Differences in estrogen receptor status, HER2, and p53 comparing metachronous bilateral breast carcinoma.

Abstract:

BACKGROUND AND OBJECTIVES:We analyzed the clinicopathologic characteristics and tumor biology of metachronous bilateral breast carcinoma with regard to p53, HER2 and hormone receptor status. METHODS:A consecutive series of 54 female metachronous bilateral breast carcinoma patients treated at the National Cancer Center Hospital between 1980 and 1997 were the primary source of these retrospective data. Clinicopathologic background factors were analyzed, and immunohistochemical staining for p53, HER2, and hormone receptor status was carried out on paraffin-embedded specimens. RESULTS:There were no significant differences in clinical stage, p53 and HER2 expression levels between the first and second primary tumors. The positive rates for ER and PR were 48% (25 of 52) and 46% (25 of 54) for the first tumors, but only 19% (10 of 52) and 32% (17 of 54) for the second tumors (P = 0.004 for ER, P = 0.16 for PR), showing a significant loss of ER. CONCLUSIONS:Our findings indicate that p53 and HER2 expression levels in the second tumors might be the same as those of the first tumors in metachronous bilateral breast carcinoma; however, loss of ER was more frequently observed in the second primary tumors than in the first tumors.

journal_name

J Surg Oncol

authors

Matsuo K,Fukutomi T,Tsuda H,Akashi-Tanaka S,Shimizu C,Hasegawa T

doi

10.1002/jso.1062

subject

Has Abstract

pub_date

2001-05-01 00:00:00

pages

31-4

issue

1

eissn

0022-4790

issn

1096-9098

pii

10.1002/jso.1062

journal_volume

77

pub_type

杂志文章
  • Comparative analysis of imaging modalities in the preoperative assessment of nodal metastasis in esophageal cancer.

    abstract::Preoperative radiological findings of nodal status in 74 patients, using endoscopic ultrasonography (EUS), computed tomography (CT), ultrasonography (US), and magnetic resonance imaging (MRI), were compared to histopathology reports following transthoracic total esophagectomy with radical lymphadenectomy (TTE), involv...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/(SICI)1096-9098(199603)61:3<214::AID-JSO10

    authors: Chandawarkar RY,Kakegawa T,Fujita H,Yamana H,Hayabuthi N

    更新日期:1996-03-01 00:00:00

  • Modern reconstructive techniques for abdominal wall defects after oncologic resection.

    abstract::Resection of abdominal wall tumors often leaves patients with debilitating soft tissue defects. Modern reconstructive techniques can be used to restore abdominal wall integrity. In this article, we present an overview of preoperative patient evaluation, analysis of the defect, surgical planning, and the spectrum of av...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章,评审

    doi:10.1002/jso.23824

    authors: Khansa I,Janis JE

    更新日期:2015-04-01 00:00:00

  • Identifying the barriers to gastric cancer care at safety-net hospitals: A novel comparison of a safety-net hospital to a neighboring quaternary referral academic center in the same healthcare system.

    abstract:BACKGROUND:The three-delays model describes delays in seeking, reaching, and receiving care for vulnerable populations needing treatment. The dominant delay for patients with gastric adenocarcinoma (GAC) is unknown. We aimed to define patients with GAC who reached and received care at our regional safety-net hospital (...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.25299

    authors: Zaidi MY,Rappaport JM,Ethun CG,Gillespie T,Hawk N,Chawla S,Cardona K,Maithel SK,Russell MC

    更新日期:2019-01-01 00:00:00

  • Prognostic factors in alveolar soft part sarcoma: A SEER analysis.

    abstract:OBJECTIVES:We reviewed the clinical characteristics and outcomes of patients treated for alveolar soft part sarcoma (ASPS) and analyzed the effect of surgery for patients presenting with and without metastatic disease (DM). METHODS:The SEER Registry was queried for patients with ASPS from 1973-2012. The Kaplan-Meier e...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.24183

    authors: Wang H,Jacobson A,Harmon DC,Choy E,Hornicek FJ,Raskin KA,Chebib IA,DeLaney TF,Chen YL

