Abstract:
:From September 1969 through 1979, 68 patients with already locally metastasized malignant melanomas of the extremities were treated by hyperthermic regional perfusion and local excision(s). Of these, 53 patients could be evaluated after a follow-up of at least 2 years: 31 had been perfused with melphalan and 22 with melphalan in combination with actinomycin D. Local recurrence rates were about the same in both groups: 32 versus 33%. The same applied to the symptom-free interval between perfusion and local recurrence: about 12 versus about 13 months. Virtually all recurrences in both groups (90 versus 85%) were seen within 2 years. The interval between perfusion and systemic metastization was also roughly the same: about 25 versus about 23 months. These results indicate the need for better chemotherapeutics in order to achieve further improvement. The results of these perfusions were otherwise by no means disappointing, and hyperthermic regional perfusion is indicated in the treatment of patients with locally metastasized malignant melanomas.
journal_name
J Surg Oncoljournal_title
Journal of surgical oncologyauthors
Martijn H,Oldhoff J,Koops HSdoi
10.1002/jso.2930200103subject
Has Abstractpub_date
1982-05-01 00:00:00pages
9-13issue
1eissn
0022-4790issn
1096-9098journal_volume
20pub_type
杂志文章abstract:BACKGROUND AND OBJECTIVES:Variants of CD44 have been proposed to be important in promoting tumor progression and metastasis. We attempted to determine the expression of CD44v6 product in advanced gastric cancer and to evaluate its prognostic value. METHODS:The expression of CD44v6 was analyzed immunohistochemically in...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.10082
更新日期:2002-04-01 00:00:00
abstract:BACKGROUND:Cytoreductive surgery plus hyperthermic intraperitoneal chemotherapy (CS + HIPEC) is a treatment combining cytoreductive surgery with hyperthermic chemotherapy directly into the peritoneal cavity. Recipients may gain extended life when compared with best supportive care; yet results often are achieved with s...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.23089
更新日期:2012-09-15 00:00:00
abstract:BACKGROUND:Locally advanced colon cancer can result in serious clinical conditions unless treated appropriately. The aim of this study was to examine the feasibility of en bloc resection and the significance of depth of invasion by analyzing the outcomes of the procedure in colon cancer invading adjacent organs. METHO...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.21165
更新日期:2009-01-01 00:00:00
abstract:BACKGROUND:Angiosarcoma is an aggressive vascular neoplasm with a high propensity for local recurrence. Electrochemotherapy is an emerging skin-directed therapy, exerting prominent cytotoxic activity, and antivascular effects. Its efficacy in angiosarcoma has not been investigated. METHODS:This multicenter retrospecti...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.24287
更新日期:2016-08-01 00:00:00
abstract::The results of treatment of desmoid tumor patients with nonsteroid antiinflammatory drugs alone or in combination with tamoxifen are described. Tumor growth was inhibited in six of seven patients. Nonsteroid antiinflammatory drugs administered along with 5-fluorouracil and cyclophosphamide and other inhibitors of T-su...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930220314
更新日期:1983-03-01 00:00:00
abstract:BACKGROUND:Since the majority of patients with early gastric cancer show long-term survival after surgery, a special attention must be directed to preserving gastric function in these patients. Little is known about the protocol of surgical treatment appropriate for early gastric cancer patients. This study was designe...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/(sici)1096-9098(199701)64:1<42::aid-jso9>3
更新日期:1997-01-01 00:00:00
abstract:BACKGROUND:Recurrent pleomorphic adenoma (PA) of the parotid gland is a challenging surgical issue with controversy regarding management and long term outcome. METHODS:All patients who were operated for recurrent PA of the parotid gland between the years 1991 and 2013 were reviewed. Patient demographics, clinicopathol...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.24392
更新日期:2016-11-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:It is not clear whether sentinel lymph node biopsy (SLNB) can be applied to patients with a second breast cancer or recurrence occurring at previously treated breast. The purpose of this study was to assess the feasibility of SLNB procedure in patients with recurrent breast cancer. METHODS:Pa...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.24423
更新日期:2016-12-01 00:00:00
abstract::Among women who have undergone surgery for breast cancer, the risk of recurrence, especially distant metastases, peaks 1-2 years postsurgery. Recent clinical trial evidence suggests that initial adjuvant therapy with an aromatase inhibitor (AI) can reduce this early risk of recurrence. According to the recently update...
