PML protein as a prognostic molecular marker for patients with esophageal squamous cell carcinomas receiving primary surgery.

Abstract:

BACKGROUND AND OBJECTIVES:We evaluated the clinicopathological associations and prognostic implications of promyelocytic leukemia gene (PML) expressions in patients with esophageal squamous cell carcinomas (ESCC) receiving primary surgery. METHODS:Expression patterns of PML and tumor protein 53 (TP53) of 132 cases of ESCC were evaluated by immunohistochemistry and correlated with clinicopathological parameters. The Cox proportional hazards model was used to determine the prognostic influence of clinicopathological factors on progression-free survival (PFS) and overall survival (OS). RESULTS:Forty-two cases (31.82%) were classified as lost expression of PML, 25 (18.94%) as focally positive, and 65 (49.24%) as diffusely expressed. Sixty-three cases (47.73%) were classified as over-expression of TP53. High expression of TP53 and down-regulation of PML were often found in advanced disease; and, in together with high pathological staging, grading, and positive margin, were associated with poor survival. However, only tumor differentiation (P = 0.016), distant metastasis (P = 0.001), and PML expression (P = 0.001) could act as independent prognostic factors for PFS, and LN metastasis (P = 0.004), TP53 (P = 0.006), and PML expression (P = 0.029) were identified as independent prognostic factors for OS in multivariate analysis. CONCLUSIONS:Our study demonstrated PML protein as an independent prognostic marker for patients with ESCC receiving primary surgery.

journal_name

J Surg Oncol

authors

Yen CC,Tsao YP,Chen PC,Wu YC,Liu JH,Pan CC,Liu CY,Tzeng CH,Chen PM,Chen YJ,Lin CH,Hsu WH

doi

10.1002/jso.21855

subject

Has Abstract

pub_date

2011-06-01 00:00:00

pages

761-7

issue

8

eissn

0022-4790

issn

1096-9098

journal_volume

103

pub_type

杂志文章
  • Nerve sheath tumors of the sciatic nerve and sacral plexus.

    abstract::Eight patients with sciatic nerve and sacral plexus nerve sheath tumors, seen at Louisiana State University Medical Center in Shreveport, are presented. These cases illustrate the broad spectrum of pathology and modes of presentation of patients with nerve sheath tumors in this region. Patients can be divided into 4 g...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.2930390103

    authors: Benzel EC,Morris DM,Fowler MR

    更新日期:1988-09-01 00:00:00

  • Clinical and histopathological appraisal of preoperative irradiation for adenocarcinoma of the pancreatoduodenal region.

    abstract::A retrospective review to elucidate the rationale of preoperative irradiation was made on 18 carcinomas of the head of the pancreas area. After 50 Gy/25 fractions of 10 MV X-ray was given, all 18 tumors decreased from 3.3 +/- 0.8 cm to 2.0 +/- 0.7 cm. At the surgical operation, 16 patients (89%) received pancreatic re...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.2930400303

    authors: Ishikawa O,Ohhigashi H,Teshima T,Chatani M,Inoue T,Tanaka S,Kitamura T,Wada A,Sasaki Y,Imaoka S

    更新日期:1989-03-01 00:00:00

  • Enhancement of metastasis development by BCG immunotherapy.

    abstract::When BALB/c mice bearing growing transplants of a syngeneic colon carcinoma--Colon Tumor 26 (CT 26)--were treated with Bacillus Calmette-Guerin (BCG), no effect on tumor growth rate or survival time was observed compared to untreated controls. However, after excision of primary tumor transplants, enhanced development ...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.2930150307

    authors: Colmerauer ME,Koziol JA,Pilch YH

    更新日期:1980-01-01 00:00:00

  • Neural cell adhesion molecule (NCAM) and perineural invasion in bile duct cancer.

