Low-heat treated autograft versus allograft for intercalary reconstruction of malignant bone tumors.

Abstract:

INTRODUCTION:Low-heat treated autograft may have an advantage over allograft in that they provide a size-matched and biologically compatible graft. MATERIALS AND METHODS:We compared the graft survival and complications between the low-heat treated autografts (n = 13) and allografts (17) for intercalary reconstruction of malignant bone tumors. Average age was 25 years with follow-up of 6.6 years (1.8-12.5). For low-heat treatment, the resected bone was treated in saline at 65°C for 30 min. Nineteen grafts were fixed with plates and 13 with intramedullary nails. RESULTS:Until last follow-up, five low-heat treated autografts (38%) and one allograft (6%) had been removed, with allografts showing a trend toward better survival on Kaplan-Meier analysis (P = 0.293). Complications were more common in low-heat treated autograft group [10/13 (77%) vs. 8/17 (47%), P = 0.098)]. Low-heat-treated autograft resulted in significantly higher rate of nonunion [11/26 (42%) vs. 5/34 (15%), P = 0.017] and required higher number of operations to treat nonunion (P = 0.004). Rates of graft fracture [3/13 (23%) vs. 2/17 (12%), P = 0.713)] or infection [2/13 (15%) vs. 1/17 (6%), P = 0.565)] were similar. CONCLUSION:Our data suggest that intercalary allograft has better survival and fewer complications than the low-heat treated autograft.

journal_name

J Surg Oncol

authors

Han I,Kim JH,Cho HS,Kim HS

doi

10.1002/jso.23727

subject

Has Abstract

pub_date

2014-12-01 00:00:00

pages

823-7

issue

7

eissn

0022-4790

issn

1096-9098

journal_volume

110

pub_type

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