Tumour excision plus continuous tamoxifen compared with modified radical mastectomy in patients over 70 years of age with operable breast cancer.

Abstract:

:Between 1985 and 1991, we randomly assigned 77 women over the age of 70 years with stage I-3a breast cancer to undergo a modified radical mastectomy or tumour excision followed by tamoxifen. Median follow-up was 45 months. Patients treated by tumour excision and tamoxifen had a significantly better survival (P = 0.04). The disease-free survival of the tumour excision and tamoxifen group was close to significantly better (P = 0.10). Only two patients in the tamoxifen group required an axillary dissection on follow-up for progressive nodal enlargement. Two patients underwent a local mastectomy for locally recurrent disease. We conclude that tumour excision followed by continuous tamoxifen is an acceptable, safe alternative to a modified radical mastectomy in patients over 70 years of age.

journal_name

J Surg Oncol

authors

van Zyl JA,Muller AG

doi

10.1002/jso.2930590304

subject

Has Abstract

pub_date

1995-07-01 00:00:00

pages

151-4

issue

3

eissn

0022-4790

issn

1096-9098

journal_volume

59

pub_type

临床试验,杂志文章,随机对照试验
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