Abstract:
:We studied the effect of tumor size on monoclonal antibody (mAb) in a murine hepatic model. Intrasplenic injection of HT-29 LMM metastatic human colon cancer cell line reproducibility results in hepatic metastases formation in congenitally athymic mice. HT-29-15, a murine mAb of the IgG1 class reactive with the HT-29 LMM cell line, and BL-3, an isotype-matched control mAb, were labeled with iodine 125. Labeled mAbs were injected intravenously into mice with hepatic metastases. Animals were sacrificed on day 5, and tumor and normal tissue weighed and counted. Specific mAb uptake (percent injected dose per gram, %ID/g) by hepatic metastases (5.16 +/- 3.96) was significantly greater than nonspecific uptake (1.41 +/- 0.42) (P less than 0.001). %ID/g of tumor was dependent upon the mAb used, and was independent of tumor weight; consequently, a linear correlation between tumor weight and total uptake (%ID) for specific mAb (r = 0.88, P less than 0.0001) and nonspecific mAb (r = 0.99, P less than 0.0001) administration was demonstrated. We have shown both specific and nonspecific mAb uptake per gram of tumor to be a constant for the given mAb/tumor system and with uptake of mAb to be linearly related to tumor weight.
journal_name
J Surg Oncoljournal_title
Journal of surgical oncologyauthors
Yoshida K,Rivoire ML,Divgi CR,Niedzwiechi D,Cohen AM,Sigurdson ERdoi
10.1002/jso.2930490409subject
Has Abstractpub_date
1992-04-01 00:00:00pages
249-52issue
4eissn
0022-4790issn
1096-9098journal_volume
49pub_type
杂志文章abstract::Matrix metalloproteinases (MMPs) are a group of at least 26 enzymes that facilitate cellular invasion via the degradation of the extracellular matrix. Specifically, the ability to degrade collagen types III and I is important in tumor invasion and metastasis. Over expression of the MMP-1 gene has been shown to correla...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.20100
更新日期:2004-09-01 00:00:00
abstract::Ten series mice of C3H/ST inbreds with spontaneous tumors have received 5-methyl cytidine (total 500 mice). Graded single doses of (1) 3.86, (2) 2.57, (3) 2.06, (4) 1.54, (5) 1.03, (6) 1.54, (7) 1.03, (8) 0.51, (9) 0.26, and (10) 0.13 mg/injection (three times weekly) were used. In series 1-5 the 5-methyl cytidine was...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930070614
更新日期:1975-01-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Remifentanil infusion is used as an intraoperative anesthetic for thyroidectomy, but has been associated with acute opioid tolerance and hyperalgesia. A national shortage of remifentanil provided an opportunity to study postoperative pain in patients undergoing thyroidectomy. METHODS:Retrospe...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.25746
更新日期:2019-12-01 00:00:00
abstract::In 1976 Stewart et al. (Annals of the New York Academy of Sciences 277:436-466) reported the effectiveness of adjuvant specific active immunotherapy of lung carcinoma in improving the postoperative survival of stage I lung carcinoma patients in a phase II study using lung carcinoma-associated antigen (TAA) and complet...
journal_title:Journal of surgical oncology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1002/jso.2930460104
更新日期:1991-01-01 00:00:00
abstract::We report a case of adenocarcinoma arising in a focus of heterotopic pancreas, occurring in the stomach of a 52-year-old man. The patient presented with gastric outlet obstruction. Radiographic studies revealed thickening of the gastric wall, but endoscopy failed to reveal a mucosal abnormality. A 50% distal gastrecto...
journal_title:Journal of surgical oncology
pub_type: 杂志文章,评审
doi:10.1002/jso.20087
更新日期:2004-07-15 00:00:00
abstract:INTRODUCTION:Isolated limb infusion (ILI) is a minimally invasive alternative to isolated limb perfusion (ILP) for delivering high-dose regional chemotherapy to treat locally advanced limb melanoma. The current study aimed to evaluate the applicability of ILI in four Australian tertiary referral centers outside of its ...
