Abstract:
BACKGROUND:Prognosis with current management strategies continues to be dismal in metastatic gastric cancer (MGC) patients. We aimed to evaluate the role of metastasectomy in improving survival. METHODS:A comprehensive search of MEDLINE, EMBASE, SCOPUS, and Cochrane central databases (1965 to present) was performed. All comparative studies measuring survival in MGC patients undergoing metastasectomy versus other therapies were included. Pooled risk ratios with corresponding 95% confidence intervals (CI) were calculated for survival at 1, 3, and 5 years. RESULTS:Sixteen studies with 1712 patients (378 patients in metastasectomy, 1334 patients in other therapies) were eligible for the final meta-analysis. Median age was 63 years. For patients undergoing metastasectomy, a significant survival advantage was observed at 1 year (RR 0.52, CI 0.43-0.62), 3 year (RR 0.75 CI 0.67-0.83), and 5 year (RR 0.82, CI 0.74-0.91); mean increased difference in survival conferred by metastasectomy averaged between 9.3 and 15.7 months; P < 0.001 for all results. Age, ECOG status, and STROBE score did not contribute to differences in survival. CONCLUSION:Metastasectomy is associated with increased survival at 1, 3, and 5 years in MGC patients. Large prospective randomized controlled trials are critically needed to evaluate the role of metastasectomy in MGC.
journal_name
J Surg Oncoljournal_title
Journal of surgical oncologyauthors
Gadde R,Tamariz L,Hanna M,Avisar E,Livingstone A,Franceschi D,Yakoub Ddoi
10.1002/jso.23945subject
Has Abstractpub_date
2015-07-01 00:00:00pages
38-45issue
1eissn
0022-4790issn
1096-9098journal_volume
112pub_type
杂志文章,meta分析,评审abstract:BACKGROUND:Recent changes in adjuvant therapies improved the prognosis of metastatic colorectal cancers. Curative resection may be considered, even for both pulmonary and hepatic metastases, but prognostic factors are not well identified. METHODS:From 1995 to 2010, 69 patients had curative resection of pulmonary metas...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.23385
更新日期:2013-09-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Intraoperative adjuncts for the localization of parathyroid glands in parathyroid surgery are limited. The aim of this study is to assess the usefulness of indocyanine green (ICG) near-infrared (NIR) fluorescent imaging in patients undergoing surgery for primary hyperparathyroidism (PHPT). ME...
journal_title:Journal of surgical oncology
pub_type: 临床试验,杂志文章
doi:10.1002/jso.24240
更新日期:2016-06-01 00:00:00
abstract::Munchausen's syndrome is a chronic factitious disorder characterized by frequent hospitalizations, self-inflicted injuries, and dramatic medical histories. People with this condition assume the role of a sick patient and submit to unnecessary invasive, painful, and even dangerous medical procedures. In review of the l...
journal_title:Journal of surgical oncology
pub_type: 杂志文章,评审
doi:10.1002/jso.2930560219
更新日期:1994-06-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:This retrospective study evaluated the feasibility and effectiveness of type II radical hysterectomies alone, or in combination with adjuvant treatment, for the treatment of patients with stage IB-IIB cervical cancer with or without high-risk factors. METHODS:A total of 960 stage IB-IIB patie...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.21800
更新日期:2011-04-01 00:00:00
abstract:BACKGROUND:Lymph node metastasis is the most important prognostic factor in patients with carcinoma of the penis. In this article, we have reviewed the outcome of the patients with pathologic node-positive carcinoma of the penis after groin dissection performed at the Cancer Institute (WIA) between 1987 and 1998. METH...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.20414
更新日期:2006-02-01 00:00:00
abstract::Malignant transformation in cells is accompanied by enzymatic changes that may be useful markers of malignancy. Studies of oncofetal antigens in gastric juice show an increased concentration in patients with gastric carcinoma. The object of the present study was to test if the concentration of lysosomal enzymes and ca...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930240320
更新日期:1983-11-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Peritoneal papillary serous carcinoma (PPSC) is histologically and clinically similar to stage III-IV ovarian papillary serous carcinoma (OPSC). The purpose of this study was to investigate the clinical findings, treatment, and outcome of PPSC patients compared with stage III-IV OPSC patients....
