Combination therapy for advanced malignant melanoma with BCNU, pseudomonas vaccine, and heparin.

Abstract:

:A study was undertaken to investigate the addition of heparin and pseudomonas vaccine to BCNU in the treatment of patients with progressive malignant melanoma refractory to front-line therapeutic regimens containing DTIC. Out of 27 evaluable patients, there was one partial remission (4%), and an additional ten patients (41%) had at least stable disease with a median survival time of 39 weeks compared to 15 weeks for those with progressive disease. The therapy was well tolerated. A schedule of pseudomonas vaccine that seemed to be tolerated has been established.

journal_name

J Surg Oncol

authors

Snyder RD,Hortobagyi GN,Bodey GP,Gutterman JU,Hersh EM

doi

10.1002/jso.2930160113

subject

Has Abstract

pub_date

1981-01-01 00:00:00

pages

87-92

issue

1

eissn

0022-4790

issn

1096-9098

journal_volume

16

pub_type

杂志文章
  • Therapeutic value of lymph node dissection for esophageal squamous cell carcinoma after neoadjuvant chemotherapy.

    abstract:BACKGROUND AND OBJECTIVES:The optimal extent of lymphadenectomy in patients with esophageal cancer is controversial. This study aimed to examine the therapeutic value of lymph node (LN) dissection for each LN station in patients with esophageal squamous cell carcinoma (ESCC) who receive neoadjuvant chemotherapy. METHO...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.23965

    authors: Miyata H,Yamasaki M,Makino T,Miyazaki Y,Takahashi T,Kurokawa Y,Nakajima K,Takiguchi S,Mori M,Doki Y

    更新日期:2015-07-01 00:00:00

  • Targeted therapy in sarcomas other than GIST tumors.

    abstract::Non-GIST soft tissue sarcomas are a heterogeneous grouping of mesenchymal tumors that comprise less than 1% of adult malignancies. Treatment continues to be based on cytotoxic chemotherapy regimens. However, characterization of the molecular pathway deregulations that drive these tumors has led to the emergence of mor...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章,评审

    doi:10.1002/jso.23802

    authors: Sborov D,Chen JL

    更新日期:2015-04-01 00:00:00

  • Hepatic artery infusion of melphalan in patients with liver metastases from ocular melanoma.

    abstract:BACKGROUND AND OBJECTIVES:Ocular melanoma has a predilection for liver metastases. Systemic treatment is ineffective and the optimal regional therapy approach is poorly defined. Isolated hepatic perfusion (IHP) with melphalan has emerged as a viable treatment option, however a subset of patients are not candidates for ...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.24984

    authors: Boone BA,Perkins S,Bandi R,Santos E,McCluskey K,Bartlett DL,Pingpank JF

    更新日期:2018-04-01 00:00:00

  • The second-time flap from the previously used anterior thigh donor site for head and neck microsurgical reconstruction.

    abstract:BACKGROUND:Multiple free tissue transfer from the same donor site is not well described for microsurgical head and neck reconstruction. METHODS:Between (8/2011 and 11/2012), 103 patients received 103 free ALT flaps for head and neck reconstruction; flaps were called first-time ALT flaps. Intra-operative findings were ...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.24558

    authors: Al Deek NF,Liao CT,Huang SF,Kan CJ,Chang KP,Fang KH,Tsao CK

    更新日期:2017-03-01 00:00:00

  • Expression of interleukin (IL)-12 mRNA in gastric carcinoma specimens: cellular antitumor immune responses.

    abstract:BACKGROUND AND OBJECTIVES:Several tumor-related antigen peptides that are recognized by autologous cytolytic T cells (CTL) have been reported. However, most human solid tumors, including gastric carcinoma, are only weakly immunogenic. In this study, we focused on interleukin (IL)-12 and interferon-gamma (IFN-gamma) as ...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/(sici)1096-9098(199801)67:1<11::aid-jso3>3

    authors: Katano M,Nakamura M,Kuwahara A,Fujimoto K,Matsunaga H,Miyazaki K,Morisaki T

    更新日期:1998-01-01 00:00:00

  • The toxicity and long-term efficacy of nedaplatin and paclitaxel treatment as neoadjuvant chemotherapy for locally advanced cervical cancer.

    abstract:BACKGROUND:The use of neoadjuvant chemotherapy (NACT) for the treatment of locally advanced cervical cancer (LACC) remains controversial. In current clinical practice, platinum-based chemotherapy is the major option for patients with LACC. However, serious adverse events have been reported after platinum-based chemothe...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.22052

    authors: Yin M,Zhang H,Li H,Li X,Liu Y,Chen X,Lou G,Li K

    更新日期:2012-02-01 00:00:00

  • Low molecular weight heparin (LMWH) increases the efficacy of cisplatinum plus gemcitabine combination in advanced pancreatic cancer.

