Abstract:
BACKGROUND AND OBJECTIVES:Tumor angiogenesis is receiving increased attention as a prognostic factor and also as a possible target for new anticancer agents. We investigated whether extent of vascular endothelial growth factor (VEGF) mRNA expression correlated with degree of neovascularization, and whether this expression in fine-needle aspirates could be a marker for assessing angiogenic potential of breast tumors. METHODS:VEGF mRNA expression was semiquantitated by reverse transcriptase-polymerase chain reaction (RT-PCR) followed by Southern blotting. Tumor neovascularization was assessed by immunohistochemical staining with anti-CD31 (PECAM) antibody. RESULTS:There was a positive correlation between degree of neovascularization and semiquantitated VEGF mRNA expression in invasive ductal carcinomas (r2 = 0.346, n = 48, P < 0.05). Extent of VEGF mRNA expression in fine-needle aspirates was closely correlated with that in resected invasive ductal carcinomas equal to or less than 3 cm in size (r2 = 0.874, n = 14, P < 0.05). CONCLUSION:These data suggest that semiquantitation of VEGF mRNA expression in fine-needle aspirates is useful for assessing angiogenic potential of invasive ductal carcinomas.
journal_name
J Surg Oncoljournal_title
Journal of surgical oncologyauthors
Anan K,Morisaki T,Katano M,Ikubo A,Tsukahara Y,Uchiyama A,Kuroki S,Tanaka M,Torisu Mdoi
10.1002/(sici)1096-9098(199712)66:4<257::aid-jso7>subject
Has Abstractpub_date
1997-12-01 00:00:00pages
257-63issue
4eissn
0022-4790issn
1096-9098pii
10.1002/(SICI)1096-9098(199712)66:4<257::AID-JSO7>journal_volume
66pub_type
杂志文章abstract::DNA nuclear content and PCNA index (proportion of PCNA reactive cells) have been studied by flow cytometry in eight pancreatic lesions producing hyperinsulinemic hypoglycemia to assess DNA ploidy and tumoral growth fraction. Adult nesidioblastosis had a diploid DNA index, two adenomas were near diploid, and four of th...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930590105
更新日期:1995-05-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:It is important to identify the initial lymph node metastasis when performing less invasive surgery. The purpose of the present study was to analyze locations of solitary lymph node metastasis and micrometastasis in esophageal carcinoma. METHODS:We retrospectively analyzed the initial sites o...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.20172
更新日期:2005-01-01 00:00:00
abstract::This review evaluates the use of robotic-assisted laparoscopic surgery in the treatment of gynecologic malignancies and objectively evaluates the use of these systems in performing radical hysterectomies and surgical staging of gynecologic malignancies. The review focuses on surgical length, blood loss, complications,...
journal_title:Journal of surgical oncology
pub_type: 杂志文章,评审
doi:10.1002/jso.22080
更新日期:2012-04-01 00:00:00
abstract::Diffuse malignant peritoneal mesothelioma (DMPM) is an uncommon and locally aggressive tumor with poor prognosis. Currently, no standard therapy is available. The biology of this disease is still poorly understood. We performed a systematic search of relevant studies on clinical management and biological research of D...
journal_title:Journal of surgical oncology
pub_type: 杂志文章,评审
doi:10.1002/jso.21787
更新日期:2011-06-01 00:00:00
abstract::Prognostic significance of blood vessel invasion in carcinoma of the female breast has been evaluated by study of 242 cases of radical mastectomy done at the Tata Memorial Hospital. The significance of axillary node involvement with the disease has been simultaneously evaluated. In the absence of blood vessel invasion...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930090613
更新日期:1977-01-01 00:00:00
abstract:BACKGROUND:Few studies describe quality of life (QoL) outcomes following gastrectomy for gastric cancer using a validated instrument. The gastric cancer module for the Functional Assessment of Cancer Therapy system of QoL measurement tools (FACT-Ga) was utilized to determine the changes in QoL following gastrectomy, an...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.22139
更新日期:2012-03-15 00:00:00
abstract:BACKGROUND AND OBJECTIVES:To evaluate the predicting value of the epidermal growth factor receptor (EGFR) for survival in patients with head and neck cancer (HNC). METHODS:Data were collected from studies comparing overall survival (OS) or progression-free survival (PFS) in patients with higher or lower EGFR levels. S...