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/(sici)1096-9098(199807)68:3<173::aid-jso8>
更新日期:1998-07-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:F-18 fluorodeoxyglucose-positron emission tomography (FDG-PET) has been used for diagnosis and staging of malignant diseases. However, the prognostic significance of FDG uptake on PET had not been sufficiently evaluated in patients with biliary carcinoma. METHODS:We performed a retrospective ...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.21356
更新日期:2009-11-01 00:00:00
abstract::To compare toxicity and efficacy of both salvage prostatectomy and salvage radiotherapy for prostate cancer a retrospective analysis was conducted. Thirty-two and 41 patients were treated with external beam radiotherapy or prostatectomy for cT1c-T2 prostate cancer later requiring salvage surgery or radiotherapy. Salva...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.20967
更新日期:2008-04-01 00:00:00
abstract:BACKGROUND:Familial soft tissue sarcomas are extremely rare. There is little information available on the clinical features and molecular findings of the hereditary occurrence of mesenchymal tumor. PATIENTS AND METHODS:A woman and her younger brother had malignant fibrous histiocytoma (pleomorphic type) and liposarcom...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.20720
更新日期:2007-03-15 00:00:00
abstract:BACKGROUND:The optimal approach to biliary drainage for patients with supra-ampullary cholangiocarcinoma remains undetermined. Violation of sphincter of Oddi results in bacterial colonization of bile ducts and may increase postdrainage infectious complications. We sought to determine if rates of cholangitis are affecte...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.25485
更新日期:2019-08-01 00:00:00
abstract:BACKGROUND:The aim of the present study was to evaluate the histopathological characteristics of gastric submucosal tumors (SMTs) according to their location. METHODS:A retrospective analysis of a prospective database of 151 consecutive patients who underwent surgery for gastric SMTs between 2001 and 2009 was performe...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.21771
更新日期:2011-07-01 00:00:00
abstract::A case of leiomyosarcoma of a Meckel's diverticulum, presenting as an acute appendicitis, is reported. The literature is reviewed with particular emphasis on current trends in the diagnosis and management of leiomyosarcomas of the small intestine. ...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930320207
更新日期:1986-06-01 00:00:00
abstract:BACKGROUND:Amongst various options of vascularized lymph node transfers, the submental flap has the lowest risk for iatrogenic lymphedema. The aim of this study was to gain insight into distribution, number, and size of lymph nodes along the mandible using computed tomography angiography (CTA). METHODS:A total of 52 C...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.26117
更新日期:2020-07-15 00:00:00
abstract::The clinical records and treatment results of 163 patients with Hodgkin's disease, who were seen at Ellis Fischel State Cancer Hospital (EFSCH) between 1940 and 1971, were reviewed and analyzed. More than 200 clinical and histological variables were recorded for each case of Hodgkin's disease, including details of rad...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930070402
更新日期:1975-01-01 00:00:00
abstract:BACKGROUND:This study aimed to compare voiding and male sexual dysfunction between open and laparoscopic rectal cancer surgery. METHODS:Ninety-seven patients (62 male and 35 female) who underwent open (n = 41) or laparoscopic (n = 56) surgery for rectal cancer were prospectively enrolled. Urine flowmetry, the internat...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.23435
更新日期:2013-12-01 00:00:00
abstract:BACKGROUNDS AND OBJECTIVES:The aim of this study was to describe the epidemiology and treatment of skin adnexal carcinoma (SAC) in the Netherlands and to identify prognostic factors for survival in patients with SAC. METHODS:We used population-based nationwide data from the Netherlands Cancer Registry with cases diagn...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.23331
更新日期:2013-06-01 00:00:00
abstract::A consecutive series of 73 patients treated with intraarterial infusion of 5-fluorouracil (5-FU) for liver metastases from colorectal primary was studied retrospectively using multivariate analysis in order to find determinants of survival. Nontreatment factors had a great impact on variation in survival with liver tu...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930310406
更新日期:1986-04-01 00:00:00
abstract::Delphian node (DN) refers to the pre-laryngeal or pre-cricoid nodal tissue often identified during laryngeal or thyroid surgery. The original nomenclature is based on the assumption that metastasis to this node was predictive of aggressive disease and poor outcome for patients. In this article, we review the existing ...
