Impact of delayed care on surgical management of patients with gastric cancer in a low-resource setting.

Abstract:

BACKGROUND:Gastric cancer is the fifth most common cancer in Eastern Africa. Diagnostic delays in low-resource countries result in advanced disease presentation. We describe perioperative management of gastric cancer in Rwanda. METHODS:A retrospective review of records at three hospitals was performed to identify gastric adenocarcinoma cases from January 2012 to June 2016. Multiple perioperative and tumor-related variables were collected. Descriptive and bivariate analyses were performed. RESULTS:The final analysis included 229 patients with gastric cancer. Median age was 58 years (interquartile range [IQR] 49-65) and 49.6% were female (n = 114). Patients reported symptoms (ie, weight loss, epigastric pain) for a median time of 12 months (IQR 7.5-24). On presentation, 18.8% ( n = 43) had gastric outlet obstruction; 13.5% ( n = 31) had a palpable mass. Fifty-one percent ( n = 117) underwent an operation; of these, 74% ( n = 86) received gastrojejunostomy or were inoperable; and 29% ( n = 34) underwent curative resection. Palliative care referrals were made for 9% ( n = 20). Pathology reports were available for 190 patients (83.0%). Only 11.3% ( n = 26) had Helicobacter pylori ( H. pylori) testing of which 65.4% tested positive ( n = 17). CONCLUSIONS:A majority of patients presented with advanced disease. Very few patients had a curative resection. Significant advances in diagnosis and treatment are needed to improve the care of gastric cancer patients in Rwanda.

journal_name

J Surg Oncol

authors

Martin AN,Silverstein A,Ssebuufu R,Lule J,Mugenzi P,Fehr A,Mpunga T,Shulman LN,Park PH,Costas-Chavarri A

doi

10.1002/jso.25286

subject

Has Abstract

pub_date

2018-12-01 00:00:00

pages

1237-1242

issue

8

eissn

0022-4790

issn

1096-9098

journal_volume

118

pub_type

杂志文章,多中心研究
  • The role and value of surgery in metastatic renal adenocarcinoma: a retrospective clinical study of 106 nephrectomized cases.

    abstract::The results of treatment of 106 consecutive nephrectomized cases with metastatic renal adenocarcinoma were analyzed. Over 50% of the patients were dead at 1 year and more than 80% at 2 years from the first metastases. The corresponding 5-year survival rate was 7.3%. Fourteen patients demonstrated a response to radioth...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.2930260213

    authors: Appelqvist P

    更新日期:1984-06-01 00:00:00

  • The role of preoperative positron emission tomography/computed tomography (PET/CT) in patients with high-risk melanoma.

    abstract:BACKGROUND:Positron emission tomography/computed tomography (PET/CT) scanning is commonly used for the preoperative staging of patients with at least intermediate thickness (>1 mm) melanomas. Its role in staging at initial diagnosis for clinically asymptomatic patients is not yet established. METHODS:We examined recor...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.23549

    authors: Barsky M,Cherkassky L,Vezeridis M,Miner TJ

    更新日期:2014-06-01 00:00:00

  • Postradiation slipped capital femoral epiphyses (SCFE).

    abstract::This study details the case reports of two children who developed slipped capital femoral epiphyses (SCFE) after receiving external irradiation. The clinical and diagnostic features of postradiation SCFE are reviewed and discussed. Guidelines for the management of children who receive pelvic irradiation are presented....

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.2930360110

    authors: Sabio H,Sussman M,Levien M

    更新日期:1987-09-01 00:00:00

  • Profunda artery perforator flap for isolated vulvar defect reconstruction after oncological resection.

    abstract:UNLABELLED:Isolated vulvar reconstruction using profunda artery-based perforator flaps have good functional as well as quality of life restoration. Surgical techniques, complications, and final evaluation using questionnaires are presented. BACKGROUND:Vulvar reconstruction remains a great challenge to reconstructive s...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.24233

    authors: Chang TN,Lee CH,Lai CH,Wu CW,Chang CS,Cheng MH,Huang JJ

    更新日期:2016-06-01 00:00:00

  • Advantages of patient-derived orthotopic mouse models and genetic reporters for developing fluorescence-guided surgery.

    abstract::Fluorescence-guided surgery can enhance the surgeon's ability to achieve a complete oncologic resection. There are a number of tumor-specific probes being developed with many preclinical mouse models to evaluate their efficacy. The current review discusses the different preclinical mouse models in the setting of probe...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章,评审

    doi:10.1002/jso.25150

    authors: Lwin TM,Hoffman RM,Bouvet M

    更新日期:2018-08-01 00:00:00

  • Lung resection for metastatic sarcomas: total survival from primary treatment.

