Abstract:
BACKGROUND AND OBJECTIVES:Apoptosis is essential to maintain homeostasis in living organisms and occurs in a variety of tissues in response to both physiological and pathological stimuli. In breast cancer, most cytotoxic drugs and hormonal treatments induce apoptosis. We studied the relationships between apoptosis and clinicopathological variables or prognosis in 143 patients with operable breast cancer. METHODS:Apoptosis was numerically graded in 5 consecutive 40x high-power fields (HPF) of hematoxylin-eosin (H&E) stained sections, since we showed that there was a significant correlation of H&E staining with terminal deoxynucleotidyl transferase-mediated dUTP-biotin nick end labeling (TUNEL) staining. RESULTS:The average number of apoptotic cells was 19.9 (0 approximately 168)/5 HPF, and cases were classified into 3 groups based on the number of apoptotic cells/5HPF: 0 to 10, 11 to 30, and 31+. The level of apoptosis increased with increasing size of the tumor, and apoptosis was rarely seen in tumors with positive ER or lower proliferative activity, as assessed by DNA polymerase alpha. As shown by DNA content analysis, apoptotic cells were observed more frequently in tumors with low G1 and high S-phase fractions. In addition, apoptosis was correlated with overexpression of p53 and poor prognosis. Although apoptosis did not correlate with EIC (extensive intraductal component) status, tumors with comedo component had higher values of apoptosis than those without comedo component. CONCLUSIONS:In breast cancer, apoptosis might reflect biological behavior, namely a higher degree of biological aggressiveness and unfavorable prognosis.
journal_name
J Surg Oncoljournal_title
Journal of surgical oncologyauthors
Nishimura R,Nagao K,Miyayama H,Matsuda M,Baba K,Matsuoka Y,Yamashita H,Fukuda M,Higuchi Adoi
10.1002/(sici)1096-9098(199908)71:4<226::aid-jso4>subject
Has Abstractpub_date
1999-08-01 00:00:00pages
226-34issue
4eissn
0022-4790issn
1096-9098pii
10.1002/(SICI)1096-9098(199908)71:4<226::AID-JSO4>journal_volume
71pub_type
杂志文章abstract:BACKGROUND AND OBJECTIVES:The aim of this study was to evaluate the role of indocyanine green (ICG) fluorescence imaging (FI) for the ex vivo detection of metastatic lymph nodes (LNs) in advanced stage ovarian cancer (AOC). METHODS:Paraffin-embedded LNs from patients included in a previous ICG-FI study (Protocol NCT01...
journal_title:Journal of surgical oncology
pub_type: 临床试验,杂志文章
doi:10.1002/jso.25263
更新日期:2018-12-01 00:00:00
abstract:BACKGROUND:Locally advanced colon cancer can result in serious clinical conditions unless treated appropriately. The aim of this study was to examine the feasibility of en bloc resection and the significance of depth of invasion by analyzing the outcomes of the procedure in colon cancer invading adjacent organs. METHO...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.21165
更新日期:2009-01-01 00:00:00
abstract::Infertility because of testicular damage is a distressing problem for survivors of cancer chemotherapy. We have previously described a cytoprotective effect of temporary testicular circulatory isolation (TCI) during doxorubicin administration in the rat. In this report we define the relationship between duration of TC...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930390410
更新日期:1988-12-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:B7-H4 is a novel molecular B7 ligand that plays an important role as a negative regulator of the T cell-mediated immune response. However, the clinical significance of B7-H4 expression in gastric cancer remains uncertain. Here, we assessed B7-H4 expression in blood of patients with gastric can...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.21722
更新日期:2010-12-01 00:00:00
abstract::A retrospective study was made of 38 myosarcomas of the small and large intestines (34 leiomyosarcomas and 4 malignant leiomyoblastomas). Endoenteric, small, and noninvasive tumors were successfully treated by simple wedge excision, cautery snare removal, or segmental bowel resection with a high 5-yr cure rate of 86% ...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930240116
更新日期:1983-09-01 00:00:00