    abstract::Perineural invasion is associated with tumor spreading and an unfavorable prognosis in a variety of cancers. Recently, neural cell adhesion molecule (NCAM) has been reported to be affinitive to neural tissues, which suggests some relationship between NCAM and perineural invasion. This study was designed to elucidate t...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.2930530205

    authors: Seki H,Tanaka J,Sato Y,Kato Y,Umezawa A,Koyama K

    更新日期:1993-06-01 00:00:00

  • Expression of RCAS1 in esophageal squamous cell carcinoma is associated with a poor prognosis.

    abstract:BACKGROUND:Receptor-binding cancer antigen expressed on SiSO cells (RCAS1) has been reported to act as a ligand for a receptor present on normal peripheral lymphocytes and to induce apoptotic cell death. We aimed to elucidate the significance of RCAS1 expression in human esophageal squamous cell carcinomas (ESCC). MET...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.20249

    authors: Kato H,Nakajima M,Masuda N,Faried A,Sohda M,Fukai Y,Miyazaki T,Fukuchi M,Tsukada K,Kuwano H

    更新日期:2005-05-01 00:00:00

  • Apoptosis in breast cancer and its relationship to clinicopathological characteristics and prognosis.

    abstract:BACKGROUND AND OBJECTIVES:Apoptosis is essential to maintain homeostasis in living organisms and occurs in a variety of tissues in response to both physiological and pathological stimuli. In breast cancer, most cytotoxic drugs and hormonal treatments induce apoptosis. We studied the relationships between apoptosis and ...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/(sici)1096-9098(199908)71:4<226::aid-jso4>

    authors: Nishimura R,Nagao K,Miyayama H,Matsuda M,Baba K,Matsuoka Y,Yamashita H,Fukuda M,Higuchi A

    更新日期:1999-08-01 00:00:00

  • Survival of patients with metastatic breast cancer diagnosed between 1955 and 1980.

    abstract::In order to determine whether current programs for the management of metastatic breast cancer have led to improved patient survival, we determined the median survival times for five-year intervals of 849 patients admitted to the City of Hope National Medical Center with metastatic breast cancer from 1955 to 1980. Surv...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.2930480304

    authors: Debonis D,Terz JJ,Eldar S,Hill LR

    更新日期:1991-11-01 00:00:00

  • Hyperthermic regional perfusion with melphalan and a combination of melphalan and actinomycin D in the treatment of locally metastasized malignant melanomas of the extremities.

    abstract::From September 1969 through 1979, 68 patients with already locally metastasized malignant melanomas of the extremities were treated by hyperthermic regional perfusion and local excision(s). Of these, 53 patients could be evaluated after a follow-up of at least 2 years: 31 had been perfused with melphalan and 22 with m...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.2930200103

    authors: Martijn H,Oldhoff J,Koops HS

    更新日期:1982-05-01 00:00:00

  • Stro-1(+) stromal cells have stem-like features in giant cell tumor of bone.

    abstract:BACKGROUND:Giant cell tumor of bone (GCTB) is an aggressive benign bone tumor with poor prognosis whose neoplastic component is stromal cells (SCs). Tumor stem-like cells (TSCs) have been demonstrated as precursors for tumor genesis and growth. The aim of this study is to identify TSCs in GCTB. METHODS:Stro-1(+) and S...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.23151

    authors: Lan J,Liu X,Rong W,Wei F,Jiang L,Yu H,Dang G,Liu Z

    更新日期:2012-12-01 00:00:00

  • Liver scanning in newly diagnosed breast carcinoma.

    abstract::The records of 111 consecutive cases of carcinoma of the breast were reviewed and yielded 66 patients who had undergone liver scanning and determination of the serum alkaline phosphatase (alk p'tase), lactic dehydrogenase (LDH), and serum glutamic oxaloacetic transaminase (SGOT). Four of the 66 patients (6.1%) had a f...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.2930130313

    authors: Haid M,Singh J,Nevinny HB

    更新日期:1980-01-01 00:00:00

  • Predictors of postoperative morbidity after laparoscopic versus open radical hysterectomy plus external beam radiotherapy: a propensity-matched comparison.