journal_title:Journal of surgical oncology
pub_type: 杂志文章,评审
doi:10.1002/jso.21640
更新日期:2010-09-15 00:00:00
abstract::A malignant tumor of the submandibular gland was found to consist predominately of spindle cell elements that initially suggested a primary sarcoma. Further examination revealed that the spindled malignant cells were derived from a high-grade mucoepidermoid carcinoma. ...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930310116
更新日期:1986-01-01 00:00:00
abstract::A case of qualitative platelet dysfunction following cancer chemotherapy is documented. Besides the numerical reduction defect, there appear to be functional changes in the platelets leading to bleeding diathesis. The present case was thoroughly evaluated, and it was observed that there is suppression of the platelet ...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930250308
更新日期:1984-03-01 00:00:00
abstract:BACKGROUND AND OBJECTIVE:This study aims to investigate the surgical outcomes observed in robotic transperitoneal aortic lymphadenectomy (AL) in gynecological cancer patients. METHODS:Retrospective data were collected and analyzed on 71 patients undergoing robotic surgical procedures for gynecological cancers, includi...
journal_title:Journal of surgical oncology
pub_type: 临床试验,杂志文章
doi:10.1002/jso.25335
更新日期:2019-03-01 00:00:00
abstract:BACKGROUND:The purpose of the present study was to assess the value of matrix metalloproteinase (MMP)-2 and MMP-9 expression and other potential prognostic factors in predicting the clinical outcome of patients after definitive surgery for pathologic stage IA non-small cell lung cancer (NSCLC). METHODS:One hundred and...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.22001
更新日期:2011-12-01 00:00:00
abstract::Intraoperative radiation therapy (IORT) was delivered to remnant rat liver after partial hepatectomy to determine the chronic effects of treatment on survival, blood chemistry, liver weight, and histology. Survival at one year was 100%. Remnant liver weight was markedly increased in all animals. Liver function appeare...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930500205
更新日期:1992-06-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Transcription factor Snail1 is a key inducer of epithelial-mesenchymal transition (EMT), a biological process implicated in the cancer progression and metastasis. The aim of the study was to investigate Snail1 expression in DCIS found on breast biopsy and assess its predictive value for the fi...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.24708
更新日期:2017-11-01 00:00:00
abstract::Infertility because of testicular damage is a distressing problem for survivors of cancer chemotherapy. We have previously described a cytoprotective effect of temporary testicular circulatory isolation (TCI) during doxorubicin administration in the rat. In this report we define the relationship between duration of TC...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930390410
更新日期:1988-12-01 00:00:00
abstract::Advances in the surgical treatment of primary malignancies and the recent chemotherapy have led to an expansion of the surgical treatment of metastatic lung tumors. However, multiple pulmonary metastases are often found and may affect both lungs. It is difficult to reach tumors in the posterior parts of the lung when ...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930500210
更新日期:1992-06-01 00:00:00
abstract::Sentinel lymph node (sN) biopsy has gained special attention among surgical and medical oncologists as it represents an accepted technique for detecting occult nodal disease in regional lymph nodes of patients with melanoma and breast cancer. The histopathologic examination of the sN may well predict regional lymph no...
journal_title:Journal of surgical oncology
pub_type: 杂志文章,评审
doi:10.1002/jso.20031
更新日期:2004-03-01 00:00:00
abstract::Breakdown of membrane phospholipids is a causative event leading to irreversible cell injury after ischemia and reperfusion insults, which might be one mechanism leading to liver tumor cell death after repeated arterial ischemia as well. After 2 hr of hepatic dearterialization followed by 30 min of reperfusion tumor p...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/(SICI)1096-9098(199604)61:4<284::AID-JSO11
更新日期:1996-04-01 00:00:00
abstract::We reviewed the literature concerning the effect of extended lymph node dissection on survival in patients with gastrointestinal cancer. Most retrospective and/or prospective nonrandomized comparative studies have claimed that extended lymph node dissection significantly improves survival rate in patients with esophag...
journal_title:Journal of surgical oncology
pub_type: 杂志文章,评审
doi:10.1002/(sici)1096-9098(199705)65:1<57::aid-jso12>
更新日期:1997-05-01 00:00:00