Abstract:
:Tumor-associated neovascularization allows tumor cells to express their critical growth advantage, whereas lymphatic invasion is crucial for the metastatic process. Various growth factors stimulate blood and lymphatic neovascularization and modulate vessel permeability in tumors. The first anti-angiogenic drugs are already in routine use, and new anti-vascular therapeutics are evaluated in clinical trials. Conversely, pro-lymphangiogenic therapy could be implemented to treat cancer survivors suffering from secondary lymphedema.
journal_name
J Surg Oncoljournal_title
Journal of surgical oncologyauthors
Holopainen T,Bry M,Alitalo K,Saaristo Adoi
10.1002/jso.21808subject
Has Abstractpub_date
2011-05-01 00:00:00pages
484-8issue
6eissn
0022-4790issn
1096-9098journal_volume
103pub_type
杂志文章,评审abstract:BACKGROUND AND OBJECTIVES:To identify breast-specific factors and the role of tumor, treatment, and patient-related items in influencing patient opinion on cosmesis and satisfaction after breast-conserving therapy (BCT). METHODS:Data from the randomized COBALT study was used. At 3, 12, and 36 months, 128 patients with...
journal_title:Journal of surgical oncology
pub_type: 杂志文章,随机对照试验
doi:10.1002/jso.25012
更新日期:2018-04-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:The aim of this study was to evaluate the role of indocyanine green (ICG) fluorescence imaging (FI) for the ex vivo detection of metastatic lymph nodes (LNs) in advanced stage ovarian cancer (AOC). METHODS:Paraffin-embedded LNs from patients included in a previous ICG-FI study (Protocol NCT01...
journal_title:Journal of surgical oncology
pub_type: 临床试验,杂志文章
doi:10.1002/jso.25263
更新日期:2018-12-01 00:00:00
abstract::The relationship between prior cholecystectomy and right-sided colon cancer was evaluated in a case-control study. The study population comprised 267 women with right-sided colon cancer (cases) and 268 women with left-sided colon cancer (controls). All patients were white females, aged between 40 and 69 years, and reg...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930300103
更新日期:1985-09-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Accurately assessing breast volume (BV) relative to the volume of breast tissue to be removed could help objectively determine the optimal surgical candidates for breast conserving surgery. The objective of this study was to determine the optimal mammography-based method of BV estimation. MET...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.25076
更新日期:2018-06-01 00:00:00
abstract:BACKGROUND:This study aimed to compare voiding and male sexual dysfunction between open and laparoscopic rectal cancer surgery. METHODS:Ninety-seven patients (62 male and 35 female) who underwent open (n = 41) or laparoscopic (n = 56) surgery for rectal cancer were prospectively enrolled. Urine flowmetry, the internat...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.23435
更新日期:2013-12-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Peritoneal papillary serous carcinoma (PPSC) is histologically and clinically similar to stage III-IV ovarian papillary serous carcinoma (OPSC). The purpose of this study was to investigate the clinical findings, treatment, and outcome of PPSC patients compared with stage III-IV OPSC patients....
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/(sici)1096-9098(199807)68:3<173::aid-jso8>
更新日期:1998-07-01 00:00:00
abstract:PURPOSE:To present the clinical data of 35 patients with T3 unresectable hepatocellular carcinoma (HCC) that were treated with (90)Y with the specific intent of downstaging to resection, radiofrequency ablation (RFA) candidate, United Network for Organ Sharing (UNOS) stage T2 or liver transplantation. MATERIALS AND ME...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.20609
更新日期:2006-12-01 00:00:00
abstract::Reconstructive procedures following chest wall resection pose a special surgical challenge. With modern surgical technique, a wide range of reconstructive options are at the surgeon's disposal and, hence it is imperative that the appropriate procedure be selected in a given patient. A total of 64 patients underwent re...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930550311
更新日期:1994-03-01 00:00:00
abstract:OBJECTIVE:To evaluate the patients with invasive cervical cancer found in simple hysterectomy and who were subjected to radical parametrectomy and upper vaginectomy with therapeutic lymphadenectomy. METHODS:Twenty-seven patients who underwent the radical parametrectomy and upper vaginectomy with therapeutic lymphadene...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.20550
更新日期:2006-07-01 00:00:00
abstract:BACKGROUND:Sentinel node biopsies (SNBs) have been clinically applied in melanoma and breast cancer for limited lymphadenectomy. However, the use of SNB remains controversial in gastric cancer due to unsatisfactory sensitivity and variability. This meta-analysis was performed to determine the sensitivity of SNB in gast...
