Abstract:
BACKGROUND AND OBJECTIVES:We evaluated the clinicopathological associations and prognostic implications of promyelocytic leukemia gene (PML) expressions in patients with esophageal squamous cell carcinomas (ESCC) receiving primary surgery. METHODS:Expression patterns of PML and tumor protein 53 (TP53) of 132 cases of ESCC were evaluated by immunohistochemistry and correlated with clinicopathological parameters. The Cox proportional hazards model was used to determine the prognostic influence of clinicopathological factors on progression-free survival (PFS) and overall survival (OS). RESULTS:Forty-two cases (31.82%) were classified as lost expression of PML, 25 (18.94%) as focally positive, and 65 (49.24%) as diffusely expressed. Sixty-three cases (47.73%) were classified as over-expression of TP53. High expression of TP53 and down-regulation of PML were often found in advanced disease; and, in together with high pathological staging, grading, and positive margin, were associated with poor survival. However, only tumor differentiation (P = 0.016), distant metastasis (P = 0.001), and PML expression (P = 0.001) could act as independent prognostic factors for PFS, and LN metastasis (P = 0.004), TP53 (P = 0.006), and PML expression (P = 0.029) were identified as independent prognostic factors for OS in multivariate analysis. CONCLUSIONS:Our study demonstrated PML protein as an independent prognostic marker for patients with ESCC receiving primary surgery.
journal_name
J Surg Oncoljournal_title
Journal of surgical oncologyauthors
Yen CC,Tsao YP,Chen PC,Wu YC,Liu JH,Pan CC,Liu CY,Tzeng CH,Chen PM,Chen YJ,Lin CH,Hsu WHdoi
10.1002/jso.21855subject
Has Abstractpub_date
2011-06-01 00:00:00pages
761-7issue
8eissn
0022-4790issn
1096-9098journal_volume
103pub_type
杂志文章abstract::Eight patients with sciatic nerve and sacral plexus nerve sheath tumors, seen at Louisiana State University Medical Center in Shreveport, are presented. These cases illustrate the broad spectrum of pathology and modes of presentation of patients with nerve sheath tumors in this region. Patients can be divided into 4 g...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930390103
更新日期:1988-09-01 00:00:00
abstract::A retrospective review to elucidate the rationale of preoperative irradiation was made on 18 carcinomas of the head of the pancreas area. After 50 Gy/25 fractions of 10 MV X-ray was given, all 18 tumors decreased from 3.3 +/- 0.8 cm to 2.0 +/- 0.7 cm. At the surgical operation, 16 patients (89%) received pancreatic re...
journal_title:Journal of surgical oncology
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doi:10.1002/jso.2930400303
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journal_title:Journal of surgical oncology
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doi:10.1002/jso.2930150307
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abstract::Perineural invasion is associated with tumor spreading and an unfavorable prognosis in a variety of cancers. Recently, neural cell adhesion molecule (NCAM) has been reported to be affinitive to neural tissues, which suggests some relationship between NCAM and perineural invasion. This study was designed to elucidate t...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930530205
更新日期:1993-06-01 00:00:00
abstract:BACKGROUND:Receptor-binding cancer antigen expressed on SiSO cells (RCAS1) has been reported to act as a ligand for a receptor present on normal peripheral lymphocytes and to induce apoptotic cell death. We aimed to elucidate the significance of RCAS1 expression in human esophageal squamous cell carcinomas (ESCC). MET...
journal_title:Journal of surgical oncology
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doi:10.1002/jso.20249
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journal_title:Journal of surgical oncology
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更新日期:1999-08-01 00:00:00
abstract::In order to determine whether current programs for the management of metastatic breast cancer have led to improved patient survival, we determined the median survival times for five-year intervals of 849 patients admitted to the City of Hope National Medical Center with metastatic breast cancer from 1955 to 1980. Surv...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930480304
更新日期:1991-11-01 00:00:00
abstract::From September 1969 through 1979, 68 patients with already locally metastasized malignant melanomas of the extremities were treated by hyperthermic regional perfusion and local excision(s). Of these, 53 patients could be evaluated after a follow-up of at least 2 years: 31 had been perfused with melphalan and 22 with m...
journal_title:Journal of surgical oncology
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doi:10.1002/jso.2930200103
更新日期:1982-05-01 00:00:00
abstract:BACKGROUND:Giant cell tumor of bone (GCTB) is an aggressive benign bone tumor with poor prognosis whose neoplastic component is stromal cells (SCs). Tumor stem-like cells (TSCs) have been demonstrated as precursors for tumor genesis and growth. The aim of this study is to identify TSCs in GCTB. METHODS:Stro-1(+) and S...
