Evaluation of the effects of type II radical hysterectomy in the treatment of 960 patients with stage IB-IIB cervical carcinoma: A retrospective study.

Abstract:

BACKGROUND AND OBJECTIVES:This retrospective study evaluated the feasibility and effectiveness of type II radical hysterectomies alone, or in combination with adjuvant treatment, for the treatment of patients with stage IB-IIB cervical cancer with or without high-risk factors. METHODS:A total of 960 stage IB-IIB patients who underwent type II radical hysterectomies between 1995 and 2004 were enrolled and retrospectively analyzed. RESULTS:Uterine corpus invasion, parametrial margin involvement, and pelvic lymph node metastasis were identified as independent prognostic factors for stage IB patients. For stage IIA-IIB patients, histologic type, parametrial margin involvement, and pelvic lymph node metastasis were identified as independent prognostic factors. The 5-year overall survival (OS) rates for patients with stage IB versus stage IIA-IIB cervical carcinomas were 88.4% and 78.5%, respectively. Moreover, adjuvant radiotherapy and chemotherapy improved the 5-year OS rates of stage IIA-IIB patients associated with high-risk factors. The overall recurrence rate for this cohort was 14.4%. CONCLUSIONS:Our findings show that type II radical hysterectomy is a feasible treatment option for stage IB-IIB cervical carcinoma patients. Furthermore, type II radical hysterectomy combined with adjuvant post-operative therapy improves the OS of women with high-risk factors for cervical carcinoma.

journal_name

J Surg Oncol

authors

Zheng M,Huang L,He L,Ding H,Wang HY,Zheng LM

doi

10.1002/jso.21800

subject

Has Abstract

pub_date

2011-04-01 00:00:00

pages

435-41

issue

5

eissn

0022-4790

issn

1096-9098

journal_volume

103

pub_type

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