Abstract:
:Matrix metalloproteinases (MMPs) are a group of at least 26 enzymes that facilitate cellular invasion via the degradation of the extracellular matrix. Specifically, the ability to degrade collagen types III and I is important in tumor invasion and metastasis. Over expression of the MMP-1 gene has been shown to correlate with poorer outcome in GI tract and gynecological tumors. This level of expression of this gene has been shown to be significantly increased by the presence of a single nucleotide polymorphism in the MMP-1 promoter sequence as a result of the creation of an ETS binding site. This SNP results from the addition of a single guanine base at -1,607 bp 24. Two chondrosarcoma cell lines and a series of 10 resected chondrosarcoma specimens underwent DNA extraction, purification, polymerase chain reaction, and sequencing. The presence of the single nucleotide polymorphism at -1,607 bp was confirmed within the promoter region for MMP-1 in human chondrosarcoma. Because all three genotypes were found in the clinical samples, the SNP may indeed provide a mechanistic explanation for a more aggressive biologic behavior locally and distally for a subset of chondrosarcomas.
journal_name
J Surg Oncoljournal_title
Journal of surgical oncologyauthors
Dickey ID,Scully SPdoi
10.1002/jso.20100subject
Has Abstractpub_date
2004-09-01 00:00:00pages
130-3issue
3eissn
0022-4790issn
1096-9098journal_volume
87pub_type
杂志文章abstract:BACKGROUND AND OBJECTIVES:Near-infrared (NIR) fluorescence optical imaging is a promising technique to assess the tumor margins during cancer surgery. This technique requires targeting by specific fluorescence agents to differentiate tumor from normal surrounding tissue. We assessed the feasibility of cancer detection ...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.22102
更新日期:2012-06-01 00:00:00
abstract::This study comprises 27 cases of male breast cancer treated at the University Hospital from 1966 through 1978. Its incidence was 0.53% of all cancer in males and 3.2% of all mammary cancers. Mean age was 52 years old. Lump in the breast was the commonest presenting feature in all patients followed by skin ulceration i...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930160206
更新日期:1981-01-01 00:00:00
abstract:BACKGROUND AND OBJECTIVE:Adjuvant radiotherapy for node positive breast cancer postmastectomy has been recommended by two previously published randomized controlled trials (RCT). The local-regional recurrence rates in the control arms, however, were considered by some critics to be excessive (> 25% at 10 years). Inadeq...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.1114
更新日期:2001-09-01 00:00:00
abstract::Superficially metastatic melanoma still represents a challenging situation for oncologists and a distressing condition for patients. In this circumstance, local treatment by electrochemotherapy, that is, the combination of brief permeabilizing electric pulses with a low‐toxicity anticancer drug, can be a valuable trea...
journal_title:Journal of surgical oncology
pub_type: 杂志文章,评审
doi:10.1002/jso.23512
更新日期:2014-03-01 00:00:00
abstract:BACKGROUND:Immediate breast reconstruction has many advantages but is associated with higher complication rates than delayed reconstruction. Complications can delay the delivery of adjuvant cancer treatments. This study aimed to develop and validate a risk stratification model for the prediction of perioperative compli...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.25714
更新日期:2019-12-01 00:00:00
abstract::Fibronectin (FN) was investigated in 75 stroma from lung adenocarcinoma patients. Distribution of FN was classified into three patterns based on immunohistochemical evidence: dense, moderate, and sparse distribution. The incidence of the sparse pattern in both stage I and stage III disease was significantly greater in...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930430208
更新日期:1990-02-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Accurately assessing breast volume (BV) relative to the volume of breast tissue to be removed could help objectively determine the optimal surgical candidates for breast conserving surgery. The objective of this study was to determine the optimal mammography-based method of BV estimation. MET...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.25076
更新日期:2018-06-01 00:00:00
abstract::A retrospective review to elucidate the rationale of preoperative irradiation was made on 18 carcinomas of the head of the pancreas area. After 50 Gy/25 fractions of 10 MV X-ray was given, all 18 tumors decreased from 3.3 +/- 0.8 cm to 2.0 +/- 0.7 cm. At the surgical operation, 16 patients (89%) received pancreatic re...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930400303
更新日期:1989-03-01 00:00:00
