Pancreatic ductal cell carcinoma producing pancreatic elastase 1.

Abstract:

:The elevation of plasma pancreatic elastase 1 in patients with pancreatic cancer is caused by concomitant pancreatitis. There is no report that pancreatic ductal cell carcinoma tissue itself produced elastase 1. A 54-year-old woman underwent total pancreatectomy for pancreatic ductal cell carcinoma. Her plasma elastase 1 level subsequently decreased from the preoperative value of 406 ng/dl to values ranging between 96 ng/dl and 119 ng/dl, until 6 months after the operation, when it began to increase gradually to a maximum of 300 ng/dl in association with local recurrence and hepatic metastasis. Immunohistochemical staining of elastase 1 was positive in the primary tumor resected at operation as well as in the locally recurrent and hepatic metastatic tumors obtained at autopsy. These findings suggested that elastase 1 was produced by the tumor cells in this patient. This is the first case in which pancreatic ductal cell carcinoma cells produced elastase 1.

journal_name

J Surg Oncol

authors

Iwase K,Miyata M,Yamaguchi T,Kawaguchi T,Tanaka Y,Matsuda H

doi

10.1002/jso.2930540316

subject

Has Abstract

pub_date

1993-11-01 00:00:00

pages

199-202

issue

3

eissn

0022-4790

issn

1096-9098

journal_volume

54

pub_type

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