Abstract:
:The clinical records and treatment results of 163 patients with Hodgkin's disease, who were seen at Ellis Fischel State Cancer Hospital (EFSCH) between 1940 and 1971, were reviewed and analyzed. More than 200 clinical and histological variables were recorded for each case of Hodgkin's disease, including details of radiotherapy and chemotherapy. Statistical studies were carried out in order to evaluate the independent prognosis significance of each of these factors. All of the lesions were reclassified according to the Lukes proposal which was modified and recommended at the 1965 Rye classification (except for hepatomegaly which was included in Stage IV). This is a retrospective study, and the modern techniques of staging were rarely used in pretreatment studies (since 1965, only ten patients have had an abdominal exploration). The basic work-up consisted of a complete blood count, urinalysis, blood type, chest X ray, and EKG. Lymphangiogram and radioisotope liver scans were used on less than 10% of the patients. About 30% of the patients had gastrointestinal X rays and 70% had IVP. Bone marrow biopsies -- the majority of which were done by needle aspiration -- were obtained for approximatley 50% of the patients. Clinical stage, histological type, and presence of absence of systemic symptoms appeared to be themost significant prognostic factors. The classification of systemic symptoms according to the criteria of either the Rye or Ann Arbor conferences showed no particular difference in determining the survival rate. Among the systemic symptoms, fever appeared to be the most important for survival rate. Survival rates were higher in nonanemic and nonlymphocytopenic patients. Eosinophilia, blood group, and Rh factor had no prognostic significance. The relapse-free interval was an important indicator of long-term prognosis. The unfavorable influence of relapse in ultimate prognosis was clearly seen; however, the extent of the relapse site was shown to have no significant influence on survival.
journal_name
J Surg Oncoljournal_title
Journal of surgical oncologyauthors
Say C,Lee YT,Hori J,Spratt JS Jrdoi
10.1002/jso.2930070402subject
Has Abstractpub_date
1975-01-01 00:00:00pages
255-67issue
4eissn
0022-4790issn
1096-9098journal_volume
7pub_type
杂志文章abstract:BACKGROUND AND OBJECTIVES:Transcription factor Snail1 is a key inducer of epithelial-mesenchymal transition (EMT), a biological process implicated in the cancer progression and metastasis. The aim of the study was to investigate Snail1 expression in DCIS found on breast biopsy and assess its predictive value for the fi...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.24708
更新日期:2017-11-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Malignant mesothelioma is a lethal disease. Aggressive multimodality treatment protocols are reportedly associated with improved survival, but the apparent survival benefits may simply reflect patient selection and the variable natural history of this malignancy. Before embarking on our own pr...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.1143
更新日期:2001-11-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:In North America, preoperative combination chemoradiation is the most commonly recommended and utilized approach to locally advanced rectal cancer. There is increasing interest in the use of induction chemotherapy (IC) before radiation and surgery in locally advanced rectal cancer. How widely ...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.25474
更新日期:2019-08-01 00:00:00
abstract::Primary lymphoma of bone (PLB) is an uncommon clinical entity and a rare presentation of non-Hodgkin's lymphoma. At the Tata Memorial Hospital, over a period of 10 years from 1976 to 1985, 39 cases with a diagnosis of PLB were seen. Twenty-seven cases completed the prescribed treatment and were evaluable for treatment...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930440408
更新日期:1990-08-01 00:00:00
abstract:BACKGROUND:Local recurrence (LR) of sacral chordoma is a difficult problem and the mortality risk associated with LR remains poorly described. The purpose of this study was to evaluate the risk of mortality in patients with LR and determine if patient age is associated with mortality. METHODS:A total of 218 patients (...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.25774
更新日期:2019-11-22 00:00:00
abstract:BACKGROUND AND OBJECTIVES:To determine whether thyroid carcinoma in elderly patients presents any peculiar characteristics, whether the greater biological aggressiveness of the neoplasm modifies the surgical treatment selected, and whether age greater than 70 years represents an independent prognostic factor. METHODS:...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.20140
更新日期:2004-12-15 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Oxaliplatin is a chemotherapeutic drug for colorectal adenocarcinoma able to extend the indications for resection of colorectal liver metastases. However, the drug may severely injure hepatic sinusoids, inducing a sinusoidal obstruction syndrome in non-tumoral parenchyma with a risk of decreas...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.21276