abstract::Reconstructive procedures following chest wall resection pose a special surgical challenge. With modern surgical technique, a wide range of reconstructive options are at the surgeon's disposal and, hence it is imperative that the appropriate procedure be selected in a given patient. A total of 64 patients underwent re...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930550311
更新日期:1994-03-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:The most common cause of failure in large segment bone allografts used for oncologic reconstruction is allograft fracture. Reinforcement with pressurized intramedullary cement may improve the mechanical properties of allografts. METHODS:We reviewed the prospectively collected records of 45 pa...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.10316
更新日期:2003-12-01 00:00:00
abstract::We report a patient with a large apocrine hidrocystoma. These tumors are almost always under 10 mm in diameter. In this 40-year-old man the tumor measured 20 mm. Apocrine hidrocystoma must be considered when evaluating a patient with a large cystic lesion of the face. Surgical management is similar to that of other be...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930270304
更新日期:1984-11-01 00:00:00
abstract:BACKGROUND:Use of hospice services among patients with pancreatic cancer following pancreatic resection remains unknown. METHODS:Patients with pancreatic cancer who underwent resection were identified in the Medicare Standard Analytic Files. Outcomes included overall hospice use, early hospice enrollment (≥4 weeks bef...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.25623
更新日期:2019-09-01 00:00:00
abstract:INTRODUCTION:Breast conservative surgery (BCS) and sentinel lymph node biopsy (SLNB) after neoadjuvant treatment (NAT) is safe and effective for selected patients. This aim of this study is to evaluate the impact of anatomic site of response on outcomes and to assess the real population who may benefit from nonsurgical...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.26236
更新日期:2021-01-01 00:00:00
abstract::Local recurrence rates after either low anterior resection or abdominoperineal resection were compared in 109 patients undergoing curative surgery for adenocarcinoma of the rectum between 1979 and 1984. Follow-up information was available for 99 patients (91%). The overall recurrence rate was 19%; ten recurrences (26....
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930410409
更新日期:1989-08-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:We retrospectively compared surgical outcomes between patients with intra-thoracic and extra-thoracic (cervical and abdominal) lymph-node metastasis. METHODS:The study population comprised 96 patients with lymph-node metastasis who had undergone curative esophagectomy for thoracic esophageal ...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.21425
更新日期:2010-01-01 00:00:00
abstract::Cell surface sialic acid levels were compared for monocytes and macrophages obtained from normal volunteers and breast cancer patients. Equal quantities of sialic acid were found on the monocytes obtained from normal volunteers and breast cancer patients. Approximately 60% more cell surface sialic acid was found on th...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930220203
更新日期:1983-02-01 00:00:00
abstract:BACKGROUND:Few studies have focused on distribution of lymph node metastasis. The aim of this study is to evaluate the prognostic significance of the location of involved lymph nodes in patients with advanced mid or low rectal cancer. METHODS:We defined proximal lymph node involvement (PLNp) as superior rectal and inf...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.21966
更新日期:2011-10-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:We analyzed the clinicopathologic characteristics and tumor biology of metachronous bilateral breast carcinoma with regard to p53, HER2 and hormone receptor status. METHODS:A consecutive series of 54 female metachronous bilateral breast carcinoma patients treated at the National Cancer Center...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.1062
更新日期:2001-05-01 00:00:00
abstract::Prognosis of peritoneal carcinomatosis (PC) from GI tract cancers remains poor. As 30% of patients develop PC after curative surgery, prevention of PC during cancer resection would be desirable. Regarding physiopathology of PC and intraperitoneal immunology, intraoperative application of trifunctional antibodies offer...
journal_title:Journal of surgical oncology
pub_type: 杂志文章,评审
doi:10.1002/jso.21338
更新日期:2009-09-15 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Intraoperative adjuncts for the localization of parathyroid glands in parathyroid surgery are limited. The aim of this study is to assess the usefulness of indocyanine green (ICG) near-infrared (NIR) fluorescent imaging in patients undergoing surgery for primary hyperparathyroidism (PHPT). ME...