journal_title:Journal of surgical oncology
pub_type: 杂志文章,评审
doi:10.1002/jso.21801
更新日期:2011-06-01 00:00:00
abstract::Three cases of metastatic cancer to inguinal lymph nodes from unknown primaries are presented. All three patients had exhaustive workups which produced no primary lesions. There were two cases of metastatic squamous cell carcinoma and one of melanoma. A review of the literature shows that it is unusual to have metasta...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930170107
更新日期:1981-01-01 00:00:00
abstract::Most solid tumors have now been reported to contain stem cell-like cells called cancer stem cells (CSCs). These cells are endowed with high tumorigenic capacity and may be the cells that drive tumor formation, maintain tumor homeostasis, and mediate tumor metastasis. Since these self-renewing cancer cells may be the s...
journal_title:Journal of surgical oncology
pub_type: 杂志文章,评审
doi:10.1002/jso.21806
更新日期:2011-05-01 00:00:00
abstract::In settings when it is biologically plausible that some patients are cured after definitive treatment, cure models present an alternative to conventional survival analysis. Cure models can inform on the group of patients cured, by estimating the probability of cure, and identifying factors that influence it; while sim...
journal_title:Journal of surgical oncology
pub_type: 杂志文章,评审
doi:10.1002/jso.23411
更新日期:2013-11-01 00:00:00
abstract::Supernatant fluids from three human cultured cell lines, K562, NALM-1, and Daudi, all isolated from patients with lymphoreticular malignancies, were tested for suppressive activity toward normal lymphocytes in vitro. It was found that the K562 line elaborated material which effectively suppressed the response of norma...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930230106
更新日期:1983-05-01 00:00:00
abstract:OBJECTIVE:This study aimed to investigate the association between different metastatic sites and survival in endometrial cancer (EC) patients with International Federation of Gynecology and Obstetrics (FIGO) stage IVB disease. METHODS:FIGO stage IVB patients with EC were selected from the surveillance, epidemiology, a...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.26102
更新日期:2020-10-01 00:00:00
abstract:BACKGROUND:Open surgery for hilar cholangiocarcinoma (HCCA) has already been widely reported and analyzed. However, the laparoscopic technique for treating HCCA remains controversial because of the lack of radicality and poor assessment of the resectability of hilar structures without direct palpation. The aim of this ...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.25739
更新日期:2019-12-01 00:00:00
abstract::A retrospective review to elucidate the rationale of preoperative irradiation was made on 18 carcinomas of the head of the pancreas area. After 50 Gy/25 fractions of 10 MV X-ray was given, all 18 tumors decreased from 3.3 +/- 0.8 cm to 2.0 +/- 0.7 cm. At the surgical operation, 16 patients (89%) received pancreatic re...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930400303
更新日期:1989-03-01 00:00:00
abstract::Prophylactic intravesical chemotherapy (IVC) reduces recurrence rates of superficial transitional cell carcinoma (TCC) of the urinary bladder. The patient cohort existed of 86 individuals (stage TaN0M0 or T1N0M0) superficial carcinoma of various grades of malignancy. Following initial transuretheral resection or diagn...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930600310
更新日期:1995-11-01 00:00:00
abstract::During the past 53 years, 105 patients with Wilms' Tumor have been treated at the Children's Hospital of Buffalo. Prospective and retrospective staging of these cases has allowed comparison with other reported series. All-stage survival improved from 37% with operation alone to 46% with operation and planned radiother...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930300410
更新日期:1985-12-01 00:00:00
abstract:OBJECTIVE:To evaluate the patients with invasive cervical cancer found in simple hysterectomy and who were subjected to radical parametrectomy and upper vaginectomy with therapeutic lymphadenectomy. METHODS:Twenty-seven patients who underwent the radical parametrectomy and upper vaginectomy with therapeutic lymphadene...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.20550
更新日期:2006-07-01 00:00:00
abstract::When BALB/c mice bearing growing transplants of a syngeneic colon carcinoma--Colon Tumor 26 (CT 26)--were treated with Bacillus Calmette-Guerin (BCG), no effect on tumor growth rate or survival time was observed compared to untreated controls. However, after excision of primary tumor transplants, enhanced development ...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930150307
更新日期:1980-01-01 00:00:00
abstract:BACKGROUND:Prognosis with current management strategies continues to be dismal in metastatic gastric cancer (MGC) patients. We aimed to evaluate the role of metastasectomy in improving survival. METHODS:A comprehensive search of MEDLINE, EMBASE, SCOPUS, and Cochrane central databases (1965 to present) was performed. A...
