Abstract:
:Neoadjuvant systemic breast cancer therapy is the administration of systemic therapy to eligible breast cancer patients prior to surgery. This treatment modality was developed out of necessity to downstage inoperable tumors, but it has evolved into a tool for breast conservation surgery. The neoadjuvant approach is also commonly used now to explore the efficacy of new therapeutics by assessing their impact on pathologic complete response or other endpoints. This article will review the foundations of this treatment modality and the latest progress in the field. Considering the heterogeneity of breast cancer, it is clear that no single treatment will fit all types of breast cancer. Thus, there is a need to understand the biological underpinnings of the different types of breast cancer in order to design better treatments that will ultimately improve the eradication rate of this disease.
journal_name
J Surg Oncoljournal_title
Journal of surgical oncologyauthors
Makhoul I,Kiwan Edoi
10.1002/jso.21696subject
Has Abstractpub_date
2011-03-15 00:00:00pages
348-57issue
4eissn
0022-4790issn
1096-9098journal_volume
103pub_type
杂志文章,评审abstract:BACKGROUND:Retroperitoneal sarcomas are connective tissue tumors arising in the retroperitoneum. Surgical resection is the mainstay of treatment. Debate has arisen over extent of resection, changes in histological classification/grading, and interest in incorporating radiotherapy. Therefore, we reviewed our institution...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.24256
更新日期:2016-07-01 00:00:00
abstract::The clinicopathologic features of a case of adenocarcinoma arising in Meckel's diverticulum are described and compared with the 21 cases reported in the literature. The prognosis is generally poor. However, the patient in the present case was alive and well 1.5 years after diagnosis, despite the fact that the lesion h...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930230111
更新日期:1983-05-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:ERCP prior to pancreaticoduodenectomy is unnecessary in select patients. When performed, it should be in conjunction with endoscopic ultrasound (EUS) to increase diagnostic sensitivity and allow for metal stent placement. The aim of this study was to determine differences in endoscopic practic...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.24191
更新日期:2016-05-01 00:00:00
abstract:BACKGROUND:The aim of this study was to determine the effect of tumor encapsulation of hepatocellular carcinoma (HCC) on long-term survival. METHODS:A retrospective review of 1,240 patients who underwent hepatectomy from January 1993 to June 2005 was conducted. There were 891 patients with tumor encapsulation (EC type...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.22060
更新日期:2012-01-01 00:00:00
abstract::Since February, 1977, 735 patients having a history of receiving radiation therapy for benign conditions of the head and neck areas during infancy and childhood were examined in a thyroid screening program, and 159 patients were found to have palpable thyroid nodules. These patients had thyroid function tests and indi...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930140316
更新日期:1980-01-01 00:00:00
abstract:BACKGROUND:The purpose of the present study was to assess the value of matrix metalloproteinase (MMP)-2 and MMP-9 expression and other potential prognostic factors in predicting the clinical outcome of patients after definitive surgery for pathologic stage IA non-small cell lung cancer (NSCLC). METHODS:One hundred and...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.22001
更新日期:2011-12-01 00:00:00
abstract::Fifteen malignant melanomas were subjected to chromosomal analysis, in order to determine whether the number of chromosomes in a tumor cell could be correlated to a clinical prognosis. The protocol involved a direct technique which utilized a Colcemid blockade of spindle formation in mitosis to allow study of metaphas...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930110107
更新日期:1979-01-01 00:00:00
abstract::To gauge the impact of screening mammography and opinions regarding surgical procedures on the pattern of primary surgical care of breast cancer, tumor registry statistics from 1980-81 were compared to those from 1987 at a large community hospital. Over the course of six years, there was a significant increase in the ...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930450104
更新日期:1990-09-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Desmoplastic melanoma (DM) is a rare variant of cutaneous melanoma. Our goal was to study the surgical management of DM, identify prognostic factors, and impact of treatment options. METHODS:Patients with DM (n = 1,735) were identified from the Surveillance, Epidemiology, and End Results data...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.21778
更新日期:2011-02-01 00:00:00
abstract::Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal neoplasm arising in the stomach. These tumors were previously classified as smooth muscle tumors, but in recent years it has become clear that they are clinically, pathologically, and molecularly distinct from other tumors and are much more common...
