Abstract:
UNLABELLED:Application of subatmospheric pressure to sites injected with doxorubicin prevented ulcer formation in treated sites (0 ulcers/16 sites) compared to control wounds (10 ulcers/16 sites) in a pig model. BACKGROUND AND OBJECTIVES:Extravasation of doxorubicin hydrochloride (Adriamycin) frequently causes chronic ulcers, which usually progress and expose underlying structures such as tendons and bone. The exact mechanism of action that causes cell death and the chronic ulcers is unknown. METHODS:Eight sites were injected intradermally with doxorubicin on each of 4 pigs. Four sites on each animal served as untreated controls. The remaining four sites were exposed to 125 mm Hg subatmospheric pressure applied 1 h after injection. The sites were observed on a three times per week schedule. Sites that did not develop ulcers were re-injected up to a total of four injections. The animals were observed for 5 weeks. RESULTS:Ten of sixteen control sites developed ulcers. No subatmospheric pressure treated sites developed ulcers. The incidence of ulcer formation was significantly less for treated wounds compared to control wounds at P < 0.001 by Fisher's exact test. CONCLUSIONS:This physical modality appears to successfully prevent ulcer formation after doxorubicin injection.
journal_name
J Surg Oncoljournal_title
Journal of surgical oncologyauthors
Morykwas MJ,Kennedy A,Argenta JP,Argenta LCdoi
10.1002/(sici)1096-9098(199909)72:1<14::aid-jso4>3subject
Has Abstractpub_date
1999-09-01 00:00:00pages
14-7issue
1eissn
0022-4790issn
1096-9098pii
10.1002/(SICI)1096-9098(199909)72:1<14::AID-JSO4>3journal_volume
72pub_type
杂志文章abstract::From August 1979 to May 1986, various brachytherapy techniques were applied at Memorial Sloan Kettering Cancer Center (MSKCC) in an adjuvant setting with/without surgery and external radiation therapy in the management of advanced malignant melanoma. Thirty-three patients underwent brachytherapy procedures. The patien...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930430407
更新日期:1990-04-01 00:00:00
abstract::We herein describe an unusual late radiation-related complication requiring surgery in a 60-year-old male affected by anal epidermoid carcinoma. The patient presented with obstructed defecation and ulcerated perianal lesions. The perianal biopsies were positive for anal squamous carcinoma. Transanal diagnostic investi...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/1096-9098(200006)74:2<167::AID-JSO17>3.0.C
更新日期:2000-06-01 00:00:00
abstract::Do age, associated diseases, general state, or the stage of tumor determine the operability of breast cancer in the elderly? Risk factors are studied on the basis of data on 465 patients over 70 years of age who had breast cancer surgery between 1977 and 1986. Operative mortality of patients is analyzed, and according...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930410108
更新日期:1989-05-01 00:00:00
abstract::A survival study for squamous carcinomas of the distal esophagus treated by the Southern California Permanente Medical Group in the interval of 1954 to 1988 was undertaken. We found radiation therapy and surgery equally efficacious in terms of cure for patients without distant disease and performance status sufficient...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930460206
更新日期:1991-02-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Re-excision surgery is undertaken to obtain clear margins after breast-conserving surgery (BCS) for localized breast cancer. This study examines patient and tumor characteristics related to re-excision surgery in the universal-access Military Health System (MHS). METHODS:Retrospective analysi...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.25788
更新日期:2019-11-29 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Apoptosis is essential to maintain homeostasis in living organisms and occurs in a variety of tissues in response to both physiological and pathological stimuli. In breast cancer, most cytotoxic drugs and hormonal treatments induce apoptosis. We studied the relationships between apoptosis and ...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/(sici)1096-9098(199908)71:4<226::aid-jso4>
更新日期:1999-08-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Accurately assessing breast volume (BV) relative to the volume of breast tissue to be removed could help objectively determine the optimal surgical candidates for breast conserving surgery. The objective of this study was to determine the optimal mammography-based method of BV estimation. MET...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.25076
