Prognosis of T4 gastric carcinoma patients: an appraisal of aggressive surgical treatment.

Abstract:

BACKGROUND AND OBJECTIVES:Despite precipitous drop in the incidence of gastric carcinoma in Japan, it is still one of the leading causes of death associated with malignant disease. Once the contiguous organs are involved the prognosis becomes dismal. Prognostic factors governing the survival of patients with T4 gastric carcinoma remain unclear. METHODS:Between 1980 and 1998, 150 patients were treated for T4 gastric carcinoma. Results and prognostic factors were evaluated by univariate and multivariate analyses. RESULTS:With a 73% resectability, patients with tumor resection had a significantly (P < 0.0001) improved survival rate. Within an acceptable operative mortality (2.6%), apparently curative cases had survival benefit (P < 0.0001) over noncurative cases. In the multivariate analysis, the death risk increased by 2.18 (relative risk) when splenectomy was spared from the operative procedure (P < 0.0071). Presence of esophageal invasion was the other independent prognostic factor in T4 gastric carcinoma patients (relative risk 2.11). Conventional prognostic factors along with the type of organs invaded by the carcinoma had no impact on prognosis. CONCLUSIONS:Patients with T4 gastric carcinoma might be benefited from aggressive surgery with a curative intent. Whenever possible, splenectomy should be done along with invaded organ resection.

journal_name

J Surg Oncol

authors

Dhar DK,Kubota H,Tachibana M,Kinugasa S,Masunaga R,Shibakita M,Kohno H,Nagasue N

doi

10.1002/jso.1046

subject

Has Abstract

pub_date

2001-04-01 00:00:00

pages

278-82

issue

4

eissn

0022-4790

issn

1096-9098

pii

10.1002/jso.1046

journal_volume

76

pub_type

杂志文章
  • Intraperitoneal cisplatin with sodium thiosulfate protection in rats with intestinal anastomoses.

    abstract::Intraperitoneal (IP) cisplatin administered at the time of intraabdominal malignancies such as gastric cancer may prevent or delay intraabdominal recurrence. Perioperative IP cisplatin raises concerns regarding systemic toxicity and retardation of wound healing. Systemic cisplatin toxicity may be reduced by administer...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.2930520415

    authors: Wile AG,Dileo SK,Gossett DA,Lao XY

    更新日期:1993-04-01 00:00:00

  • Gastrointestinal carcinoids: extrahepatic metastases and symptomatology following resection.

    abstract::Of 49 patients with midgut and hindgut carcinoids, second primary distinct carcinomas occurred in 12. The most aggressive carcinoids were the 24 that arose in the distal small bowel and cecum. Of the patients affected, 15 had lymph node metastases and eight had liver metastases at the time of diagnosis. That only five...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.2930110309

    authors: Dilawari RA,Douglass HO Jr

    更新日期:1979-01-01 00:00:00

  • Inhibition of melanoma growth in hamsters by type-2 adenovirus.

    abstract::Type-2 adenovirus was shown to inhibit the growth of transplantable hamster melanoma in 70% of Syrian hamsters without any injurious effect to the host. Greatest inhibition of tumor formation was seen when animals were injected with 10(6) TCD50 of adenovirus and 2.5 x 10(5) tumor cells, or 10(6) TCD50 of virus and 5.0...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.2930070514

    authors: Khoobyarian N,Barone F,Sabet T,El-Domeiri AA,Das Gupta TK

    更新日期:1975-01-01 00:00:00

  • Oncologic safety of propeller flap and free flap in reconstruction after soft tissue sarcoma resection.

    abstract:BACKGROUND AND OBJECTIVES:The propeller flap is a reliable option for reconstruction after soft tissue sarcoma resection. However, some parts of the resection margin may move away from its original position during flap rotation and thus can be excluded from the clinical target volume of adjuvant radiotherapy. This stud...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.26076

    authors: Cha HG,Kang MK,Kim W,Lee JS,Hong JP,Suh HP

    更新日期:2020-06-28 00:00:00

  • Prognostic utility of albumin-bilirubin grade for short- and long-term outcomes following hepatic resection for intrahepatic cholangiocarcinoma: A multi-institutional analysis of 706 patients.