    abstract:BACKGROUND:Identification of peri-operative variables predicting postoperative morbidity may improve postoperative patients' care. We aimed to identify patients' characteristics and operative factors predictive of early (≤ 30-day) and late (≤ 6-month) morbidity in cervical cancer patients undergoing surgery plus extern...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.23747

    authors: Bogani G,Cromi A,Serati M,Di Naro E,Uccella S,Donadello N,Ghezzi F

    更新日期:2014-12-01 00:00:00

  • Patient generated health data and electronic health record integration in oncologic surgery: A call for artificial intelligence and machine learning.

    abstract::In this review, we aim to assess the current state of science in relation to the integration of patient-generated health data (PGHD) and patient-reported outcomes (PROs) into routine clinical care with a focus on surgical oncology populations. We will also describe the critical role of artificial intelligence and mach...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章,评审

    doi:10.1002/jso.26232

    authors: Melstrom LG,Rodin AS,Rossi LA,Fu P Jr,Fong Y,Sun V

    更新日期:2021-01-01 00:00:00

  • Does age influence disease-specific survival in patients with squamous cell carcinomas of the head and neck?

    abstract:BACKGROUND AND OBJECTIVES:The number of patients diagnosed with head and neck squamous cell carcinoma (HNSCC) at an advanced age has increased. The aim of this study is to evaluate the age at which disease-specific survival (DSS) significantly decreases in HNSCC. METHODS:We performed a retrospective study of 5469 pati...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.25895

    authors: Lop J,Valero C,García J,Quer M,Ganly I,Shah JP,Patel SG,León X

    更新日期:2020-06-01 00:00:00

  • Extra-abdominal desmoid tumors: a report of 234 cases.

    abstract:BACKGROUND/OBJECTIVES:To report on the clinical presentation and outcome for 234 patients with extra-abdominal desmoids tumors. METHODS:Since 1977, the authors have treated 234 patients with extra-abdominal desmoid tumors. The patients had an average age of 36.7 and 61% were female. The tumors arose adjacent to muscle...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.21433

    authors: Mankin HJ,Hornicek FJ,Springfield DS

    更新日期:2010-10-01 00:00:00

  • Encapsulation is a significant prognostic factor for better outcome in large hepatocellular carcinoma.

    abstract:BACKGROUND:The aim of this study was to determine the effect of tumor encapsulation of hepatocellular carcinoma (HCC) on long-term survival. METHODS:A retrospective review of 1,240 patients who underwent hepatectomy from January 1993 to June 2005 was conducted. There were 891 patients with tumor encapsulation (EC type...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.22060

    authors: Wu TH,Yu MC,Chen TC,Lee CF,Chan KM,Wu TJ,Chou HS,Lee WC,Chen MF

    更新日期:2012-01-01 00:00:00

  • Duodenal neuroendocrine tumors: Somewhere between the pancreas and small bowel?

    abstract:BACKGROUND:While sub-2 cm pancreatic neuroendocrine tumors (NETs) are often observed, small bowel-NETs undergo resection and lymphadenectomy regardless of size. Aim was to define the natural history of duodenal (D-NETs), determine the role of resection, and define the factors associated with overall survival (OS) after...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.25731

    authors: Gamboa AC,Liu Y,Lee RM,Zaidi MY,Staley CA,Kooby DA,Winer JH,Shah MM,Russell MC,Cardona K,Maithel SK

    更新日期:2019-12-01 00:00:00

  • Breast-specific factors determine cosmetic outcome and patient satisfaction after breast-conserving therapy: Results from the randomized COBALT study.

