Abstract:
PURPOSE:Imatinib mesylate (IM) demonstrates substantial efficacy in most patients with metastatic gastrointestinal stromal tumors (GISTs). However, progression of GIST eventually develops and emerges as a challenge. To assess the role of surgery in the multidisciplinary management of GISTs, we studied the surgical outcomes in GIST patients receiving IM. MATERIALS AND METHODS:Between 2001 and May 2009, 161 metastatic GIST patients received IM. Among them, 35 patients undergoing 38 surgeries were investigated. Patients were categorized based on extent of disease before surgery (responsive or stable disease (PR, SD), local progression (LP), and generalized progression (GP)). Each tumor was investigated for genetic alteration before and after surgery. RESULTS:Disease status before surgery was significantly associated with surgical result. Gross tumor clearance was achieved in 42.9% of patients with responsive disease, but only 4.8% of those with focal resistance and 0% of those with disease progression (P = 0.022). GIST patients with PR, SD, and LP had significant better 2-year progression-free survival and overall survival than those with GP. Secondary mutations tended to be found more frequently in GIST patients with LP after surgery than those with response (10/21 (47.6%) vs. 2/14 (14.3%); P = 0.07), indicating that surgery may prevent potential development of secondary mutation in GIST patients with response. Secondary kit mutations were also found more frequently with primary exon 11 mutation than those with exon 9 mutation (38.7% vs. 16.7%; P = 0.394). CONCLUSIONS:Surgery may benefit selected GIST patients with PR, SD, and LP, especially for patients with LP because patients with LP had comparable survival to that of patients with responsive lesion. Surgery may prevent potential development of secondary mutations in selected patients with response after IM treatment. Secondary kit mutation was found more frequently in GIST patients with a primary kit exon 11 mutation than those with a primary kit exon 9 mutation.
journal_name
J Surg Oncoljournal_title
Journal of surgical oncologyauthors
Yeh CN,Chen TW,Tseng JH,Liu YY,Wang SY,Tsai CY,Chiang KC,Hwang TL,Jan YY,Chen MFdoi
10.1002/jso.21630subject
Has Abstractpub_date
2010-11-01 00:00:00pages
599-603issue
6eissn
0022-4790issn
1096-9098journal_volume
102pub_type
杂志文章abstract:BACKGROUND:Skip metastasis to mediastinal lymph nodes is a well-known phenomenon in non-small cell lung cancer (NSCLC). Little is reported in the literature about its clinical importance. It is still under discussion whether any prognostic differences exist between resected NSCLC with either skip metastases or continuo...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.10219
更新日期:2003-04-01 00:00:00
abstract:BACKGROUND:After resection of colorectal liver metastases (CRLM), recurrent disease in the liver is a major cause of death but may be reduced with the addition of adjuvant hepatic arterial infusion (HAI) chemotherapy to systemic chemotherapy (SYS). OBJECTIVE:This study investigates organ-specific causes of death in pa...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.25916
更新日期:2020-06-01 00:00:00
abstract::Neoadjuvant systemic breast cancer therapy is the administration of systemic therapy to eligible breast cancer patients prior to surgery. This treatment modality was developed out of necessity to downstage inoperable tumors, but it has evolved into a tool for breast conservation surgery. The neoadjuvant approach is al...
journal_title:Journal of surgical oncology
pub_type: 杂志文章,评审
doi:10.1002/jso.21696
更新日期:2011-03-15 00:00:00
abstract:OBJECTIVE:This study aimed to investigate the association between different metastatic sites and survival in endometrial cancer (EC) patients with International Federation of Gynecology and Obstetrics (FIGO) stage IVB disease. METHODS:FIGO stage IVB patients with EC were selected from the surveillance, epidemiology, a...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.26102
更新日期:2020-10-01 00:00:00
abstract::Pancreatic cancer is a highly lethal malignancy that often presents at an advanced stage. Surgical resection can prolong survival and offers the only potential for cure. However, pancreatectomy is associated with significant morbidity and mortality. This article reviews perioperative outcomes, post-resection long-term...