    abstract::The results of surgical management of 63 cases of pulmonary metastases from bone and soft tissue sarcomas, admitted at the Istituto Nazionale Tumori of Milan, between 1970 and 1987, are reviewed in this paper. To estimate the relative impact of metastasectomy on the overall performance of treatment, survival curves we...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.2930400414

    authors: Pastorino U,Valente M,Gasparini M,Azzarelli A,Santoro A,Alloisio M,Ongari M,Tavecchio L,Ravasi G

    更新日期:1989-04-01 00:00:00

  • Effect of tumor size on monoclonal antibody uptake in a metastatic model.

    abstract::We studied the effect of tumor size on monoclonal antibody (mAb) in a murine hepatic model. Intrasplenic injection of HT-29 LMM metastatic human colon cancer cell line reproducibility results in hepatic metastases formation in congenitally athymic mice. HT-29-15, a murine mAb of the IgG1 class reactive with the HT-29 ...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.2930490409

    authors: Yoshida K,Rivoire ML,Divgi CR,Niedzwiechi D,Cohen AM,Sigurdson ER

    更新日期:1992-04-01 00:00:00

  • Patient generated health data and electronic health record integration in oncologic surgery: A call for artificial intelligence and machine learning.

    abstract::In this review, we aim to assess the current state of science in relation to the integration of patient-generated health data (PGHD) and patient-reported outcomes (PROs) into routine clinical care with a focus on surgical oncology populations. We will also describe the critical role of artificial intelligence and mach...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章,评审

    doi:10.1002/jso.26232

    authors: Melstrom LG,Rodin AS,Rossi LA,Fu P Jr,Fong Y,Sun V

    更新日期:2021-01-01 00:00:00

  • Therapeutic significance of palliative operations for gastric cancer for survival and quality of life.

    abstract:BACKGROUND AND OBJECTIVES:There have been few reports on the objective assessment of quality of life (QOL) in patients with gastric cancer following palliative operations. The benefit of a palliative operation for survival and QOL of patients with gastric cancer is not clear. METHODS:Survival and hospital-free surviva...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/(sici)1096-9098(199809)69:1<41::aid-jso8>3

    authors: Ouchi K,Sugawara T,Ono H,Fujiya T,Kamiyama Y,Kakugawa Y,Mikuni J,Yamanami H

    更新日期:1998-09-01 00:00:00

  • New therapeutic strategy for gastric carcinoma: a two-step evaluation of malignant potential from its molecular biologic and pathologic characteristics.

    abstract:BACKGROUND AND OBJECTIVES:A previous study of ours indicated that platelet-derived growth factor-A (PDGF-A) mRNA expression in biopsy specimens can identify a subgroup of high-risk gastric carcinoma patients, while clinicopathologic studies have shown that lymph node involvement is an important risk factor for predicti...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/(sici)1096-9098(199911)72:3<142::aid-jso6>

    authors: Kuwahara A,Katano M,Nakamura M,Fujimoto K,Miyazaki K,Mori M,Morisaki T

    更新日期:1999-11-01 00:00:00

  • Novel nomogram combining depth of invasion and size can accurately predict the risk for regional nodal metastases for appendiceal neuroendocrine tumors (A-NET).

    abstract:INTRODUCTION:The need for regional lymphadenectomy for treating appendiceal neuroendocrine tumors (A-NET) is determined by the risk of nodal metastasis. Current guidelines for A-NET are solely based on tumor size. Methods Patients with A-NET from 1988 to 2012 were identified from the SEER registry. The depth of invasio...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.24714

    authors: Mosquera C,Fitzgerald TL,Vora H,Grzybowski M

    更新日期:2017-11-01 00:00:00

  • Long noncoding RNA LINC01133 inhibits oral squamous cell carcinoma metastasis through a feedback regulation loop with GDF15.

    abstract:BACKGROUND AND OBJECTIVES:Long noncoding RNAs (lncRNAs) play key roles in carcinoma metastasis. We aimed to investigate lncRNA LINC01133 in oral squamous cell carcinoma (OSCC) metastasis. METHODS:The RNA levels of LINC01133 and growth and differentiation factor 15 (GDF15) in tissue samples from OSCC patients, and OSCC...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.25278

    authors: Kong J,Sun W,Zhu W,Liu C,Zhang H,Wang H

    更新日期:2018-12-01 00:00:00

  • Ongoing and future directions in the management of metastatic colorectal cancer: Update on clinical trials.

    abstract::Metastatic colorectal cancer (mCRC) continues to show poor outcomes, with many patients exhausting effective standard-of-care therapy. To explore the current landscape of clinical trials for mCRC, we reviewed over 600 clinical trials that are currently ongoing for mCRC patients. Immunotherapeutic agents form approxima...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章,评审

    doi:10.1002/jso.25441

    authors: Advani S,Kopetz S

    更新日期:2019-04-01 00:00:00

  • Modified radiofrequency-assisted liver resection: a new device.