abstract:BACKGROUND:Detection of tumor cells in lymph nodes (LNs) removed during the treatment of pulmonary tumor by radical surgery is limited by the possibilities of standard histopathological methods. The goal of this study was to obtain more accurate pTNM status by a more sensitive detection of micrometastases in LNs. METH...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.24826
更新日期:2018-02-01 00:00:00
abstract::The cases of 42 patients with malignant ascites treated with a peritoneal venous shunt over a 5-year period are reviewed to establish the incidence of surgical and postsurgical complications. Although the yield of malignant cells found in the peripheral blood was increased after shunting, no new hematogenous metastase...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930330109
更新日期:1986-09-01 00:00:00
abstract::Prognostic significance of blood vessel invasion in carcinoma of the female breast has been evaluated by study of 242 cases of radical mastectomy done at the Tata Memorial Hospital. The significance of axillary node involvement with the disease has been simultaneously evaluated. In the absence of blood vessel invasion...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930090613
更新日期:1977-01-01 00:00:00
abstract:INTRODUCTION:Two to three percent of the patients with extremity melanoma develop in-transit metastases in the course of their disease. When local treatments fail, isolated limb perfusion (ILP) is a reasonable option, but is generally only applied to patients without evidence of distant metastases. We assessed the valu...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.20297
更新日期:2005-08-01 00:00:00
abstract:BACKGROUND:CD109, a TGF-β co-receptor, is reported to be preferentially expressed during the early stages of tumorigenesis in several carcinoma types. Myxofibrosarcoma is one of the most common soft-tissue sarcomas found in elderly patients. This study aimed to elucidate the impact of CD109 expression in myxofibrosarco...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.23934
更新日期:2015-06-01 00:00:00
abstract::In vivo skin tests using multiple recall and primary antigens such as dinitrochlorobenzine (DNCB) have established that there is decreased cellular-mediated immune response in patients with squamous cell carcinomas of the head and neck. In vitro testing of lymphocytes using blastogenic mitogens as a measure of lymphoc...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930090111
更新日期:1977-01-01 00:00:00
abstract::Significant destruction of the Pollard III rat prostate adenocarcinoma was achieved by treatment with rhodamine 123 at a dosage of 15 mg/kg every other day for 33 to 38 days. Injection of tumor remnants into untreated animals produced no tumor regrowth. Our data have demonstrated rhodamine 123 to be a significant drug...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930440209
更新日期:1990-06-01 00:00:00
abstract::A poorly differentiated transitional cell carcinoma in C3H/He mice results from the oral ingestion of the urinary tract carcinogen FANFT. This model, designated MBT2, is readily transplantable into syngeneic animals and has proven to be very useful in the development of chemotherapy. Prior to the use of this model for...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930240113
更新日期:1983-09-01 00:00:00
abstract::UDP-galactose:N-acetylglucosamine galactosyltransferase (GT) is a membrane-bound enzyme active in the biosynthesis of the carbohydrate moiety of glycoproteins and glycolipids. A soluble form of GT, present in human serum, has recently been found to be elevated in the presence of various neoplasms. In this study, GT le...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930150110
更新日期:1980-01-01 00:00:00
abstract:OBJECTIVES:The objective of this study is to present two series of cases of pigmented villonodular disease of joints (PVNS) treated at different periods. The 215 cases from our hospital are current (1972-2009) and those 62 from the Jaffe collection from 1920 to 1968. METHODS:By use of our computerized tumor data syste...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.21835
更新日期:2011-04-01 00:00:00
abstract::Prognosis of peritoneal carcinomatosis (PC) from GI tract cancers remains poor. As 30% of patients develop PC after curative surgery, prevention of PC during cancer resection would be desirable. Regarding physiopathology of PC and intraperitoneal immunology, intraoperative application of trifunctional antibodies offer...