    abstract:BACKGROUND AND OBJECTIVES:To identify breast-specific factors and the role of tumor, treatment, and patient-related items in influencing patient opinion on cosmesis and satisfaction after breast-conserving therapy (BCT). METHODS:Data from the randomized COBALT study was used. At 3, 12, and 36 months, 128 patients with...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章,随机对照试验

    doi:10.1002/jso.25012

    authors: Volders JH,Negenborn VL,Haloua MH,Krekel NMA,Jóźwiak K,Meijer S,van den Tol PM

    更新日期:2018-04-01 00:00:00

  • Post-mastectomy radiation therapy and overall survival after neoadjuvant chemotherapy.

    abstract:BACKGROUND:The role of postmastectomy radiation therapy (PMRT) after neoadjuvant chemotherapy (NAC) and mastectomy is unclear, especially in patients that have post-treatment tumor negative axillary nodes (ypN0). METHODS:The National Cancer Data Base was used to identify women that had PMRT after NAC and mastectomy fo...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.24551

    authors: Kantor O,Pesce C,Singh P,Miller M,Tseng J,Wang CH,Winchester DJ,Yao K

    更新日期:2017-05-01 00:00:00

  • Nodal stage of stage III colon cancer: the impact of metastatic lymph node ratio.

    abstract:PURPOSE:We assessed which classification of lymph node metastasis better predicted outcomes in patients with colorectal carcinoma. METHODS:We identified 318 patients (176 men) with stage III colon cancer who underwent curative resection. The number of LNs dissected, LNR, and disease-free survival time, were analyzed. ...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.21273

    authors: Park IJ,Choi GS,Jun SH

    更新日期:2009-09-01 00:00:00

  • Long-term follow-up of patients with superficial transitional cell carcinoma of the urinary bladder treated by intravesical mitomycin C.

    abstract::Prophylactic intravesical chemotherapy (IVC) reduces recurrence rates of superficial transitional cell carcinoma (TCC) of the urinary bladder. The patient cohort existed of 86 individuals (stage TaN0M0 or T1N0M0) superficial carcinoma of various grades of malignancy. Following initial transuretheral resection or diagn...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.2930600310

    authors: Pavlotsky A,Eidelman A,Barak F,Walach N,Horn Y

    更新日期:1995-11-01 00:00:00

  • Comparative analysis of imaging modalities in the preoperative assessment of nodal metastasis in esophageal cancer.

    abstract::Preoperative radiological findings of nodal status in 74 patients, using endoscopic ultrasonography (EUS), computed tomography (CT), ultrasonography (US), and magnetic resonance imaging (MRI), were compared to histopathology reports following transthoracic total esophagectomy with radical lymphadenectomy (TTE), involv...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/(SICI)1096-9098(199603)61:3<214::AID-JSO10

    authors: Chandawarkar RY,Kakegawa T,Fujita H,Yamana H,Hayabuthi N

    更新日期:1996-03-01 00:00:00

  • Further evaluation by ultrasound of mammographically determined breast dysplasia.

    abstract::Evaluation of 135 consecutive patients was made for breast masses by the same surgeon and the patients were subsequently referred for ultrasound mammography of the breast after xeromammography revealed a "dysplastic" (DY) pattern only, with no evidence of malignancy. Three patients had carcinoma of the breast detected...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.2930190203

    authors: Frazier TG,Cole-Beuglet C,Kurtz AB,Goldberg BB,Ryan SM

    更新日期:1982-02-01 00:00:00

  • An apparent danazol-induced primary hepatocellular carcinoma: case report.

    abstract::This paper presents an apparent case of danazol-induced primary hepatocellular carcinoma in a 49-year-old patient, following two years of continuous therapy with this inhibitor of pituitary gonadotrophin. Discontinuation of the drug failed to cause regression of the tumour. ...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.2930280209

    authors: Buamah PK

    更新日期:1985-02-01 00:00:00

  • The accuracy of three predictive models in the evaluation of recurrence rates for gastrointestinal stromal tumors.