    更新日期:2016-04-01 00:00:00

  • Is the sentinel node biopsy clinically applicable for limited lymphadenectomy and modified gastric resection in gastric cancer? A meta-analysis of feasibility studies.

    abstract:BACKGROUND:Sentinel node biopsies (SNBs) have been clinically applied in melanoma and breast cancer for limited lymphadenectomy. However, the use of SNB remains controversial in gastric cancer due to unsatisfactory sensitivity and variability. This meta-analysis was performed to determine the sensitivity of SNB in gast...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章,meta分析

    doi:10.1002/jso.21995

    authors: Ryu KW,Eom BW,Nam BH,Lee JH,Kook MC,Choi IJ,Kim YW

    更新日期:2011-11-01 00:00:00

  • Treatment of metastatic melanoma with electrochemotherapy.

    abstract::Superficially metastatic melanoma still represents a challenging situation for oncologists and a distressing condition for patients. In this circumstance, local treatment by electrochemotherapy, that is, the combination of brief permeabilizing electric pulses with a low‐toxicity anticancer drug, can be a valuable trea...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章,评审

    doi:10.1002/jso.23512

    authors: Campana LG,Testori A,Mozzillo N,Rossi CR

    更新日期:2014-03-01 00:00:00

  • Impact of lymph-node metastasis site in patients with thoracic esophageal cancer.

    abstract:BACKGROUND AND OBJECTIVES:We retrospectively compared surgical outcomes between patients with intra-thoracic and extra-thoracic (cervical and abdominal) lymph-node metastasis. METHODS:The study population comprised 96 patients with lymph-node metastasis who had undergone curative esophagectomy for thoracic esophageal ...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.21425

    authors: Kunisaki C,Makino H,Kimura J,Oshima T,Fujii S,Takagawa R,Kosaka T,Ono HA,Akiyama H

    更新日期:2010-01-01 00:00:00

  • A prediction model for lymph node metastasis in early-stage gastric cancer: Toward tailored lymphadenectomy.

    abstract:BACKGROUND:The aim of this study was to develop a prediction model for the presence and location of lymph node metastasis (LNM) in early gastric cancer. METHOD:We reviewed medical records of 4 929 patients who underwent radical gastrectomy for early gastric cancer. Variables of age, sex, lymphatic invasion, depth of i...

    journal_title:Journal of surgical oncology

    pub_type: 临床试验,杂志文章

    doi:10.1002/jso.25628

    authors: Kim SM,Lee H,Min BH,Kim JJ,An JY,Choi MG,Bae JM,Kim S,Sohn TS,Lee JH

    更新日期:2019-09-01 00:00:00

  • Lymphatic-venous anastomosis in a rat model: A novel exercise for microsurgical training.

    abstract:BACKGROUND AND OBJECTIVES:Lymphedema is a condition of localized fluid retention and tissue swelling caused by a compromised lymphatic system. Lymphaticovenular anastomoses (LVA) and multiple lymphatic-venous anastomoses (MLVAs) have been recognized as efficient methods to treat chronic lymphedema. Because few models f...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.25234

    authors: Leuzzi S,Maruccia M,Elia R,Annoscia P,Vestita M,Nacchiero E,Giudice G

    更新日期:2018-11-01 00:00:00

  • A comparative study of breast cancer in the black and white populations of two inner-city hospitals.

    abstract::A comparative study of breast cancer was made among black and white populations admitted to two inner-city hospitals from 1971 through 1976, inclusive. There were 306 patients in the study group of which 162 were black and 144 were white. Age, sex, color, duration of illness, different quadrants of breast involved, st...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.2930150104

    authors: Mittra NK,Rush BF Jr,Verner E

    更新日期:1980-01-01 00:00:00

  • Biodistribution of monoclonal antibody A7 and its F(ab')2 fragment in athymic nude mice bearing human pancreatic carcinoma.

