Abstract:
INTRODUCTION:Two to three percent of the patients with extremity melanoma develop in-transit metastases in the course of their disease. When local treatments fail, isolated limb perfusion (ILP) is a reasonable option, but is generally only applied to patients without evidence of distant metastases. We assessed the value of ILP in stage IV melanoma patients with symptomatic unresectable limb melanoma at our institutions. PATIENTS AND METHODS:A computerized database, containing all patient, tumor, ILP, and follow-up data of 505 ILPs performed in 451 patients between 1978 and 2001, allowed the selection of eight (1.8%) stage IV patients who underwent a palliative ILP for unresectable melanoma lesions on the limbs. All patients had high tumor burden limb disease, according to the combined Fraker and Rossi criteria. RESULTS:The overall tumor response rate was 88%, with 13% complete and 75% partial response rates. One patient did not respond to ILP. Three partial responding patients attained a complete remission (CR) after excision of the remaining limb lesions. The median duration of hospital stay was 12 days and acute regional toxicity was mild with slight erythema and edema in six and no signs of reaction in two patients. The median limb recurrence-free interval after CR was 6 months and the median duration from the time of distant metastases to death was 15 months. Overall ILP leads to the desired palliative effect in six patients (75%). CONCLUSION:ILP should be considered as a palliative treatment in selected stage IV melanoma patients with symptomatic advanced limb disease.
journal_name
J Surg Oncoljournal_title
Journal of surgical oncologyauthors
Takkenberg RB,Vrouenraets BC,van Geel AN,Nieweg OE,Noorda EM,Eggermont AM,Kroon BBdoi
10.1002/jso.20297subject
Has Abstractpub_date
2005-08-01 00:00:00pages
107-11issue
2eissn
0022-4790issn
1096-9098journal_volume
91pub_type
杂志文章abstract::With the rapid uptake of the robotic approach in gynecologic surgery, a thorough understanding of the technology, including its uses and limitations, is critical to maximize patient outcomes and safety. This review discusses the role of training modalities and development of curricula for robotic surgery. Furthermore,...
journal_title:Journal of surgical oncology
pub_type: 杂志文章,评审
doi:10.1002/jso.24006
更新日期:2015-12-01 00:00:00
abstract::A retrospective review to elucidate the rationale of preoperative irradiation was made on 18 carcinomas of the head of the pancreas area. After 50 Gy/25 fractions of 10 MV X-ray was given, all 18 tumors decreased from 3.3 +/- 0.8 cm to 2.0 +/- 0.7 cm. At the surgical operation, 16 patients (89%) received pancreatic re...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930400303
更新日期:1989-03-01 00:00:00
abstract:OBJECTIVES:This study investigated late toxicity and infield progression-free survival in patients with locally recurrent rectal cancer (LRRC) who had previously received irradiation to the pelvis. METHODS:Twenty-two patients were treated by reirradiation to the pelvis between January 2000 and August 2007. All patient...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.23023
更新日期:2012-06-01 00:00:00
abstract::Fresh homogenized mammary gland adenocarcinoma (C3HBA) material was subcutaneously inoculated in the anterior right thigh of transplant host mice (C3H/HeJ). When tumors were palpable, the mice were separated into three groups. The test group received biweekly intratumoral injections of Mycobacterium ulcerans filtrate ...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930110210
更新日期:1979-01-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Development of second primary carcinomas after thoracic esophagectomy has become of much concern, because recently the prognosis of thoracic esophageal carcinoma after esophagectomy with extended lymph node dissection has been improving. We report our experience of diagnosing and treatment sec...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/(sici)1096-9098(199710)66:2<130::aid-jso11
更新日期:1997-10-01 00:00:00
abstract:BACKGROUND:Hepatic arterial infusion chemotherapy (HAIC) has been recognized as one of the effective treatments for patients with hepatic metastatic tumor. However it is difficult to perform HAIC in the long term without complications. This report describes the laparotomic approach using the side holed catheter, which ...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.20283
更新日期:2005-08-01 00:00:00
abstract:OBJECTIVES:This study investigated disparities in the delivery of definitive therapy for early stage non-small-cell lung cancer (ESNSCLC) between Caucasian (CS) and African American (AA) populations. METHODS:The National Cancer Data Base was queried for AA and CS patients, diagnosed with c stage I Non small cell lung ...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.26206
更新日期:2020-12-01 00:00:00
abstract:BACKGROUND:Receptor-binding cancer antigen expressed on SiSO cells (RCAS1) has been reported to act as a ligand for a receptor present on normal peripheral lymphocytes and to induce apoptotic cell death. We aimed to elucidate the significance of RCAS1 expression in human esophageal squamous cell carcinomas (ESCC). MET...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.20249
