Abstract:
:Breakdown of membrane phospholipids is a causative event leading to irreversible cell injury after ischemia and reperfusion insults, which might be one mechanism leading to liver tumor cell death after repeated arterial ischemia as well. After 2 hr of hepatic dearterialization followed by 30 min of reperfusion tumor phospholipid was measured chromatographically, glutathione (GSH) analyzed by determining nonprotein sulfhydryl and activity of glutathione-S-transferase (GST) determined spectrophotometrically using 1-chloro-2,4-dinitrobenzene (CDNB) as the substrate. A transient, arterial ischemia for 2 hr induced a substantial decrease of phosphatidylserine (PS) and phosphatidylinosital (PI) compared with sham treatment (P < 0.01). Although phosphatidylcholine (PC) and phosphatidylethanolamine (PE) did not significantly decline after a single arterial ischemia for 2 hr, they dropped dramatically following repeated arterial ischemia for 2 hr during 5 days (P < 0.01 and P < 0.05 respectively). GSH was depleted in tumors after both a single (P < 0.01) and repeated arterial ischemia (P < 0.05) and GST was inactivated as well (P < 0.001). By contrast, neither liver phospholipid nor liver GSH or GST was significantly changed. Tumor growth was significantly retarded in rats subjected to repeated arterial ischemia compared with sham treatment (P < 0.01). Repeated arterial ischemia facilitated degradation of tumor membrane phospholipids and induced depletion of GSH and inactivation of GST without affecting the normal liver. Thus, ischemia/reperfusion induced depletion of membrane phospholipids and of GSH might represent two mechanisms by which repeated arterial ischemia led to tumor growth delay.
journal_name
J Surg Oncoljournal_title
Journal of surgical oncologyauthors
Wang LQ,Persson BG,Xu N,Seidegård J,Jeppsson B,Bengmark Sdoi
10.1002/(SICI)1096-9098(199604)61:4<284::AID-JSO11subject
Has Abstractpub_date
1996-04-01 00:00:00pages
284-9issue
4eissn
0022-4790issn
1096-9098pii
10.1002/(SICI)1096-9098(199604)61:4<284::AID-JSO11journal_volume
61pub_type
杂志文章abstract:BACKGROUND AND OBJECTIVES:The purpose of this study was to estimate the risk factors having relationships with pathologic fracture of osteosarcoma of extremities and to evaluate the role of limb salvage surgery in this group of patients. METHODS:We retrospectively analyzed 28 consecutive cases of pathologic fracture o...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.23150
更新日期:2012-12-01 00:00:00
abstract::Oncogenes, tumor suppressor genes, and growth factors are being explored as to their role in the initiation and progression of most neoplasms, but little information exists on the expression of oncoproteins or growth factors in adenocarcinoma of the duodenum or ampulla of Vater. This report covers expressions of p53, ...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/(SICI)1096-9098(199602)61:2<100::AID-JSO3>
更新日期:1996-02-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Malignant cartilage tumors demonstrate chemotherapeutic resistance through undetermined mechanisms. P-glycoprotein is the protein product of the multiple drug resistance gene 1 (MDR-1) and confers multidrug chemotherapeutic resistance in a variety of malignancies. METHODS:MDR-1 expression was...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/(sici)1096-9098(199706)65:2<95::aid-jso5>3
更新日期:1997-06-01 00:00:00
abstract::We herein describe an unusual late radiation-related complication requiring surgery in a 60-year-old male affected by anal epidermoid carcinoma. The patient presented with obstructed defecation and ulcerated perianal lesions. The perianal biopsies were positive for anal squamous carcinoma. Transanal diagnostic investi...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/1096-9098(200006)74:2<167::AID-JSO17>3.0.C
更新日期:2000-06-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Several studies report the health-related quality of life (HRQoL) after total gastrectomy in short term but long-term results have been less published. METHODS:One hundred and seventy two patients underwent total gastrectomy between years 1987-1999 for gastric carcinoma. In 2005, 30% of them ...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.20925
更新日期:2008-02-01 00:00:00
abstract:INTRODUCTION:Low-heat treated autograft may have an advantage over allograft in that they provide a size-matched and biologically compatible graft. MATERIALS AND METHODS:We compared the graft survival and complications between the low-heat treated autografts (n = 13) and allografts (17) for intercalary reconstruction ...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.23727
更新日期:2014-12-01 00:00:00
abstract::To gauge the impact of screening mammography and opinions regarding surgical procedures on the pattern of primary surgical care of breast cancer, tumor registry statistics from 1980-81 were compared to those from 1987 at a large community hospital. Over the course of six years, there was a significant increase in the ...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930450104
更新日期:1990-09-01 00:00:00
abstract:BACKGROUND AND OBJECTIVE:This study aims to investigate the surgical outcomes observed in robotic transperitoneal aortic lymphadenectomy (AL) in gynecological cancer patients. METHODS:Retrospective data were collected and analyzed on 71 patients undergoing robotic surgical procedures for gynecological cancers, includi...