journal_title:Journal of surgical oncology
pub_type: 杂志文章,多中心研究
doi:10.1002/jso.23590
更新日期:2014-06-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Although race and socioeconomic status have been shown to affect outcomes in pancreatic ductal adenocarcinoma (PDAC), the impact of rural residence on the delivery of adjuvant therapy (AT) has not been studied. METHODS:Patients with resected PDAC were identified using the National Cancer Data...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.25060
更新日期:2018-06-01 00:00:00
abstract::Cecal carcinoma has been associated with a poorer prognosis than other colon carcinomas because of the presumed longstanding obscure symptoms. In a combined study of three Dutch hospitals, a total of 166 patients with cecal carcinoma were evaluated after right hemicolectomy. Special emphasis was placed on clinical sym...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930440309
更新日期:1990-07-01 00:00:00
abstract::A jaundiced patient due to inoperable bile duct carcinoma was treated by a combination of surgery, radiotherapy, and chemotherapy. At the operation an intra-abdominal, extra-choledochal bypass of the tumor was performed with a T-tube obstruction 10 months after diagnosis, and no evidence of malignancy was seen. The T-...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930130308
更新日期:1980-01-01 00:00:00
abstract::A 38-year-old woman with early stage invasive breast cancer was treated with wide excision of the tumor, axillary lymph node dissection, and breast irradiation. Three years later, she gave birth to a normal baby. She attempted breast feeding and had full lactation from the untreated breast. The irradiated breast under...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930460214
更新日期:1991-02-01 00:00:00
abstract::Tumors attached or adjacent to critical structures can often not be completely resected or resected with adequate surgical margins. Sites involving major blood vessels, the paravertebral spaces, or critical abdominal structures often present technical difficulties for standard brachytherapy procedures using I-125 or I...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930420112
更新日期:1989-09-01 00:00:00
abstract::We have operated upon six patients with cervical esophageal carcinoma and reconstructed these with free jejunal graft. The pathology of all six patients was squamous cell carcinoma, and no patient had apparent distant metastasis. The procedure was a two team approach. While the surgical oncology team resected the esop...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930420307
更新日期:1989-11-01 00:00:00
abstract::Inflammatory carcinoma of the breast is rare and lethal. Since the early 1940s, operation except for biopsy has been contraindicated in patients with inflammatory breast cancer. Results with radiotherapy alone and with radiotherapy and chemotherapy are reviewed. Results of treating patients with initial chemotherapy a...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930230408
更新日期:1983-08-01 00:00:00
abstract::While hepatic resection of metastatic colorectal carcinoma is accepted as effective in selected patients, resection of metastases to other solid organs has not gained wide acceptance. We retrospectively reviewed the records of 49 patients who had resection of isolated pulmonary (18 patients) and hepatic (31 patients) ...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930430303
更新日期:1990-03-01 00:00:00
abstract::Involvement of nose and maxilla by fibrosarcoma is extremely rare. Only a few cases of fibrosarcoma arising in this region are reported in the world literature. Two cases of fibrosarcoma are described, and the literature relating to this disease entity is briefly reviewed. Salient features helping in the diagnosis and...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930150109
更新日期:1980-01-01 00:00:00
abstract:BACKGROUND:Retroperitoneal lymphangiomatosis (RL) is a rare form of primary lymphedema featuring aberrant retroperitoneal lymphatic proliferation. It causes recurrent cellulitis, repeated interventions, and poor life quality. This study aimed to investigate proper diagnositc criteria and surgical outcomes for RL with e...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.25514
更新日期:2020-01-01 00:00:00
abstract::Recently we resected and reconstructed the sternum in two female patients with thyroid carcinoma metastatic to the sternum. Histological diagnosis of the metastatic lesion was follicular carcinoma in the first case and papillary carcinoma in the second case. Reconstruction of the sternum was accomplished by using an a...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930600413
更新日期:1995-12-01 00:00:00
abstract::There are a number of retroperitoneal pathologies that may be confused with adrenal tumors. It is important to suspect and recognize these conditions as their management and work up might be different than adrenal tumors. This review will go in to the differential diagnosis and unique features of these conditions. A m...
