Abstract:
BACKGROUND AND OBJECTIVES:Small lung adenocarcinomas are detected more frequently than in the past. However, the clinicopathologic characteristics and prognostic significance of EGFR/p53 mutations in these tumors remains unclear. METHODS:We evaluated the correlation of EGFR/p53 mutations with clinicopathologic characteristics and tumor relapse in 172 surgically resected lung adenocarcinomas ≤2 cm in maximal dimension. EGFR/p53 mutational analysis was performed on DNA extracted from paraffin-embedded tumors. RESULTS:EGFR and p53 mutations were identified in 104 (60.5%) and 36 (20.9%) small adenocarcinomas, respectively. EGFR/p53 mutations were associated with tumor size >1 cm, whereas p53 mutations were frequently observed in moderately differentiated tumors. Disease-free survival analysis showed that p53 mutation, presence of visceral pleural surface invasion, elevated preoperative serum carcinoembryonic antigen, and moderate histologic differentiation were significantly correlated with tumor relapse in patients with stage I disease. The 5-year survival rate was higher in relapsed patients with EGFR-mutated tumors who were treated with tyrosine kinase inhibitor (TKI) than in those who were not treated with TKI. CONCLUSIONS:p53 mutation was significantly correlated with tumor progression, and our findings may provide a rationale for the selective use of adjuvant chemotherapy in stage IB patients with p53 mutations. EGFR mutation was a predictor of EGFR TKI response in relapsed patients.
journal_name
J Surg Oncoljournal_title
Journal of surgical oncologyauthors
Lin MW,Wu CT,Shih JY,Chang YL,Yang PCdoi
10.1002/jso.23628subject
Has Abstractpub_date
2014-08-01 00:00:00pages
99-106issue
2eissn
0022-4790issn
1096-9098journal_volume
110pub_type
杂志文章abstract:BACKGROUND:Inflammation plays an important role in the progression and prognosis of hepatocellular carcinoma (HCC). Our aim is to explore the prognostic value of preoperative and postoperative peripheral lymphocyte differences and to develop a dynamic prognosis nomogram in hepatitis B virus-related HCC patients. METHO...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.26195
更新日期:2020-12-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Outcomes and recommendations regarding adjuvant therapy (AT) for stage I ampullary adenocarcinoma (AAC) are inadequately described. We sought to determine factors associated with survival and better define the impact of AT. METHODS:The NCDB was queried for stage I AAC patients undergoing rese...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.25021
更新日期:2018-06-01 00:00:00
abstract:BACKGROUND:The aim of this study was to determine the effect of tumor encapsulation of hepatocellular carcinoma (HCC) on long-term survival. METHODS:A retrospective review of 1,240 patients who underwent hepatectomy from January 1993 to June 2005 was conducted. There were 891 patients with tumor encapsulation (EC type...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.22060
更新日期:2012-01-01 00:00:00
abstract:BACKGROUND:This study evaluates several tumor-related markers to examine the expression pattern of markers according to the invasiveness and histopathologic differentiation of squamous cell carcinoma and basal cell carcinoma. METHODS:Ninety-four cases of squamous cell carcinoma and 108 cases of basal cell carcinoma us...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.21006
更新日期:2008-06-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Variants of CD44 have been proposed to be important in promoting tumor progression and metastasis. We attempted to determine the expression of CD44v6 product in advanced gastric cancer and to evaluate its prognostic value. METHODS:The expression of CD44v6 was analyzed immunohistochemically in...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.10082
更新日期:2002-04-01 00:00:00
abstract::To define more precisely the prognostic index for patients with primary carcinoma of the gallbladder in Taiwan, we retrospectively reviewed the data of 74 patients with gallbladder carcinoma treated over a period of 15 years, from 1979 to 1993. Of these patients, 75% had Nevin stage V gallbladder cancer. The most comm...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/(SICI)1096-9098(199601)61:1<49::AID-JSO11>
更新日期:1996-01-01 00:00:00
abstract::The use of plasma albumin (ALB), transferrin (TFN), prealbumin (TBPA), retinol-binding protein (RBP), triceps skin fold (TSF), and midarm muscle circumference (MAMC) as determinants of response to nutritional therapy (TPN) was investigated in 40 cancer patients during preoperative TPN. Thirty-one patients received 90%...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930290306
更新日期:1985-07-01 00:00:00
abstract:PURPOSE:Imatinib mesylate (IM) demonstrates substantial efficacy in most patients with metastatic gastrointestinal stromal tumors (GISTs). However, progression of GIST eventually develops and emerges as a challenge. To assess the role of surgery in the multidisciplinary management of GISTs, we studied the surgical outc...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.21630