journal_title:Journal of surgical oncology
pub_type: 杂志文章,评审
doi:10.1002/jso.21338
更新日期:2009-09-15 00:00:00
abstract::A comparative study of alpha-fetoprotein (AFP) and carcinoembryonic antigen (CEA) in serum was made by radioimmunoassay in 66 patients with pancreatobiliary disease with and without obstructive jaundice. biliary concentrations of these proteins were assayed in 12 patients with benign and 7 patients with malignant dise...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930190411
更新日期:1982-04-01 00:00:00
abstract:BACKGROUND AND OBJECTIVE:Brain metastasis is a rare but dismal event in sarcomas. However, the pattern of occurrence and the prognostic factors associated with post-brain metastasis survival (PBMS) are not yet well-characterized. METHODS:Sarcoma patients treated at one institute within 10-year period were retrospectiv...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.22011
更新日期:2011-12-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Immune status in the peritoneal cavity of patients with gastric cancer remains largely unknown. To clarify the clinical significance of the host immune response within the peritoneal cavity, we examined the levels of interferon-gamma (IFN-gamma), a type 1 cytokine, and interleukin-10 (IL-10), ...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.1131
更新日期:2001-10-01 00:00:00
abstract::The efficacy of killing small cell lung cancer (SCLC) cells at the G1, S, and G2-M phase of the cell-cycle by a new 111In-bleomycin complex (111In-BLMC) was investigated. SCLC cells (N417, H526, H209) were synchronized by double thymidine block and assessed by DNA content with flow cytometry, and the period for the ma...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930400203
更新日期:1989-02-01 00:00:00
abstract::Malignant arterial tumor emboli large enough to cause ischemia or organ infarction are a rare, but often fatal, complication of neoplastic disease. The majority of arterial emboli are associated with primary or secondary pulmonary malignancies. The sites where they impact are similar in distribution to arterioscleroti...
journal_title:Journal of surgical oncology
pub_type: 杂志文章,评审
doi:10.1002/jso.2930520317
更新日期:1993-03-01 00:00:00
abstract:BACKGROUND:Pathological staging and regression grading may affect the clinical outcome in rectal carcinoma patients treated with neoadjuvant chemoradiation (NACRT). Oncocytic change (OC) has also been described in the residual tumor. This study assesses the correlation of degree of pathological response and OC with cli...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.22073
更新日期:2012-02-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Previous in vitro studies have suggested that IGF-1 stimulation can lead a more aggressive breast cancers and subsequent poor prognosis in breast cancer patients. We aim to how IGF-1 and IGF-1R mRNA levels in breast cancer are associated with disease-free survival (DFS) and other clinicopathol...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.21916
更新日期:2011-09-01 00:00:00
abstract::The relationship of acute appendicitis occurring previous to cancer in colon and rectum was studied in the consecutive records of 561 patients, of 40 years of age and older, operated upon with an appendectomy because of acute appendicitis. Sixteen (2.9%) of these patients were readmitted within three years because of ...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930200105
更新日期:1982-05-01 00:00:00
abstract::This study details the case reports of two children who developed slipped capital femoral epiphyses (SCFE) after receiving external irradiation. The clinical and diagnostic features of postradiation SCFE are reviewed and discussed. Guidelines for the management of children who receive pelvic irradiation are presented....
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930360110
更新日期:1987-09-01 00:00:00
abstract::We studied survival and prognostic factors in all cases of hepatocellular carcinoma seen at a Midwestern teaching hospital from 1947 through 1986. Of the 70 cases, 56 were diagnosed during life and 14 at autopsy. There were 47 males and 23 females with age at diagnosis ranging from 14 to 88. Median survival for the 56...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930450409
更新日期:1990-12-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Recent advancements in the technology of cryosurgery along with the development and refinement of intraoperative ultrasound have led to a feasible alternative for some patients with unresectable hepatic malignancy. This paper reports our first year's experience with cryosurgical ablation of un...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/(sici)1096-9098(199808)68:4<242::aid-jso7>
更新日期:1998-08-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:The study of pathology and prognosis for patients with ovarian tumors of low malignant potential (LMP) has been well documented. The treatment, particularly the secondary surgery, for recurrent disease is less documented. This study was conducted to investigate the role of secondary surgical c...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.20280
更新日期:2005-07-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:D2-40 staining has been reported to be useful for both identifying lymphatic vessel invasion (LVI) and counting lymphatic vessel density (LVD) in various cancers. The aim of this study was to clarify the prognostic significance of D2-40 staining in patients with esophageal squamous cell carcin...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.22079
更新日期:2012-03-01 00:00:00
abstract::This report reviews the methods and goals of treatment of gastrointestinal stromal tumor (GIST), the most common mesenchymal tumor of the gastrointestinal tract. GISTs express CD117, which serves as an immunohistochemical diagnostic marker. Surgical excision is the definitive treatment for all primary GISTs greater th...
journal_title:Journal of surgical oncology
pub_type: 杂志文章,评审
doi:10.1002/jso.21030
更新日期:2008-12-15 00:00:00