更新日期:2009-06-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Among several long-term effects, people treated for cancer may experience an altered appearance. Our study aims to identify how visible body changes following surgical treatment affect the life and identity of primary bone sarcoma survivors 3-10 years after diagnosis. A qualitative, phenomenol...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.24138
更新日期:2016-02-01 00:00:00
abstract:BACKGROUND:Among the various controversies in the treatment strategies for patients with thymoma, the optimal mode of resection needs to be defined. To explore whether or not the mode of resection affects the prognosis/recurrence in patients with thymoma, we evaluated the treatment outcome of patients with resected thy...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.23499
更新日期:2014-03-01 00:00:00
abstract:BACKGROUND:Receptor-binding cancer antigen expressed on SiSO cells (RCAS1) has been reported to act as a ligand for a receptor present on normal peripheral lymphocytes and to induce apoptotic cell death. We aimed to elucidate the significance of RCAS1 expression in human esophageal squamous cell carcinomas (ESCC). MET...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.20249
更新日期:2005-05-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Pemetrexed is an appealing agent to use for cytoreductive surgery with hyperthermic intraperitoneal chemotherapy (HIPEC). However, the optimal method of pemetrexed delivery still remains undefined. Using a murine model, we compared the use of open and closed abdomen techniques on the absorptio...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.24960
更新日期:2018-05-01 00:00:00
abstract:BACKGROUND AND OBJECTIVE:Tumor-associated macrophages (TAMs) are well known to have distinct roles in tumor progression and metastasis. However, the role of TAMs in chemoresistance has not been fully investigated. The aim of this study is to examine whether TAMs, especially M2 macrophages, are associated with the tumor...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.23881
更新日期:2015-05-01 00:00:00
abstract:INTRODUCTION:Breast conservative surgery (BCS) and sentinel lymph node biopsy (SLNB) after neoadjuvant treatment (NAT) is safe and effective for selected patients. This aim of this study is to evaluate the impact of anatomic site of response on outcomes and to assess the real population who may benefit from nonsurgical...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.26236
更新日期:2021-01-01 00:00:00
abstract::A patient with squamous cell carcinoma of the esophagus developed fatal aortoesophageal (AE) fistula following a preoperative course of combined chemotherapy plus radiation therapy. This is the first reported case of AE fistula following preoperative chemoradiotherapy. This complication is potentially correctable if s...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930480316
更新日期:1991-11-01 00:00:00
abstract::A patient with a feminizing malignant Leydig cell tumor is presented. Hormonal assays revealed increased production of prolactin, estradiol, and total estrogens. Eleven years after the onset of his disease he remains clinically well. ...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930270203
更新日期:1984-10-01 00:00:00
abstract::Two hundred fifty-one patients with colorectal carcinoma were studied following complete primary resection to determine patterns of failure. Seventy-two patients (29%) subsequently developed failures: Local failure (LF) occurred as the only failure in 49% of the failure group and as some component in 81%; distant meta...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930220118
更新日期:1983-01-01 00:00:00
abstract::Intraoperative partial breast radiotherapy is an alternative or an adjunct to fractionated whole breast irradiation for the administration of adjuvant radiotherapy in breast cancer following breast conserving surgery. Establishing intraoperative radiotherapy as a therapeutic modality requires a multidisciplinary appro...
journal_title:Journal of surgical oncology
pub_type: 杂志文章,评审
doi:10.1002/jso.24734
更新日期:2017-12-01 00:00:00
abstract:BACKGROUND:Randomized controlled trials have demonstrated comparable survival outcomes for short-course (SCRT) and long-course neoadjuvant radiotherapy (LCRT) in patients with rectal cancer. METHODS:Using the National Cancer Data Base (2004-2015), a propensity score was used to match 188 patients with rectal cancer re...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.25355
更新日期:2019-03-01 00:00:00
abstract::Oncoplastic surgery combines plastic surgical techniques with sound surgical oncologic principles. The goal is to completely excise the cancer, with wide surgical margins while maintaining or improving cosmesis. For large, poorly defined, or unfavorably situated tumors, standard lumpectomies may lead to unacceptable c...