    abstract:BACKGROUND:In this non-randomized study we aimed to assess the efficacy of the addition of low molecular weight heparin (LMWH) to gemcitabine (GEM) plus cisplatinum (CDDP) combination chemotherapy on survival by prevention of thromboembolic complications in patients with advanced pancreatic cancer (APC). PATIENTS AND ...

    journal_title:Journal of surgical oncology

    pub_type: 临床试验,杂志文章

    doi:10.1002/jso.20728

    authors: Icli F,Akbulut H,Utkan G,Yalcin B,Dincol D,Isikdogan A,Demirkazik A,Onur H,Cay F,Büyükcelik A

    更新日期:2007-05-01 00:00:00

  • A computerized tumor-registry system for persons who do not love computers.

    abstract::A new simplified system for updating a cancer registry has been developed in the Biostatistics Department of Roswell Park Memorial Institute. It was designed to serve the needs of maintaining a registry for a cooperative cancer research group. The Data-Update Procedure at a Remote Terminal (DUPART) system has general ...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.2930070508

    authors: Johnson IC,Blumenson LE,Bross ID

    更新日期:1975-01-01 00:00:00

  • Association of insulinoma with subcutaneous nodular fat necrosis.

    abstract::A 57-year-old man first noted tender subcutaneous nodules on his extremities and abdomen. Six months later symptoms of insulin hypersecretion became evident and hyperinsulinemia was documented. An exploratory laparotomy revealed an islet cell tumor measuring 12 cm in diameter extending anteriorly from head of the panc...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.2930160402

    authors: Schwartz RA,Fleishman JS

    更新日期:1981-01-01 00:00:00

  • Gastric cancer molecular classification and adjuvant therapy: Is there a different benefit according to the subtype?

    abstract:BACKGROUND:Gastric cancer (GC) has been defined in distinct molecular subtypes with different therapeutic implications. However, its clinical significance and prognosis regarding standard chemotherapy (CMT) remains unclear. This study aimed to analyze the impact of perioperative or adjuvant treatment among subtypes of ...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.25792

    authors: Ramos MFKP,Pereira MA,Amorim LC,de Mello ES,Faraj SF,Ribeiro U,Hoff PMG,Cecconello I,de Castria TB

    更新日期:2020-04-01 00:00:00

  • Full-term gestation and transvaginal delivery after wide resection of an abdominal desmoid tumor during pregnancy.

    abstract::A 29-year-old female was diagnosed with a symptomatic, extra-abdominal desmoid tumor during the first trimester of pregnancy. Computerized tomography (CT) and transabdominal ultrasound (US) noted a mass within the left rectus sheath measuring up to 15 cm in greatest diameter, with mild compression of the uterus. Preop...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.20189

    authors: Durkin AJ,Korkolis DP,Al-Saif O,Zervos EE

    更新日期:2005-02-01 00:00:00

  • Outcome after reconstruction of proximal femoral tumors: A systematic review.

    abstract::Tumor resection followed by reconstruction with a proximal femoral endoprosthesis or an allograft-prosthesis composite are the two main alternatives for treatment of proximal femoral malignancies. This review describes the revision rate, implant survival, limb salvage rate, and function. Overall revision rates are hig...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章,meta分析

    doi:10.1002/jso.25297

    authors: Janssen SJ,Langerhuizen DWG,Schwab JH,Bramer JAM

    更新日期:2019-01-01 00:00:00

  • Epididymal metastasis from prostatic cancer.

    abstract::A case of prostatic adenocarcinoma metastasizing to the epididymis is described, and the literature is reviewed. ...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章,评审

    doi:10.1002/jso.2930240416

    authors: Sarma DP,Weiner M,Weilbaecher TG

    更新日期:1983-12-01 00:00:00

  • Expression of CD44v6 in advanced gastric cancer and its relationship to hematogenous metastasis and long-term prognosis.

    abstract:BACKGROUND AND OBJECTIVES:Variants of CD44 have been proposed to be important in promoting tumor progression and metastasis. We attempted to determine the expression of CD44v6 product in advanced gastric cancer and to evaluate its prognostic value. METHODS:The expression of CD44v6 was analyzed immunohistochemically in...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.10082

    authors: Yamaguchi A,Goi T,Yu J,Hirono Y,Ishida M,Iida A,Kimura T,Takeuchi K,Katayama K,Hirose K

    更新日期:2002-04-01 00:00:00

  • Temporal trends in liver-directed therapy of patients with intrahepatic cholangiocarcinoma in the United States: a population-based analysis.

