Abstract:
:Colorectal cancer progression originates when accumulated genetic and epigenetic alterations cause genomic instability and a malignant phenotype. Subsequent molecular pathway deregulation leads to histopathologic changes that are clinically evident as aberrant crypt foci (ACF) and visualized by high-magnification chromoscopic colonoscopy. ACF are biomarkers of increased colorectal cancer risk, particularly those with dysplastic features. Genetic profiling using genomic instability, loss of heterozygosity, and methylation analysis has revealed a minority population of ACF genotypically analogous to cancer.
journal_name
J Surg Oncoljournal_title
Journal of surgical oncologyauthors
Orlando FA,Tan D,Baltodano JD,Khoury T,Gibbs JF,Hassid VJ,Ahmed BH,Alrawi SJdoi
10.1002/jso.21106subject
Has Abstractpub_date
2008-09-01 00:00:00pages
207-13issue
3eissn
0022-4790issn
1096-9098journal_volume
98pub_type
杂志文章,评审abstract::In this review, we aim to assess the current state of science in relation to the integration of patient-generated health data (PGHD) and patient-reported outcomes (PROs) into routine clinical care with a focus on surgical oncology populations. We will also describe the critical role of artificial intelligence and mach...
journal_title:Journal of surgical oncology
pub_type: 杂志文章,评审
doi:10.1002/jso.26232
更新日期:2021-01-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Stage III malignant melanoma is a heterogeneous disease where those cases deemed marginally resectable or irresecatble are frequently incurable by surgery alone. Targeted therapy takes advantage of the high incidence of BRAF mutations in melanomas, most notably the V600E mutation. These agents...
journal_title:Journal of surgical oncology
pub_type: 临床试验,杂志文章
doi:10.1002/jso.24744
更新日期:2017-12-01 00:00:00
abstract::We report a patient with a large apocrine hidrocystoma. These tumors are almost always under 10 mm in diameter. In this 40-year-old man the tumor measured 20 mm. Apocrine hidrocystoma must be considered when evaluating a patient with a large cystic lesion of the face. Surgical management is similar to that of other be...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930270304
更新日期:1984-11-01 00:00:00
abstract:AIM:To evaluate the efficacy of stereotactic body radiation therapy (SBRT) in small hepatocellular carcinoma (HCC) patients. METHODS:From March 2009 to April 2015, we treated 132 small HCC patients with SBRT. Eligibility criteria included longest tumor diameter ≤5.0 cm; Child-Turcotte-Pugh (CTP) Class A or B; unfeasib...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.24128
更新日期:2016-02-01 00:00:00
abstract:BACKGROUND:Recent changes in adjuvant therapies improved the prognosis of metastatic colorectal cancers. Curative resection may be considered, even for both pulmonary and hepatic metastases, but prognostic factors are not well identified. METHODS:From 1995 to 2010, 69 patients had curative resection of pulmonary metas...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.23385
更新日期:2013-09-01 00:00:00
abstract:BACKGROUND:The accurate staging of hepatocellular carcinoma (HCC) is important in establishing treatment strategies and prognosis. Among tumor factors, microvascular invasion, one of TNM staging components and prognostic factors, is underestimated preoperatively, due to inaccuracy of imaging modalities. We investigated...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.20953
更新日期:2008-03-01 00:00:00
abstract::There is no information available in the literature on the blood levels of tamoxifen in patients with decreased renal function. As serious side effects of tamoxifen administered at high doses have been reported, a patient with decreased renal function and metastatic breast cancer was studied to determine the blood lev...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930270404
更新日期:1984-12-01 00:00:00
abstract::Intraoperative partial breast radiotherapy is an alternative or an adjunct to fractionated whole breast irradiation for the administration of adjuvant radiotherapy in breast cancer following breast conserving surgery. Establishing intraoperative radiotherapy as a therapeutic modality requires a multidisciplinary appro...
