Abstract:
BACKGROUND AND OBJECTIVES:The aim of this study was to evaluate the expression and prognostic roles of human ether à go-go related gene (hERG1) potassium channels in resected esophageal squamous cell carcinoma. METHODS:Expression of hERG1 protein and mRNA was detected by immunohistochemistry and reverse transcription PCR in resected esophageal squamous cell carcinomas (ESCCs) and non-cancerous matched tissues, and the correlation was examined between expression of hERG1 protein and clinicopathological factors and prognosis of ESCC patients. RESULTS:Frequency of positive expression of hERG1 protein was 77.9% (53/68), mRNA was 81.8% (9/11). hERG1 protein and mRNA were negatively expressed in all non-cancerous matched tissues. There was no significant correlation between hERG1 protein expression and lymph node metastases, depth of penetration, stage, and other clinicopathological factors. Completeness was 92.5% for hERG1-positive group and 92.0% for hERG1-negative group. ESCC patients with positive expression of hERG1 protein had a significantly shorter postoperative survival time than those with negative expression (median, 30 vs. 56 months). Survival rates at each time-point for hERG1-positive group were lower than that for hERG1-negative group, and hERG1 was identified as an independent prognostic factor of long-term survival by multivariate analysis. CONCLUSION:In ESCC, hERG1 was aberrantly expressed and correlated with poor prognosis after surgery.
journal_name
J Surg Oncoljournal_title
Journal of surgical oncologyauthors
Ding XW,Luo HS,Luo B,Xu DQ,Gao Sdoi
10.1002/jso.20891subject
Has Abstractpub_date
2008-01-01 00:00:00pages
57-62issue
1eissn
0022-4790issn
1096-9098journal_volume
97pub_type
杂志文章abstract::A 46-year-old man with a second local recurrence of a myxoid liposarcoma in the fossa poplitea, after surgery and high-dose external beam radiotherapy, was successfully treated by a limb-sparing procedure combining marginal excision, intraoperative radiotherapy and reconstructive surgery. After a 48-month follow-up, t...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930530116
更新日期:1993-05-01 00:00:00
abstract:BACKGROUND:Minimally invasive and functional therapy represents an inevitable trend in breast surgery. Improved visualization during mastoscopic axillary lymph node dissection (MALND) realizes a clear exposure of axillary anatomy, but it differs from a general laparoscopic operation. There are some challenges in techni...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.21080
更新日期:2008-08-01 00:00:00
abstract::A patient undergoing treatment with cytotoxic chemotherapy for Hodgkin's disease developed graft versus host disease (GVHD) following a transfusion of packed red cells. This is the 28th reported patient with a malignancy who did not have a bone marrow transplant and developed GVHD after transfusion of normal blood or ...
journal_title:Journal of surgical oncology
pub_type: 杂志文章,评审
doi:10.1002/jso.2930360311
更新日期:1987-11-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:To determine how inhomogeneities in blood perfusion might affect the number of metastases that develop within an individual with cancer. METHODS:Experiments with lung metastases in mice, involving 320 treatment groups and 3165 mice, were reviewed. Inhomogeneities in the distribution of metast...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/1096-9098(200006)74:2<116::AID-JSO7>3.0.CO
更新日期:2000-06-01 00:00:00
abstract::Laparoscopic resection of colon cancer became mired in controversy when it appeared that the technique might be associated with an increased risk of tumor recurrence within the surgical incisions. This was not a uniform finding among all surgeons, however, and other evidence suggested that this did not occur in experi...