    abstract:BACKGROUND AND OBJECTIVES:Data on outcomes after liver-directed therapy for intrahepatic cholangiocarcinoma (ICC) are limited due to the rarity of the disease. We sought to define overall utilization and temporal trends of liver-directed therapy for ICC. METHODS:We identified 5,388 patients with ICC using the Surveill...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.23605

    authors: Amini N,Ejaz A,Spolverato G,Kim Y,Herman JM,Pawlik TM

    更新日期:2014-08-01 00:00:00

  • Limb-sparing treatment with surgery and intraoperative radiotherapy (IORT) for a second local recurrence of myxoid liposarcoma in the popliteal region, after previous surgery and high-dose radiation.

    abstract::A 46-year-old man with a second local recurrence of a myxoid liposarcoma in the fossa poplitea, after surgery and high-dose external beam radiotherapy, was successfully treated by a limb-sparing procedure combining marginal excision, intraoperative radiotherapy and reconstructive surgery. After a 48-month follow-up, t...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.2930530116

    authors: Wijffels RT,Mehta DM,Spauwen PH,Hoekstra HJ

    更新日期:1993-05-01 00:00:00

  • Delphian node metastasis in head and neck cancers--oracle or myth?

    abstract::Delphian node (DN) refers to the pre-laryngeal or pre-cricoid nodal tissue often identified during laryngeal or thyroid surgery. The original nomenclature is based on the assumption that metastasis to this node was predictive of aggressive disease and poor outcome for patients. In this article, we review the existing ...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章,评审

    doi:10.1002/jso.21640

    authors: Iyer NG,Shaha AR,Ferlito A,Thomas Robbins K,Medina JE,Silver CE,Rinaldo A,Takes RP,Suárez C,Rodrigo JP,Bradley PJ,Werner JA

    更新日期:2010-09-15 00:00:00

  • Neural cell adhesion molecule (NCAM) and perineural invasion in bile duct cancer.

    abstract::Perineural invasion is associated with tumor spreading and an unfavorable prognosis in a variety of cancers. Recently, neural cell adhesion molecule (NCAM) has been reported to be affinitive to neural tissues, which suggests some relationship between NCAM and perineural invasion. This study was designed to elucidate t...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.2930530205

    authors: Seki H,Tanaka J,Sato Y,Kato Y,Umezawa A,Koyama K

    更新日期:1993-06-01 00:00:00

  • Symptomatic pericardial effusion in lung cancer patients: the role of fluid cytology.

    abstract::During the years 1975-1988, twenty lung cancer patients with symptomatic pericardial effusion were treated conservatively at our center. Echocardiography demonstrated small pericardial effusion in 2 patients, medium size effusion in 3 patients and large amount of fluid in 15 patients. Fifteen patients developed cardia...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.2930450212

    authors: Edoute Y,Malberger E,Kuten A,Moscovitcz M,Ben-Haim SA

    更新日期:1990-10-01 00:00:00

  • The impact of re-excision of inadequately resected soft tissue sarcomas on surgical therapy, results, and prognosis: A single institution experience with 682 patients.

    abstract:BACKGROUND AND OBJECTIVES:Due to their rare incidence soft tissue sarcomas (STS) are often resected without clear margins. The aim of this study was to investigate the impact of re-excision of STS on survival. METHODS:Out of 752 patients with STS (406 men and 346 women, average age 51 years), 310 patients were referre...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.21639

    authors: Funovics PT,Vaselic S,Panotopoulos J,Kotz RI,Dominkus M

    更新日期:2010-11-01 00:00:00

  • Intraperitoneal cisplatin with sodium thiosulfate protection in rats with intestinal anastomoses.

    abstract::Intraperitoneal (IP) cisplatin administered at the time of intraabdominal malignancies such as gastric cancer may prevent or delay intraabdominal recurrence. Perioperative IP cisplatin raises concerns regarding systemic toxicity and retardation of wound healing. Systemic cisplatin toxicity may be reduced by administer...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.2930520415

    authors: Wile AG,Dileo SK,Gossett DA,Lao XY

    更新日期:1993-04-01 00:00:00

  • Predictive value of preoperative and postoperative peripheral lymphocyte difference in hepatitis B virus-related hepatocellular cancer patients: Based on the analysis of dynamic nomogram.

    abstract:BACKGROUND:Inflammation plays an important role in the progression and prognosis of hepatocellular carcinoma (HCC). Our aim is to explore the prognostic value of preoperative and postoperative peripheral lymphocyte differences and to develop a dynamic prognosis nomogram in hepatitis B virus-related HCC patients. METHO...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.26195

    authors: Luo D,Li H,Yu H,Zhang M,Hu J,Jin C,Chua M,Han B

    更新日期:2020-12-01 00:00:00

  • Free jejunal graft for repair of cervical esophagus.

