Perspectives on lymphangiogenesis and angiogenesis in cancer.

Abstract:

:Tumor-associated neovascularization allows tumor cells to express their critical growth advantage, whereas lymphatic invasion is crucial for the metastatic process. Various growth factors stimulate blood and lymphatic neovascularization and modulate vessel permeability in tumors. The first anti-angiogenic drugs are already in routine use, and new anti-vascular therapeutics are evaluated in clinical trials. Conversely, pro-lymphangiogenic therapy could be implemented to treat cancer survivors suffering from secondary lymphedema.

journal_name

J Surg Oncol

authors

Holopainen T,Bry M,Alitalo K,Saaristo A

doi

10.1002/jso.21808

subject

Has Abstract

pub_date

2011-05-01 00:00:00

pages

484-8

issue

6

eissn

0022-4790

issn

1096-9098

journal_volume

103

pub_type

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