journal_title:Journal of surgical oncology
pub_type: 杂志文章,评审
doi:10.1002/jso.23641
更新日期:2014-07-01 00:00:00
abstract:BACKGROUND:Long term patient-reported symptoms and quality of life (QOL) are important outcome metrics following cancer operations, but have been poorly described in patients who have previously undergone pancreatectomy. METHODS:We conducted a cross-sectional survey of recurrence-free survivors of pancreatic ductal ad...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.24499
更新日期:2017-02-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Near-infrared (NIR) fluorescence optical imaging is a promising technique to assess the tumor margins during cancer surgery. This technique requires targeting by specific fluorescence agents to differentiate tumor from normal surrounding tissue. We assessed the feasibility of cancer detection ...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.22102
更新日期:2012-06-01 00:00:00
abstract::Gastric cancer with peritoneal carcinomatosis has an extremely poor prognosis, which may be improved with cytoreductive surgery (CRS) combined with heated intraperitoneal chemotherapy (HIPEC). We systematically reviewed the literature regarding the efficacy of CRS + HIPEC in these patients. Electronic databases were s...
journal_title:Journal of surgical oncology
pub_type: 杂志文章,评审
doi:10.1002/jso.22017
更新日期:2011-11-01 00:00:00
abstract::Advances in the surgical treatment of primary malignancies and the recent chemotherapy have led to an expansion of the surgical treatment of metastatic lung tumors. However, multiple pulmonary metastases are often found and may affect both lungs. It is difficult to reach tumors in the posterior parts of the lung when ...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930500210
更新日期:1992-06-01 00:00:00
abstract::The hanging liver maneuver is a useful technique to guide the transection of liver parenchyma by lifting a tape passed between the anterior surface of the inferior vena cava and the liver. Modified hanging liver maneuvers have been described in different types of liver resection. Surgical resection of hilar cholangioc...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.24154
更新日期:2016-03-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:The aim of this study was to evaluate the expression and prognostic roles of human ether à go-go related gene (hERG1) potassium channels in resected esophageal squamous cell carcinoma. METHODS:Expression of hERG1 protein and mRNA was detected by immunohistochemistry and reverse transcription ...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.20891
更新日期:2008-01-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Neoadjuvant protocols in the management of upper extremity sarcoma have improved local control rates but have been associated with high complication rates. We present a refinement of the Eilber protocol using judicious preoperative chemoradiation, limb salvage surgery, and flap coverage to ach...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.20629
更新日期:2007-02-01 00:00:00
abstract:BACKGROUND:Little data regarding the selection of nonsurgical therapies for localized intrahepatic cholangiocarcinoma (ICC) are available. METHODS:A cohort of nonsurgically managed patients with American Joint Commission on Cancer clinical stage I/II ICC in the United States from 2004 to 2013 were identified in the Na...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.25736
更新日期:2019-12-01 00:00:00
abstract::Eighty-nine breast cancer patients were studied for the end result of therapy. During surgery, the anaesthesia administered was either halothane (61 cases) or ether (28 cases) mixture with nitrogen and oxygen. The holstead method for mastectomy was used for all cases. The results showed that the type of anaesthesia in...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930110312
更新日期:1979-01-01 00:00:00
abstract::This review evaluates the use of robotic-assisted laparoscopic surgery in the treatment of gynecologic malignancies and objectively evaluates the use of these systems in performing radical hysterectomies and surgical staging of gynecologic malignancies. The review focuses on surgical length, blood loss, complications,...
journal_title:Journal of surgical oncology
pub_type: 杂志文章,评审
doi:10.1002/jso.22080
更新日期:2012-04-01 00:00:00
abstract::Breakdown of membrane phospholipids is a causative event leading to irreversible cell injury after ischemia and reperfusion insults, which might be one mechanism leading to liver tumor cell death after repeated arterial ischemia as well. After 2 hr of hepatic dearterialization followed by 30 min of reperfusion tumor p...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/(SICI)1096-9098(199604)61:4<284::AID-JSO11
更新日期:1996-04-01 00:00:00