journal_title:Journal of surgical oncology
pub_type: 临床试验,杂志文章
doi:10.1002/jso.24240
更新日期:2016-06-01 00:00:00
abstract:BACKGROUND:Retroperitoneal sarcomas are connective tissue tumors arising in the retroperitoneum. Surgical resection is the mainstay of treatment. Debate has arisen over extent of resection, changes in histological classification/grading, and interest in incorporating radiotherapy. Therefore, we reviewed our institution...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.24256
更新日期:2016-07-01 00:00:00
abstract::Pseudomyxoma peritonei is a rare neoplastic condition in that gelatinous intraperitoneal fluid collections and mucinous implants on the peritoneal surfaces and omentum are found. The pathological origin is usually an adenoma or well-differentiated adenocarcinoma of the appendix. A smaller number of cases arises from o...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/1096-9098(200012)75:4<270::aid-jso9>3.0.co
更新日期:2000-12-01 00:00:00
abstract:BACKGROUND:Staging laparoscopy (SL) is used to avoid resection failure and thus increase the curative resection rate. SL utilization in extra-hepatic biliary tumors (EHBT) is variable. METHODS:Data from 1090 patients with potentially resectable EHBT including gallbladder (GBC), distal (DC), and hilar (HC) subtypes wer...
journal_title:Journal of surgical oncology
pub_type: 杂志文章,多中心研究
doi:10.1002/jso.25323
更新日期:2019-03-01 00:00:00
abstract::Tumor markers such as carcinoembryonic antigen (CEA) and CA19-9 were analyzed as response indicators and prognostic factors in advanced colorectal carcinoma. Eighty-five patients participated in a phase II chemotherapy study from October 1984 to July 1990. A three-drug schedule was administered including low dose epir...
journal_title:Journal of surgical oncology
pub_type: 临床试验,杂志文章
doi:10.1002/jso.2930490204
更新日期:1992-02-01 00:00:00
abstract::Diffuse malignant peritoneal mesothelioma (DMPM) has been traditionally regarded as a rapidly lethal disease. Recently, several independent prospective trials have reported improved survival with an intensive loco-regional treatment strategy including cytoreductive surgery (CRS) along with peri-operative intra-periton...
journal_title:Journal of surgical oncology
pub_type: 杂志文章,评审
doi:10.1002/jso.21055
更新日期:2008-09-15 00:00:00
abstract::Eighty-nine breast cancer patients were studied for the end result of therapy. During surgery, the anaesthesia administered was either halothane (61 cases) or ether (28 cases) mixture with nitrogen and oxygen. The holstead method for mastectomy was used for all cases. The results showed that the type of anaesthesia in...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930110312
更新日期:1979-01-01 00:00:00
abstract::The clinical evidence suggests that the steroid hormones may influence the biologic course of tumors of soft tissue. In an attempt to characterize the possible steroid hormone dependency of soft tissue, we studied the incidence and distribution of cytosolic receptors for the steroid hormones in benign and malignant tu...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930280203
更新日期:1985-02-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Current NCCN guidelines recommend epirubicin (E), cisplatin (C), and 5-fluorouracil (F) as a first-line therapeutic approach for operable gastric adenocarcinoma (GC). Molecular profiling (MP) was used to evaluate the expression of chemotherapy targeted biomarkers associated with ECF therapy an...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.23639
更新日期:2014-09-01 00:00:00
abstract::With the rapid uptake of the robotic approach in gynecologic surgery, a thorough understanding of the technology, including its uses and limitations, is critical to maximize patient outcomes and safety. This review discusses the role of training modalities and development of curricula for robotic surgery. Furthermore,...
journal_title:Journal of surgical oncology
pub_type: 杂志文章,评审
doi:10.1002/jso.24006
更新日期:2015-12-01 00:00:00
abstract::The results of surgical management of 63 cases of pulmonary metastases from bone and soft tissue sarcomas, admitted at the Istituto Nazionale Tumori of Milan, between 1970 and 1987, are reviewed in this paper. To estimate the relative impact of metastasectomy on the overall performance of treatment, survival curves we...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930400414
更新日期:1989-04-01 00:00:00