journal_title:Journal of surgical oncology
pub_type: 杂志文章,评审
doi:10.1002/jso.23744
更新日期:2014-10-01 00:00:00
abstract:BACKGROUND:Among the various controversies in the treatment strategies for patients with thymoma, the optimal mode of resection needs to be defined. To explore whether or not the mode of resection affects the prognosis/recurrence in patients with thymoma, we evaluated the treatment outcome of patients with resected thy...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.23499
更新日期:2014-03-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:This study aimed to analyze the association between health-related quality of life and treatment modality among esophageal squamous cell carcinoma (ESCC) survivors. METHODS:Patients completed the EORTC QLQ-C30 and EORTC QLQ-OES18 at baseline and follow-up. A time to deterioration model analys...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.26264
更新日期:2021-01-01 00:00:00
abstract::Liver metastasis represents a common systemic complication of colorectal cancers (CRCs). Partial liver resection has been demonstrated to result in long-term survival in certain well-selected patients with otherwise well-controlled systemic disease. Neoadjuvant therapy has been demonstrated to result in improved resec...
journal_title:Journal of surgical oncology
pub_type: 杂志文章,评审
doi:10.1002/jso.21691
更新日期:2010-12-15 00:00:00
abstract:BACKGROUND AND OBJECTIVES:The aggressiveness and greater malignant potential of cancers are characterized by several biological phenomena such as accelerated growth invasiveness, and the ability to form distant metastasis. Thus, knowledge of such biological difference may be a more accurate prognosticator for cancer pa...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.20309
更新日期:2005-12-15 00:00:00
abstract::Eight patients with sciatic nerve and sacral plexus nerve sheath tumors, seen at Louisiana State University Medical Center in Shreveport, are presented. These cases illustrate the broad spectrum of pathology and modes of presentation of patients with nerve sheath tumors in this region. Patients can be divided into 4 g...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930390103
更新日期:1988-09-01 00:00:00
abstract:PURPOSE:The aim of this study was to determine which clinicopathological factors influenced the long-term survival after potentially curative resection of patients with colon cancer having fewer than 12 retrieved lymph nodes. METHODS:Prospective data were collected from 179 patients who had fewer than 12 resected lymp...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.22072
更新日期:2012-02-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:The aim of this study was to evaluate the role of indocyanine green (ICG) fluorescence imaging (FI) for the ex vivo detection of metastatic lymph nodes (LNs) in advanced stage ovarian cancer (AOC). METHODS:Paraffin-embedded LNs from patients included in a previous ICG-FI study (Protocol NCT01...
journal_title:Journal of surgical oncology
pub_type: 临床试验,杂志文章
doi:10.1002/jso.25263
更新日期:2018-12-01 00:00:00
abstract:BACKGROUND:The aim of this study was to determine the effect of tumor encapsulation of hepatocellular carcinoma (HCC) on long-term survival. METHODS:A retrospective review of 1,240 patients who underwent hepatectomy from January 1993 to June 2005 was conducted. There were 891 patients with tumor encapsulation (EC type...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.22060
更新日期:2012-01-01 00:00:00
abstract::A case of vulvar carcinoma with 0.5 mm of invasion treated by radical wide local excision only, which later developed ipsilateral inguinal lymph node recurrence, is presented. This represents the least amount of invasion reported resulting in inguinal lymph node metastasis. Review of the literature of stage I vulvar c...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930540418
更新日期:1993-12-01 00:00:00
abstract::Over the past decade, there has been a considerable increase in the utilization of cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) in the management of patients with peritoneal metastases. This is due to improved safety and favorable oncologic outcomes, including curative potential. C...
journal_title:Journal of surgical oncology
pub_type: 杂志文章,评审
doi:10.1002/jso.25939
更新日期:2020-07-01 00:00:00
abstract:BACKGROUND/AIMS:We compared overall survival (OS) of patients with a solitary large (>5 cm) hepatocellular carcinoma (HCC) treated surgically or by transarterial chemoembolization (TACE). METHODS:The archived records of HCC patients registered at the Korean Central Cancer Registry from 2003 through 2005 (registry A, n...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.24519
更新日期:2017-03-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Differences in the expression levels of Thyroglobulin (Tg), Thyroid peroxidase (TPO) and thyrotropin receptor (TSH-R) in primary and recurrent specimens under a suppressive serum TSH condition were elucidated in 26 papillary carcinoma patients. METHODS:Immunohistochemical detection was perfor...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/1096-9098(200010)75:2<108::aid-jso7>3.0.co
更新日期:2000-10-01 00:00:00
abstract:BACKGROUND:Retroperitoneal lymphangiomatosis (RL) is a rare form of primary lymphedema featuring aberrant retroperitoneal lymphatic proliferation. It causes recurrent cellulitis, repeated interventions, and poor life quality. This study aimed to investigate proper diagnositc criteria and surgical outcomes for RL with e...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.25514
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND:Familial soft tissue sarcomas are extremely rare. There is little information available on the clinical features and molecular findings of the hereditary occurrence of mesenchymal tumor. PATIENTS AND METHODS:A woman and her younger brother had malignant fibrous histiocytoma (pleomorphic type) and liposarcom...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.20720
更新日期:2007-03-15 00:00:00
abstract::Colorectal cancer progression originates when accumulated genetic and epigenetic alterations cause genomic instability and a malignant phenotype. Subsequent molecular pathway deregulation leads to histopathologic changes that are clinically evident as aberrant crypt foci (ACF) and visualized by high-magnification chro...