更新日期:2005-05-01 00:00:00
abstract::Two hundred fifty-one patients with colorectal carcinoma were studied following complete primary resection to determine patterns of failure. Seventy-two patients (29%) subsequently developed failures: Local failure (LF) occurred as the only failure in 49% of the failure group and as some component in 81%; distant meta...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930220118
更新日期:1983-01-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:This retrospective study evaluated the feasibility and effectiveness of type II radical hysterectomies alone, or in combination with adjuvant treatment, for the treatment of patients with stage IB-IIB cervical cancer with or without high-risk factors. METHODS:A total of 960 stage IB-IIB patie...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.21800
更新日期:2011-04-01 00:00:00
abstract::Although the incidence of locally recurrent colorectal cancer has been reduced by improved surgical techniques and the frequent use of multimodality therapy, pelvic recurrence remains a significant problem. Radiation or chemotherapy may provide palliation but it is often short-lived. For fit candidates without evidenc...
journal_title:Journal of surgical oncology
pub_type: 杂志文章,评审
doi:10.1002/jso.21571
更新日期:2010-06-15 00:00:00
abstract:BACKGROUND:Malignant hip lesions can be managed operatively by intramedullary (IM) nail fixation and hemiarthroplasty. METHODS:A retrospective review was performed on 86 patients who underwent hemiarthroplasty (n = 22) or IM nail fixation (n = 64) for prophylactic treatment of impending pathologic fracture due to mali...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.24792
更新日期:2017-12-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Pheochromocytoma (PHEO) and paraganglioma (PGL) are rare tumors. Aims of this study were to describe and to compare demographic, clinical, pathologic, and survival characteristics of malignant PHEO and PGL. METHODS:Patients were identified in SEER, 1988-2009. Analyses included chi-square, ANO...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.23297
更新日期:2013-05-01 00:00:00
abstract::Oncoplastic surgery combines plastic surgical techniques with sound surgical oncologic principles. The goal is to completely excise the cancer, with wide surgical margins while maintaining or improving cosmesis. For large, poorly defined, or unfavorably situated tumors, standard lumpectomies may lead to unacceptable c...
journal_title:Journal of surgical oncology
pub_type: 杂志文章,评审
doi:10.1002/jso.23641
更新日期:2014-07-01 00:00:00
abstract:INTRODUCTION:Patients with Stage IV melanoma have limited therapeutic options with few long-term survivors. Our goal was to study the impact of metastasectomy on survival in these patients. METHODS:Patients with Stage IV melanoma were identified from the Surveillance, Epidemiology, and End Results (SEER) database (198...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.21903
更新日期:2011-08-01 00:00:00
abstract::Tumor infiltrating lymphocytes (TILs) are capable of mediating significant tumor regressions in vitro and in vivo in animal systems. In humans, however, many TIL cell lines are not cytotoxic in vitro, and clinical trials thus far have been less than encouraging. We attempted to correlate TIL cytotoxicity with time of ...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930430104
更新日期:1990-01-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:There have been few reports on the objective assessment of quality of life (QOL) in patients with gastric cancer following palliative operations. The benefit of a palliative operation for survival and QOL of patients with gastric cancer is not clear. METHODS:Survival and hospital-free surviva...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/(sici)1096-9098(199809)69:1<41::aid-jso8>3
更新日期:1998-09-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Remifentanil infusion is used as an intraoperative anesthetic for thyroidectomy, but has been associated with acute opioid tolerance and hyperalgesia. A national shortage of remifentanil provided an opportunity to study postoperative pain in patients undergoing thyroidectomy. METHODS:Retrospe...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.25746
更新日期:2019-12-01 00:00:00
abstract::The records of 111 consecutive cases of carcinoma of the breast were reviewed and yielded 66 patients who had undergone liver scanning and determination of the serum alkaline phosphatase (alk p'tase), lactic dehydrogenase (LDH), and serum glutamic oxaloacetic transaminase (SGOT). Four of the 66 patients (6.1%) had a f...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930130313
更新日期:1980-01-01 00:00:00
abstract::Lymph node status is not part of the staging system for cervical cancer, but provides important information for prognosis and treatment. This article reviews the incidence and patterns of lymph node metastasis, and the issues surrounding surgical assessment of lymph nodes. The preoperative assessment of lymph nodes by...