journal_title:Journal of surgical oncology
pub_type: 临床试验,杂志文章
doi:10.1002/jso.25335
更新日期:2019-03-01 00:00:00
abstract::Cryotechnology is currently used for both treatment and diagnosis of breast disease. Due to the natural analgesic effect of cold, cryoablation is potentially more patient-friendly than other technologies which raise tissue temperature. Freezing produces a predictable volume of necrosis and is easily observed and contr...
journal_title:Journal of surgical oncology
pub_type: 杂志文章,评审
doi:10.1002/jso.20201
更新日期:2005-04-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Arterial resection (AR) has traditionally been considered as a contraindication to pancreatic resection for locally advanced pancreatic adenocarcinoma. The objective was to evaluate if pancreatic resection with AR was worthwhile. METHODS:Between January 1990 and December 2008 the records of 2...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.21769
更新日期:2011-01-01 00:00:00
abstract::The clinicopathologic features of a case of malignant Brenner tumor with bilateral ovarian involvement are described. The tumor was apparently confined within the ovaries at initial laparotomy. However, multiple skeletal metastases developed 4 months later and the patient died of the disease 6 months after diagnosis. ...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930260312
更新日期:1984-07-01 00:00:00
abstract::Matrix metalloproteinases (MMPs) are a group of at least 26 enzymes that facilitate cellular invasion via the degradation of the extracellular matrix. Specifically, the ability to degrade collagen types III and I is important in tumor invasion and metastasis. Over expression of the MMP-1 gene has been shown to correla...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.20100
更新日期:2004-09-01 00:00:00
abstract::There are a number of retroperitoneal pathologies that may be confused with adrenal tumors. It is important to suspect and recognize these conditions as their management and work up might be different than adrenal tumors. This review will go in to the differential diagnosis and unique features of these conditions. A m...
journal_title:Journal of surgical oncology
pub_type: 杂志文章,评审
doi:10.1002/jso.23133
更新日期:2012-10-01 00:00:00
abstract:BACKGROUND:Sentinel node biopsies (SNBs) have been clinically applied in melanoma and breast cancer for limited lymphadenectomy. However, the use of SNB remains controversial in gastric cancer due to unsatisfactory sensitivity and variability. This meta-analysis was performed to determine the sensitivity of SNB in gast...
journal_title:Journal of surgical oncology
pub_type: 杂志文章,meta分析
doi:10.1002/jso.21995
更新日期:2011-11-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Stage III malignant melanoma is a heterogeneous disease where those cases deemed marginally resectable or irresecatble are frequently incurable by surgery alone. Targeted therapy takes advantage of the high incidence of BRAF mutations in melanomas, most notably the V600E mutation. These agents...