journal_title:Journal of surgical oncology
pub_type: 杂志文章,评审
doi:10.1002/jso.24734
更新日期:2017-12-01 00:00:00
abstract:BACKGROUND:In this non-randomized study we aimed to assess the efficacy of the addition of low molecular weight heparin (LMWH) to gemcitabine (GEM) plus cisplatinum (CDDP) combination chemotherapy on survival by prevention of thromboembolic complications in patients with advanced pancreatic cancer (APC). PATIENTS AND ...
journal_title:Journal of surgical oncology
pub_type: 临床试验,杂志文章
doi:10.1002/jso.20728
更新日期:2007-05-01 00:00:00
abstract::The incidence of anastomotic leakage after esophagectomy for cancer and reconstruction with the stomach was analyzed with respect to the presence of coexistent atrophic chronic gastritis (ACG). Of a total of 28 operated esophageal cancer patients with ACG, 6 patients developed an anastomotic leak at the cervical esoph...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930510107
更新日期:1992-09-01 00:00:00
abstract:BACKGROUND:Unresectable tumors of the pancreatic head are encountered in up to 20% of patients taken for resection. The objective of this study was to evaluate the complications and outcome associated with palliative surgical procedures to help guide management decisions in these patients. METHODS:Patients with pancre...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.23560
更新日期:2014-06-01 00:00:00
abstract::When BALB/c mice bearing growing transplants of a syngeneic colon carcinoma--Colon Tumor 26 (CT 26)--were treated with Bacillus Calmette-Guerin (BCG), no effect on tumor growth rate or survival time was observed compared to untreated controls. However, after excision of primary tumor transplants, enhanced development ...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930150307
更新日期:1980-01-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Prolonged air leaks (PAL) are the most frequent complication after lobectomy for non-small cell lung cancer, even in case of minimally invasive approaches. We developed a novel score to identify high-risk patients for PAL during minimally invasive lobectomy. METHODS:A dedicated database was c...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.25289
更新日期:2018-12-01 00:00:00
abstract:BACKGROUND:The objective of the current study was to define the impact of albumin-bilirubin (ALBI) grade on short- as well as long-term outcomes among patients with intrahepatic cholangiocarcinoma (ICC). METHODS:Patients who underwent hepatectomy for ICC between 1990 and 2016 were identified using an international mul...
journal_title:Journal of surgical oncology
pub_type: 杂志文章,多中心研究
doi:10.1002/jso.25486
更新日期:2019-08-01 00:00:00
abstract:BACKGROUND:Adjuvant radiation is rarely used to treat medullary thyroid carcinoma (MTC). We hypothesized that external beam radiation therapy (EBRT) would improve overall survival (OS) in MTC patients. METHODS:The Surveillance, Epidemiology, and End Results (SEER) database identified patients who underwent total thyro...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.21557
更新日期:2010-08-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:The optimal management of symptomatic advanced peritoneal carcinomatosis of non-gynecologic origin is not defined. Historic controls of surgical efforts report high postoperative mortality and morbidity rates with equivocal palliation. Novel surgical procedures need to be tested in terms of th...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.10270
更新日期:2003-08-01 00:00:00
abstract:BACKGROUND:Locally advanced colon cancer can result in serious clinical conditions unless treated appropriately. The aim of this study was to examine the feasibility of en bloc resection and the significance of depth of invasion by analyzing the outcomes of the procedure in colon cancer invading adjacent organs. METHO...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.21165
更新日期:2009-01-01 00:00:00
abstract::A patient-specific 3-dimensional printed model (3DPM) of a woman with breast cancer was created. Mastectomy was favored as BCS would necessitate significant breast size alteration due to the extent of disease. After review of the 3D printed model, the patient and surgeon agreed on breast-conserving surgery. Use of pat...
journal_title:Journal of surgical oncology
pub_type:
doi:10.1002/jso.25680
更新日期:2019-11-01 00:00:00
abstract:BACKGROUND:Signet ring cell cancer (SRCC) patients have a poor oncologic outcome. The aim of this study was to determine whether the potential drawbacks of hyperthermic intraperitoneal chemotherapy (HIPEC) outweigh the benefits in patients with peritoneally metastasized SRCC. METHODS:Patients with peritoneal carcinoma...