journal_title:Journal of surgical oncology
pub_type: 杂志文章,meta分析
doi:10.1002/jso.23406
更新日期:2013-11-01 00:00:00
abstract:OBJECTIVES:Gasless transaxillary endoscopic thyroidectomy offers a distinct advantage over the conventional open operation because it leaves no visible neck scar. Indications have expanded with the development of new surgical techniques and instruments. However, because of the two-dimensional view and the nonflexible i...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.22106
更新日期:2012-06-01 00:00:00
abstract::A case of desmoid tumor of 17 years' duration associated with cystosarcoma phyllodes of 17 months' duration is presented. Good initial response to radiation therapy of the desmoid tumor was shown. Poor response of cytosarcoma phyllodes to radiation therapy was noted. A comparison between the similarities and differenc...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930080107
更新日期:1976-01-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Retinoids are metabolized in human intestinal epithelial cells to all-trans retinoic acid; however, it is unknown whether these cells express retinoid receptors, and whether sensitivity or resistance to the hormone is associated with a particular pattern of expression of retinoid-responsive ge...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/(sici)1096-9098(199711)66:3<156::aid-jso2>
更新日期:1997-11-01 00:00:00
abstract:BACKGROUND:Gastric cancer is the fifth most common cancer in Eastern Africa. Diagnostic delays in low-resource countries result in advanced disease presentation. We describe perioperative management of gastric cancer in Rwanda. METHODS:A retrospective review of records at three hospitals was performed to identify gast...
journal_title:Journal of surgical oncology
pub_type: 杂志文章,多中心研究
doi:10.1002/jso.25286
更新日期:2018-12-01 00:00:00
abstract::This article reviews immediate and delayed breast reconstruction with prosthetic implants, and the effect of irradiation therapy. Despite widespread use of breast conserving surgery for early breast cancer, many breast cancer patients still undergo mastectomy. Some of these patients choose breast reconstruction. Over ...
journal_title:Journal of surgical oncology
pub_type: 杂志文章,评审
doi:10.1002/jso.20484
更新日期:2006-11-01 00:00:00
abstract::Twelve women who developed breast cancer at the site of old surgical scars in the breast are presented. Six had had former breast biopsies, 3 drainage of breast abscesses, and 3 developed breast cancer in old thoracotomy scars transversing the breast. The combination of trauma as an oncogen and scar tissue as a functi...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930080606
更新日期:1976-01-01 00:00:00
abstract::We studied the influence of surgical trauma to the iliac bone on the implantation of I.V. injected tumor cells, which formed tumor in the surgical wounds of 27/84 mice (32%). None of these mice or nonsurgical mice developed tumor in the opposite or uninjured pelvic bone (P < 0.0001). When different numbers (10(5), 5 x...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930560311
更新日期:1994-07-01 00:00:00
abstract:BACKGROUND:Use of hospice services among patients with pancreatic cancer following pancreatic resection remains unknown. METHODS:Patients with pancreatic cancer who underwent resection were identified in the Medicare Standard Analytic Files. Outcomes included overall hospice use, early hospice enrollment (≥4 weeks bef...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.25623
更新日期:2019-09-01 00:00:00
abstract::The poor outcome associated with surgical resection alone for most patients with locoregional esophageal cancer has generated intensive investigation of combined-modality treatment approaches that include systemic chemotherapy. This review discusses the current role of chemotherapy in the treatment of patients with ad...