更新日期:2018-06-01 00:00:00
abstract:BACKGROUND:Rapid genetic counseling and testing (RGCT) in newly diagnosed high-risk breast cancer (BC) patients may influence surgical treatment decisions. To successfully integrate RGCT in practice, knowledge of professionals', and patients' attitudes toward RGCT is essential. METHODS:Between 2008 and 2010, we perfor...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.24763
更新日期:2017-12-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:The optimal extent of lymphadenectomy in patients with esophageal cancer is controversial. This study aimed to examine the therapeutic value of lymph node (LN) dissection for each LN station in patients with esophageal squamous cell carcinoma (ESCC) who receive neoadjuvant chemotherapy. METHO...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.23965
更新日期:2015-07-01 00:00:00
abstract:BACKGROUND:Inflammation plays an important role in the progression and prognosis of hepatocellular carcinoma (HCC). Our aim is to explore the prognostic value of preoperative and postoperative peripheral lymphocyte differences and to develop a dynamic prognosis nomogram in hepatitis B virus-related HCC patients. METHO...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.26195
更新日期:2020-12-01 00:00:00
abstract::Perineural invasion is associated with tumor spreading and an unfavorable prognosis in a variety of cancers. Recently, neural cell adhesion molecule (NCAM) has been reported to be affinitive to neural tissues, which suggests some relationship between NCAM and perineural invasion. This study was designed to elucidate t...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930530205
更新日期:1993-06-01 00:00:00
abstract::Upper extremity malignancies have the potential to create significant functional impairment, and as such represent an opportunity for collaborative reconstruction to minimize potential morbidity. Given the increased complexity and array of potential reconstruction solutions, functional limb preservation is overwhelmin...
journal_title:Journal of surgical oncology
pub_type: 杂志文章,评审
doi:10.1002/jso.24196
更新日期:2016-06-01 00:00:00
abstract::Three patients treated with bilateral subcutaneous mastectomies and implants for fibrocystic disease or carcinoma in situ subsequently developed invasive breast carcinoma. These cases emphasize that subcutaneous mastectomy does not prevent the development of breast cancer. If the circumstances in an individual patient...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930260313
更新日期:1984-07-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Hepatic arterial infusion (HAI) chemotherapy offers improved hepatic control for liver metastases from colon cancer. Optimal catheter insertion requires an adequate gastroduodenal artery (GDA). Limited data exists on using saphenous vein grafts (SVG) as conduits when native vasculature is inad...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.20890
更新日期:2008-01-01 00:00:00
abstract:OBJECTIVES:To investigate the immunoreactivity of TTF-1 and PAX8 in neuroendocrine carcinoma of thymic (TNEC) and pulmonary origins (PNEC), and whether their immunophenotyping could be used to distinguish between NEC of the two sites, as well as prognosis of patients with TNEC. METHODS:Twenty-two cases of TNEC and 20 ...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.24393
更新日期:2016-11-01 00:00:00
abstract::This article is a brief review alluding to the multidisciplinary modalities including basic science technologies that are available in the treatment of today's cancer victim. The roles are discussed of the general surgeon and of the surgical fellow, later a surgical oncologist, as they merge into their respective posi...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930340202
更新日期:1987-02-01 00:00:00
abstract::A retrospective review to elucidate the rationale of preoperative irradiation was made on 18 carcinomas of the head of the pancreas area. After 50 Gy/25 fractions of 10 MV X-ray was given, all 18 tumors decreased from 3.3 +/- 0.8 cm to 2.0 +/- 0.7 cm. At the surgical operation, 16 patients (89%) received pancreatic re...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930400303
更新日期:1989-03-01 00:00:00
abstract::Patients undergoing neoadjuvant therapy for esophageal cancer are at a high risk for malnutrition due to the effects of chemoradiation, dysphagia, and malignancy induced cachexia. Preparation for esophagectomy requires careful assessment of nutritional risk and adequate supplementation as indicated. Supplementation vi...
