  • Multi-institutional analysis of recurrence and survival after hepatectomy for fibrolamellar carcinoma.

    abstract:BACKGROUND AND OBJECTIVES:Fibrolamellar carcinoma (FLC) presents in young, otherwise-healthy individuals. This study examined recurrence and survival characteristics after surgical resection for FLC by utilizing an international multi-institutional database. METHODS:Consecutive patients undergoing hepatectomy for FLC ...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.23658

    authors: Groeschl RT,Miura JT,Wong RK,Bloomston M,Lidsky ML,Clary BM,Martin RC,Belli G,Buell JF,Gamblin TC

    更新日期:2014-09-01 00:00:00

  • Interstitial laser thermotherapy in the treatment of colorectal liver metastases.

    abstract::Metastatic liver disease is the commonest cause of death in patients with colorectal cancer. A small proportion of these patients (10%) may be treated by surgical resection with five year survival approaching 35-40%. Alternative treatment modalities for localised hepatic disease include in situ ablative techniques tha...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章,评审

    doi:10.1002/1096-9098(200101)76:1<73::aid-jso1014>3.0.

    authors: Muralidharan V,Christophi C

    更新日期:2001-01-01 00:00:00

  • Prognosis of T4 gastric carcinoma patients: an appraisal of aggressive surgical treatment.

    abstract:BACKGROUND AND OBJECTIVES:Despite precipitous drop in the incidence of gastric carcinoma in Japan, it is still one of the leading causes of death associated with malignant disease. Once the contiguous organs are involved the prognosis becomes dismal. Prognostic factors governing the survival of patients with T4 gastric...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.1046

    authors: Dhar DK,Kubota H,Tachibana M,Kinugasa S,Masunaga R,Shibakita M,Kohno H,Nagasue N

    更新日期:2001-04-01 00:00:00

  • Nerve sheath tumors of the sciatic nerve and sacral plexus.

    abstract::Eight patients with sciatic nerve and sacral plexus nerve sheath tumors, seen at Louisiana State University Medical Center in Shreveport, are presented. These cases illustrate the broad spectrum of pathology and modes of presentation of patients with nerve sheath tumors in this region. Patients can be divided into 4 g...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.2930390103

    authors: Benzel EC,Morris DM,Fowler MR

    更新日期:1988-09-01 00:00:00

  • Isolated limb perfusion in Merkel cell carcinoma offers high rate of complete response and durable local-regional control: Systematic review and institutional experience.

    abstract:INTRODUCTION:Hyperthermic isolated limb perfusion (HILP) has an established role in the management of melanoma, but its role for Merkel cell carcinoma (MCC) is less well defined. METHODS:Retrospective review of our institutional experience with HILP for MCC was conducted (2009-2015). Literature search was performed th...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章,评审

    doi:10.1002/jso.24289

    authors: Thiels CA,Gonzalez AB,Gray RJ,Jakub JW

    更新日期:2016-08-01 00:00:00

  • Immune-competent cells of regional lymph nodes in colorectal cancer patients: II. Immunohistochemical analysis of Leu-7+ cells.

    abstract::Distribution of Leu-7+ cells in cancer tissues and regional lymph nodes was immunohistochemically examined to estimate the role of NK cells in colorectal cancer patients. Leu-7+ cells were rarely observed both in the primary and distant metastatic lesions, but the number of these cells was large in the germinal center...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.2930450406

    authors: Adachi W,Usuda N,Sugenoya A,Iida F

    更新日期:1990-12-01 00:00:00

  • Breast cancer and meningioma.

    abstract::A unique association between meningioma and breast cancer has recently been observed. A review of the literature reveals 33 such cases. Certain similarities exist between these two tumors. They each occur more frequently in women in the fifth and sixth decade, and pregnancy accelerates the symptoms of both entities. F...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.2930310309

    authors: Miller RE

    更新日期:1986-03-01 00:00:00

  • Nomograms for predicting overall and recurrence-free survival after trimodality therapy for esophageal adenocarcinoma.

    abstract:BACKGROUND:Locally advanced esophageal carcinoma is treated with neoadjuvant chemoradiation and esophagectomy. Patients may still experience recurrence and death despite undergoing potentially curative trimodality therapy. This study describes predictive nomograms for recurrence-free (RFS) and overall survival (OS) aft...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.26349

    authors: Merritt RE,Abdel-Rasoul M,Souza DM,Kneuertz PJ

    更新日期:2020-12-17 00:00:00