journal_title:Journal of surgical oncology
pub_type: 杂志文章,meta分析
doi:10.1002/jso.21995
更新日期:2011-11-01 00:00:00
abstract::Colorectal cancer progression originates when accumulated genetic and epigenetic alterations cause genomic instability and a malignant phenotype. Subsequent molecular pathway deregulation leads to histopathologic changes that are clinically evident as aberrant crypt foci (ACF) and visualized by high-magnification chro...
journal_title:Journal of surgical oncology
pub_type: 杂志文章,评审
doi:10.1002/jso.21106
更新日期:2008-09-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Argyrophilic nucleolar organizer regions (AgNORs) have been recently identified as a marker of proliferative index in various tumors. These were evaluated in 46 patients with primary breast carcinoma and were correlated with clinical prognostic parameters of breast cancer. Ten patients with be...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/(sici)1096-9098(199707)65:3<201::aid-jso10
更新日期:1997-07-01 00:00:00
abstract::Two hundred fifty-one patients with colorectal carcinoma were studied following complete primary resection to determine patterns of failure. Seventy-two patients (29%) subsequently developed failures: Local failure (LF) occurred as the only failure in 49% of the failure group and as some component in 81%; distant meta...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930220118
更新日期:1983-01-01 00:00:00
abstract::Non-GIST soft tissue sarcomas are a heterogeneous grouping of mesenchymal tumors that comprise less than 1% of adult malignancies. Treatment continues to be based on cytotoxic chemotherapy regimens. However, characterization of the molecular pathway deregulations that drive these tumors has led to the emergence of mor...
journal_title:Journal of surgical oncology
pub_type: 杂志文章,评审
doi:10.1002/jso.23802
更新日期:2015-04-01 00:00:00
abstract::A patient with squamous cell carcinoma of the esophagus developed fatal aortoesophageal (AE) fistula following a preoperative course of combined chemotherapy plus radiation therapy. This is the first reported case of AE fistula following preoperative chemoradiotherapy. This complication is potentially correctable if s...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930480316
更新日期:1991-11-01 00:00:00
abstract:BACKGROUND AND OBJECTIVE:Neoadjuvant chemotherapy (nCMT) has been increasingly used in advanced gastric cancer (GC). However, the prognostic impact of tumor response remains unclear. This study aimed to evaluate if tumor response at the primary site and lymph nodes (LN) correlate with survival in GC patients after nCMT...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.25785
更新日期:2020-04-01 00:00:00
abstract::Ossifying skeletal muscle angiomas are relatively rare occurrences. The preoperative diagnosis is exceedingly difficult, although ossification may be reflected radiologically as a "Swiss cheese" appearance. Two patients are described whose skeletal muscle angiomas contained osseous tissue. The osseus tissue varied fro...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930250110
更新日期:1984-01-01 00:00:00
abstract::Munchausen's syndrome is a chronic factitious disorder characterized by frequent hospitalizations, self-inflicted injuries, and dramatic medical histories. People with this condition assume the role of a sick patient and submit to unnecessary invasive, painful, and even dangerous medical procedures. In review of the l...