    abstract:BACKGROUND:The objective of the current study was to define the impact of albumin-bilirubin (ALBI) grade on short- as well as long-term outcomes among patients with intrahepatic cholangiocarcinoma (ICC). METHODS:Patients who underwent hepatectomy for ICC between 1990 and 2016 were identified using an international mul...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章,多中心研究

    doi:10.1002/jso.25486

    authors: Tsilimigras DI,Hyer JM,Moris D,Sahara K,Bagante F,Guglielmi A,Aldrighetti L,Alexandrescu S,Marques HP,Shen F,Koerkamp BG,Endo I,Pawlik TM,other members of the International Intrahepatic Cholangiocarcinoma Study Group.

    更新日期:2019-08-01 00:00:00

  • Preoperative chemotherapy followed by mastectomy for locally advanced breast cancer.

    abstract::Six patients with advanced local-regional breast cancer were reviewed. Five out of the six patients previously had had radiation therapy as part of the initial therapy. All patients had preoperative cycles of combination chemotherapy, either CMF or CAF. The two stage III patients had greater than 75% reduction in meas...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.2930220415

    authors: Schick P,Goodstein J,Moor J,Butler J,Senter KL

    更新日期:1983-04-01 00:00:00

  • Src activity is increased in gastrointestinal stromal tumors--analysis of associations with clinical and other molecular tumor characteristics.

    abstract:BACKGROUND:Increased activity of Src has been found in several human cancers, and often is associated with poor clinical outcome. The present study aimed to determine whether Src activity is increased in gastrointestinal stromal tumors (GIST), and whether it correlates with established tumor or patient characteristics ...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.23544

    authors: Rotert JV,Leupold J,Hohenberger P,Nowak K,Allgayer H

    更新日期:2014-05-01 00:00:00

  • Liver resection for metastatic melanoma: equivalent survival for cutaneous and ocular primaries.

    abstract:BACKGROUND:The value of surgical resection in patients with hepatic metastases from melanoma is poorly documented in the literature. This study sought to determine the clinicopathologic and surgical factors predictive of outcome for melanoma patients who underwent resection of hepatic metastases. METHODS:Thirty-three ...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.23361

    authors: Ryu SW,Saw R,Scolyer RA,Crawford M,Thompson JF,Sandroussi C

    更新日期:2013-08-01 00:00:00

  • Desmoplastic melanoma - the step-child in the melanoma family?

    abstract:BACKGROUND AND OBJECTIVES:Desmoplastic melanoma (DM) is a rare variant of cutaneous melanoma. Our goal was to study the surgical management of DM, identify prognostic factors, and impact of treatment options. METHODS:Patients with DM (n = 1,735) were identified from the Surveillance, Epidemiology, and End Results data...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.21778

    authors: Wasif N,Gray RJ,Pockaj BA

    更新日期:2011-02-01 00:00:00

  • Human papillomavirus-related cell cycle markers can predict survival outcomes following a transoral lateral oropharyngectomy for tonsillar squamous cell carcinoma.

    abstract:OBJECTIVES:To identify the prognostic implications of human papillomavirus (HPV)-related cell cycle marker profiles in patients who have received a transoral lateral oropharyngectomy (TLO) as a primary treatment for tonsillar squamous cell carcinoma (TSCC). PATIENTS AND METHODS:Immunohistochemical profiles of HPV-rela...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.23672

    authors: Ryu CH,Ryu J,Cho KH,Moon SH,Yun T,Lee SH,Choi MK,Park WS,Jung YS

    更新日期:2014-09-01 00:00:00

  • Community melanoma research: from start up to follow up.