更新日期:2010-11-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Vascularized lymph node transfer (LNT) is gaining popularity in the treatment of lymphedema. However, it is unclear whether the vascularization of transferred lymph nodes (LNs) contributes to functional improvement. High endothelial venules (HEVs) are specialized vessels that allow lymphocytes...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.25365
更新日期:2019-05-01 00:00:00
abstract::Of 134 patients with thymoma, 79 (59%) also had myasthenia gravis (MG). The thymoma with MG differed from that in the absence of MG in the following aspects: The ratio of lymphocytes to epithelial cells in the tumor was larger, the polygonal cell type was more prominent (i.e., in 83% of the MG patients this cell type ...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930380305
更新日期:1988-07-01 00:00:00
abstract:BACKGROUND:Identification of functional lymphatic vessels and localization of lymphatic vessels are important for lymphaticovenular anastomosis (LVA). Indocyanine green (ICG) lymphography is useful for localization of superficial lymphatic vessels where dermal backflow is not observed, but not for lymphatic vessels in ...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.24812
更新日期:2018-02-01 00:00:00
abstract:BACKGROUND:For tumours of the adrenal gland different surgical retroperitoneal approaches have been established, including the lateral and the dorsal approach. It is still unclear if the lateral or the dorsal approach should be preferred. PATIENTS AND METHODS:A retrospective comparison between 21 patients who underwen...
journal_title:Journal of surgical oncology
pub_type: 信件
doi:10.1002/jso.20793
更新日期:2008-01-01 00:00:00
abstract::Oncogenes, tumor suppressor genes, and growth factors are being explored as to their role in the initiation and progression of most neoplasms, but little information exists on the expression of oncoproteins or growth factors in adenocarcinoma of the duodenum or ampulla of Vater. This report covers expressions of p53, ...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/(SICI)1096-9098(199602)61:2<100::AID-JSO3>
更新日期:1996-02-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:To describe the use of the mastoid skull post of a surgical image guidance system for image guided surgery and intraoperative navigation of the nasopharynx. This adaptation overcomes the limitations of a headset frame or head clamp and can be applied to open and closed surgery of the nasal cav...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.21005
更新日期:2008-05-01 00:00:00
abstract::This is a review of a rare case of acute appendicitis secondary to metastatic nasopharyngeal carcinoma (NPC) that had never before been reported in the literature. The clinical presentation did not differ from usual cases of acute appendicitis, but the pathology caused us to re-evaluate the NPC stage of the patient. ...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930600213
更新日期:1995-10-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:The study of pathology and prognosis for patients with ovarian tumors of low malignant potential (LMP) has been well documented. The treatment, particularly the secondary surgery, for recurrent disease is less documented. This study was conducted to investigate the role of secondary surgical c...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.20280
更新日期:2005-07-01 00:00:00
abstract:BACKGROUND:The Goldilocks mastectomy procedure involves local contouring of completely autologous breast tissue created by preserving and de-epithelializing the residual mastectomy flaps. The purpose of this study was to provide outcomes data for 96-Goldilocks mastectomy procedures analyzing indications, complications,...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.25465
更新日期:2019-06-01 00:00:00
abstract::The association of some cases of endometrial carcinoma (EC) with hyperestrogenism is well known. The prognostic significance of concomitant endometrial hyperplasia (EH) in EC were evaluated in 142 patients with clinical stage I EC in whom lymph node assessment was carried out in 121 patients. The presence of EH was si...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930460312
更新日期:1991-03-01 00:00:00
abstract::Adenocarcinomas of the trachea are rare but important because the only reported treatment in the past (radiation) has resulted in uniformly poor results. The authors recently had the opportunity to treat a young woman with a mucin-producing adenocarcinoma of the trachea. A sleeve resection of the involved trachea with...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930280108
更新日期:1985-01-01 00:00:00
abstract::We report a case of adenocarcinoma arising in a focus of heterotopic pancreas, occurring in the stomach of a 52-year-old man. The patient presented with gastric outlet obstruction. Radiographic studies revealed thickening of the gastric wall, but endoscopy failed to reveal a mucosal abnormality. A 50% distal gastrecto...