journal_title:Journal of surgical oncology
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更新日期:2012-12-01 00:00:00
abstract::The records of 111 consecutive cases of carcinoma of the breast were reviewed and yielded 66 patients who had undergone liver scanning and determination of the serum alkaline phosphatase (alk p'tase), lactic dehydrogenase (LDH), and serum glutamic oxaloacetic transaminase (SGOT). Four of the 66 patients (6.1%) had a f...
journal_title:Journal of surgical oncology
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更新日期:1980-01-01 00:00:00
abstract:BACKGROUND:Identification of peri-operative variables predicting postoperative morbidity may improve postoperative patients' care. We aimed to identify patients' characteristics and operative factors predictive of early (≤ 30-day) and late (≤ 6-month) morbidity in cervical cancer patients undergoing surgery plus extern...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.23747
更新日期:2014-12-01 00:00:00
abstract::In this review, we aim to assess the current state of science in relation to the integration of patient-generated health data (PGHD) and patient-reported outcomes (PROs) into routine clinical care with a focus on surgical oncology populations. We will also describe the critical role of artificial intelligence and mach...
journal_title:Journal of surgical oncology
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更新日期:2021-01-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:The number of patients diagnosed with head and neck squamous cell carcinoma (HNSCC) at an advanced age has increased. The aim of this study is to evaluate the age at which disease-specific survival (DSS) significantly decreases in HNSCC. METHODS:We performed a retrospective study of 5469 pati...
journal_title:Journal of surgical oncology
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doi:10.1002/jso.25895
更新日期:2020-06-01 00:00:00
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journal_title:Journal of surgical oncology
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更新日期:2010-10-01 00:00:00
abstract:BACKGROUND:The aim of this study was to determine the effect of tumor encapsulation of hepatocellular carcinoma (HCC) on long-term survival. METHODS:A retrospective review of 1,240 patients who underwent hepatectomy from January 1993 to June 2005 was conducted. There were 891 patients with tumor encapsulation (EC type...
journal_title:Journal of surgical oncology
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更新日期:2012-01-01 00:00:00
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journal_title:Journal of surgical oncology
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更新日期:2019-12-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:To identify breast-specific factors and the role of tumor, treatment, and patient-related items in influencing patient opinion on cosmesis and satisfaction after breast-conserving therapy (BCT). METHODS:Data from the randomized COBALT study was used. At 3, 12, and 36 months, 128 patients with...
journal_title:Journal of surgical oncology
pub_type: 杂志文章,随机对照试验
doi:10.1002/jso.25012
更新日期:2018-04-01 00:00:00
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journal_title:Journal of surgical oncology
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更新日期:2017-05-01 00:00:00
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journal_title:Journal of surgical oncology
pub_type: 杂志文章
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abstract::Prophylactic intravesical chemotherapy (IVC) reduces recurrence rates of superficial transitional cell carcinoma (TCC) of the urinary bladder. The patient cohort existed of 86 individuals (stage TaN0M0 or T1N0M0) superficial carcinoma of various grades of malignancy. Following initial transuretheral resection or diagn...
journal_title:Journal of surgical oncology
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journal_title:Journal of surgical oncology
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doi:10.1002/(SICI)1096-9098(199603)61:3<214::AID-JSO10
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journal_title:Journal of surgical oncology
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journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930280209
更新日期:1985-02-01 00:00:00
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journal_title:Journal of surgical oncology
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更新日期:2015-03-15 00:00:00
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journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.25760
更新日期:2019-12-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:To evaluate the impact of plasminogen activator (PA) system genes, including urokinase plasminogen activator (uPA), uPA receptor (uPAR), and plasminogen activator inhibitor-1 (PAI-1) gene polymorphisms in patients with the cervical neoplasia. METHODS:In total, 336 blood samples were collected...
journal_title:Journal of surgical oncology
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journal_title:Journal of surgical oncology
pub_type: 杂志文章,评审
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doi:10.1002/jso.21137
更新日期:2008-12-01 00:00:00
abstract::Serum copper levels (SCL) have been done in 106 patients of squamous cell carcinoma of the cervix and in 15 cases of local recurrences. The mean SCL has been significantly elevated in them in comparison to controls (P less than 0.001). The SCL falls to near normal range following successful therapy. There is a trend t...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930220313
更新日期:1983-03-01 00:00:00