journal_title:Journal of surgical oncology
pub_type: 杂志文章,评审
doi:10.1002/jso.20230
更新日期:2005-06-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Data on outcomes after liver-directed therapy for intrahepatic cholangiocarcinoma (ICC) are limited due to the rarity of the disease. We sought to define overall utilization and temporal trends of liver-directed therapy for ICC. METHODS:We identified 5,388 patients with ICC using the Surveill...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.23605
更新日期:2014-08-01 00:00:00
abstract::Three patients treated with bilateral subcutaneous mastectomies and implants for fibrocystic disease or carcinoma in situ subsequently developed invasive breast carcinoma. These cases emphasize that subcutaneous mastectomy does not prevent the development of breast cancer. If the circumstances in an individual patient...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930260313
更新日期:1984-07-01 00:00:00
abstract::Cancer patients undergoing surgery often present with unusual and challenging problems. Their age and the fact that they are often chronically ill place them at increased surgical risk. In many instances the need for surgical intervention is crucial to the extent that risk-assessment becomes an academic issue, especia...
journal_title:Journal of surgical oncology
pub_type: 杂志文章,评审
doi:10.1002/jso.2930440312
更新日期:1990-07-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Intraoperative adjuncts for the localization of parathyroid glands in parathyroid surgery are limited. The aim of this study is to assess the usefulness of indocyanine green (ICG) near-infrared (NIR) fluorescent imaging in patients undergoing surgery for primary hyperparathyroidism (PHPT). ME...
journal_title:Journal of surgical oncology
pub_type: 临床试验,杂志文章
doi:10.1002/jso.24240
更新日期:2016-06-01 00:00:00
abstract::A retrospective study was made of 38 myosarcomas of the small and large intestines (34 leiomyosarcomas and 4 malignant leiomyoblastomas). Endoenteric, small, and noninvasive tumors were successfully treated by simple wedge excision, cautery snare removal, or segmental bowel resection with a high 5-yr cure rate of 86% ...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930240116
更新日期:1983-09-01 00:00:00
abstract::Cancer of the oral cavity remains a major problem in the United States as well as in many other countries, some of which record as much as 30% of all their cancers to be in the oral region. Despite numerous advances in the fields of epidemiology and etiology, little is known of the molecular basis of oral cancer. Adva...
journal_title:Journal of surgical oncology
pub_type: 杂志文章,评审
doi:10.1002/jso.2930470209
更新日期:1991-06-01 00:00:00
abstract:INTRODUCTION:Breast conservative surgery (BCS) and sentinel lymph node biopsy (SLNB) after neoadjuvant treatment (NAT) is safe and effective for selected patients. This aim of this study is to evaluate the impact of anatomic site of response on outcomes and to assess the real population who may benefit from nonsurgical...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.26236
更新日期:2021-01-01 00:00:00
abstract::Lymph node involvement in colorectal cancer, one of the most important prognostic factors, can be sometimes underestimated. In this study the authors report the results of two different techniques of specimen preparation and examination. In 240 patients (Group I), histologic examination was performed using a conventio...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930510305
更新日期:1992-11-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:We retrospectively compared surgical outcomes between patients with intra-thoracic and extra-thoracic (cervical and abdominal) lymph-node metastasis. METHODS:The study population comprised 96 patients with lymph-node metastasis who had undergone curative esophagectomy for thoracic esophageal ...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.21425
更新日期:2010-01-01 00:00:00
abstract::The choice of palliative therapy in patients with carcinoma of the lower esophagus and cardia is mainly between irradiation and surgery. The present report is a retrospective analysis of 40 consecutive patients who recovered after resection of the tumor. The operation was considered to be palliative in all patients. T...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930320402