journal_title:Journal of surgical oncology
pub_type: 杂志文章,评审
doi:10.1002/jso.20364
更新日期:2005-12-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Reports of clinicopathological features and prognosis in patients with mucinous gastric carcinoma (MGC) are conflicting. The aim was to describe the clinicopathological features and prognosis of patients with MGC in comparison with nonmucinous gastric carcinoma (NMGC). METHODS:We reviewed the...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.21533
更新日期:2010-07-01 00:00:00
abstract:BACKGROUND:The object of the current study was to review the outcomes of hepatic resection for hepatocellular carcinoma (HCC) ≥ 10 cm. METHODS:Between 1995 and 2007, fifty-three patients with HCC ≥ 10 cm underwent hepatic resection, and clinical data were compared to those of patients with non-surgical treatment (n = ...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.21931
更新日期:2011-09-01 00:00:00
abstract:INTRODUCTION:Patients with Stage IV melanoma have limited therapeutic options with few long-term survivors. Our goal was to study the impact of metastasectomy on survival in these patients. METHODS:Patients with Stage IV melanoma were identified from the Surveillance, Epidemiology, and End Results (SEER) database (198...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.21903
更新日期:2011-08-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Tumor markers are a clinical tool frequently used in oncology in association with other clinical and radiologic information. For gastrointestinal cancer, carcinoembryonic antigen (CEA) and carbohydrate antigen 19-9 (CA 19-9) tumor markers have found selected clinical application. The use of th...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.20107
更新日期:2004-09-15 00:00:00
abstract::Carcinoma of the lung should be considered in the search for an unknown primary lesion when there is evidence of cervical lymph node involvement. Of 1,686 patients with a final diagnosis of bronchogenic carcinoma seen during a 10-year period at the University of Louisville Hospitals, 26 presented one or more clinicall...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930090513
更新日期:1977-01-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Second look surgery has been previously studied in patients with recurrent peritoneal dissemination from appendiceal malignancy. However, selection criteria for third, fourth, and subsequent reoperations are not available. METHODS:Five hundred and one patients with epithelial peritoneal surfa...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.10234
更新日期:2003-05-01 00:00:00
abstract:BACKGROUND:Unresectable tumors of the pancreatic head are encountered in up to 20% of patients taken for resection. The objective of this study was to evaluate the complications and outcome associated with palliative surgical procedures to help guide management decisions in these patients. METHODS:Patients with pancre...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.23560
更新日期:2014-06-01 00:00:00
abstract::The incidence of anastomotic leakage after esophagectomy for cancer and reconstruction with the stomach was analyzed with respect to the presence of coexistent atrophic chronic gastritis (ACG). Of a total of 28 operated esophageal cancer patients with ACG, 6 patients developed an anastomotic leak at the cervical esoph...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930510107
更新日期:1992-09-01 00:00:00
abstract:OBJECTIVES:The objective of this study is to present two series of cases of pigmented villonodular disease of joints (PVNS) treated at different periods. The 215 cases from our hospital are current (1972-2009) and those 62 from the Jaffe collection from 1920 to 1968. METHODS:By use of our computerized tumor data syste...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.21835
更新日期:2011-04-01 00:00:00
abstract::A prospective randomized phase III trial was carried out at Songklanagarind Hospital from August 1988 to December 1990. The objectives of the study were to evaluate the effect of chemotherapy regimen in squamous cell carcinoma of the esophagus and to determine whether induction chemotherapy improves symptom-free perio...
journal_title:Journal of surgical oncology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1002/jso.2930560314
更新日期:1994-07-01 00:00:00
abstract::A unique epileptic patient with intracranial neoplasm is reported in which a meningioma with lipomatous and osseous components was found associated with cerebral arteriovenous malformation at the same location in the right frontal lobe. The development of the leptomeningeal neoplasm may have been influenced by the und...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930260109
更新日期:1984-05-01 00:00:00
abstract::A patient with a feminizing malignant Leydig cell tumor is presented. Hormonal assays revealed increased production of prolactin, estradiol, and total estrogens. Eleven years after the onset of his disease he remains clinically well. ...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930270203
更新日期:1984-10-01 00:00:00
abstract:BACKGROUND:Long-term results of the ESPAC-3 trial suggest that while completing adjuvant therapy (AT) is necessary after resection of pancreatic ductal adenocarcinoma (PDAC), early initiation (within 8 weeks) may not be associated with improved overall survival (OS). The primary aim of this study was to evaluate the OS...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.24314
更新日期:2016-09-01 00:00:00
abstract:BACKGROUND:Prone extralevator abdominoperineal excision of the rectum (ELAPE) has been introduced to improve the circumferential resection margins (CRM) compared with traditional APER. OBJECTIVE:We present short-term results achieved with prone ELAPE preceded by neoadjuvant chemoradiotherapy during the last 5 years of...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.24257
更新日期:2016-07-01 00:00:00