Impact of specific modes of circumferential resection margin involvement in rectal cancer local recurrence: A retrospective study.

Abstract:

PURPOSE:To compare the local recurrence rate and overall survival between patients with circumferential resection margin (CRM) involvement by direct tumor spread and by a tumor within a lymph node. METHODS:A total of 776 patients diagnosed with rectal cancer underwent rectal resection. Patients with CRM involvement by direct tumor spread were named group A. CRM involvement by tumor within a lymph node formed group B. Patient data, including sex, age, pT, pN, stage I-III versus IV, neoadjuvant radiotherapy, adjuvant chemotherapy, carcinoembryonic antigen, primary tumor location, lymph node retrieval, and need for abdominoperineal resection, were compared between both groups. RESULTS:In total, 10.5% of the patients had CRM involvement. Of these, in 57 cases (7.3%), it was by direct tumor spread and in 19 cases (2.4%) by tumor within a lymph node. Other types of CRM involvement were found in six patients. With a mean follow-up of 32.9 months, 18 patients from group A (31.5%) and one patient from group B (5.2%) suffered a local recurrence. Local recurrence-free survival was significantly higher in patients from group B (P = 0.049). Patients in stage I-III (P = 0.037) and from group B ( P = 0.049) had better overall survival. CONCLUSION:Patients with CRM involvement by tumor within a lymph node have a low risk of local recurrence and better overall survival than patients with CRM involvement by direct tumor spread.

journal_name

J Surg Oncol

authors

Suárez J,Goicoetxea A,Gómez ML,Jiménez G,Llanos MC,Jiménez J,Montes B,de Miguel M

doi

10.1002/jso.25252

subject

Has Abstract

pub_date

2018-12-01 00:00:00

pages

1122-1128

issue

7

eissn

0022-4790

issn

1096-9098

journal_volume

118

pub_type

杂志文章
  • Free vascularized fibular grafting for reconstruction after tumor resection in the upper extremity.

    abstract:BACKGROUND:Limb salvage is viable in the majority of patients with malignant bone tumors, but especially in case of extensive tumors and bad soft tissue conditions, it is challenging in upper extremity. OBJECTIVES/METHOD:The clinical and radiological results of 21 patients, who had free vascularized fibular grafts (VF...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.20326

    authors: Gebert C,Hillmann A,Schwappach A,Hoffmann Ch,Hardes J,Kleinheinz J,Gosheger G

    更新日期:2006-08-01 00:00:00

  • The surgeon's future role in the conquest of cancer.

    abstract::This article is a brief review alluding to the multidisciplinary modalities including basic science technologies that are available in the treatment of today's cancer victim. The roles are discussed of the general surgeon and of the surgical fellow, later a surgical oncologist, as they merge into their respective posi...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.2930340202

    authors: Hutchinson WB

    更新日期:1987-02-01 00:00:00

  • DNA index by image analysis in advanced endometrial carcinoma.

    abstract:BACKGROUND:Endometrial carcinoma is the most common gynecologic malignancy in developed countries, affecting an estimated 140,000 women. More than 32,000 women will be diagnosed with endometrial cancer this year in the United States, and approximately 6,000 will die from this disease. METHODS:Twenty consecutive patien...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/(SICI)1096-9098(199610)63:2<91::AID-JSO4>3

    authors: Geisler JP,Wiemann MC,Zhou Z,Miller GA,Geisler HE

    更新日期:1996-10-01 00:00:00

  • Determinants of unresectability and outcome of patients with occult colorectal hepatic metastases.

    abstract:BACKGROUND:Patients chosen for liver resection of colorectal liver metastases are a select group with minimal disease, favorable tumor biology and earlier presentation when compared to unresectable patients. Despite intense preoperative assessments, operative detection of occult unresectable disease is inevitable for a...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.20341

    authors: Bennett JJ,Cao D,Posner MC

    更新日期:2005-10-01 00:00:00

  • Expression of intercellular adhesion molecule-1 in hepatocellular carcinoma.

    abstract::The expression of intercellular adhesion molecule-1 (ICAM-1) was investigated in frozen sections obtained from 40 resected liver specimens of patients with hepatocellular carcinoma using immunoperoxidase techniques and immunoelectron microscopy. ICAM-1 was expressed in 80% of the HCC specimens on the membrane of cance...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.2930530410

    authors: Torii A,Harada A,Nakao A,Nonami T,Ito M,Takagi H

    更新日期:1993-08-01 00:00:00

  • Lymph node regression after neoadjuvant chemotherapy: A predictor of survival in gastric cancer.