journal_title:Journal of surgical oncology
pub_type: 杂志文章,评审
doi:10.1002/jso.23133
更新日期:2012-10-01 00:00:00
abstract::From September 1969 through 1979, 68 patients with already locally metastasized malignant melanomas of the extremities were treated by hyperthermic regional perfusion and local excision(s). Of these, 53 patients could be evaluated after a follow-up of at least 2 years: 31 had been perfused with melphalan and 22 with m...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930200103
更新日期:1982-05-01 00:00:00
abstract:BACKGROUND AND OBJECTIVE:The therapeutic role of systematic lymph node dissection (LND) remains unclear in advanced epithelial ovarian cancer (EOC), especially during interval debulking surgery (IDS) performed after neoadjuvant chemotherapy (NAC). We analyzed the therapeutic and prognostic roles of systematic LND in ad...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.24669
更新日期:2017-09-01 00:00:00
abstract:BACKGROUND:The ARM technique was proposed to prevent arm lymphedema after ALND and/or SLN biopsy. However, several problems remain to be resolved in the practical application of this technique. METHODS:The fluorescent ARM nodes and/or lymphatics were identified using a fluorescence imaging system with subdermal inject...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.21473
更新日期:2010-03-01 00:00:00
abstract:OBJECTIVE:We investigate the neutrophil to lymphocyte ratio (NLR) as a potential prognostic factor for patients undergoing curative liver resection for colorectal liver metastasis (CRLM). METHODS:We identified patients who underwent liver resection, via our prospectively accumulated surgical database at the Royal Mars...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.23845
更新日期:2015-03-15 00:00:00
abstract::Palliative care (PC) seeks to improve the quality of life for patients facing serious illness. Several oncology organizations have guidelines about PC, reflecting the need to integrate PC into standard oncology care. Many surgical patients do not receive PC despite the need for these services and established surgical ...
journal_title:Journal of surgical oncology
pub_type: 杂志文章,评审
doi:10.1002/jso.25449
更新日期:2019-07-01 00:00:00
abstract::The association of some cases of endometrial carcinoma (EC) with hyperestrogenism is well known. The prognostic significance of concomitant endometrial hyperplasia (EH) in EC were evaluated in 142 patients with clinical stage I EC in whom lymph node assessment was carried out in 121 patients. The presence of EH was si...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930460312
更新日期:1991-03-01 00:00:00
abstract::Eight patients with sciatic nerve and sacral plexus nerve sheath tumors, seen at Louisiana State University Medical Center in Shreveport, are presented. These cases illustrate the broad spectrum of pathology and modes of presentation of patients with nerve sheath tumors in this region. Patients can be divided into 4 g...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930390103
更新日期:1988-09-01 00:00:00
abstract::Treatment of gastric cancer has evolved with the advent of randomized trials demonstrating chemotherapeutic agents with efficacy in advanced disease. Level I evidence supports delivering chemotherapy in the neoadjuvant setting; the data shows improvement in progression-free and overall survival. A clinical response to...
journal_title:Journal of surgical oncology
pub_type: 杂志文章,评审
doi:10.1002/jso.21483
更新日期:2010-03-15 00:00:00
abstract:BACKGROUND:A treatment option for patients with peritoneal mucinous carcinomatosis (PMCA) from an appendiceal neoplasm is cytoreductive surgery and perioperative intraperitoneal chemotherapy. Also, these patients are recommended for systemic chemotherapy using an oxaliplatin and 5-fluorouracil (FOLFOX) regimen. A major...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.21679
更新日期:2010-11-01 00:00:00
abstract:BACKGROUND:Leiomyosarcoma of the inferior vena cava (IVC) is a rare tumor which presents a unique surgical challenge. We present a series of six cases of leiomyosarcoma resection performed with IVC reconstruction. METHODS:Retrospective chart review was performed for patients undergoing initial operative resection of p...
journal_title:Journal of surgical oncology
pub_type: 杂志文章,评审
doi:10.1002/jso.23798
更新日期:2015-03-01 00:00:00
abstract::A comparative study of alpha-fetoprotein (AFP) and carcinoembryonic antigen (CEA) in serum was made by radioimmunoassay in 66 patients with pancreatobiliary disease with and without obstructive jaundice. biliary concentrations of these proteins were assayed in 12 patients with benign and 7 patients with malignant dise...
journal_title:Journal of surgical oncology
pub_type: 杂志文章
doi:10.1002/jso.2930190411
更新日期:1982-04-01 00:00:00
abstract::Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal neoplasm arising in the stomach. These tumors were previously classified as smooth muscle tumors, but in recent years it has become clear that they are clinically, pathologically, and molecularly distinct from other tumors and are much more common...
journal_title:Journal of surgical oncology
pub_type: 杂志文章,评审
doi:10.1002/jso.20230
更新日期:2005-06-01 00:00:00