    abstract:BACKGROUND:Radiofrequency ablation (RF) is emerging as new therapeutic method for the management of hepatic tumors. So far the RF-assisted hepatectomy has been described using an electrode initially designed for ablation of unresectable tumors. Herein, we describe a new technique for liver resection using a bipolar rad...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.20770

    authors: Zacharoulis D,Tzovaras G,Rountas C,Poultsidis A,Katsogridakis E,Sioka E,Hatzitheofilou C

    更新日期:2007-09-01 00:00:00

  • Liver scanning in newly diagnosed breast carcinoma.

    abstract::The records of 111 consecutive cases of carcinoma of the breast were reviewed and yielded 66 patients who had undergone liver scanning and determination of the serum alkaline phosphatase (alk p'tase), lactic dehydrogenase (LDH), and serum glutamic oxaloacetic transaminase (SGOT). Four of the 66 patients (6.1%) had a f...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.2930130313

    authors: Haid M,Singh J,Nevinny HB

    更新日期:1980-01-01 00:00:00

  • Extra-adrenal paraganglioma and pulmonary chondroma: a case report and review of the literature.

    abstract::This report describes the findings of an extra-adrenal paraganglioma and chondroma of the lung in an elderly man. Tissue analysis of the paraganglioma showed a high level of catecholamines, as well as the presence of somatostatin and small amounts of other peptide hormones. Immunoperoxidase staining demonstrated the d...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.2930350205

    authors: Keyhani-Rofagha S,O'Dorisio TM,Lucas JG,Fontana MB,Tuttle SE

    更新日期:1987-06-01 00:00:00

  • Colony stimulating activity in sera of erythroleukemic mice (RLV-A).

    abstract::RLV-A serum activity was measured by the agar colony assay to determine the effect of this erythroid dyscrasia on the granulopoietic humoral regulator, colony stimulating factor (CSF). In general, the sera of early, midstage and terminal animals not given endotoxin had high cluster forming properties compared to norma...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.2930130312

    authors: Koltun L,Lobue J,Gordon AS,Fredrickson TN

    更新日期:1980-01-01 00:00:00

  • Duodenojejunostomy and stapled occlusion for distal duodenal perforation from malignant retroperitoneal tumors.

    abstract::Three patients with unresectable malignant retroperitoneal tumors that invaded and perforated the distal duodenum presented with sepsis unresponsive to antibiotics. A technique of proximal side-to-side duodenojejunostomy with stapled occlusion of the distal duodenum resulted in successful diversion and immediate resol...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.2930260410

    authors: Kostroff KM,Turnbull AD,Rotstein LE,Raaf JH

    更新日期:1984-08-01 00:00:00

  • Plasma proteins as indices of response to nutritional therapy in cancer patients.

    abstract::The use of plasma albumin (ALB), transferrin (TFN), prealbumin (TBPA), retinol-binding protein (RBP), triceps skin fold (TSF), and midarm muscle circumference (MAMC) as determinants of response to nutritional therapy (TPN) was investigated in 40 cancer patients during preoperative TPN. Thirty-one patients received 90%...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.2930290306

    authors: Ota DM,Frasier P,Guevara J,Foulkes M

    更新日期:1985-07-01 00:00:00

  • Early postoperative outcomes among patients with delayed surgeries after preoperative positive test for SARS-CoV-2: A case-control study from a single institution.

    abstract:BACKGROUND:There are limited data on surgical complications for patients that have delayed surgery after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. We aimed to analyze the surgical outcomes of patients submitted to surgery after recovery from SARS-CoV-2 infection. METHODS:Asymptomatic pati...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.26377

    authors: Baiocchi G,Aguiar S Jr,Duprat JP,Coimbra FJF,Makdissi FB,Vartanian JG,Zequi SC,Gross JL,Nakagawa SA,Yazbek G,Diniz TP,Gonçalves BT,Zurstrassen CE,Campos HGDA,Joaquim EHG,França E Silva IA,Kowalski LP

    更新日期:2021-01-11 00:00:00

  • Unusual origins of Pseudomyxoma peritonei.

    abstract::Pseudomyxoma peritonei is a rare neoplastic condition in that gelatinous intraperitoneal fluid collections and mucinous implants on the peritoneal surfaces and omentum are found. The pathological origin is usually an adenoma or well-differentiated adenocarcinoma of the appendix. A smaller number of cases arises from o...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/1096-9098(200012)75:4<270::aid-jso9>3.0.co

    authors: de Bree E,Witkamp A,Van De Vijver M,Zoetmulde F

    更新日期:2000-12-01 00:00:00

  • Shared decision-making: applying a person-centered approach to tailored breast reconstruction information provides high satisfaction across a variety of breast reconstruction options.