    abstract::Xenografts of a human pancreatic carcinoma cell line, HPC-YS, which reacted with the monoclonal antibody (MAb) A7, were used to investigate the in vivo localization of radioiodinated MAb A7 after intraperitoneal injection. MAb A7 localized to the tumor 4 days and 8 days after injection with a tissue/blood ratio of 1.4...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.2930500309

    authors: Otsuji E,Yamaguchi T,Yamaoka N,Yamaguchi N,Imanishi J,Takahashi T

    更新日期:1992-07-01 00:00:00

  • Correlation between serum prealbumin and prognosis of patients with hepatocellular carcinoma after hepatectomy.

    abstract:OBJECTIVE:To determine whether serum prealbumin levels are associated with long-term survival after hepatectomy in patients with primary hepatocellular carcinoma(HCC). METHODS:A consecutive sample of 526 patients with HCC who underwent potentially curative hepatectomy from August 2007 to August 2010 was retrospectivel...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.25378

    authors: Jia RR,Zhong JH,Huo RR,Su QB,Xiang X,Zhao FL,Qin ZB,Chen JH,Liao YY,Ma L,Xiang BD,Zhang CY,Li LQ

    更新日期:2019-05-01 00:00:00

  • Leiomyosarcoma of Meckel's diverticulum: a case report and review of the literature.

    abstract::A case of leiomyosarcoma of a Meckel's diverticulum, presenting as an acute appendicitis, is reported. The literature is reviewed with particular emphasis on current trends in the diagnosis and management of leiomyosarcomas of the small intestine. ...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.2930320207

    authors: Saadia R,Decker GA

    更新日期:1986-06-01 00:00:00

  • Radiation therapy for advanced and metastatic melanoma.

    abstract::Radiation therapy (RT) is an important modality in cancer treatment. However, the general perception is that melanoma is radio-resistant. High quality clinical trials are helping to establish the place of RT in select scenarios of advanced disease at primary, regional, and distant sites. New RT techniques need to be i...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章,评审

    doi:10.1002/jso.23509

    authors: Fogarty GB,Hong A

    更新日期:2014-03-01 00:00:00

  • Atrophic chronic gastritis and esophagogastric anastomotic leak after resection and reconstruction for esophageal carcinoma.

    abstract::The incidence of anastomotic leakage after esophagectomy for cancer and reconstruction with the stomach was analyzed with respect to the presence of coexistent atrophic chronic gastritis (ACG). Of a total of 28 operated esophageal cancer patients with ACG, 6 patients developed an anastomotic leak at the cervical esoph...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.2930510107

    authors: Rakic S,Pesko P,Milicevic M,Gerzic Z

    更新日期:1992-09-01 00:00:00

  • Prognostic significance of blood vessel invasion in carcinoma of the breast in women.

    abstract::Prognostic significance of blood vessel invasion in carcinoma of the female breast has been evaluated by study of 242 cases of radical mastectomy done at the Tata Memorial Hospital. The significance of axillary node involvement with the disease has been simultaneously evaluated. In the absence of blood vessel invasion...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.2930090613

    authors: Sampat MB,Sirsat MV,Gangadharan P

    更新日期:1977-01-01 00:00:00

  • Indications and techniques for robotic pelvic and para-aortic lymphadenectomy in gynecologic oncology.

    abstract::Robotic-assisted laparoscopy is now the most common surgical method for treatment of early-stage endometrial, cervical, and a growing number of ovarian cancers in the U.S. Para-aortic and pelvic lymphadenectomy is integral to surgical staging and subsequent treatment planning. This article reviews current staging outc...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章,评审

    doi:10.1002/jso.24005

    authors: Wisner KP,Gupta S,Ahmad S,Holloway RW

    更新日期:2015-12-01 00:00:00

  • Tumor differentiation and histological type in human breast cancer.