更新日期:1986-08-01 00:00:00
abstract:BACKGROUND AND OBJECTIVE:Brain metastasis is a rare but dismal event in sarcomas. However, the pattern of occurrence and the prognostic factors associated with post-brain metastasis survival (PBMS) are not yet well-characterized. METHODS:Sarcoma patients treated at one institute within 10-year period were retrospectiv...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.22011
更新日期:2011-12-01 00:00:00
abstract:BACKGROUND:Malignant hip lesions can be managed operatively by intramedullary (IM) nail fixation and hemiarthroplasty. METHODS:A retrospective review was performed on 86 patients who underwent hemiarthroplasty (n = 22) or IM nail fixation (n = 64) for prophylactic treatment of impending pathologic fracture due to mali...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.24792
更新日期:2017-12-01 00:00:00
abstract:INTRODUCTION:We report our institutional experience with extrahepatic metastasectomy (EM) in a cohort of hepatocellular carcinoma (HCC) patients with focus on predictors of survival. METHODS:All patients diagnosed with metastatic HCC from 2001 to 2014 were retrospectively reviewed to identify those who underwent EM wi...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.24340
更新日期:2016-09-01 00:00:00
abstract:BACKGROUND:Pulmonary metastasectomy (PM) for metastatic sarcoma can result in long-term survival. The purpose of this study was to describe factors associated with survival in a series of patients undergoing PM for metastatic sarcoma. METHODS:We reviewed all patients undergoing PM for metastatic sarcoma over a 12-year...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.23961
更新日期:2015-07-01 00:00:00
abstract::Intraperitoneal (IP) cisplatin administered at the time of intraabdominal malignancies such as gastric cancer may prevent or delay intraabdominal recurrence. Perioperative IP cisplatin raises concerns regarding systemic toxicity and retardation of wound healing. Systemic cisplatin toxicity may be reduced by administer...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930520415
更新日期:1993-04-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Stages II and III rectal tumors are known as locally advanced rectal cancer (LARC) because they are characterized by a high incidence of local and distant relapses and a low probability of long-term survival. Adjuvant treatments have been advocated to ameliorate overall survival (OS), local re...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/1096-9098(200005)74:1<2::aid-jso2>3.0.co;2
更新日期:2000-05-01 00:00:00
abstract:BACKGROUND:The optimal treatment strategy for patients with esophageal adenocarcinoma (EAC) remains undetermined. This study compared outcomes in patients undergoing neoadjuvant chemotherapy (nCT) and neoadjuvant chemoradiotherapy (nCRT) for EAC. METHODS:Patients who underwent nCT or nCRT followed by surgery for EAC w...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.25089
更新日期:2018-06-01 00:00:00
abstract:OBJECTIVES:We reviewed the clinical characteristics and outcomes of patients treated for alveolar soft part sarcoma (ASPS) and analyzed the effect of surgery for patients presenting with and without metastatic disease (DM). METHODS:The SEER Registry was queried for patients with ASPS from 1973-2012. The Kaplan-Meier e...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.24183
更新日期:2016-04-01 00:00:00
abstract:BACKGROUND AND OBJECTIVE:The psychosocial impact of local-regional thyroid cancer recurrence is not known. The aim of this study was to explore thyroid cancer patients' experiences relating to diagnosis and treatment of local-regional disease recurrence. METHODS:We conducted 15 semi-structured interviews with survivor...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.23345
更新日期:2013-07-01 00:00:00
abstract::The elevation of plasma pancreatic elastase 1 in patients with pancreatic cancer is caused by concomitant pancreatitis. There is no report that pancreatic ductal cell carcinoma tissue itself produced elastase 1. A 54-year-old woman underwent total pancreatectomy for pancreatic ductal cell carcinoma. Her plasma elastas...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930540316
更新日期:1993-11-01 00:00:00