    abstract::We have operated upon six patients with cervical esophageal carcinoma and reconstructed these with free jejunal graft. The pathology of all six patients was squamous cell carcinoma, and no patient had apparent distant metastasis. The procedure was a two team approach. While the surgical oncology team resected the esop...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.2930420307

    authors: Sohrabi A,Nowzari P,Ashairi M,Moghari A,Watne A

    更新日期:1989-11-01 00:00:00

  • Bacterial adherence to bladder tumors in the mouse.

    abstract::Mice with intravesical urothelial tumors (MBT-2) were challenged with E coli inoculated intravesically. Adherence of bacteria measured at 15 min or persistent infection at 24 h was significantly greater in the tumor-bearing bladders than in normal non-tumor-bearing mice. The tumor-bearing portion of the bladder contai...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.2930230405

    authors: Bagley DH,Velanovich V,Jones KW,Heggers JP

    更新日期:1983-08-01 00:00:00

  • Seeding and perineal implantation of prostatic cancer in the track of the biopsy needle: three case reports and a review of the literature.

    abstract::Several months (an average of 12.86 months) after perineal needling of the cancerous prostate for the purpose of obtaining tissue for biopsy, a tumor nodule becomes clinically evident in the subcutaneous tissue of the perineum, at the site of the needling in 0.34% of the cases. This nodule presents the same histologic...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章,评审

    doi:10.1002/jso.2930350309

    authors: Haddad FS,Somsin AA

    更新日期:1987-07-01 00:00:00

  • Human colorectal carcinoma: patterns of sensitivity to chemotherapeutic agents in the human tumor stem cell assay.

    abstract::The human tumor stem cell assay (HTSCA) was applied to 103 primary and metastatic colorectal carcinomas. Thirty-four carcinomas could not be evaluated for colony formation (clonogenicity) because of microbial contamination. Of the remaining 69 carcinomas, 18 (26%) demonstrated clonal growth in vitro. Colony formation ...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.2930200311

    authors: Agrez MV,Kovach JS,Beart RW Jr,Rubin J,Moertel CG,Lieber MM

    更新日期:1982-07-01 00:00:00

  • Electrothermal bipolar coagulation decreases the rate of red blood cell transfusions for pelvic exenterations.

    abstract:BACKGROUND:We evaluated whether electrothermal bipolar coagulation (Ligasure) for pelvic exenterations decreases operative morbidity. METHODS:All cases of pelvic exenterations, for all malignancies, performed at Moffitt Cancer Center from 1999 to 2008, were identified through retrospective review of medical records. E...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.21372

    authors: Bansal N,Roberts WS,Apte SM,Lancaster JM,Wenham RM

    更新日期:2009-11-01 00:00:00

  • Intraoperative bile spillage is associated with worse survival in gallbladder adenocarcinoma.

    abstract:BACKGROUND:Gallbladder adenocarcinoma is often incidentally identified following cholecystectomy. We hypothesized that intraoperative bile spillage would be a negative prognostic factor. METHODS:A retrospective review of patients treated at a cancer center with histologically confirmed gallbladder adenocarcinoma, 2009...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.25617

    authors: Blakely AM,Wong P,Chu P,Warner SG,Raoof M,Singh G,Fong Y,Melstrom LG

    更新日期:2019-09-01 00:00:00

  • Multi-institutional analysis of recurrence and survival after hepatectomy for fibrolamellar carcinoma.

    abstract:BACKGROUND AND OBJECTIVES:Fibrolamellar carcinoma (FLC) presents in young, otherwise-healthy individuals. This study examined recurrence and survival characteristics after surgical resection for FLC by utilizing an international multi-institutional database. METHODS:Consecutive patients undergoing hepatectomy for FLC ...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.23658

    authors: Groeschl RT,Miura JT,Wong RK,Bloomston M,Lidsky ML,Clary BM,Martin RC,Belli G,Buell JF,Gamblin TC

    更新日期:2014-09-01 00:00:00

  • High infiltration of tumor-associated macrophages is associated with a poor response to chemotherapy and poor prognosis of patients undergoing neoadjuvant chemotherapy for esophageal cancer.

    abstract:BACKGROUND AND OBJECTIVE:Tumor-associated macrophages (TAMs) are well known to have distinct roles in tumor progression and metastasis. However, the role of TAMs in chemoresistance has not been fully investigated. The aim of this study is to examine whether TAMs, especially M2 macrophages, are associated with the tumor...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.23881

    authors: Sugimura K,Miyata H,Tanaka K,Takahashi T,Kurokawa Y,Yamasaki M,Nakajima K,Takiguchi S,Mori M,Doki Y

    更新日期:2015-05-01 00:00:00