    abstract:BACKGROUND AND OBJECTIVE:Neoadjuvant chemotherapy (nCMT) has been increasingly used in advanced gastric cancer (GC). However, the prognostic impact of tumor response remains unclear. This study aimed to evaluate if tumor response at the primary site and lymph nodes (LN) correlate with survival in GC patients after nCMT...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.25785

    authors: Pereira MA,Ramos MFKP,Dias AR,Cardili L,Ribeiro RRE,Charruf AZ,de Castria TB,Zilberstein B,Ceconello I,Avancini Ferreira Alves V,Ribeiro U Jr,de Mello ES

    更新日期:2020-04-01 00:00:00

  • Synovial sarcoma of the abdominal wall: a case report and study of its fine structure.

    abstract::A case of synovial sarcoma in the abdominal wall of a 50-year-old Iraq female is reported. The ultrastructure of the tumor has been studied. Eight other cases of synovial sarcoma in the abdominal wall which reported in the English literature up to 1978 have been reviewed. Synovial sarcomas in the abdominal wall tend t...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.2930180403

    authors: Al-Dewachi HS,Sangal BC,Zakaria MA

    更新日期:1981-01-01 00:00:00

  • Perioperative BRAF inhibitors in locally advanced stage III melanoma.

    abstract:BACKGROUND AND OBJECTIVES:Stage III malignant melanoma is a heterogeneous disease where those cases deemed marginally resectable or irresecatble are frequently incurable by surgery alone. Targeted therapy takes advantage of the high incidence of BRAF mutations in melanomas, most notably the V600E mutation. These agents...

    journal_title:Journal of surgical oncology

    pub_type: 临床试验,杂志文章

    doi:10.1002/jso.24744

    authors: Zippel D,Markel G,Shapira-Frommer R,Ben-Betzalel G,Goitein D,Ben-Ami E,Nissan A,Schachter J,Schneebaum S

    更新日期:2017-12-01 00:00:00

  • Palliation of patients with carcinoma of the lower esophagus and cardia: the question of quality of life.

    abstract::The choice of palliative therapy in patients with carcinoma of the lower esophagus and cardia is mainly between irradiation and surgery. The present report is a retrospective analysis of 40 consecutive patients who recovered after resection of the tumor. The operation was considered to be palliative in all patients. T...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.2930320402

    authors: Welvaart K,de Jong PL

    更新日期:1986-08-01 00:00:00

  • Survival after secondary cytoreduction for recurrent ovarian cancer: which are the prognostic factors?

    abstract:OBJECTIVE:Significant controversy exists concerning the factors affecting survival after secondary cytoreduction (SCR) in recurrent ovarian cancer. This study aims to identify factors independently associated with survival after SCR. METHODS:We retrospectively retrieved 39 patients with recurrent ovarian cancer. All p...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.21686

    authors: Biliatis I,Haidopoulos D,Rodolakis A,Vlachos G,Protopapas A,Thomakos N,Sergentanis T,Akrivos N,Antsaklis A

    更新日期:2010-11-01 00:00:00

  • Adjuvant external beam radiation for medullary thyroid carcinoma.

    abstract:BACKGROUND:Adjuvant radiation is rarely used to treat medullary thyroid carcinoma (MTC). We hypothesized that external beam radiation therapy (EBRT) would improve overall survival (OS) in MTC patients. METHODS:The Surveillance, Epidemiology, and End Results (SEER) database identified patients who underwent total thyro...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.21557

    authors: Martinez SR,Beal SH,Chen A,Chen SL,Schneider PD

    更新日期:2010-08-01 00:00:00

  • Cryoablation and cryolocalization in the management of breast disease.

    abstract::Cryotechnology is currently used for both treatment and diagnosis of breast disease. Due to the natural analgesic effect of cold, cryoablation is potentially more patient-friendly than other technologies which raise tissue temperature. Freezing produces a predictable volume of necrosis and is easily observed and contr...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章,评审

    doi:10.1002/jso.20201

    authors: Whitworth PW,Rewcastle JC

    更新日期:2005-04-01 00:00:00

  • Australian multi-center experience outside of the Sydney Melanoma Unit of isolated limb infusion chemotherapy for melanoma.

    abstract:INTRODUCTION:Isolated limb infusion (ILI) is a minimally invasive alternative to isolated limb perfusion (ILP) for delivering high-dose regional chemotherapy to treat locally advanced limb melanoma. The current study aimed to evaluate the applicability of ILI in four Australian tertiary referral centers outside of its ...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章,多中心研究

    doi:10.1002/jso.23590

    authors: Coventry BJ,Kroon HM,Giles MH,Henderson M,Speakman D,Wall M,Barbour A,Serpell J,Paddle P,Coventry AG,Sullivan T,Smithers BM

    更新日期:2014-06-01 00:00:00

  • Adenocarcinoma of Meckel's diverticulum.

