Abstract:
BACKGROUND:Randomized controlled trials have demonstrated comparable survival outcomes for short-course (SCRT) and long-course neoadjuvant radiotherapy (LCRT) in patients with rectal cancer. METHODS:Using the National Cancer Data Base (2004-2015), a propensity score was used to match 188 patients with rectal cancer receiving SCRT to 376 patients receiving LCRT. Perioperative, oncologic, and survival outcomes were compared. RESULTS:Patient and clinical tumor characteristics were similar between groups. Patients in the LCRT were more likely to undergo surgery (91% vs 85%; P = 0.03). The LCRT group were more likely to have tumor (T) (56% vs 43%) and nodal (N) (25% vs 19%) downstaging, and a complete pathological response (15% vs 6%) compared with the SCRT group (all P < 0.05). Length of stay (6 vs 8 days), 30-day (1% vs 5%) mortality, and 90-day mortality (1% vs 10%) were significantly lower in the LCRT group (all P < 0.05). After adjusting for patient and tumor-related characteristics, LCRT was associated with a 50% reduction in the risk of mortality compared with SCRT (hazard ratios, 0.50; 95% confidence interval, 0.35-0.70). CONCLUSIONS:In this analysis, LCRT was superior to SCRT in terms of tumor response to neoadjuvant therapy, perioperative mortality, and overall survival. These findings provide evidence for the use of LCRT when neoadjuvant therapy is indicated.
journal_name
J Surg Oncoljournal_title
Journal of surgical oncologyauthors
Chapman BC,Goodman K,Hosokawa P,Gleisner A,Cowan ML,Birnbaum E,Vogel JDdoi
10.1002/jso.25355subject
Has Abstractpub_date
2019-03-01 00:00:00pages
518-531issue
4eissn
0022-4790issn
1096-9098journal_volume
119pub_type
杂志文章abstract:BACKGROUND:The benefit derived from lymph node dissection (LND) in patients with pancreatic neuroendocrine tumors (pNETs) based on clinicopathological characteristics remains unclear. METHODS:Patients undergoing surgery for pNET between 1997 and 2016 were identified using a multi-institutional dataset. The therapeutic...
journal_title:Journal of surgical oncology
pub_type: 杂志文章,多中心研究
doi:10.1002/jso.25689
更新日期:2019-12-01 00:00:00
abstract::Seventy tumors of invasive ductal carcinoma of the breast were examined for p53 alteration by the RT-PCR-SSCP method. Sixty-five samples (92.9%) were investigated in the regions of codons 101-200 and 201-300. In total, 16 samples (24.6%) showed p53 gene alteration. We found that p53 gene alteration showed a correlatio...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930560110
更新日期:1994-05-01 00:00:00
abstract::Metastatic liver disease is the commonest cause of death in patients with colorectal cancer. A small proportion of these patients (10%) may be treated by surgical resection with five year survival approaching 35-40%. Alternative treatment modalities for localised hepatic disease include in situ ablative techniques tha...
journal_title:Journal of surgical oncology
pub_type: 杂志文章,评审
doi:10.1002/1096-9098(200101)76:1<73::aid-jso1014>3.0.
更新日期:2001-01-01 00:00:00
abstract::A pharmacokinetic analysis of cis-diamminedichloroplatinum (II) (DDP) was conducted comparing low-dose daily bolus infusions, and high-dose drip infusions. Eight patients with gastric cancer were treated with low-dose daily bolus infusions of DDP to a total daily dose of 75 mg/m2 bid for 5 days. Four patients with eso...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/(SICI)1096-9098(199606)62:2<135::AID-JSO10
更新日期:1996-06-01 00:00:00
abstract:BACKGROUND:Unresectable tumors of the pancreatic head are encountered in up to 20% of patients taken for resection. The objective of this study was to evaluate the complications and outcome associated with palliative surgical procedures to help guide management decisions in these patients. METHODS:Patients with pancre...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.23560
更新日期:2014-06-01 00:00:00
abstract::A large number of adrenal tumors are now identified either incidentally or associated with a metastatic workup for cancer. While the vast majority of these lesions are benign, those that prove to be primary or secondary cancers are traditionally treated with surgical resection. A wide variety of alternative, less inva...