    abstract::Most surgical oncologists receive exposure to clinical studies in their fellowships; however they receive little if any practical knowledge as to how to become a clinical researcher. This article will provide a broad introduction to setting up a community based surgical oncology research program with emphasis on the p...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章,评审

    doi:10.1002/jso.21780

    authors: Beitsch P,Huber T

    更新日期:2011-09-01 00:00:00

  • Growth index, assessed with Ki-67 and ssDNA labeling; a significant prognosticator for patients undergoing curative resection for hepatocellular carcinoma.

    abstract:BACKGROUND AND OBJECTIVES:The aggressiveness and greater malignant potential of cancers are characterized by several biological phenomena such as accelerated growth invasiveness, and the ability to form distant metastasis. Thus, knowledge of such biological difference may be a more accurate prognosticator for cancer pa...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.20309

    authors: Morinaga S,Ishiwa N,Noguchi Y,Yamamoto Y,Rino Y,Imada T,Takanashi Y,Akaike M,Sugimasa Y,Takemiya S

    更新日期:2005-12-15 00:00:00

  • Extrahepatic metastasectomy for hepatocellular carcinoma: Predictors of long-term survival.

    abstract:INTRODUCTION:We report our institutional experience with extrahepatic metastasectomy (EM) in a cohort of hepatocellular carcinoma (HCC) patients with focus on predictors of survival. METHODS:All patients diagnosed with metastatic HCC from 2001 to 2014 were retrospectively reviewed to identify those who underwent EM wi...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.24340

    authors: Berger Y,Spivack JH,Heskel M,Aycart SN,Labow DM,Sarpel U

    更新日期:2016-09-01 00:00:00

  • Levels of tissue polypeptide antigen in serum and the progression of gastric cancer.

    abstract::Correlations between levels of tissue polypeptide antigen (TPA) in serum and histologic stage or progression of cancer were studied in 94 patients with gastric cancer. Levels of TPA in serum from patients with cancerous invasion into the vein of the stomach wall (v-invasion) were elevated in parallel to the progressio...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.2930410214

    authors: Hamazoe R,Koga S,Maeta M,Shimizu N,Inoue Y,Ishiguro M,Murakami A

    更新日期:1989-06-01 00:00:00

  • Comparison of R1 and R2 gastrectomy for gastric cancer in patients over 80 years of age.

    abstract::To evaluate the benefit of R2 gastrectomy for gastric cancer in Japanese patients over 80 years of age, data on 93 patients who underwent gastrectomy between 1967 and 1989 were collected retrospectively from charts filed in the Kyushu University Hospital and two affiliated national hospitals. Of 93 patients, 62 had a ...

    journal_title:Journal of surgical oncology

    pub_type: 临床试验,杂志文章

    doi:10.1002/jso.2930480213

    authors: Korenaga D,Baba H,Kakeji Y,Orita H,Haraguchi M,Maehara Y,Saku M,Sugimachi K

    更新日期:1991-10-01 00:00:00

  • Prognostic impact of extra-nodal extension in thyroid cancer: A meta-analysis.

    abstract:BACKGROUND AND OBJECTIVES:Lymph node involvement is common in thyroid cancer, but the system of staging does not consider the histological features of lymph node metastases. We conducted a meta-analysis to investigate the prognostic role of extranodal extension (ENE) in thyroid cancer patients. METHODS:We ran PubMed a...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章,meta分析,评审

    doi:10.1002/jso.24070

    authors: Veronese N,Luchini C,Nottegar A,Kaneko T,Sergi G,Manzato E,Solmi M,Scarpa A

    更新日期:2015-12-01 00:00:00

  • The mortality rate from lung metastases in animals inhaling nitrogen dioxide (NO2).