journal_title:Journal of surgical oncology
pub_type: 杂志文章,评审
doi:10.1002/jso.21106
更新日期:2008-09-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Two staged tissue expander-implant with acellular dermal matrix (TE/I + ADM) and deep inferior epigastric perforator (DIEP) flap are the most common implant and autologous methods of reconstruction in the U.S. Implant-based techniques are disproportionally more popular, partially due to its pr...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.24692
更新日期:2017-09-01 00:00:00
abstract:BACKGROUND:A treatment option for patients with peritoneal mucinous carcinomatosis (PMCA) from an appendiceal neoplasm is cytoreductive surgery and perioperative intraperitoneal chemotherapy. Also, these patients are recommended for systemic chemotherapy using an oxaliplatin and 5-fluorouracil (FOLFOX) regimen. A major...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.21679
更新日期:2010-11-01 00:00:00
abstract:BACKGROUND:CD109, a TGF-β co-receptor, is reported to be preferentially expressed during the early stages of tumorigenesis in several carcinoma types. Myxofibrosarcoma is one of the most common soft-tissue sarcomas found in elderly patients. This study aimed to elucidate the impact of CD109 expression in myxofibrosarco...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.23934
更新日期:2015-06-01 00:00:00
abstract:BACKGROUND:Malignant hip lesions can be managed operatively by intramedullary (IM) nail fixation and hemiarthroplasty. METHODS:A retrospective review was performed on 86 patients who underwent hemiarthroplasty (n = 22) or IM nail fixation (n = 64) for prophylactic treatment of impending pathologic fracture due to mali...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.24792
更新日期:2017-12-01 00:00:00
abstract::The records of 111 consecutive cases of carcinoma of the breast were reviewed and yielded 66 patients who had undergone liver scanning and determination of the serum alkaline phosphatase (alk p'tase), lactic dehydrogenase (LDH), and serum glutamic oxaloacetic transaminase (SGOT). Four of the 66 patients (6.1%) had a f...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930130313
更新日期:1980-01-01 00:00:00
abstract::The classical concepts pertaining to the natural history of mammary carcinoma and its treatment must be reviewed if survival rate is to be improved. By the time diagnosis is established, a fair amount of cases of carcinoma of the breast present distant, clinically undetectable micrometastases, which will not be affect...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930140211
更新日期:1980-01-01 00:00:00
abstract::Of 49 patients with midgut and hindgut carcinoids, second primary distinct carcinomas occurred in 12. The most aggressive carcinoids were the 24 that arose in the distal small bowel and cecum. Of the patients affected, 15 had lymph node metastases and eight had liver metastases at the time of diagnosis. That only five...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930110309
更新日期:1979-01-01 00:00:00
abstract:BACKGROUND:Open extended cholecystectomy (O-EC) has long been the recommended treatment for resectable gallbladder cancer (GBC), while the minimally-invasive approach for EC (MIS-EC) remains controversial. Our aim was to analyze overall survival of GBC patients treated with MIS-EC vs O-EC at the national level. METHOD...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.26062
更新日期:2020-06-12 00:00:00
abstract::A new combined cancer chemotherapy regimen of mitomycin C (MMC) and cisplatin (DDP) showed synergistic antitumor activity against human gastric cancer xenografts St-40 and SC-1-NU in BALB/c nu/nu mice. The drugs were administered intraperitoneally at doses of 2 or 4 mg/kg for MMC and 3 or 6 mg/kg for DDP, respectively...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930560408
更新日期:1994-08-01 00:00:00
abstract:INTRODUCTION:The role of adjuvant chemotherapy (AC) for synovial sarcoma (SS) is controversial. Using a large national dataset we evaluate the impact of AC on overall survival (OS) following curative-intent resection of SS. METHODS:Patients with stage I-III SS 2004-2012 undergoing resection were identified in the Nati...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.24688
更新日期:2017-09-01 00:00:00