journal_title:Journal of surgical oncology
pub_type: 杂志文章,评审
doi:10.1002/jso.20921
更新日期:2007-12-15 00:00:00
abstract::Desmoglein I (DGI) is major component of the desmosomal membrane core that plays an important role in epithelial cell adhesion. The aim of this study was to explore the correlation between the expression of DGI and the clinicopathological findings of esophageal cancer. DGI expression was immunohistochemically examined...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930570207
更新日期:1994-10-01 00:00:00
abstract::A survival study for squamous carcinomas of the distal esophagus treated by the Southern California Permanente Medical Group in the interval of 1954 to 1988 was undertaken. We found radiation therapy and surgery equally efficacious in terms of cure for patients without distant disease and performance status sufficient...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930460206
更新日期:1991-02-01 00:00:00
abstract::A case of symptomatic granular cell tumor of the esophagus is described. Another 32 cases collected from the English literature are analyzed. The reported cases have occurred mostly in women of less than 50 years of age presenting with dysphagia. Excision of the lesion is curative. ...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930330409
更新日期:1986-12-01 00:00:00
abstract::We reviewed the records of 66 consecutive patients who underwent placement of totally implantable venous access devices (TIVADs). Fourteen patients (21%) experienced complications related to the TIVAD. Complications included hematoma, infection, pneumothorax, subclavian vein thrombosis, and chronic clavicular pain. Th...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930440112
更新日期:1990-05-01 00:00:00
abstract:BACKGROUND:Cardiac myxoma, the most common primary tumor in the adult, is less often encountered in infants and children. We reviewed our series of children with cardiac myxoma over a 22-year period and present the long-term results of surgical resection of the tumor. PATIENTS AND METHODS:From January 1985 to December...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.21175
更新日期:2009-01-01 00:00:00
abstract::Cancer patients undergoing surgery often present with unusual and challenging problems. Their age and the fact that they are often chronically ill place them at increased surgical risk. In many instances the need for surgical intervention is crucial to the extent that risk-assessment becomes an academic issue, especia...
journal_title:Journal of surgical oncology
pub_type: 杂志文章,评审
doi:10.1002/jso.2930440312
更新日期:1990-07-01 00:00:00
abstract:BACKGROUNDS AND OBJECTIVES:The aim of this study was to describe the epidemiology and treatment of skin adnexal carcinoma (SAC) in the Netherlands and to identify prognostic factors for survival in patients with SAC. METHODS:We used population-based nationwide data from the Netherlands Cancer Registry with cases diagn...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.23331
更新日期:2013-06-01 00:00:00
abstract:BACKGROUND:A prospective randomized trial was conducted to compare the impact of systemic chemotherapy versus multi-modality therapy (complete cytoreductive surgery (CRS), hyperthermic intraperitoneal chemotherapy (HIPEC), and systemic chemotherapy) on overall survival (OS) in patients with gastric carcinomatosis. MET...
journal_title:Journal of surgical oncology
pub_type: 杂志文章,随机对照试验
doi:10.1002/jso.23633
更新日期:2014-09-01 00:00:00
abstract::The Author describes criteria for selection of patients who might be eligible for entry into a clinical trial of definitive Radiation Therapy for adenocarcinoma of the pancreas. Most emphasis is placed on careful surgical staging, target volume and location, and the use of bypass procedures when appropriate. ...
journal_title:Journal of surgical oncology
pub_type: 临床试验,杂志文章
doi:10.1002/jso.2930070208
更新日期:1975-01-01 00:00:00
abstract:PURPOSE:To compare the local recurrence rate and overall survival between patients with circumferential resection margin (CRM) involvement by direct tumor spread and by a tumor within a lymph node. METHODS:A total of 776 patients diagnosed with rectal cancer underwent rectal resection. Patients with CRM involvement by...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.25252
更新日期:2018-12-01 00:00:00
abstract::Interleukin-2 and hyperthermia have been used individually to treat a variety of tumors in both experimental and human trials. Combined adoptive immunotherapy and hyperthermia is an exciting new line of investigation. Previous work in our laboratory has shown that combined local hyperthermia and rIL-2 therapy can sign...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930530310
更新日期:1993-07-01 00:00:00
abstract:OBJECTIVE:To determine whether the presence of prostate stem cell antigen (PSCA) mRNA in peripheral blood can predict biochemical recurrence (BCR) after radical prostatectomy in patients with high-risk prostate cancer. METHODS:High-risk disease was defined based on the presence of any one of the following three risk f...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.21445
