Expression of B7-H4 in blood of patients with gastric cancer predicts tumor progression and prognosis.

Abstract:

BACKGROUND AND OBJECTIVES:B7-H4 is a novel molecular B7 ligand that plays an important role as a negative regulator of the T cell-mediated immune response. However, the clinical significance of B7-H4 expression in gastric cancer remains uncertain. Here, we assessed B7-H4 expression in blood of patients with gastric cancer to determine whether or not it can predict tumor progression and prognosis. METHODS:We measured B7-H4 mRNA expression by quantitative RT-PCR in five gastric cell lines as well as in blood specimens from 94 patients with gastric cancer and from 22 healthy volunteers. RESULTS:Significantly more B7-H4 mRNA copies were found in gastric cell lines and in blood from patients with gastric cancer than in blood from healthy volunteers (P < 0.0001 and P < 0.0001, respectively). B7-H4 expressed in 71 (75.5%) of 94 patients with gastric cancer significantly correlated with depth of tumor invasion, lymph node metastasis, and overall stage (P = 0.006, P = 0.001, and P < 0.001, respectively). The 5-year survival rate was significantly lower in patients with than without B7-H4 expression (P = 0.04). CONCLUSIONS:The evaluation of B7-H4 expression in blood is a useful tool for predicting the progression of gastric cancer and prognosis.

journal_name

J Surg Oncol

authors

Arigami T,Uenosono Y,Hirata M,Hagihara T,Yanagita S,Ishigami S,Natsugoe S

doi

10.1002/jso.21722

subject

Has Abstract

pub_date

2010-12-01 00:00:00

pages

748-52

issue

7

eissn

0022-4790

issn

1096-9098

journal_volume

102

pub_type

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