journal_title:Journal of surgical oncology
pub_type: 杂志文章,评审
doi:10.1002/jso.21289
更新日期:2009-07-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Development of second primary carcinomas after thoracic esophagectomy has become of much concern, because recently the prognosis of thoracic esophageal carcinoma after esophagectomy with extended lymph node dissection has been improving. We report our experience of diagnosing and treatment sec...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/(sici)1096-9098(199710)66:2<130::aid-jso11
更新日期:1997-10-01 00:00:00
abstract:BACKGROUND:Lymph node metastasis is the most important prognostic factor in patients with carcinoma of the penis. In this article, we have reviewed the outcome of the patients with pathologic node-positive carcinoma of the penis after groin dissection performed at the Cancer Institute (WIA) between 1987 and 1998. METH...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.20414
更新日期:2006-02-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Desmoplastic melanoma (DM) is a rare variant of cutaneous melanoma. Our goal was to study the surgical management of DM, identify prognostic factors, and impact of treatment options. METHODS:Patients with DM (n = 1,735) were identified from the Surveillance, Epidemiology, and End Results data...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.21778
更新日期:2011-02-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Differences in the expression levels of Thyroglobulin (Tg), Thyroid peroxidase (TPO) and thyrotropin receptor (TSH-R) in primary and recurrent specimens under a suppressive serum TSH condition were elucidated in 26 papillary carcinoma patients. METHODS:Immunohistochemical detection was perfor...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/1096-9098(200010)75:2<108::aid-jso7>3.0.co
更新日期:2000-10-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:To evaluate the impact of plasminogen activator (PA) system genes, including urokinase plasminogen activator (uPA), uPA receptor (uPAR), and plasminogen activator inhibitor-1 (PAI-1) gene polymorphisms in patients with the cervical neoplasia. METHODS:In total, 336 blood samples were collected...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.23072
更新日期:2012-08-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:The aim of this study was to evaluate the role of indocyanine green (ICG) fluorescence imaging (FI) for the ex vivo detection of metastatic lymph nodes (LNs) in advanced stage ovarian cancer (AOC). METHODS:Paraffin-embedded LNs from patients included in a previous ICG-FI study (Protocol NCT01...
journal_title:Journal of surgical oncology
pub_type: 临床试验,杂志文章
doi:10.1002/jso.25263
更新日期:2018-12-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:To evaluate the predicting value of the epidermal growth factor receptor (EGFR) for survival in patients with head and neck cancer (HNC). METHODS:Data were collected from studies comparing overall survival (OS) or progression-free survival (PFS) in patients with higher or lower EGFR levels. S...
journal_title:Journal of surgical oncology
pub_type: 杂志文章,meta分析
doi:10.1002/jso.23406
更新日期:2013-11-01 00:00:00
abstract:BACKGROUND:We evaluated the efficacy and feasibility of hyperthermic intraperitoneal chemotherapy (HIPEC) using paclitaxel as consolidation therapy in patients with epithelial ovarian cancer. METHODS:Between November 1999 and January 2004, 18 patients with a negative second-look and 1 patient with positive peritoneal ...
journal_title:Journal of surgical oncology
pub_type: 临床试验,杂志文章
doi:10.1002/jso.21448
更新日期:2010-02-01 00:00:00
abstract::The growth of knowledge and complexity now seen in General Surgery, has led to the sub-specialization of the discipline. Although it is considered by some to have led to the fragmentation of General Surgery and the erosion of the specialty as we know it today, others would argue that it has and will continue to lead t...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.20176
更新日期:2005-03-01 00:00:00
abstract::A retrospective study was made of 38 myosarcomas of the small and large intestines (34 leiomyosarcomas and 4 malignant leiomyoblastomas). Endoenteric, small, and noninvasive tumors were successfully treated by simple wedge excision, cautery snare removal, or segmental bowel resection with a high 5-yr cure rate of 86% ...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930240116
更新日期:1983-09-01 00:00:00
abstract::Fifty-four patients with advanced upper gastrointestinal cancer were assessed for their nutritional status prior to any form of therapy. Anthropometric parameters--weight loss, arm muscle circumference, skin-fold thickness--and biochemical parameters--serum albumin and delayed cutaneous hypersensitivity reactions to p...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930290417
更新日期:1985-08-01 00:00:00
abstract::Pseudomyxoma peritonei is a rare neoplastic condition in that gelatinous intraperitoneal fluid collections and mucinous implants on the peritoneal surfaces and omentum are found. The pathological origin is usually an adenoma or well-differentiated adenocarcinoma of the appendix. A smaller number of cases arises from o...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/1096-9098(200012)75:4<270::aid-jso9>3.0.co
更新日期:2000-12-01 00:00:00