journal_title:Journal of surgical oncology
pub_type: 杂志文章,评审
doi:10.1002/jso.2930560219
更新日期:1994-06-01 00:00:00
abstract::A total of 239 determinations of CEA plasma levels were performed for 83 breast cancer patients during chemotherapy or follow-up. In addition, 137 plasma samples were assayed for interferon levels. Patient clinical status was carefully scored according to objective criteria and recorded at each evaluation. Liver funct...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930220409
更新日期:1983-04-01 00:00:00
abstract::The ability to redefine risk factors and to predict prognosis in patients with malignant melanoma at the time they manifest nodal metastasis can be a benefit to the patient emotionally and to the physician therapeutically. A retrospective review of 1,273 patients with stage II malignant melanoma was performed at our i...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930390302
更新日期:1988-11-01 00:00:00
abstract::Tumor resection followed by reconstruction with a proximal femoral endoprosthesis or an allograft-prosthesis composite are the two main alternatives for treatment of proximal femoral malignancies. This review describes the revision rate, implant survival, limb salvage rate, and function. Overall revision rates are hig...
journal_title:Journal of surgical oncology
pub_type: 杂志文章,meta分析
doi:10.1002/jso.25297
更新日期:2019-01-01 00:00:00
abstract::A poorly differentiated transitional cell carcinoma in C3H/He mice results from the oral ingestion of the urinary tract carcinogen FANFT. This model, designated MBT2, is readily transplantable into syngeneic animals and has proven to be very useful in the development of chemotherapy. Prior to the use of this model for...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930240113
更新日期:1983-09-01 00:00:00
abstract::Cancer of the oral cavity remains a major problem in the United States as well as in many other countries, some of which record as much as 30% of all their cancers to be in the oral region. Despite numerous advances in the fields of epidemiology and etiology, little is known of the molecular basis of oral cancer. Adva...
journal_title:Journal of surgical oncology
pub_type: 杂志文章,评审
doi:10.1002/jso.2930470209
更新日期:1991-06-01 00:00:00
abstract::Cell surface sialic acid levels were compared for monocytes and macrophages obtained from normal volunteers and breast cancer patients. Equal quantities of sialic acid were found on the monocytes obtained from normal volunteers and breast cancer patients. Approximately 60% more cell surface sialic acid was found on th...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930220203
更新日期:1983-02-01 00:00:00
abstract:BACKGROUND:To evaluate the efficacy and toxicity of pre-operative radiotherapy (RT) combined with oral tegafur-uracil (UFUR) plus leucovorin (LV) in rectal cancer. PATIENTS:Sixty-five patients with rectal adenocarcinoma (clinical staged T2-4N0-2M0) received pelvic RT of 45 Gy in 20 fractions over 28 days. Concurrent c...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.20168
更新日期:2005-03-15 00:00:00
abstract:INTRODUCTION:Hyperthermic isolated limb perfusion (HILP) has an established role in the management of melanoma, but its role for Merkel cell carcinoma (MCC) is less well defined. METHODS:Retrospective review of our institutional experience with HILP for MCC was conducted (2009-2015). Literature search was performed th...
journal_title:Journal of surgical oncology
pub_type: 杂志文章,评审
doi:10.1002/jso.24289
更新日期:2016-08-01 00:00:00
abstract:BACKGROUND:Recent changes in adjuvant therapies improved the prognosis of metastatic colorectal cancers. Curative resection may be considered, even for both pulmonary and hepatic metastases, but prognostic factors are not well identified. METHODS:From 1995 to 2010, 69 patients had curative resection of pulmonary metas...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.23385
更新日期:2013-09-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:The poorer outcome amongst younger breast cancer patients continues to be an issue of debate. In order to clarify the prognostic value of patient age, we retrospectively analyzed the data of 1098 breast cancer patients. METHODS:Patients were divided into two groups based on the age 35 (Group ...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.10088
更新日期:2002-05-01 00:00:00
abstract:PURPOSE:Imatinib mesylate (IM) demonstrates substantial efficacy in most patients with metastatic gastrointestinal stromal tumors (GISTs). However, progression of GIST eventually develops and emerges as a challenge. To assess the role of surgery in the multidisciplinary management of GISTs, we studied the surgical outc...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.21630
更新日期:2010-11-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:ERCP prior to pancreaticoduodenectomy is unnecessary in select patients. When performed, it should be in conjunction with endoscopic ultrasound (EUS) to increase diagnostic sensitivity and allow for metal stent placement. The aim of this study was to determine differences in endoscopic practic...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.24191
更新日期:2016-05-01 00:00:00