journal_title:Journal of surgical oncology
pub_type: 临床试验,杂志文章
doi:10.1002/jso.24744
更新日期:2017-12-01 00:00:00
abstract::A retrospective study of 74 cases of cancer of the mobile tongue and floor of the mouth, diagnosed between 1949 and 1975, with a two-year minimum follow-up was undertaken. The lesions were TNM staged, stages I and II accounting for 56 cases (76%) and stages III and IV accounting for 18 cases (24%). The analysis was ...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930100408
更新日期:1978-01-01 00:00:00
abstract::Cancer registries are sources of epidemiological, patterns-of-care, and outcome data for local, regional, state, and national studies of patients with cancer. Since 1976, these registries have formed a voluntary network of contributors to annual patient care studies under the aegis of the National Cancer Data Committe...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930580304
更新日期:1995-03-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Argyrophilic nucleolar organizer regions (AgNORs) have been recently identified as a marker of proliferative index in various tumors. These were evaluated in 46 patients with primary breast carcinoma and were correlated with clinical prognostic parameters of breast cancer. Ten patients with be...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/(sici)1096-9098(199707)65:3<201::aid-jso10
更新日期:1997-07-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:miR-301a is significantly overexpressed in many cancers. However, its expression and biological role in gastric cancer remain poorly understood. We investigated microRNA-301a (miR-301a) expression in gastric cancer and determined its effects on cancer cell behavior and its clinical significanc...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.23374
更新日期:2013-09-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:The diagnosis of invasive breast cancer is most commonly made on image-guided core biopsy (CB). The presence of extensive intraductal component (EIC), as identified on subsequent lumpectomy, is associated with an increased risk of positive margins and need for further surgery. CBs demonstratin...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.20242
更新日期:2005-05-01 00:00:00
abstract:BACKGROUND:Angiosarcoma is an aggressive vascular neoplasm with a high propensity for local recurrence. Electrochemotherapy is an emerging skin-directed therapy, exerting prominent cytotoxic activity, and antivascular effects. Its efficacy in angiosarcoma has not been investigated. METHODS:This multicenter retrospecti...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.24287
更新日期:2016-08-01 00:00:00
abstract::Fifteen fetal thymuses and 100 thymomas were examined concerning the degree of differentiation of thymic epithelial cells by light and electron microscopy. The following results were obtained. The embryologic process of the fetal thymus was categorized into four stages (8, 12, 15, and 17 weeks or more of gestation) ba...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930310212
更新日期:1986-02-01 00:00:00
abstract:BACKGROUND:Malignant hip lesions can be managed operatively by intramedullary (IM) nail fixation and hemiarthroplasty. METHODS:A retrospective review was performed on 86 patients who underwent hemiarthroplasty (n = 22) or IM nail fixation (n = 64) for prophylactic treatment of impending pathologic fracture due to mali...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.24792
更新日期:2017-12-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Among several long-term effects, people treated for cancer may experience an altered appearance. Our study aims to identify how visible body changes following surgical treatment affect the life and identity of primary bone sarcoma survivors 3-10 years after diagnosis. A qualitative, phenomenol...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.24138
更新日期:2016-02-01 00:00:00
abstract:BACKGROUND:The optimal approach to biliary drainage for patients with supra-ampullary cholangiocarcinoma remains undetermined. Violation of sphincter of Oddi results in bacterial colonization of bile ducts and may increase postdrainage infectious complications. We sought to determine if rates of cholangitis are affecte...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.25485
更新日期:2019-08-01 00:00:00
abstract::A case of qualitative platelet dysfunction following cancer chemotherapy is documented. Besides the numerical reduction defect, there appear to be functional changes in the platelets leading to bleeding diathesis. The present case was thoroughly evaluated, and it was observed that there is suppression of the platelet ...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930250308
更新日期:1984-03-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:The use of antibiotic prophylaxis for soft tissue sarcoma resection varies widely while little evidence on this topic exists. The aim of this study was to determine the impact of antibiotic prophylaxis on the occurrence of wound infections. METHODS:A single institutional retrospective cohort ...
journal_title:Journal of surgical oncology
pub_type: 临床试验,杂志文章
doi:10.1002/jso.26188
更新日期:2020-12-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Recent studies have disclosed the presence of somatic mutations in the epidermal growth factor receptor (EGFR) gene in non-small cell lung cancers (NSCLC), and susceptibility to the EGFR tyrosine kinase inhibitor (gefitinib) was determined by the presence of mutations in the kinase domain of t...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.20426
更新日期:2006-01-01 00:00:00
abstract:BACKGROUND:The most effective treatment for patients with esophageal small cell carcinoma has not yet been established because of the overall extremely poor prognosis regardless of the mode of treatment. The role of esophagectomy has been controversial in the management of patients with this disease. METHODS:The clini...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/(sici)1096-9098(199702)64:2<130::aid-jso8>
更新日期:1997-02-01 00:00:00
abstract::A 38-year-old woman with early stage invasive breast cancer was treated with wide excision of the tumor, axillary lymph node dissection, and breast irradiation. Three years later, she gave birth to a normal baby. She attempted breast feeding and had full lactation from the untreated breast. The irradiated breast under...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930460214
更新日期:1991-02-01 00:00:00