Effect of trauma on implantation of metastatic tumor in bone in mice.

Abstract:

:We studied the influence of surgical trauma to the iliac bone on the implantation of I.V. injected tumor cells, which formed tumor in the surgical wounds of 27/84 mice (32%). None of these mice or nonsurgical mice developed tumor in the opposite or uninjured pelvic bone (P < 0.0001). When different numbers (10(5), 5 x 10(5), and 10 x 10(5)) of TA3Ha cells were injected I.V. immediately after surgery, the frequency of tumor formation showed an increase (respectively, 32%, 63%, 71%). As the interval between induction of trauma and tumor cell injection was increased from 0 to 15 days, the frequency of tumor formation declined from 32% to 0%. These results suggest that the healing wound is a privileged site for experimental metastasis, particularly in the early stages. It is likely that the proteins in the blood clotting cascade are involved in local tumor implantation.

journal_name

J Surg Oncol

authors

Lee JY,Murphy SM,Scanlon EF

doi

10.1002/jso.2930560311

subject

Has Abstract

pub_date

1994-07-01 00:00:00

pages

178-84

issue

3

eissn

0022-4790

issn

1096-9098

journal_volume

56

pub_type

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