    abstract::Biopsies from 61 women with breast cancer were assessed for various histological features. These results were statistically analyzed for associations of gross tumor size, patient age, stage of disease, tumor hormone receptor status, with accepted systems of nuclear and histological grading for differentiation. Tumors ...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.2930310109

    authors: Bell CD,Stadler J,Waizbard E,Chaitchik S,Greif F

    更新日期:1986-01-01 00:00:00

  • Changes in the body image of bone sarcoma survivors following surgical treatment--A qualitative study.

    abstract:BACKGROUND AND OBJECTIVES:Among several long-term effects, people treated for cancer may experience an altered appearance. Our study aims to identify how visible body changes following surgical treatment affect the life and identity of primary bone sarcoma survivors 3-10 years after diagnosis. A qualitative, phenomenol...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.24138

    authors: Fauske L,Lorem G,Grov EK,Bondevik H

    更新日期:2016-02-01 00:00:00

  • Submental flap for vascularized lymph node transfer; a CTA-based study on lymph node distribution.

    abstract:BACKGROUND:Amongst various options of vascularized lymph node transfers, the submental flap has the lowest risk for iatrogenic lymphedema. The aim of this study was to gain insight into distribution, number, and size of lymph nodes along the mandible using computed tomography angiography (CTA). METHODS:A total of 52 C...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.26117

    authors: Paulus VAA,Winters H,Hummelink S,Schulten S,Ulrich DJO,Vasilic D

    更新日期:2020-07-15 00:00:00

  • Proposal for anatomical classification of the superior pole in thyroid surgery.

    abstract:OBJECTIVE:To propose a distinct anatomical classification for the superior thyroid pole that may serve as a surgical landmark and could help reduce complications in thyroid surgery. MATERIALS AND METHODS:A comprehensive anatomical study based on existing literature and surgical observations. RESULTS:The proposed supe...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.23950

    authors: Mizrachi A,Swartzwelder CE,Shaha AR

    更新日期:2015-07-01 00:00:00

  • Use of subatmospheric pressure to prevent doxorubicin extravasation ulcers in a swine model.

    abstract:UNLABELLED:Application of subatmospheric pressure to sites injected with doxorubicin prevented ulcer formation in treated sites (0 ulcers/16 sites) compared to control wounds (10 ulcers/16 sites) in a pig model. BACKGROUND AND OBJECTIVES:Extravasation of doxorubicin hydrochloride (Adriamycin) frequently causes chronic...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/(sici)1096-9098(199909)72:1<14::aid-jso4>3

    authors: Morykwas MJ,Kennedy A,Argenta JP,Argenta LC

    更新日期:1999-09-01 00:00:00

  • Invasive cutaneous fungal infections requiring radical resection in cancer patients undergoing chemotherapy.

    abstract::Invasive fungal infections have emerged as a significant problem in patients with cancer with the development of better systemic therapies for malignancy and more effective antibacterial agents. The currently available world published medical literature was reviewed on invasive fungal infections in cancer patients wit...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章,评审

    doi:10.1002/jso.20115

    authors: Radhakrishnan R,Donato ML,Prieto VG,Mays SR,Raad II,Kuerer HM

    更新日期:2004-10-01 00:00:00

  • Contemporary diagnostics: sarcoma pathology update.

    abstract::Sarcoma diagnosis continues to evolve as new information is discovered. Certain tumors have been downgraded (dermal leiomyosarcoma) and an atypical category designed for others. Recently entities include myxoinflammatory fibroblastic sarcoma, myoepithelioma, and pseudomyogenic hemangioendothelioma. The terms malignant...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章,评审

    doi:10.1002/jso.23853

    authors: Brooks JS,Lee S

    更新日期:2015-04-01 00:00:00

  • When is hemiarthroplasty preferable to intramedullary prophylactic fixation of malignant lesions of the proximal femur?