journal_title:Journal of surgical oncology
pub_type: 杂志文章,meta分析,评审
doi:10.1002/jso.23945
更新日期:2015-07-01 00:00:00
abstract::A patient undergoing treatment with cytotoxic chemotherapy for Hodgkin's disease developed graft versus host disease (GVHD) following a transfusion of packed red cells. This is the 28th reported patient with a malignancy who did not have a bone marrow transplant and developed GVHD after transfusion of normal blood or ...
journal_title:Journal of surgical oncology
pub_type: 杂志文章,评审
doi:10.1002/jso.2930360311
更新日期:1987-11-01 00:00:00
abstract:OBJECTIVE:The aim was to compare leak rate between hand-sewn end-to-end anastomosis (ETE) and semi-mechanical anastomosis (SMA) after esophagectomy with gastric tube reconstruction. BACKGROUND DATA:The optimal surgical technique for creation of an anastomosis in the neck after esophagectomy is unclear. METHODS:Patien...
journal_title:Journal of surgical oncology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1002/jso.26209
更新日期:2020-12-01 00:00:00
abstract::Three patients with unresectable malignant retroperitoneal tumors that invaded and perforated the distal duodenum presented with sepsis unresponsive to antibiotics. A technique of proximal side-to-side duodenojejunostomy with stapled occlusion of the distal duodenum resulted in successful diversion and immediate resol...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930260410
更新日期:1984-08-01 00:00:00
abstract:INTRODUCTION:Local recurrence and peritoneal dissemination is common after intentionally curative resection of colorectal carcinoma. It is not yet clear which mechanisms stimulate post-operative intra-abdominal tumor development. Enhanced adhesion or growth of tumor cells and/or post-operative immuno suppression may in...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.20273
更新日期:2005-11-01 00:00:00
abstract::Analysis of functional status of 197 breast cancer patients three years after curative radical mastectomy indicated a cumulative probability of disability of 25%, whereas the probability of death regardless of prior disability was 40.5%. Analysis of functional status by patient characteristics indicated that nonwhites...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930110408
更新日期:1979-01-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Accurately assessing breast volume (BV) relative to the volume of breast tissue to be removed could help objectively determine the optimal surgical candidates for breast conserving surgery. The objective of this study was to determine the optimal mammography-based method of BV estimation. MET...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.25076
更新日期:2018-06-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Argyrophilic nucleolar organizer regions (AgNORs) have been recently identified as a marker of proliferative index in various tumors. These were evaluated in 46 patients with primary breast carcinoma and were correlated with clinical prognostic parameters of breast cancer. Ten patients with be...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/(sici)1096-9098(199707)65:3<201::aid-jso10
更新日期:1997-07-01 00:00:00
abstract::Retroperitoneal sarcoma (RPS) patients can have variable of outcomes after surgery. The chance to recur locally or at distant sites varies according to tumor grade, histologic subtype, and other patient- and tumor-related characteristics. The relative contribution of each prognostic variable on the oncological outcome...
journal_title:Journal of surgical oncology
pub_type: 杂志文章,评审
doi:10.1002/jso.24903
更新日期:2018-01-01 00:00:00
abstract:BACKGROUND:Unresectable tumors of the pancreatic head are encountered in up to 20% of patients taken for resection. The objective of this study was to evaluate the complications and outcome associated with palliative surgical procedures to help guide management decisions in these patients. METHODS:Patients with pancre...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.23560
更新日期:2014-06-01 00:00:00