    abstract::A study was carried out to determine the interrelationship between the inhalation of nitrogen dioxide (0.4 +/- 0.50 ppm), lung metastases development from circulating cancer cells, and death rate from such metastases. C57 BL/6J mice were used in these experiments. Animals were divided into control and NO2-exposed grou...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.2930280115

    authors: Richters A,Richters V,Alley WP

    更新日期:1985-01-01 00:00:00

  • Advantages of patient-derived orthotopic mouse models and genetic reporters for developing fluorescence-guided surgery.

    abstract::Fluorescence-guided surgery can enhance the surgeon's ability to achieve a complete oncologic resection. There are a number of tumor-specific probes being developed with many preclinical mouse models to evaluate their efficacy. The current review discusses the different preclinical mouse models in the setting of probe...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章,评审

    doi:10.1002/jso.25150

    authors: Lwin TM,Hoffman RM,Bouvet M

    更新日期:2018-08-01 00:00:00

  • Human colorectal carcinoma: patterns of sensitivity to chemotherapeutic agents in the human tumor stem cell assay.

    abstract::The human tumor stem cell assay (HTSCA) was applied to 103 primary and metastatic colorectal carcinomas. Thirty-four carcinomas could not be evaluated for colony formation (clonogenicity) because of microbial contamination. Of the remaining 69 carcinomas, 18 (26%) demonstrated clonal growth in vitro. Colony formation ...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.2930200311

    authors: Agrez MV,Kovach JS,Beart RW Jr,Rubin J,Moertel CG,Lieber MM

    更新日期:1982-07-01 00:00:00

  • Prognostic significance of the age factor in the thyroid cancer: statistical analysis.

    abstract:BACKGROUND AND OBJECTIVES:To determine whether thyroid carcinoma in elderly patients presents any peculiar characteristics, whether the greater biological aggressiveness of the neoplasm modifies the surgical treatment selected, and whether age greater than 70 years represents an independent prognostic factor. METHODS:...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.20140

    authors: Falvo L,Catania A,Sorrenti S,D'Andrea V,Berni A,De Stefano M,De Antoni E

    更新日期:2004-12-15 00:00:00

  • Contiguous invasion per se does not affect prognosis in colon cancer.

    abstract:BACKGROUND:Locally advanced colon cancer can result in serious clinical conditions unless treated appropriately. The aim of this study was to examine the feasibility of en bloc resection and the significance of depth of invasion by analyzing the outcomes of the procedure in colon cancer invading adjacent organs. METHO...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.21165

    authors: Oh SY,Kim YB,Paek OJ,Suh KW

    更新日期:2009-01-01 00:00:00

  • Impact of delayed care on surgical management of patients with gastric cancer in a low-resource setting.

    abstract:BACKGROUND:Gastric cancer is the fifth most common cancer in Eastern Africa. Diagnostic delays in low-resource countries result in advanced disease presentation. We describe perioperative management of gastric cancer in Rwanda. METHODS:A retrospective review of records at three hospitals was performed to identify gast...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章,多中心研究

    doi:10.1002/jso.25286

    authors: Martin AN,Silverstein A,Ssebuufu R,Lule J,Mugenzi P,Fehr A,Mpunga T,Shulman LN,Park PH,Costas-Chavarri A

    更新日期:2018-12-01 00:00:00

  • Augmentation of lymphoproliferative activity of tumor-bearing BALB/c mice to soluble tumor antigens by surgical manipulation: the possible role of macrophages.

    abstract::Lymphoproliferative activity was assessed by 3H-thymidine incorporation in spleen cells of mammary tumor bearing BALB/c mice, mice which had their tumors surgically removed, and mice with sham surgery after stimulation in vitro with a soluble extract of syngeneic tumor antigens. Surgical removal of tumors caused an av...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.2930350102

    authors: Laing CA,Japal KM,Baker ME

    更新日期:1987-05-01 00:00:00

  • Prognostic factors in patients with recurrent differentiated thyroid carcinoma.