journal_title:Journal of surgical oncology
pub_type: 杂志文章,评审
doi:10.1002/jso.20087
更新日期:2004-07-15 00:00:00
abstract::Fifty-four patients with advanced upper gastrointestinal cancer were assessed for their nutritional status prior to any form of therapy. Anthropometric parameters--weight loss, arm muscle circumference, skin-fold thickness--and biochemical parameters--serum albumin and delayed cutaneous hypersensitivity reactions to p...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930290417
更新日期:1985-08-01 00:00:00
abstract::The relationship between prior cholecystectomy and right-sided colon cancer was evaluated in a case-control study. The study population comprised 267 women with right-sided colon cancer (cases) and 268 women with left-sided colon cancer (controls). All patients were white females, aged between 40 and 69 years, and reg...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930300103
更新日期:1985-09-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:The diagnosis of invasive breast cancer is most commonly made on image-guided core biopsy (CB). The presence of extensive intraductal component (EIC), as identified on subsequent lumpectomy, is associated with an increased risk of positive margins and need for further surgery. CBs demonstratin...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.20242
更新日期:2005-05-01 00:00:00
abstract::Twenty cases of neoplasms in skin and subcutaneous tissue over the breast were reviewed. There were 17 women, from 15 to 70 years of age, and three men, from 25 to 66 years of age. Among the benign skin neoplasms, superficial leiomyoma, granular cell tumor, and eccrine acrospiroma were misdiagnosed clinically as prima...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930310312
更新日期:1986-03-01 00:00:00
abstract::Although the incidence of locally recurrent colorectal cancer has been reduced by improved surgical techniques and the frequent use of multimodality therapy, pelvic recurrence remains a significant problem. Radiation or chemotherapy may provide palliation but it is often short-lived. For fit candidates without evidenc...
journal_title:Journal of surgical oncology
pub_type: 杂志文章,评审
doi:10.1002/jso.21571
更新日期:2010-06-15 00:00:00
abstract:BACKGROUND AND OBJECTIVES:In this study, we identified matrix metalloproteinase (MMP)-2 and 9 expression in exophytic papilloma (EP), inverted papilloma (IP) with dysplasia, IP with carcinoma, and invasive squamous cell carcinoma (SCC). We also compared the presence of MMP-2 and 9 with human papilloma virus (HPV) infec...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.20386
更新日期:2006-01-01 00:00:00
abstract::Surgery is a mainstay of primary breast cancer therapy. Alterations in surgical technique have reduced normal tissue injury, yet pain and functional compromise continue to occur following treatment. A tenuous evidence base bolstered by considerable expert opinion suggests that early intervention with conventional reha...
journal_title:Journal of surgical oncology
pub_type: 杂志文章,评审
doi:10.1002/jso.20782
更新日期:2007-04-01 00:00:00
abstract::The aim of our study was to evaluate the clinical efficacy of preoperative injection of activated carbon in delineation of cancer location in laparoscopic colectomy. Activated carbon particles were injected during endoscopy into the normal colonic wall surrounding cancer lesions in five cases of early colon cancer, pr...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930580107
更新日期:1995-01-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:F-18 fluorodeoxyglucose-positron emission tomography (FDG-PET) has been used for diagnosis and staging of malignant diseases. However, the prognostic significance of FDG uptake on PET had not been sufficiently evaluated in patients with biliary carcinoma. METHODS:We performed a retrospective ...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.21356
更新日期:2009-11-01 00:00:00
abstract::Wilms' tumor, renal cell carcinoma, and neuroblastoma in animals were transplanted from donors to recipients with strong histocompatibility differences. No strong evidence of the privileged site theory was found in this study and no obvious evidence of an immunosuppressive effect of testosterone was found. The most im...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930140111
更新日期:1980-01-01 00:00:00