Aberrant crypt foci as precursors in colorectal cancer progression.

Abstract:

:Colorectal cancer progression originates when accumulated genetic and epigenetic alterations cause genomic instability and a malignant phenotype. Subsequent molecular pathway deregulation leads to histopathologic changes that are clinically evident as aberrant crypt foci (ACF) and visualized by high-magnification chromoscopic colonoscopy. ACF are biomarkers of increased colorectal cancer risk, particularly those with dysplastic features. Genetic profiling using genomic instability, loss of heterozygosity, and methylation analysis has revealed a minority population of ACF genotypically analogous to cancer.

journal_name

J Surg Oncol

authors

Orlando FA,Tan D,Baltodano JD,Khoury T,Gibbs JF,Hassid VJ,Ahmed BH,Alrawi SJ

doi

10.1002/jso.21106

subject

Has Abstract

pub_date

2008-09-01 00:00:00

pages

207-13

issue

3

eissn

0022-4790

issn

1096-9098

journal_volume

98

pub_type

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