journal_title:Journal of surgical oncology
pub_type: 杂志文章,多中心研究
doi:10.1002/jso.23784
更新日期:2015-02-01 00:00:00
abstract::A patient with metastasizing glucagonoma producing multiple molecular forms of glucagon is reported. The patient responded to symptomatic treatment with a somatostatin analogue (SMS 201-995). Glucagonoma tumour cells were studied in two tissue culture systems: intraocular transplants of immunosuppressed rats and long-...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930440313
更新日期:1990-07-01 00:00:00
abstract:BACKGROUND:The role of surgical resection in the treatment of patients with metastatic/recurrent gastrointestinal stromal tumors (GIST) is unclear. The aim of this study was to identify preoperative factors associated with oncologic outcomes for recurrent/metastatic GIST after tyrosine kinase inhibitor (TKI) therapy. ...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.24988
更新日期:2018-04-01 00:00:00
abstract::The majority of patients with pulmonary metastases from primary soft tissue sarcomas have peripheral lesions that can be removed by wedge excision. A subset of these patients, however, present with, or develop, clinically significant endobronchial metastases. These patients require a preoperative evaluation that inclu...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930320305
更新日期:1986-07-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:The objectives of this study were to investigate the role of growth factors and matrix metalloproteinases in the brain metastasis. METHODS:Tumors from 40 patients with brain metastasis (30 lung cancer, 10 breast cancer) were studied to investigate the expression-patterns of EGFR, MT1-MMP, MMP...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.21296
更新日期:2009-07-01 00:00:00
abstract::Robotic-assisted laparoscopy is now the most common surgical method for treatment of early-stage endometrial, cervical, and a growing number of ovarian cancers in the U.S. Para-aortic and pelvic lymphadenectomy is integral to surgical staging and subsequent treatment planning. This article reviews current staging outc...
journal_title:Journal of surgical oncology
pub_type: 杂志文章,评审
doi:10.1002/jso.24005
更新日期:2015-12-01 00:00:00
abstract::The limb model of in-transit disease can expand our understanding of treating melanoma because of the ease of obtaining tissue biopsies for correlative studies and the availability of preclinical animal models that allow validation of novel therapeutic strategies. This review will focus on regional therapy for in-tran...
journal_title:Journal of surgical oncology
pub_type: 杂志文章,评审
doi:10.1002/jso.23502
更新日期:2014-03-01 00:00:00
abstract::A retrospective analysis was performed of 20 patients with Ewing's sarcoma treated by combined modality therapy, consisting of surgery, radiotherapy, and chemotherapy. Fourteen patients (70%) achieved complete remission and 5 patients (25%) were in partial remission at the end of treatment. One patient (5%) failed to ...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930480110
更新日期:1991-09-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Outcomes and recommendations regarding adjuvant therapy (AT) for stage I ampullary adenocarcinoma (AAC) are inadequately described. We sought to determine factors associated with survival and better define the impact of AT. METHODS:The NCDB was queried for stage I AAC patients undergoing rese...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.25021
更新日期:2018-06-01 00:00:00
abstract::Early postoperative intraperitoneal chemotherapy (EPIC) and intraoperative peritoneal hypertermic chemotherapy (IPHC) are used in addition with cytoreductive surgery to treat with curative intent peritoneal carcinomatosis arising from colorectal adenocarcinomas. Three patients with such a disease were treated with per...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.20267
更新日期:2005-07-01 00:00:00
abstract:BACKGROUND:We sometimes encounter hepatocellular carcinoma (HCC) with a central scar and a scalloped tumor margin resembling focal nodular hyperplasia (FNH) in macroscopic appearance. The fibrolamellar variant sometimes shows this appearance; however, this type of HCC can be clearly differentiated from fibrolamellar va...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.20615
更新日期:2006-12-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Immunohistochemical methods were used to study Tenascin (TN) expression in invasive duct cell carcinoma (IDCC) of the breast and its established prognostic factors. METHODS:We studied 115 patients with IDCC. The mean patient age was 62 years; all tumors were graded according to Scarf-Bloom an...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/(sici)1096-9098(199806)68:2<107::aid-jso7>
更新日期:1998-06-01 00:00:00