Multi-institutional analysis of recurrence and survival after hepatectomy for fibrolamellar carcinoma.

Abstract:

BACKGROUND AND OBJECTIVES:Fibrolamellar carcinoma (FLC) presents in young, otherwise-healthy individuals. This study examined recurrence and survival characteristics after surgical resection for FLC by utilizing an international multi-institutional database. METHODS:Consecutive patients undergoing hepatectomy for FLC from six institutions (1993-2010) were reviewed retrospectively. Survival was studied with life tables and Cox regression models. RESULTS:Thirty-five patients (13 female, 37%) were included (median age: 32 years). R0 resection was achieved in all curative-intent operations (n = 30), and palliative operations were performed for five patients. Crude 30-day morbidity and mortality rates were 22% and 3%, respectively. For curative-intent surgery, overall and recurrence-free survivals at 5 years were 62% and 45%, respectively. In patients who achieved a 4-year disease-free interval after surgery, none subsequently developed recurrence. In multivariate models, presence of extrahepatic disease was the only factor that independently predicted overall (hazard ratio [HR]: 5.58, 95% confidence interval [CI]: 1.38-22.55, P = 0.016) and recurrence-free survival (HR: 5.64, 95% CI: 1.48-21.49, P = 0.011). CONCLUSIONS:Patients with surgically amenable FLC had encouraging long-term survival. Recurrence-free survival to 4 years suggested possible freedom from disease thereafter. Recurrent resectable disease was associated with an excellent prognosis, and repeat surgery should be strongly considered.

journal_name

J Surg Oncol

authors

Groeschl RT,Miura JT,Wong RK,Bloomston M,Lidsky ML,Clary BM,Martin RC,Belli G,Buell JF,Gamblin TC

doi

10.1002/jso.23658

subject

Has Abstract

pub_date

2014-09-01 00:00:00

pages

412-5

issue

4

eissn

0022-4790

issn

1096-9098

journal_volume

110

pub_type

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