journal_title:Journal of surgical oncology
pub_type: 杂志文章,评审
doi:10.1002/jso.23191
更新日期:2012-10-01 00:00:00
abstract::The clinicopathologic features of a case of adenocarcinoma arising in Meckel's diverticulum are described and compared with the 21 cases reported in the literature. The prognosis is generally poor. However, the patient in the present case was alive and well 1.5 years after diagnosis, despite the fact that the lesion h...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930230111
更新日期:1983-05-01 00:00:00
abstract::Preoperative radiological findings of nodal status in 74 patients, using endoscopic ultrasonography (EUS), computed tomography (CT), ultrasonography (US), and magnetic resonance imaging (MRI), were compared to histopathology reports following transthoracic total esophagectomy with radical lymphadenectomy (TTE), involv...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/(SICI)1096-9098(199603)61:3<214::AID-JSO10
更新日期:1996-03-01 00:00:00
abstract::The association of some cases of endometrial carcinoma (EC) with hyperestrogenism is well known. The prognostic significance of concomitant endometrial hyperplasia (EH) in EC were evaluated in 142 patients with clinical stage I EC in whom lymph node assessment was carried out in 121 patients. The presence of EH was si...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930460312
更新日期:1991-03-01 00:00:00
abstract::The efficacy of killing small cell lung cancer (SCLC) cells at the G1, S, and G2-M phase of the cell-cycle by a new 111In-bleomycin complex (111In-BLMC) was investigated. SCLC cells (N417, H526, H209) were synchronized by double thymidine block and assessed by DNA content with flow cytometry, and the period for the ma...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930400203
更新日期:1989-02-01 00:00:00
abstract:BACKGROUND:Patients chosen for liver resection of colorectal liver metastases are a select group with minimal disease, favorable tumor biology and earlier presentation when compared to unresectable patients. Despite intense preoperative assessments, operative detection of occult unresectable disease is inevitable for a...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.20341
更新日期:2005-10-01 00:00:00
abstract:PURPOSE:The epidemiology and clinicopathology of aneurysmal bone cysts (ABCs) secondary to giant cell tumors of bone (GCTBs) have been well documented in the previous literature. However, reports on whether secondary ABCs could affect the postoperative recurrence of GCTBs are rare. This study analyzed the effects of se...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.25588
更新日期:2019-09-01 00:00:00
abstract::A new simplified system for updating a cancer registry has been developed in the Biostatistics Department of Roswell Park Memorial Institute. It was designed to serve the needs of maintaining a registry for a cooperative cancer research group. The Data-Update Procedure at a Remote Terminal (DUPART) system has general ...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930070508
更新日期:1975-01-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:In highly selected patients with peritoneal carcinomatosis, cytoreductive surgery (CRS) combined with hyperthermic intraperitoneal chemotherapy (HIPEC) can be an aggressive but worthwhile treatment regimen. Resection of the rectosigmoid is frequently performed with CRS. The aim of the study wa...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.25189
更新日期:2018-09-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Immune status in the peritoneal cavity of patients with gastric cancer remains largely unknown. To clarify the clinical significance of the host immune response within the peritoneal cavity, we examined the levels of interferon-gamma (IFN-gamma), a type 1 cytokine, and interleukin-10 (IL-10), ...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.1131
更新日期:2001-10-01 00:00:00
abstract:BACKGROUND AND OBJECTIVE:Only a few surgeons with much experience of laparoscopic surgery perform laparoscopy-assisted total gastrectomy (LATG), because of its technical difficulty and concern about subsequent complications. The aim of this study was to evaluate the technical feasibility and safety of LATG as compared ...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.21345
更新日期:2009-10-01 00:00:00
abstract::Munchausen's syndrome is a chronic factitious disorder characterized by frequent hospitalizations, self-inflicted injuries, and dramatic medical histories. People with this condition assume the role of a sick patient and submit to unnecessary invasive, painful, and even dangerous medical procedures. In review of the l...