    abstract:BACKGROUND:Malignant hip lesions can be managed operatively by intramedullary (IM) nail fixation and hemiarthroplasty. METHODS:A retrospective review was performed on 86 patients who underwent hemiarthroplasty (n = 22) or IM nail fixation (n = 64) for prophylactic treatment of impending pathologic fracture due to mali...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.24792

    authors: Lin JS,Santiago-Torres JE,Everhart JS,Zayan NE,Mayerson JL,Scharschmidt TJ

    更新日期:2017-12-01 00:00:00

  • Impact of specific modes of circumferential resection margin involvement in rectal cancer local recurrence: A retrospective study.

    abstract:PURPOSE:To compare the local recurrence rate and overall survival between patients with circumferential resection margin (CRM) involvement by direct tumor spread and by a tumor within a lymph node. METHODS:A total of 776 patients diagnosed with rectal cancer underwent rectal resection. Patients with CRM involvement by...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.25252

    authors: Suárez J,Goicoetxea A,Gómez ML,Jiménez G,Llanos MC,Jiménez J,Montes B,de Miguel M

    更新日期:2018-12-01 00:00:00

  • Phase II study of a modified combination of etoposide, doxorubicin, and cisplatin for patients with advanced gastric cancer.

    abstract:BACKGROUND:Based on the promising results of EAP (etoposide, doxorubicin, and cisplatin) combination, a phase II study of modified EAP combination was performed in patients with advanced gastric cancer to evaluate the response, toxicity, and survival. METHOD:Fifty-two consecutive patients with measurable or evaluable ...

    journal_title:Journal of surgical oncology

    pub_type: 临床试验,杂志文章

    doi:10.1002/(sici)1096-9098(199704)64:4<318::aid-jso13

    authors: Içli F,Karaoguz H,Akbulut H,Dinçol D,Demirkazik A,Cay F

    更新日期:1997-04-01 00:00:00

  • Local recurrence after curative resection of rectal cancer: a comparison of low anterior resection and abdominoperineal resection.

    abstract::Local recurrence rates after either low anterior resection or abdominoperineal resection were compared in 109 patients undergoing curative surgery for adenocarcinoma of the rectum between 1979 and 1984. Follow-up information was available for 99 patients (91%). The overall recurrence rate was 19%; ten recurrences (26....

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.2930410409

    authors: Vlasak JW,Wagner D,Passaro E Jr,Wilson SE

    更新日期:1989-08-01 00:00:00

  • Pre-operative chemoradiotherapy with oral tegafur-uracil and leucovorin for rectal cancer.

    abstract:BACKGROUND:To evaluate the efficacy and toxicity of pre-operative radiotherapy (RT) combined with oral tegafur-uracil (UFUR) plus leucovorin (LV) in rectal cancer. PATIENTS:Sixty-five patients with rectal adenocarcinoma (clinical staged T2-4N0-2M0) received pelvic RT of 45 Gy in 20 fractions over 28 days. Concurrent c...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.20168

    authors: Wang LW,Yang SH,Lin JK,Lin TC,Chan WK,Chen WS,Wang HS,Jiang JK,Lee RC,Li AF,Chao Y,Chi KH,Yen SH

    更新日期:2005-03-15 00:00:00

  • Semi-automated delineation of breast cancer tumors and subsequent materialization using three-dimensional printing (rapid prototyping).

    abstract:OBJECTIVE:Three-dimensional (3D) printing has become widely available, and a few cases of its use in clinical practice have been described. The aim of this study was to explore facilities for the semi-automated delineation of breast cancer tumors and to assess the feasibility of 3D printing of breast cancer tumors. ME...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.24510

    authors: Schulz-Wendtland R,Harz M,Meier-Meitinger M,Brehm B,Wacker T,Hahn HK,Wagner F,Wittenberg T,Beckmann MW,Uder M,Fasching PA,Emons J

    更新日期:2017-03-01 00:00:00