Intraperitoneal cisplatin with sodium thiosulfate protection in rats with intestinal anastomoses.

Abstract:

:Intraperitoneal (IP) cisplatin administered at the time of intraabdominal malignancies such as gastric cancer may prevent or delay intraabdominal recurrence. Perioperative IP cisplatin raises concerns regarding systemic toxicity and retardation of wound healing. Systemic cisplatin toxicity may be reduced by administering its antidote, sodium thiosulfate (STS). A preclinical study of IP cisplatin in rats undergoing a small intestinal anastomosis was carried out. All animals that had received only cisplatin died in the postoperative period as a consequence of cisplatin toxicity. Tensile strength of the intestinal anastomoses was determined on the tenth postoperative day in the surviving animals. Animals that had received intravenous (IV) cisplatin with STS had significantly lower tensile strengths than both those receiving IP cisplatin with STS and STS alone. This study demonstrates the safety of perioperative cisplatin with STS protection by the avoidance of systemic toxicity and minimizing the cisplatin-related retardation of wound healing.

journal_name

J Surg Oncol

authors

Wile AG,Dileo SK,Gossett DA,Lao XY

doi

10.1002/jso.2930520415

subject

Has Abstract

pub_date

1993-04-01 00:00:00

pages

265-8

issue

4

eissn

0022-4790

issn

1096-9098

journal_volume

52

pub_type

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