更新日期:2010-02-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Uncertainty exists about the value of cancer therapy in patients aged 90 years and older. Because of the relative paucity of these patients, as well as the possibility of selection bias in any one institution, the use of a large, total population-based cancer registry was employed. METHODS:Th...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.10160
更新日期:2002-11-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Pemetrexed is an appealing agent to use for cytoreductive surgery with hyperthermic intraperitoneal chemotherapy (HIPEC). However, the optimal method of pemetrexed delivery still remains undefined. Using a murine model, we compared the use of open and closed abdomen techniques on the absorptio...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.24960
更新日期:2018-05-01 00:00:00
abstract::A specific red cell adhesion test was done in 243 patients with carcinoma of the cervix uteri and showed the presence of isoantigens in only 27.16% of the patients with infiltrating squamous cell carcinoma. There was a gradual loss of isoantigens during the development of carcinoma. The test can be usefully employed i...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930160111
更新日期:1981-01-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Reports of clinicopathological features and prognosis in patients with mucinous gastric carcinoma (MGC) are conflicting. The aim was to describe the clinicopathological features and prognosis of patients with MGC in comparison with nonmucinous gastric carcinoma (NMGC). METHODS:We reviewed the...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.21533
更新日期:2010-07-01 00:00:00
abstract:OBJECTIVES:The objective of this study is to present two series of cases of pigmented villonodular disease of joints (PVNS) treated at different periods. The 215 cases from our hospital are current (1972-2009) and those 62 from the Jaffe collection from 1920 to 1968. METHODS:By use of our computerized tumor data syste...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.21835
更新日期:2011-04-01 00:00:00
abstract::Radiation therapy (RT) is an important modality in cancer treatment. However, the general perception is that melanoma is radio-resistant. High quality clinical trials are helping to establish the place of RT in select scenarios of advanced disease at primary, regional, and distant sites. New RT techniques need to be i...
journal_title:Journal of surgical oncology
pub_type: 杂志文章,评审
doi:10.1002/jso.23509
更新日期:2014-03-01 00:00:00
abstract::A study of the effectiveness of preoperative radiation as an adjuvant for surgery for patients with invasive bladder carcinoma revealed a subpopulation of patients having advanced disease who could not benefit from radiation treatment. The effect of such a group of patients on the efficiency of 2 common nonparametric ...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930100111
更新日期:1978-01-01 00:00:00
abstract:BACKGROUND:Cytoreductive surgery (CRS) and hyperthermic intra-peritoneal chemotherapy (HIPEC) treatment of colorectal peritoneal metastases (PM) is an established treatment alternative. The study aim was, first, to investigate the outcome of high-volume disease defined by the peritoneal cancer index (PCI) 20; second, t...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.23610
更新日期:2014-08-01 00:00:00
abstract::Quality of care measurement and reporting at the provider, hospital, or health system level has become increasingly common in health systems around the world. Health system performance reports, whether they be confidentially distributed to the provider or made available to the public, are not only used as a stimulus f...
journal_title:Journal of surgical oncology
pub_type: 杂志文章,评审
doi:10.1002/jso.21188
更新日期:2009-06-15 00:00:00
abstract:BACKGROUND:Angiosarcomas comprise less than 1% of all sarcomas, arising from endothelial cells of blood or lymph vessels. Chronic immunosuppression increases the risk of many malignancies and an association between the development of angiosarcoma with an immunosuppressed state is established. A few cases have been repo...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.21516
更新日期:2010-05-01 00:00:00
abstract::Three cases of metastatic cancer to inguinal lymph nodes from unknown primaries are presented. All three patients had exhaustive workups which produced no primary lesions. There were two cases of metastatic squamous cell carcinoma and one of melanoma. A review of the literature shows that it is unusual to have metasta...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930170107
更新日期:1981-01-01 00:00:00
abstract:BACKGROUND:Recently, we have shown in a murine model that radiofrequency ablation (RFA) induces accelerated outgrowth of colorectal micrometastases in the transition zone (TZ) surrounding the ablated lesion. Conversely, RFA also induces an anti-tumor T-cell response that may limit tumor growth at distant sites. Here we...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.21570
更新日期:2010-06-01 00:00:00
abstract:BACKGROUND:Mutation of the KRAS oncogene (mKRAS) in colorectal cancer has been associated with aggressive tumor biology, resistance to epidermal growth factor inhibitors, and decreased overall survival (OS). The aim of the current study was to analyze the association of mKRAS with pathologic complete response (pCR) and...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.26244
更新日期:2021-01-01 00:00:00