journal_title:Journal of surgical oncology
pub_type: 杂志文章,评审
doi:10.1002/jso.21199
更新日期:2009-03-15 00:00:00
abstract::The tumor registry of a community hospital has been reviewed, and 60 patients with untreated colon and rectal cancer have been identified. Thirty-four patients were black and 26 patients were white. Sixty-five percent of black patients had specified colonic lesions primarily distributed in the right colon and proximal...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930290314
更新日期:1985-07-01 00:00:00
abstract::Diffuse malignant peritoneal mesothelioma (DMPM) is an uncommon and locally aggressive tumor with poor prognosis. Currently, no standard therapy is available. The biology of this disease is still poorly understood. We performed a systematic search of relevant studies on clinical management and biological research of D...
journal_title:Journal of surgical oncology
pub_type: 杂志文章,评审
doi:10.1002/jso.21787
更新日期:2011-06-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:The purpose of this study was to estimate the risk factors having relationships with pathologic fracture of osteosarcoma of extremities and to evaluate the role of limb salvage surgery in this group of patients. METHODS:We retrospectively analyzed 28 consecutive cases of pathologic fracture o...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.23150
更新日期:2012-12-01 00:00:00
abstract:BACKGROUND:Endometrial carcinoma is the most common gynecologic malignancy in developed countries, affecting an estimated 140,000 women. More than 32,000 women will be diagnosed with endometrial cancer this year in the United States, and approximately 6,000 will die from this disease. METHODS:Twenty consecutive patien...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/(SICI)1096-9098(199610)63:2<91::AID-JSO4>3
更新日期:1996-10-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Having shown that intra-dermal injection of fibroblasts decreases the effect of radiation on healing of superficial wounds, we now test the effect of fibroblasts and syngeneic marrow stromal cells on irradiated deep and superficial wounds. METHODS:Wistar rats received bilateral buttock irradi...
journal_title:Journal of surgical oncology
pub_type: 杂志文章,评审
doi:10.1002/jso.10242
更新日期:2003-07-01 00:00:00
abstract:BACKGROUND:Open surgery for hilar cholangiocarcinoma (HCCA) has already been widely reported and analyzed. However, the laparoscopic technique for treating HCCA remains controversial because of the lack of radicality and poor assessment of the resectability of hilar structures without direct palpation. The aim of this ...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.25739
更新日期:2019-12-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Sentinel node (SN) biopsy is a new standard of care for axillary node staging in patients with early-stage, clinically node-negative breast cancer. A second operation can be avoided when the results are available intraoperatively. However, there is no standard intraoperative method for SN asse...
journal_title:Journal of surgical oncology
pub_type: 杂志文章,评审
doi:10.1002/jso.20067
更新日期:2004-06-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:The aim of this study was to analyze the stage migration and survival of endometrial cancer by the revised FIGO 2008 staging system compared with the 1988 staging system. METHODS:A total of 355 patients with endometrial cancer, who underwent complete surgical staging, were enrolled. We compar...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.23203
更新日期:2012-12-01 00:00:00
abstract:BACKGROUND:A prospective randomized controlled trial has established the efficacy of targeted intraoperative radiotherapy (TARGIT) in the management of invasive breast cancer treated with breast-conserving surgery (BCS). The purpose of this analysis is to evaluate the efficacy of TARGIT in the management of ductal carc...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.25347
更新日期:2019-03-01 00:00:00
abstract:BACKGROUND:The presence of human papillomavirus (HPV)-specific antibodies in patients with head and neck cancer at enrollment has prognostic significance. In cervical carcinoma patients, the decrease of HPV E6/E7-specific antibodies appears to be associated with a better prognosis. METHODS:This prospective study with ...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.25473
更新日期:2019-08-01 00:00:00