Abstract:
BACKGROUND:Recently, we have shown in a murine model that radiofrequency ablation (RFA) induces accelerated outgrowth of colorectal micrometastases in the transition zone (TZ) surrounding the ablated lesion. Conversely, RFA also induces an anti-tumor T-cell response that may limit tumor growth at distant sites. Here we have evaluated whether an altered density of inflammatory cells could be observed in the perinecrotic (TZ) metastases compared to hepatic metastases in the distant reference zone (RZ). METHODS:RFA-treated tumor-bearing mice (n = 10) were sacrificed. The inflammatory cell density (neutrophils, macrophages, CD4(+) T-cells, and CD8(+) T-cells) of tumors in the TZ (TZ tumors) was compared to that in tumors in the RZ (RZ tumors). Sham-operated, tumor-bearing mice (n = 10) were analyzed simultaneously as controls (sham-treated tumors). RESULTS:In RFA-treated, tumor-bearing mice RZ tumors contained a significantly higher density of neutrophils and CD4(+) T-cells, but not macrophages and CD8(+) T-cells compared to sham-treated tumors. Notably, TZ tumors had a significantly lower density of neutrophils, CD4(+) T-cells, and CD8(+) T-cells, but not macrophages, when compared to RZ tumors. CONCLUSIONS:The accelerated perinecrotic tumor outgrowth following RFA is associated with a reduced density of neutrophils and T-cells compared to distant hepatic metastases. This may have implications for local tumor recurrence following RFA.
journal_name
J Surg Oncoljournal_title
Journal of surgical oncologyauthors
Nijkamp MW,Borren A,Govaert KM,Hoogwater FJ,Molenaar IQ,van Diest PJ,Kranenburg O,Borel Rinkes IHdoi
10.1002/jso.21570subject
Has Abstractpub_date
2010-06-01 00:00:00pages
551-6issue
7eissn
0022-4790issn
1096-9098journal_volume
101pub_type
杂志文章abstract::The only acceptable definitive diagnosis of a soft tissue mass is histologic or cytologic examination. In recent years, fine-needle aspiration cytology is used in more and more centers for diagnosis of soft tissue masses. We studied 196 aspiration cytologies performed on soft tissue lesions. Out of these, in 48 cases ...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930370307
更新日期:1988-03-01 00:00:00
abstract::Most surgical oncologists receive exposure to clinical studies in their fellowships; however they receive little if any practical knowledge as to how to become a clinical researcher. This article will provide a broad introduction to setting up a community based surgical oncology research program with emphasis on the p...
journal_title:Journal of surgical oncology
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doi:10.1002/jso.21780
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abstract:BACKGROUND AND OBJECTIVES:Local control of disease is one of the main goals of osteosarcoma management. We conducted a retrospective evaluation of 95 operated cases of osteosarcoma over 7 years to know about the factors associated with local recurrence in resource-challenged environment of the developing world. METHOD...
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abstract::A malignant tumor of the submandibular gland was found to consist predominately of spindle cell elements that initially suggested a primary sarcoma. Further examination revealed that the spindled malignant cells were derived from a high-grade mucoepidermoid carcinoma. ...
journal_title:Journal of surgical oncology
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doi:10.1002/jso.2930310116
更新日期:1986-01-01 00:00:00
abstract:BACKGROUND:A prospective randomized controlled trial has established the efficacy of targeted intraoperative radiotherapy (TARGIT) in the management of invasive breast cancer treated with breast-conserving surgery (BCS). The purpose of this analysis is to evaluate the efficacy of TARGIT in the management of ductal carc...
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abstract:BACKGROUND AND OBJECTIVES:Stage II colon cancer is primarily a surgical disease. Only a still not well-defined subset of patients may benefit from postoperative adjuvant chemotherapy. The relationship between adjuvant chemotherapy and survival after relapse is furthermore still not definitely explored in this group of ...
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abstract:PURPOSE:To explore the time and pattern of recurrence of proximal gastric cancer and estimate the risk factors and prognostic factors for it. Considering these risk factors, postoperative adjuvant therapies and follow-up program can be individualized. METHODS:The data of 135 recurrence proximal gastric cancer patients...
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abstract::Intraoperative radiation therapy (IORT) was delivered to remnant rat liver after partial hepatectomy to determine the chronic effects of treatment on survival, blood chemistry, liver weight, and histology. Survival at one year was 100%. Remnant liver weight was markedly increased in all animals. Liver function appeare...
journal_title:Journal of surgical oncology
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abstract::Lymphoproliferative activity was assessed by 3H-thymidine incorporation in spleen cells of mammary tumor bearing BALB/c mice, mice which had their tumors surgically removed, and mice with sham surgery after stimulation in vitro with a soluble extract of syngeneic tumor antigens. Surgical removal of tumors caused an av...
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journal_title:Journal of surgical oncology
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pub_type: 杂志文章,评审
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更新日期:2016-03-01 00:00:00
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更新日期:1980-01-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:There is paucity of studies on the predictors of bladder cancer (BC) management costs. We aimed to determine predictors of costs associated with radical cystectomy (RC) for BC. METHODS:We conducted a retrospective analysis in a cohort of 2,759 patients who underwent RC for BC between 2000 and...
journal_title:Journal of surgical oncology
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更新日期:2016-02-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Previous in vitro studies have suggested that IGF-1 stimulation can lead a more aggressive breast cancers and subsequent poor prognosis in breast cancer patients. We aim to how IGF-1 and IGF-1R mRNA levels in breast cancer are associated with disease-free survival (DFS) and other clinicopathol...
journal_title:Journal of surgical oncology
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doi:10.1002/jso.21916
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journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930570312
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abstract::The records of 130 patients with soft tissue and bone sarcomas were retrospectively analyzed to identify the subgroups of patients that would benefit from tomographic studies for pulmonary metastasis. Sixty-six of 96 patients with a normal conventional chest roentgenogram (CXR) had tomography to diagnose pulmonary met...
journal_title:Journal of surgical oncology
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journal_title:Journal of surgical oncology
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journal_title:Journal of surgical oncology
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journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.24714
更新日期:2017-11-01 00:00:00
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journal_title:Journal of surgical oncology
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journal_title:Journal of surgical oncology
pub_type: 杂志文章
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更新日期:2018-09-01 00:00:00
abstract::In vivo skin tests using multiple recall and primary antigens such as dinitrochlorobenzine (DNCB) have established that there is decreased cellular-mediated immune response in patients with squamous cell carcinomas of the head and neck. In vitro testing of lymphocytes using blastogenic mitogens as a measure of lymphoc...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930090111
更新日期:1977-01-01 00:00:00
abstract::Mucin-producing tumors of the pancreas (MPT) are characterized by the production of much mucin and a benign course after surgical treatment. We examined 16 cases of MPT and 20 cases of "common" pancreatic duct cell carcinomas (DCC) in regard to K-ras and p53 mutations. The mutations were detected by constant denaturan...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930550205
更新日期:1994-02-01 00:00:00
abstract::Inflammatory carcinoma of the breast is rare and lethal. Since the early 1940s, operation except for biopsy has been contraindicated in patients with inflammatory breast cancer. Results with radiotherapy alone and with radiotherapy and chemotherapy are reviewed. Results of treating patients with initial chemotherapy a...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930230408
更新日期:1983-08-01 00:00:00
abstract::A totally implantable venous access system is described which greatly improved the ability to gain long-term venous access in selected patients. The external jugular approach has been demonstrated to be a safe and simple technique. The only major problem associated with the implantable venous access system was the dev...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930370413
更新日期:1988-04-01 00:00:00