    abstract::The clinicopathologic features of a case of adenocarcinoma arising in Meckel's diverticulum are described and compared with the 21 cases reported in the literature. The prognosis is generally poor. However, the patient in the present case was alive and well 1.5 years after diagnosis, despite the fact that the lesion h...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.2930230111

    authors: Chen KT,Workman RD,Kirkegaard DD

    更新日期:1983-05-01 00:00:00

  • The prognostic utility of baseline alpha-fetoprotein for hepatocellular carcinoma patients.

    abstract:INTRODUCTION:Alpha-fetoprotein (AFP) has a valuable role in postoperative surveillance for hepatocellular carcinoma (HCC) recurrence. The utility of pretreatment or baseline AFP remains controversial. The present study hypothesized that elevated baseline AFP levels are associated with worse overall survival in HCC pati...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.24742

    authors: Silva JP,Gorman RA,Berger NG,Tsai S,Christians KK,Clarke CN,Mogal H,Gamblin TC

    更新日期:2017-12-01 00:00:00

  • DNA ploidy and PCNA index in pancreatic lesions producing hyperinsulinemic hypoglycemia.

    abstract::DNA nuclear content and PCNA index (proportion of PCNA reactive cells) have been studied by flow cytometry in eight pancreatic lesions producing hyperinsulinemic hypoglycemia to assess DNA ploidy and tumoral growth fraction. Adult nesidioblastosis had a diploid DNA index, two adenomas were near diploid, and four of th...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.2930590105

    authors: Losada J,Sarria R,Fernandez Val JF,Lopez Ariztegui MA

    更新日期:1995-05-01 00:00:00

  • Growth index, assessed with Ki-67 and ssDNA labeling; a significant prognosticator for patients undergoing curative resection for hepatocellular carcinoma.

    abstract:BACKGROUND AND OBJECTIVES:The aggressiveness and greater malignant potential of cancers are characterized by several biological phenomena such as accelerated growth invasiveness, and the ability to form distant metastasis. Thus, knowledge of such biological difference may be a more accurate prognosticator for cancer pa...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.20309

    authors: Morinaga S,Ishiwa N,Noguchi Y,Yamamoto Y,Rino Y,Imada T,Takanashi Y,Akaike M,Sugimasa Y,Takemiya S

    更新日期:2005-12-15 00:00:00

  • Primary mucinous adenocarcinoma of the trachea: the case for complete surgical resection.

    abstract::Adenocarcinomas of the trachea are rare but important because the only reported treatment in the past (radiation) has resulted in uniformly poor results. The authors recently had the opportunity to treat a young woman with a mucin-producing adenocarcinoma of the trachea. A sleeve resection of the involved trachea with...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.2930280108

    authors: Reed DN Jr,Hassan AA,Wilson RF

    更新日期:1985-01-01 00:00:00

  • Expression of desmoglein I in squamous cell carcinoma of the esophagus.

    abstract::Desmoglein I (DGI) is major component of the desmosomal membrane core that plays an important role in epithelial cell adhesion. The aim of this study was to explore the correlation between the expression of DGI and the clinicopathological findings of esophageal cancer. DGI expression was immunohistochemically examined...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.2930570207

    authors: Natsugoe S,Aikou T,Shimada M,Kumanohoso T,Tezuka Y,Sagara M,Yoshinaka H,Baba M,Fukumoto T

    更新日期:1994-10-01 00:00:00

  • Perspectives on lymphangiogenesis and angiogenesis in cancer.

    abstract::Tumor-associated neovascularization allows tumor cells to express their critical growth advantage, whereas lymphatic invasion is crucial for the metastatic process. Various growth factors stimulate blood and lymphatic neovascularization and modulate vessel permeability in tumors. The first anti-angiogenic drugs are al...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章,评审

    doi:10.1002/jso.21808

    authors: Holopainen T,Bry M,Alitalo K,Saaristo A

    更新日期:2011-05-01 00:00:00

  • Malignant mesenchymoma of median nerve: combined nerve sheath sarcoma and liposarcoma.

    abstract::A malignant mesenchymoma consisting of nerve sheath sarcoma and liposarcoma occurred in the right median nerve of a 29-year-old man who did not have stigmata of von Recklinghausen neurofibromatosis. It produced pain at the affected part, referred pain to the palm, and weakness of muscles supplied by branches of this n...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.2930250214

    authors: Shuangshoti S,Benjavongkulchai S,Chittmittrapap S

    更新日期:1984-02-01 00:00:00

  • Ossified skeletal muscle angioma: report of two cases.

    abstract::Ossifying skeletal muscle angiomas are relatively rare occurrences. The preoperative diagnosis is exceedingly difficult, although ossification may be reflected radiologically as a "Swiss cheese" appearance. Two patients are described whose skeletal muscle angiomas contained osseous tissue. The osseus tissue varied fro...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.2930250110

    authors: Hoag GN,Murphy MM,Major PA

    更新日期:1984-01-01 00:00:00

  • Modified radiofrequency-assisted liver resection: a new device.