    abstract:BACKGROUND:A person-centered approach to co-decision-making using tailored information respects each woman's preferences and may heighten breast reconstruction satisfaction. METHODS:Women seeking breast reconstruction underwent initial and follow-up consultations wherein suitable options were discussed, and take-away ...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.23721

    authors: Temple-Oberle C,Ayeni O,Webb C,Bettger-Hahn M,Ayeni O,Mychailyshyn N

    更新日期:2014-12-01 00:00:00

  • Prognostic factors in alveolar soft part sarcoma: A SEER analysis.

    abstract:OBJECTIVES:We reviewed the clinical characteristics and outcomes of patients treated for alveolar soft part sarcoma (ASPS) and analyzed the effect of surgery for patients presenting with and without metastatic disease (DM). METHODS:The SEER Registry was queried for patients with ASPS from 1973-2012. The Kaplan-Meier e...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.24183

    authors: Wang H,Jacobson A,Harmon DC,Choy E,Hornicek FJ,Raskin KA,Chebib IA,DeLaney TF,Chen YL

    更新日期:2016-04-01 00:00:00

  • National quality measurement using clinical indicators: the Danish National Indicator Project.

    abstract::This article describes the Danish National Indicator Project that aims to document and improve the quality of care at national level. Specific clinical indicators, standards, and prognostic factors have been developed for eight diseases (e.g. lung cancer). It has been implemented in all clinical departments in Denmark...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.21192

    authors: Mainz J,Hansen AM,Palshof T,Bartels PD

    更新日期:2009-06-15 00:00:00

  • Cecal carcinoma: a different colon malignancy?

    abstract::Cecal carcinoma has been associated with a poorer prognosis than other colon carcinomas because of the presumed longstanding obscure symptoms. In a combined study of three Dutch hospitals, a total of 166 patients with cecal carcinoma were evaluated after right hemicolectomy. Special emphasis was placed on clinical sym...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.2930440309

    authors: Leenen LP,Wobbes T,Hoekstra HJ,van der Werken C

    更新日期:1990-07-01 00:00:00

  • Expression of desmoglein I in squamous cell carcinoma of the esophagus.

    abstract::Desmoglein I (DGI) is major component of the desmosomal membrane core that plays an important role in epithelial cell adhesion. The aim of this study was to explore the correlation between the expression of DGI and the clinicopathological findings of esophageal cancer. DGI expression was immunohistochemically examined...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.2930570207

    authors: Natsugoe S,Aikou T,Shimada M,Kumanohoso T,Tezuka Y,Sagara M,Yoshinaka H,Baba M,Fukumoto T

    更新日期:1994-10-01 00:00:00

  • The epidermal growth factor receptor gene sequence is highly conserved in primary gastric cancers.

    abstract:BACKGROUND AND OBJECTIVES:Recent studies have disclosed the presence of somatic mutations in the epidermal growth factor receptor (EGFR) gene in non-small cell lung cancers (NSCLC), and susceptibility to the EGFR tyrosine kinase inhibitor (gefitinib) was determined by the presence of mutations in the kinase domain of t...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.20426

    authors: Mimori K,Nagahara H,Sudo T,Ishii H,Yamashita K,Barnard GF,Mori M

    更新日期:2006-01-01 00:00:00

  • Effect of impaired renal function on tamoxifen.

    abstract::There is no information available in the literature on the blood levels of tamoxifen in patients with decreased renal function. As serious side effects of tamoxifen administered at high doses have been reported, a patient with decreased renal function and metastatic breast cancer was studied to determine the blood lev...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.2930270404

    authors: Sutherland CM,Sternson LA,Muchmore JH,Ball JE,Cerise EJ

    更新日期:1984-12-01 00:00:00

  • Gastric cancer: biology and clinical manifestations in Israel.

    abstract:BACKGROUND:Gastric cancer (GC) in Israel remains incompletely characterized. The aim of this study was to define the clinical and pathological characteristics of GC in Israel and to compare them to the general Western population. PATIENTS AND METHODS:This is a retrospective analysis of 461 consecutive GC patients trea...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章

    doi:10.1002/jso.22078

    authors: Dreznik A,Purim O,Idelevich E,Kundel Y,Sulkes J,Sulkes A,Brenner B

    更新日期:2012-03-01 00:00:00

  • MR lymphangiography in the treatment of lymphedema.

    abstract::Lymphedema is a common condition frequently seen in cancer patients who have had lymph node dissection +/- radiation treatment. Traditional management is mainly non-surgical and unsatisfactory. Surgical treatment has relied on excisional techniques in the past. Physiologic operations have more recently been devised to...

    journal_title:Journal of surgical oncology

    pub_type: 杂志文章,评审

    doi:10.1002/jso.24337

    authors: Neligan PC,Kung TA,Maki JH

    更新日期:2017-01-01 00:00:00