    abstract:BACKGROUND:Treatment decisions for gastrointestinal stromal tumors (GIST) are frequently guided by tumor characteristics. An accurate prediction of recurrence is important to determine the benefit from targeted therapy. Our goal was to compare the concordance of three validated risk stratification schemes with observed...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.23839

    authors: Racz JM,Brar SS,Cleghorn MC,Jimenez MC,Azin A,Atenafu EG,Jackson TD,Okrainec A,Quereshy FA

    更新日期:2015-03-15 00:00:00

  • Preoperative systemic inflammatory markers are prognostic indicators in recurrent adrenocortical carcinoma.

    abstract:BACKGROUND:Recurrent adrenocortical carcinoma (ACC) has a poor prognosis with minimal clinical and biochemical factors to guide management. The aim of this study was to evaluate the prognostic significance of systemic inflammatory response in patients with recurrent ACC. METHODS:Patients who underwent resection for re...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.25760

    authors: Gaitanidis A,Wiseman D,El Lakis M,Nilubol N,Kebebew E,Patel D

    更新日期:2019-12-01 00:00:00

  • Genetic polymorphism of urokinase-type plasminogen activator is interacting with plasminogen activator inhibitor-1 to raise risk of cervical neoplasia.

    abstract:BACKGROUND AND OBJECTIVES:To evaluate the impact of plasminogen activator (PA) system genes, including urokinase plasminogen activator (uPA), uPA receptor (uPAR), and plasminogen activator inhibitor-1 (PAI-1) gene polymorphisms in patients with the cervical neoplasia. METHODS:In total, 336 blood samples were collected...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.23072

    authors: Tee YT,Wang PH,Tsai HT,Lin LY,Lin HT,Yang SF,Hsieh YH,Ying TH

    更新日期:2012-08-01 00:00:00

  • Measuring and reporting on quality in health care: a framework and road map for improving care.

    abstract::Quality of care measurement and reporting at the provider, hospital, or health system level has become increasingly common in health systems around the world. Health system performance reports, whether they be confidentially distributed to the provider or made available to the public, are not only used as a stimulus f...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章,评审

    doi:10.1002/jso.21188

    authors: Brien SE,Dixon E,Ghali WA

    更新日期:2009-06-15 00:00:00

  • Reconstruction of chest wall defects following extirpative surgery.

    abstract::Reconstructive procedures following chest wall resection pose a special surgical challenge. With modern surgical technique, a wide range of reconstructive options are at the surgeon's disposal and, hence it is imperative that the appropriate procedure be selected in a given patient. A total of 64 patients underwent re...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.2930550311

    authors: Savant DN,Patel SG,Bokil KP,Bhathena HM,Kavarana NM,Vyas JJ

    更新日期:1994-03-01 00:00:00

  • Modified radical lymphadenectomy without splenectomy in patients with proximal gastric cancer: comparison with standard D2 lymphadenectomy for distal gastric cancer.

    abstract:BACKGROUND AND OBJECTIVES:We assessed the optimal extent of lymph node dissection and the effect of splenectomy in patients with proximal gastric cancer. METHOD:Recurrence and survival rates were compared between 881 patients with proximal gastric cancer who underwent modified radical lymphadenectomy and 3,098 patient...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.21137

    authors: Cheong O,Kim BS,Yook JH,Oh ST,Park YK,Ryu SY

    更新日期:2008-12-01 00:00:00

  • Serum copper in carcinoma of cervix uteri as an indicator of successful radiotherapy.

    abstract::Serum copper levels (SCL) have been done in 106 patients of squamous cell carcinoma of the cervix and in 15 cases of local recurrences. The mean SCL has been significantly elevated in them in comparison to controls (P less than 0.001). The SCL falls to near normal range following successful therapy. There is a trend t...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.2930220313

    authors: Birdi A,Gupta S,Gambhir SS

    更新日期:1983-03-01 00:00:00