    abstract:BACKGROUND:Radiofrequency ablation (RF) is emerging as new therapeutic method for the management of hepatic tumors. So far the RF-assisted hepatectomy has been described using an electrode initially designed for ablation of unresectable tumors. Herein, we describe a new technique for liver resection using a bipolar rad...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.20770

    authors: Zacharoulis D,Tzovaras G,Rountas C,Poultsidis A,Katsogridakis E,Sioka E,Hatzitheofilou C

    更新日期:2007-09-01 00:00:00

  • Tritiated thymidine labeling index of benign and malignant human breast epithelium.

    abstract::38 specimens of benign breast tissue from young women and 92 primary breast carcinomas were evaluated for tritiated thymidine ([3H]TdR) labeling index (TLI) by in vitro pulse labeling. The TLI on nonneoplastic, terminal breast ducts was significantly higher during the latter half than during the first half of the mens...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.2930080212

    authors: Meyer JS,Bauer WC

    更新日期:1976-01-01 00:00:00

  • Combination therapy for advanced malignant melanoma with BCNU, pseudomonas vaccine, and heparin.

    abstract::A study was undertaken to investigate the addition of heparin and pseudomonas vaccine to BCNU in the treatment of patients with progressive malignant melanoma refractory to front-line therapeutic regimens containing DTIC. Out of 27 evaluable patients, there was one partial remission (4%), and an additional ten patient...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.2930160113

    authors: Snyder RD,Hortobagyi GN,Bodey GP,Gutterman JU,Hersh EM

    更新日期:1981-01-01 00:00:00

  • Factors predictive for long-term survival of male patients with hepatocellular carcinoma after curative resection.

    abstract:BACKGROUND AND OBJECTIVES:Curative hepatic resection (CHR) was a modality that provides possibility of long-term survival for hepatocellular carcinoma (HCC). So far, prognostic factors of male patients with HCC after CHR remain unclear. Purposes of the present study were to identify these factors and to compare them wi...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.20678

    authors: Zhou L,Rui JA,Wang SB,Chen SG,Qu Q,Chi TY,Wei X,Han K,Zhang N,Zhao HT

    更新日期:2007-03-15 00:00:00

  • Comparative analysis of imaging modalities in the preoperative assessment of nodal metastasis in esophageal cancer.

    abstract::Preoperative radiological findings of nodal status in 74 patients, using endoscopic ultrasonography (EUS), computed tomography (CT), ultrasonography (US), and magnetic resonance imaging (MRI), were compared to histopathology reports following transthoracic total esophagectomy with radical lymphadenectomy (TTE), involv...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/(SICI)1096-9098(199603)61:3<214::AID-JSO10

    authors: Chandawarkar RY,Kakegawa T,Fujita H,Yamana H,Hayabuthi N

    更新日期:1996-03-01 00:00:00

  • Thyroid carcinoma metastasized to the sternum: resection of the sternum and reconstruction with acrylic resin.

    abstract::Recently we resected and reconstructed the sternum in two female patients with thyroid carcinoma metastatic to the sternum. Histological diagnosis of the metastatic lesion was follicular carcinoma in the first case and papillary carcinoma in the second case. Reconstruction of the sternum was accomplished by using an a...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.2930600413

    authors: Ozaki O,Kitagawa W,Koshiishi H,Sugino K,Mimura T,Ito K

    更新日期:1995-12-01 00:00:00

  • Cyclic adenosine monophosphate-phosphodiesterase (cAMP-PDE) in lymphocytes from patients with stage III and IV squamous cell carcinoma of the head and neck.

    abstract::In vivo skin tests using multiple recall and primary antigens such as dinitrochlorobenzine (DNCB) have established that there is decreased cellular-mediated immune response in patients with squamous cell carcinomas of the head and neck. In vitro testing of lymphocytes using blastogenic mitogens as a measure of lymphoc...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.2930090111

    authors: Banner RL,Vaughn WK,Hagey KA,Thompson WJ,Hersh EM

    更新日期:1977-01-01 00:00:00

  • Outcome after ovarian/adnexal metastectomy in metastatic colorectal carcinoma.

    abstract:BACKGROUND:Ovarian metastases are reported to occur in 3-8% of women undergoing surgical resection of a primary colorectal adenocarcinoma. Information on clinical outcome after metastectomy for these patients is limited. Patients and Methods A computerized search of the medical record archive at the London Regional Can...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/1096-9098(200011)75:3<186::aid-jso6>3.0.co

    authors: Rayson D,Bouttell E,Whiston F,Stitt L

    更新日期:2000-11-01 00:00:00