journal_title:Journal of surgical oncology
pub_type: 杂志文章,评审
doi:10.1002/jso.2930560219
更新日期:1994-06-01 00:00:00
abstract:PURPOSE:To describe venous thromboembolism (VTE) rates in patients with pancreatic cancer (PC) during neoadjuvant therapy. METHODS:Factors associated with VTE were evaluated using multivariable logistic regression modeling in patients with resectable and BLR PC treated with neoadjuvant therapy between 2009 and 2014. ...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.24361
更新日期:2016-10-01 00:00:00
abstract::Two unusual presentations of perforated mucoid adenocarcinoma of the appendix are described. One patient presented with a large periappendicular abscess that extended into the gluteal region, the other with a retroperitoneal abscess and abscesses in the right flank and groin. Recognition of the source of the abscess m...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930250409
更新日期:1984-04-01 00:00:00
abstract::To search for possible untoward effects of ethanol injection into a malignant tumor, a series of experiments was carried out using the model of RBT-1 carcinoma. Ten days after the inoculation of RBT-1 carcinoma into the rat liver, the animals were separated into three groups: Group A, ethanol injection during relaparo...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930540105
更新日期:1993-09-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Peritoneal papillary serous carcinoma (PPSC) is histologically and clinically similar to stage III-IV ovarian papillary serous carcinoma (OPSC). The purpose of this study was to investigate the clinical findings, treatment, and outcome of PPSC patients compared with stage III-IV OPSC patients....
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/(sici)1096-9098(199807)68:3<173::aid-jso8>
更新日期:1998-07-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Oxaliplatin is a chemotherapeutic drug for colorectal adenocarcinoma able to extend the indications for resection of colorectal liver metastases. However, the drug may severely injure hepatic sinusoids, inducing a sinusoidal obstruction syndrome in non-tumoral parenchyma with a risk of decreas...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.21276
更新日期:2009-06-01 00:00:00
abstract:BACKGROUND:Increased activity of Src has been found in several human cancers, and often is associated with poor clinical outcome. The present study aimed to determine whether Src activity is increased in gastrointestinal stromal tumors (GIST), and whether it correlates with established tumor or patient characteristics ...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.23544
更新日期:2014-05-01 00:00:00
abstract::Lymph node status is not part of the staging system for cervical cancer, but provides important information for prognosis and treatment. This article reviews the incidence and patterns of lymph node metastasis, and the issues surrounding surgical assessment of lymph nodes. The preoperative assessment of lymph nodes by...
journal_title:Journal of surgical oncology
pub_type: 杂志文章,评审
doi:10.1002/jso.21199
更新日期:2009-03-15 00:00:00
abstract:BACKGROUND:The value of surgical resection in patients with hepatic metastases from melanoma is poorly documented in the literature. This study sought to determine the clinicopathologic and surgical factors predictive of outcome for melanoma patients who underwent resection of hepatic metastases. METHODS:Thirty-three ...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.23361
更新日期:2013-08-01 00:00:00
abstract::The relationship of acute appendicitis occurring previous to cancer in colon and rectum was studied in the consecutive records of 561 patients, of 40 years of age and older, operated upon with an appendectomy because of acute appendicitis. Sixteen (2.9%) of these patients were readmitted within three years because of ...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930200105
更新日期:1982-05-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:The single-arm ROSiA study evaluated frontline bevacizumab for advanced ovarian cancer. We explored how discordant surgically and radiologically assessed postoperative residual disease affects outcomes. METHODS:After debulking surgery, 1021 patients received 4 to 8 cycles of carboplatin-pacli...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.25647
更新日期:2019-09-01 00:00:00
abstract:INTRODUCTION:Two to three percent of the patients with extremity melanoma develop in-transit metastases in the course of their disease. When local treatments fail, isolated limb perfusion (ILP) is a reasonable option, but is generally only applied to patients without evidence of distant metastases. We assessed the valu...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.20297
更新日期:2005-08-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Argyrophilic nucleolar organizer regions (AgNORs) have been recently identified as a marker of proliferative index in various tumors. These were evaluated in 46 patients with primary breast carcinoma and were correlated with clinical prognostic parameters of breast cancer. Ten patients with be...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/(sici)1096-9098(199707)65:3<201::aid-jso10
更新日期:1997-07-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Retinoids are metabolized in human intestinal epithelial cells to all-trans retinoic acid; however, it is unknown whether these cells express retinoid receptors, and whether sensitivity or resistance to the hormone is associated with a particular pattern of expression of retinoid-responsive ge...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/(sici)1096-9098(199711)66:3<156::aid-jso2>
更新日期:1997-11-01 00:00:00