    abstract:BACKGROUND:Approximately 20% of patients with thyroid carcinoma have relapse. To evaluate the factors affecting their disease-free survival and prognosis, we studied 68 patients with recurrent differentiated thyroid carcinoma, ranging in age from 5 to 73 years (mean: 47.6 years). Three-fourths of patients were followed...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/(sici)1096-9098(199703)64:3<202::aid-jso5>

    authors: Asakawa H,Kobayashi T,Komoike Y,Tamaki Y,Matsuzawa Y,Monden M

    更新日期:1997-03-01 00:00:00

  • Survival after conservative (palliative) management of pleural malignant mesothelioma.

    abstract:BACKGROUND AND OBJECTIVES:Malignant mesothelioma is a lethal disease. Aggressive multimodality treatment protocols are reportedly associated with improved survival, but the apparent survival benefits may simply reflect patient selection and the variable natural history of this malignancy. Before embarking on our own pr...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.1143

    authors: Merritt N,Blewett CJ,Miller JD,Bennett WF,Young JE,Urschel JD

    更新日期:2001-11-01 00:00:00

  • A complication of the implantable constant infusion chemotherapy pump.

    abstract::The treatment of metastatic colorectal cancer to the liver has been a significant problem for clinicians in the past. Recent technical advances in infusion systems in the form of the infusaid pump has allowed delivery of chemotherapeutic agents to the liver with great reliability. As more chemotherapy pumps are implan...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.2930270410

    authors: Pietrafitta JJ

    更新日期:1984-12-01 00:00:00

  • Recurrent pleomorphic adenoma of the parotid gland: Institutional experience and review of the literature.

    abstract:BACKGROUND:Recurrent pleomorphic adenoma (PA) of the parotid gland is a challenging surgical issue with controversy regarding management and long term outcome. METHODS:All patients who were operated for recurrent PA of the parotid gland between the years 1991 and 2013 were reviewed. Patient demographics, clinicopathol...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.24392

    authors: Abu-Ghanem Y,Mizrachi A,Popovtzer A,Abu-Ghanem N,Feinmesser R

    更新日期:2016-11-01 00:00:00

  • Actual 10-year survivors and 10-year recurrence free survivors after primary liver resection for hepatocellular carcinoma in the 21st century: A single institution contemporary experience.

    abstract:BACKGROUND:At present, the majority of outcome studies of survival of hepatocellular carcinoma (HCC) post-liver resection (post-LR) present actuarial survival data, which often results in overestimation of survival. We sought to evaluate the actual 10-year survival post-LR for HCC and identify variables that are associ...

    journal_title:Journal of surgical oncology

    pub_type: 临床试验,杂志文章

    doi:10.1002/jso.26259

    authors: Linn YL,Chee MY,Koh YX,Teo JY,Cheow PC,Chow PKH,Chan CY,Chung AYF,Ooi LLPJ,Goh BKP

    更新日期:2021-01-01 00:00:00

  • Argyrophilic nucleolar organizer regions: their value and correlation with clinical prognostic factors in breast carcinoma.

    abstract:BACKGROUND AND OBJECTIVES:Argyrophilic nucleolar organizer regions (AgNORs) have been recently identified as a marker of proliferative index in various tumors. These were evaluated in 46 patients with primary breast carcinoma and were correlated with clinical prognostic parameters of breast cancer. Ten patients with be...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/(sici)1096-9098(199707)65:3<201::aid-jso10

    authors: Kumar A,Kushwaha AK,Kumar M,Gupta S

    更新日期:1997-07-01 00:00:00

  • Kindred spirits of the endocrines: the training of the future endocrine surgeons.

    abstract::The growth of knowledge and complexity now seen in General Surgery, has led to the sub-specialization of the discipline. Although it is considered by some to have led to the fragmentation of General Surgery and the erosion of the specialty as we know it today, others would argue that it has and will continue to lead t...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.20176

    authors: Pasieka JL

    更新日期:2005-03-01 00:00:00